Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    ATXN1 ataxin 1 ATXN1 was not found to be associated with longevity [21612516]. Human
    RHOBTB3 Rho-related BTB domain containing 3 RHOBTB3 was not found to be associated with longevity [21612516]. Human
    MGST2 microsomal glutathione S-transferase 2 MGST2 was not found to be associated with longevity [21612516]. Human
    IMPG2 interphotoreceptor matrix proteoglycan 2 IMPG2 was not found to be associated with longevity [21612516]. Human
    GRM7 glutamate receptor, metabotropic 7 GRM7 was not found to be associated with longevity [21612516]. Human
    SH3BP4 SH3-domain binding protein 4 SH3BP4 was not found to be associated with longevity [21612516]. Human
    CFLAR CASP8 and FADD-like apoptosis regulator CFLAR was not found to be associated with longevity [21612516]. Human
    TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa TAF5L was not found to be associated with longevity [21612516]. Human
    KCNH1 potassium voltage-gated channel, subfamily H (eag-related), member 1 KCNH1 was not found to be associated with longevity [21612516]. Human
    TMEM61 transmembrane protein 61 TMEM61 was not found to be associated with longevity [21612516]. Human
    rs135416 Human
    rs130329 Human
    rs2070325 Human
    rs6504441 Human
    rs2967137 Human
    rs1582594 Human
    rs81647 Human
    rs4777170 Human
    rs10134056 Human
    rs2277472 Human
    rs4594173 Human
    rs1584547 Human
    rs285097 Human
    rs731287 Human
    rs2147556 Human
    Factors are an extension of GenAge and GenDR.

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