Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    C4B complement component 4B (Chido blood group) Genetic variations in C4B are not associated with longevity in Italian [10219002]. Human
    C3 complement component 3 Genetic variations in C3 are not associated with longevity in Italian [10219002]. Human
    CFB complement factor B Genetic variations in CFB are not associated with longevity in Italian [10219002]. Human
    C4A complement component 4A (Rodgers blood group) Genetic variations in C4A are not associated with longevity in Italian [10219002]. Human
    ADIPOQ adiponectin, C1Q and collagen domain containing Human
    nhr-62 Nuclear Hormone Receptor family NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. *nhr-62* mediates the longevity response of *eat-2* mutants and blunts the longevity by bacterial food dilution [Heestand, et al. 2012]. Mutation in *nhr-62* suppresses the lifespan extension of eat-2(ad465) animals (p<0.001) [Heestand et al. 2013]. Wild-type (N2) worms with extrachromosomal array dhEx627 (carrying a wild-type nhr-62) exhibit a significant increase in lifespan compared to wild-type (p<0.001) [Heestand et al. 2013]. Nematode
    PDE10A phosphodiesterase 10A SNPs near PDE10A were associated to longevity [22773346]. Human
    QKI quaking homolog, KH domain RNA binding (mouse) SNPs close to SQKI were associated with longevity [22773346]. Human
    XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) XRCC5 was found to be associated with longevity [22406557; 16518718]. Human
    XDH xanthine dehydrogenase XDH was found to be associated with longevity [22406557; 22279548]. Human
    NTHL1 nth endonuclease III-like 1 (E. coli) NTHL1 was found to be associated with longevity [22406557]. Human
    FOXO4 forkhead box O4 FOXO4 was found to be associated with longevity [21388494]. Human
    NTLH1 nescient helix loop helix 1 NTLH1 was found to be associated with longevity [22406557]. Human
    POLB polymerase (DNA directed), beta POLB was found to be associated with longevity [22406557]. Human
    RAD23B RAD23 homolog B (S. cerevisiae) RAD23B was found to be associated with longevity [22406557]. Human
    RAD52 RAD52 homolog (S. cerevisiae) RAD52 was found to be associated with longevity [22406557]. Human
    IGF2R insulin-like growth factor 2 receptor IGF2R was found to be associated with longevity [22406557]. Human
    GHSR growth hormone secretagogue receptor GHSR was found to be associated with longevity [22406557]. Human
    GHRHR growth hormone releasing hormone receptor GHRHR was found to be associated with longevity [22406557]. GHRHR was not found to be associated with longevity [19489743]. Human
    GSR glutathione reductase GSR was found to be associated with longevity [22406557]. Human
    ICAM1 intercellular adhesion molecule 1 ICAM1 was found to be associated with longevity [22174011]. Human
    RIMBP2 RIMS binding protein 2 RIMBP2 was found to be associated with longevity [22174011]. Human
    TUBB4B tubulin, beta 2C TUBB4B was found to be associated with longevity [22174011]. Human
    XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 XRCC4 was found to be associated with longevity [16518718]. Human
    XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 XRCC3 was found to be associated with longevity [16518718]. Human
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    • 25 of 223 factors
    Factors are an extension of GenAge and GenDR.

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