Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Types: + -
  • symbol name observation species
    AFUA_1G13190 copper-activated transcription factor GRISEA In Grisea (AFUA_1G13190) loss of function mutants, senescence is delayed two-fold [8804410]. Grisea disruption extends mean and maximum lifespan by 195 and 210% [17173038]. Grisea mutant has altered norphology and defects in formation of female gametangia [9380708]. Podospora anserine
    COX5 Disruption of the nuclear COX5 gene delays senescence, increase longevity between 7- and 15-fold (in 30 tested isolates) and the onset of senescence is not associated by accumulation of senescence-specific mtDNA molecules. COX5 deletion results in exclusive use of the alternative respiratory pathway and a decrease in production of reactive oxygen species and the prevention of the accumulation of several senescence-specific mitochondrial DNA molecules [10759557]. Podospora anserine
    cyc1 cytochrome c(1) cyc1 mutants have a reduced growth rate, a reduced reactive oxygen species production, and are long-lived [17081785]. Podospora anserine
    COX1 Cytochrome c oxidase I Deletion of mobile group II intron (intron alpha) from COX1 doubles lifespan and prevents accumulation of senescence-associated DNA concatemer corresponding to this of the mitochondrial genome [10330149]. Deletion encompassing COX1's intron alpha and its upstream exon abolishes the senescence process entirely [2999848]. Podospora anserine
    • 4 factors
    Factors are an extension of GenAge and GenDR.

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