Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    RAGE Human
    CDKN2B Human
    CYBA Human
    NOS2 NOS2 was found to be associated with longevity [23572278]. Human
    PVRL2 PVRL2 was found to be associated with longevity [24924924]. PVRL2 was not found to be associated with longevity [24924924]. Human
    PTK2 PTK2 was found to be associated with longevity [24930376]. PTK2 was not found to be associated with longevity [24930376]. Human
    OR5AS1 olfactory receptor, family 5, subfamily AS, member 1 OR5AS1 was found to be associated with longevity [22445811]. Human
    ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 ST6GAL1 was found to be associated with longevity [22445811]. Human
    CNTN5 contactin 5 CNTN5 was found to be associated with longevity [22445811]. Human
    ANK2 ankyrin 2, neuronal ANK2 was found to be associated with longevity [22445811]. Human
    PDLIM5 PDZ and LIM domain 5 PDLIM5 was found to be associated with longevity [22445811]. Human
    FRMD4A FERM domain containing 4A FRMD4A was found to be associated with longevity [22445811]. Human
    FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 FAM19A1 was found to be associated with longevity [22445811]. Human
    FAT4 FAT tumor suppressor homolog 4 (Drosophila) FAT4 was found to be associated with longevity [22445811]. Human
    UCK2 uridine-cytidine kinase 2 UCK2 was found to be associated with longevity [22445811]. Human
    GRIA4 glutamate receptor, ionotrophic, AMPA 4 GRIA4 was found to be associated with longevity [22445811]. Human
    ABL1 c-abl oncogene 1, non-receptor tyrosine kinase ABL1 was found to be associated with longevity [22445811]. Human
    RPA3 replication protein A3, 14kDa RPA3 was found to be associated with longevity [22445811]. Human
    BDH1 3-hydroxybutyrate dehydrogenase, type 1 BDH1 was found to be associated with longevity [22445811]. Human
    PSCD3 cytohesin 3 PSCD3 was found to be associated with longevity [22445811]. Human
    ACPL2 acid phosphatase-like 2 ACPL2 was found to be associated with longevity [22445811]. Human
    ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 ARHGEF19 was found to be associated with longevity [22445811]. Human
    ART3 ADP-ribosyltransferase 3 ART3 was found to be associated with longevity [22445811]. Human
    MOBKL2B MOB1, Mps One Binder kinase activator-like 2B (yeast) MOBKL2B was found to be associated with longevity [22445811]. Human
    SDAD1 SDA1 domain containing 1 SDAD1 was found to be associated with longevity [22445811]. Human
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    • 25 of 584 factors
    Factors are an extension of GenAge and GenDR.

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