Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    nhr-62 Nuclear Hormone Receptor family NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. *nhr-62* mediates the longevity response of *eat-2* mutants and blunts the longevity by bacterial food dilution [Heestand, et al. 2012]. Mutation in *nhr-62* suppresses the lifespan extension of eat-2(ad465) animals (p<0.001) [Heestand et al. 2013]. Wild-type (N2) worms with extrachromosomal array dhEx627 (carrying a wild-type nhr-62) exhibit a significant increase in lifespan compared to wild-type (p<0.001) [Heestand et al. 2013]. Nematode
    mrpl-37 Knockdown of mrpl-37 increases lifespan by 41% [23698443]. Nematode
    mrpl-2 Knockdown of mrpl-2 increases lifespan by 54% [23698443]. Nematode
    mrpl-1 Knockdown of mrpl-1 increases lifespan by 57% [23698443]. Nematode
    ttll-9 Tubulin Tyrosine Ligase Like Knockdown of ttll-9 throughout the entire life increases the lifespan by 3% [23698443]. Nematode
    nkcc-1 Na-K-Cl Cotransporter homolog Knockdown of nkcc-1 throughout the entire life increases the lifespan by 23% [23698443]. Nematode
    mrps-5 Knockdown of mrps-5 throughout the entire life increases the lifespan by 60%. mrps-5 RNAi prevents aging-associated functional decline and alters mitochondrial function. Knocking down mrps-5 after early development no longer affects nematode lifespan. When RNAi of mrps-5 was performed during the larval stages only, lifespan increases by 48%, whereas RNAi started from the L4 stage has no effect. mrps-5 RNAi results in fragmented mitochondria. mrps-5 RNAi increases lifespan by 40% in widltype, 37% in daf-16(mu86), 40% in sir-2.1(ok434) 69% in aak-2(ok524) and 112% in mev-1(kn1). Knockdown of cco-1 does not extend the lifespan of mrps-5 RNAi [23698443]. Nematode
    frh-1 FRataxin (involved in human Friedrich's ataxia) Homolog Complete absence of frataxin,the mitochondrial protein defective in individuals with Friedreich ataxia is lethal, while its partial deficiency extends animal lifespan in a p53 dependent manner. Frataxin knockdown via RNAi extends mean and maximum lifespan by 19 and 37%, respectively [23247094]. Substantial reduction of frataxin protein expression is required to extend lifespan, affect sensory neurons functionality, remodel lipid metabolism and trigger autophagy. Beclin and p53 genes are required to induce autophagy and concurrently reduce lipid storages and extend animal lifespan in response to frataxin suppression. Frataxin expression modulates autophagy in the absence of p53 [23247094]. Nematode
    wrn-1 human WRN (Werner's syndrome) related RNAi kockdown of wrn-1 shortens the lifespan, increases sensitivity to DNA damage, and accelerates aging phenoypes [15115755]. A nonfunctional wrn-1 DNA helicase decreases the lifespan. The expression of miR-124 in whole wrn-1 mutant worms is significantly reduced. Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants [23075628]. Nematode
    mir-124 Loss of mir-124 increases reactive oxygen species formation and accumulation of the aging marker lipofuscin, reduces whole body ATP levels and results in reduction in lifespan [23075628]. Supplementation of vitamin C normalizes the reduced median lifespan of mir-124 mutants [23075628]. The expression of the conserved mir-124 in whole wrn-1 mutants (which premature age) is significantly reduced [23075628]. Nematode
    mir-58 mir-58(n4640) mutation decreases the mean lifespan by 20% [22482727]. Nematode
    mir-239 Mutating mir-239 increases mean and maximum lifespan by 12 and 36%, respectively, whereas overexpressing mir-239 decreases mean and maximum lifespan by 13 and 17 - 33%, respectively [21129974]. Nematode
    mir-246 Mutating mir-246 decreases mean and maximum lifespan by 12%, while its overexpression increases mean and maximum lifespan by 6 and 5 - 14%, respectively [21129974]. Nematode
    mir-238 Mutating mir-238 decreases mean and maximum lifespan by 18 and 24% [21129974]. mir-238(n4112) mutation decreases mean lifespan by 20% [22482727]. Nematode
    mir-71 Loss and gain-of-function of mir-71 decreases and increases lifespan, respectively [21129974]. mir-71 mutants have a reduced lifespan with 40% decrease in mean lifespan, while extra copies of mir-71 extend the lifespan with an increase in lifespan by 15 - 25% [22482727], Loss of mir-71 function suppresses the long lifespan of glp-1(e2141) mutants [22482727], During adulthood mir-71 is strongly expressed in the intestine, body wall muscles and neurons. mir-71 is upregulated in aging adults [22482727], Nematode
    alg-1 Argonaute (plant)-Like Gene Adult-specific knockdown of the C. elegans argonaute-like gene 1 alg-1 results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. Nematode
    pash-1 PArtner of DroSHa (DRSH-1 interactor) Inactivation of DGCR8/pash-1 in nematode reduces lifespan apparently due to accelerated aging. This intervention abrogates (lin-14 mutation and jnk-1(OE)) and suppresses (eat-2 and glp-1 mutants) several lifespan extending interventions, but not that conferred insulin-like signalling inhibition (daf-2 mutant) [23097426]. pash-1 mutants have a decreased lifespan and display phenotypic and molecular signs of advantaged age earlier. pash-1(mj100) temperature sensitive loss-of-function mutation decreases (at the permissive temperature) mean and maximum lifespan by 31 and 71%, respectively. At the restrictive temperature pash-1 mutants are slightly short-lived with a mean and maximum lifespan reduction by 13 and 54%. Lifespan of pash-1 mutants is reduced by a 24h upshift to 25 degree Celsius at the young adult stage with (36 and 78% reduction mean and maximum lifespan, respectively) [23097426]. The rescue of pash-1 expression all tissues restored almost normal lifespan. Rescue specifically in hypodermis, pharynx muscle, gut had no effect on lifespan. Rescue in body wall muscle marginal extended the lifespan, while rescue specifically in the neurons significantly restored mean but not maximum lifespan. Lifespan was also restored by combined rescue in hypodermis and muscle [23097426]. Nematode
    sir-2.4 yeast SIR related 2.4 RNA interference against sir-2.4 or overexpression of SIR-2.4 do not change the mean or maximum lifespan. Neither sir-2.4 RNAi nor SIR-2.4 overexpression affects the increased lifespan of daf-2(e1370) mutants [Tishkoff et al. 2012]. Nematode
    gei-4 GEX Interacting protein 4 gei-4 RNAi in the adulthood reduces mean and maximum lifespan by 27 and 38% [23144747]. Nematode
    let-23 LEThal 23 Postdevelopmental inactivation of let-23 by RNA interference extends the lifespan by 5.6% [New Longevity Regulators]. Nematode
    phi-50 RNA interference of phi-50 decreases mean lifespan by 29% and suppresses lifespan extension by isp-1 and eat-2 mutation but does not significantly affect lifespan extension by daf-2 [22829775]. Nematode
    nekl-2 NEK (NEver in mitosis Kinase) Like 2 RNA intereference of nekl-2 decreases lifespan by 24% and suppresses lifespan extension by eat-2 mutation [22829775]. Nematode
    wnk-1 mammalian WNK-type protein kinase homolog 1 RNA interference of wnk-1 decreases lifespan by 9% and suppresses lifespan extension by eat-2 mutation [22829775]. Nematode
    cpf-2 Cleavage and Polyadenylation Factor 2 RNA interference of cpf-2 decreases mean lifespan by 6% and suppresses lifespan extension by eat-2 mutation [22829775]. Nematode
    pas-3 Proteasome Alpha Subunit 3 RNA interference of pas-3 shortens mean lifespan by 7% and suppresses lifespan extension by isp-1 mutation [22829775]. Nematode
    • Page 1 of 35
    • 25 of 864 factors
    Factors are an extension of GenAge and GenDR.

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