Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

prometheus--2.jpg

  • Species: + -
  • Types: + -
  • symbol name observation species
    tim timeless TIMELESS (TIM) oscillation are attenuated in the cerebral clock neurons of elderly flies [23223368]. Tim01 mutants have nearly a 50% reduced fecundity [14667147]. Fruit fly
    Pdf Pigment-dispersing factor Pdf declines with aging. Age-dependent Pdf decline is responsible for the circadian rhythm attenuation [23223368]. Overexpression of Pdf suppresses age-associated changes in the period and strength of free-running locomotor rhythms and amplifies TIM oscillations in many pacemaker neurons in the elder flies [23223368]. Age-associated reduction of Pdf may cause attenuation of intercellular communication in the circadian neuronal network and of TIM cycling, which may result in the age-related rhythm decay [23223368]. Fruit fly
    • 2 factors
    Factors are an extension of GenAge and GenDR.

    Comment on This Data Unit


    Please log in for making a comment without the need to specify any credentials.