Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    tert telomerase reverse transcriptase First-generation tert(-/-) zebrafish die prematurely with shorter telomeres. tert(-/-) fish develop degenerative phenotypes, including premature infertility, gastrointestinal atrophy, and sarcopenia. tert(-/-) mutants have impaired cell proliferation, accumulation of DNA damage markers, and a p53 response leading to early apoptosis, followed by accumulation of senescence cells. Apoptosis is primarily observed in the proliferative niche and germ cells. Cell proliferation, but not apoptosis, is rescued in tp53(-/-)tert(-/-) mutants, underscoring p53 as mediator of telomerase deficiency and consequent telomere instability [http://denigma.de/url/3p]. Zebrafish
    camk1gb calcium/calmodulin-dependent protein kinase IGb camk1gb appears to link the pineal master clock with the periphery. camk1gb is a rhythmically expressed gene that connects the clock with donwstream physiology of the pineal gland. Knockdown of camk1gb disrupts locomotor activity in the whole larva, even through it is predominantly expressed within the pineal gland [Tovin et al. 2012; http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003116]. Zebrafish
    • 2 factors
    Factors are an extension of GenAge and GenDR.

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