Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Types: + -
    Gene (1)  
  • symbol name observation species
    Srf Serum Response Factor SRF is activated by the daily variations of a blood signal, resulting in significant changes in the structure and size of live cells throughout the course of the day [23374345]. Daily variations of plasma signal cyclically stimulates SRF. SRF is solicited in an antiphasic manner in humans and rats, a fact that is linked to their activity, diurnal and nocturnal, respectively. SRF activation is accompanied by a remodeling of the cellular "skeleton", resulting in morphological change in cells based on their activity [23374345]. House mouse
    camk1gb calcium/calmodulin-dependent protein kinase IGb camk1gb appears to link the pineal master clock with the periphery. camk1gb is a rhythmically expressed gene that connects the clock with donwstream physiology of the pineal gland. Knockdown of camk1gb disrupts locomotor activity in the whole larva, even through it is predominantly expressed within the pineal gland [Tovin et al. 2012; http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003116]. Zebrafish
    tim timeless TIMELESS (TIM) oscillation are attenuated in the cerebral clock neurons of elderly flies [23223368]. Tim01 mutants have nearly a 50% reduced fecundity [14667147]. Fruit fly
    Pdf Pigment-dispersing factor Pdf declines with aging. Age-dependent Pdf decline is responsible for the circadian rhythm attenuation [23223368]. Overexpression of Pdf suppresses age-associated changes in the period and strength of free-running locomotor rhythms and amplifies TIM oscillations in many pacemaker neurons in the elder flies [23223368]. Age-associated reduction of Pdf may cause attenuation of intercellular communication in the circadian neuronal network and of TIM cycling, which may result in the age-related rhythm decay [23223368]. Fruit fly
    Arntl aryl hydrocarbon receptor nuclear translocator-like Arntl knockout mice display symptoms of premature aging including a shorter lifespan, sarcopenia, cataracts, less subcutaneous fat, and organ shrinkage [16847346]. House mouse
    • 5 factors
    Factors are an extension of GenAge and GenDR.

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