References Archive

Denigma references all information very accurately. A reference is commonly a scientific article.

Specifically Denigma's References is an online reference management system for collaborative efforts which enables organising, searching and co-annotating papers.

It enables to store, organize, and more effectively search annotated data of biomedical literature on aging-related topics.

One of its ultimately aims is to a evolve into a resource which Denigma provides a corpus that aids to generate predictions and discovery implicit relationhips via machine learning and logical inference. o

There are currently 1807 references in Denigma db:

Author(s), Year Title PMID
Laun P et al., 2001 Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. 11251834
Schlotterer A et al., 2010 Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans. 20346071
Wijeyesekera A et al., 2012 Metabotyping of long-lived mice using 1H NMR spectroscopy. 22225495
Fontana L et al., 2004 Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. 15096581
Apfeld J et al., 2004 The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. 15574588
Petersen KF et al., 2003 Mitochondrial dysfunction in the elderly: possible role in insulin resistance. 12750520
Shmookler Reis RJ et al., 2011 Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. 21386131
Hillyard SL & German JB, 2009 Quantitative lipid analysis and life span of the fat-3 mutant of Caenorhabditis elegans. 19301819
Steffen KK et al., 2008 Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. 18423200
Barros MH et al., 2004 Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. 15383542
Kirchman PA et al., 1999 Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. 10224252
Eisenberg T et al., 2009 Induction of autophagy by spermidine promotes longevity. 19801973
Basso A et al., 2010 Noninvasive neonatal thymus graft into the axillary cavity extends the lifespan of old mice. 19954334
Minois N, 2000 Longevity and aging: beneficial effects of exposure to mild stress. 11707916
Yang Y & Wilson DL, 1999 Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans. 10219000
Sun K et al., 2012 Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression. 22484922
Willcox BJ et al., 2007 Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span. 17986602
Igwebuike, Ada et al., 2008 Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women. 18029465
Hinson JP & Raven PW, 1999 DHEA deficiency syndrome: a new term for old age? 10495400
Lane MA et al., 1997 Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restriction. 9215277
Mesquita A et al., 2010 Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity. 20696905
Weinberger M et al., 2010 Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence. 21076178
Fabrizio P et al., 2003 SOD2 functions downstream of Sch9 to extend longevity in yeast. 12586694
Petrascheck M et al., 2009 A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans. 19686215
Samanez-Larkin GR et al., 2012 Frontostriatal white matter integrity mediates adult age differences in probabilistic reward learning. 22496578
Zarse K et al., 2012 Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. 22482728
Roorda S et al., 1991 Structural relaxation and defect annihilation in pure amorphous silicon. 9999999
Curran SP & Ruvkun G, 2007 Lifespan regulation by evolutionarily conserved genes essential for viability. 17411345
Olsen A et al., 2006 Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. 16741121
Kim Y & Sun H, 2007 Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan. 17608836
Schächter F et al., 1994 Genetic associations with human longevity at the APOE and ACE loci. 8136829
Alafuzoff I et al., 2000 Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia. 10818513
Corder EH et al., 1996 Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition. 8624216
Ruiu G et al., 1995 Apolipoprotein E allele frequencies in an Italian population: relation to age and lipid profile. 8541369
Galinsky D et al., 1997 Analysis of the apo E/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity. 9105559
Schwanke CH et al., 2002 Analysis of the association between apolipoprotein E polymorphism and cardiovascular risk factors in an elderly population with longevity. 12185856
Stessman J et al., 2005 Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. 15621215
Forero DA et al., 2006 Analysis of common polymorphisms in angiotensin-converting enzyme and apolipoprotein e genes and human longevity in Colombia. 16971231
, 1985 Ataxia-telangiectasia: genetics, neuropathology, and immunology of a degenerative disease of childhood. Proceedings of a conference. Solvang, California, January 16-20, 1984. 3864931
Hansen M et al., 2005 New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. 16103914
Dillin A et al., 2002 Rates of behavior and aging specified by mitochondrial function during development. 12471266
Hamilton B et al., 2005 A systematic RNAi screen for longevity genes in C. elegans. 15998808
Lai CY et al., 2002 A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae. 12242224
Smith ED et al., 2008 Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. 18340043
Stein JL et al., 2012 Identification of common variants associated with human hippocampal and intracranial volumes. 22504417
Bis JC et al., 2012 Common variants at 12q14 and 12q24 are associated with hippocampal volume. 22504421
Zhou B et al., 2012 Midlife gene expressions identify modulators of aging through dietary interventions. 22509016
Xue H et al., 2007 A modular network model of aging. 18059442
Lee SS et al., 2003 A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. 12447374
Lakowski B & Hekimi S, 1996 Determination of life-span in Caenorhabditis elegans by four clock genes. 8638122
Lin SJ et al., 2000 Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. 11000115
Suthammarak W et al., 2009 Complex I function is defective in complex IV-deficient Caenorhabditis elegans. 19074434
Kenyon C et al., 1993 A C. elegans mutant that lives twice as long as wild type. 8247153
Van Voorhies WA, 1992 Production of sperm reduces nematode lifespan. 1448167
Reis-Rodrigues P et al., 2012 Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan. 22103665
Ghazi A et al., 2007 Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. 17392428
Jia K & Levine B, 2007 Autophagy is required for dietary restriction-mediated life span extension in C. elegans. 17912023
Luo S et al., 2009 TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. 20041217
Riddle DL et al., 1997 Genetic and Environmental Regulation of Dauer Larva Development 21413222
Shaw WM et al., 2007 The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. 17900898
Fabrizio P et al., 2010 Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. 20657825
List EO et al., 2011 Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. 21123740
Zhou Y et al., 1997 A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). 9371826
Coschigano KT et al., 2003 Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. 12933651
García-Cao I et al., 2002 "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. 12426394
Tyner SD et al., 2002 p53 mutant mice that display early ageing-associated phenotypes. 11780111
Matheu A et al., 2004 Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. 15520276
Fuellen, Georg et al., 2012 Systems Biology and Bioinformatics in Aging Research: A Workshop Report. 22950424
Ortega-Molina A et al., 2012 Pten positively regulates brown adipose function, energy expenditure, and longevity. 22405073
Price NL et al., 2012 SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. 22560220
Li J et al., 2008 Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. 18828672
Harrison DE et al., 2009 Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. 19587680
Robida-Stubbs S et al., 2012 TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. 22560223
Tullet JM et al., 2008 Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. 18358814
Honjoh S et al., 2009 Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. 19079239
Jia K et al., 2004 The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. 15253933
Hansen M et al., 2007 Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. 17266679
Scott RC et al., 2004 Role and regulation of starvation-induced autophagy in the Drosophila fat body. 15296714
Kumsta C & Hansen M, 2012 C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline. 22574120
Wysocka J & Herr W, 2003 The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. 12826401
Wang Y et al., 2006 C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. 16860373
Tissenbaum HA & Guarente L, 2001 Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. 11242085
Wolff S et al., 2006 SMK-1, an essential regulator of DAF-16-mediated longevity. 16530049
Panowski SH et al., 2007 PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. 17476212
Essers MA et al., 2005 Functional interaction between beta-catenin and FOXO in oxidative stress signaling. 15905404
Arantes-Oliveira N et al., 2002 Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. 11799246
Julien E & Herr W, 2003 Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1. 12743030
Julien E & Herr W, 2004 A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1. 15200950
Tyagi S et al., 2007 E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases. 17612494
Lee S et al., 2007 Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells. 18043729
Alvers AL et al., 2009 Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. 19302372
Longo VD et al., 2010 Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. 20953148
Di Cianni F et al., 2012 MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping. 22576335
Tomás-Loba A et al., 2008 Telomerase reverse transcriptase delays aging in cancer-resistant mice. 19013273
González-Suárez E et al., 2005 Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice. 15688016
Jaskelioff M et al., 2011 Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. 21113150
Bernardes de Jesus B et al., 2012 Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. 22585399
Ferguson VL et al., 2003 Bone development and age-related bone loss in male C57BL/6J mice. 13678781
Shimokata H et al., 1989 Studies in the distribution of body fat: I. Effects of age, sex, and obesity. 2921472
Hammerman MR, 1987 Insulin-like growth factors and aging. 3322823
Krishnamurthy J et al., 2006 p16INK4a induces an age-dependent decline in islet regenerative potential. 16957737
Molofsky AV et al., 2006 Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. 16957738
Chien KR & Karsenty G, 2005 Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. 15734685
Geiger H & Van Zant G, 2002 The aging of lympho-hematopoietic stem cells. 11919569
Flores I et al., 2008 The longest telomeres: a general signature of adult stem cell compartments. 18283121
García-Cao I et al., 2006 Increased p53 activity does not accelerate telomere-driven ageing. 16582880
Shulman GI & Helfand SL, 2011 Indy knockdown in mice mimics elements of dietary restriction. 21937764
Vartiainen S et al., 2006 Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein. 16782295
Steinkraus KA et al., 2008 Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. 18331616
Greer EL & Brunet A, 2009 Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. 19239417
Mair W et al., 2009 Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. 19229346
Apfeld J & Kenyon C, 1999 Regulation of lifespan by sensory perception in Caenorhabditis elegans. 10617200
Bell R et al., 2009 A human protein interaction network shows conservation of aging processes between human and invertebrate species. 19293945
Murakami S & Johnson TE, 1998 Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene. 9768365
Murakami S & Johnson TE, 2001 The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. 11591319
Murphy CT et al., 2003 Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. 12845331
Arum O et al., 2009 The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet. 19747233
Lindstrom DL et al., 2011 Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae. 21436897
Tang F et al., 2008 A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery. 18690010
Kaeberlein M et al., 2005 Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. 16293764
Waaijer ME et al., 2012 The number of p16INK4a positive cells in human skin reflects biological age. 22612594
Doroszuk A et al., 2012 Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. 22559237
Yan L et al., 2007 Type 5 adenylyl cyclase disruption increases longevity and protects against stress. 17662940
Enns LC et al., 2009 Disruption of protein kinase A in mice enhances healthy aging. 19536287
Steffen KK et al., 2012 Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. 22377630
Yang W & Hekimi S, 2010 A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. 21151885
Neumann-Haefelin E et al., 2008 SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans. 18832074
Cai WJ et al., 2011 Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. 22216122
Shen LR et al., 2012 Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. 22653297
Liao VH et al., 2011 Curcumin-mediated lifespan extension in Caenorhabditis elegans. 21855561
Caesar I et al., 2012 Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. 22348084
Pietsch K et al., 2009 Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43. 19043800
Hashimoto T et al., 2010 Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16. 19370397
Bonkowski MS et al., 2006 Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. 16682650
Kabil H et al., 2011 Increased transsulfuration mediates longevity and dietary restriction in Drosophila. 21930912
Grönke S et al., 2010 Molecular evolution and functional characterization of Drosophila insulin-like peptides. 20195512
Zid BM et al., 2009 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. 19804760
Bahadorani S et al., 2010 Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila. 19968629
Copeland JM et al., 2009 Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. 19747824
Bauer JH et al., 2005 Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. 16303568
van Heemst D et al., 2005 Variation in the human TP53 gene affects old age survival and cancer mortality. 15732191
Hwangbo DS et al., 2004 Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. 15175753
Giannakou ME et al., 2008 Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. 18241326
Wang PY et al., 2009 Long-lived Indy and calorie restriction interact to extend life span. 19470468
Rogina B et al., 2000 Extended life-span conferred by cotransporter gene mutations in Drosophila. 11118146
Marden JH et al., 2003 Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. 12626742
Toivonen JM et al., 2007 No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. 17571923
Rogina B & Helfand SL, 2004 Sir2 mediates longevity in the fly through a pathway related to calorie restriction. 15520384
Kapahi P et al., 2004 Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. 15186745
Clancy DJ et al., 2001 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. 11292874
Clancy DJ et al., 2002 Dietary restriction in long-lived dwarf flies. 11951037
Libert S et al., 2007 Regulation of Drosophila life span by olfaction and food-derived odors. 17272684
Rogina B et al., 2002 Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. 12459580
Sánchez-Blanco A et al., 2006 Involvement of Drosophila uncoupling protein 5 in metabolism and aging. 16387864
Budovskaya YV et al., 2008 An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. 18662544
Lucanic M et al., 2011 N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. 21562563
Schleit J et al., 2011 The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans. 22132200
Kaeberlein TL et al., 2006 Lifespan extension in Caenorhabditis elegans by complete removal of food. 17081160
Lee GD et al., 2006 Dietary deprivation extends lifespan in Caenorhabditis elegans. 17096674
Miranda-Vizuete A et al., 2006 Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons. 16387300
Fierro-González JC et al., 2011 The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans. 21334311
Mouchiroud L et al., 2011 Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. 21040400
Park SK et al., 2010 Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. 19783783
Artal-Sanz M & Tavernarakis N, 2009 Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. 19812672
Zhang M et al., 2009 Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. 19924292
Lee SJ et al., 2009 Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. 19883616
Tóth ML et al., 2008 Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. 18219227
Streeper RS et al., 2012 Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. 22291164
Sunagawa T et al., 2011 Procyanidins from apples (Malus pumila Mill.) extend the lifespan of Caenorhabditis elegans. 20717869
Chen S et al., 2009 The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. 19164523
Iser WB & Wolkow CA, 2007 DAF-2/insulin-like signaling in C. elegans modifies effects of dietary restriction and nutrient stress on aging, stress and growth. 18043747
Wu CY et al., 2012 A persistent level of Cisd2 extends healthy lifespan and delays aging in mice. 22661501
Chen YF et al., 2009 Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. 19451219
Anisimov VN et al., 2012 The second international conference "genetics of aging and longevity". 22661237
D'mello NP et al., 1994 Cloning and characterization of LAG1, a longevity-assurance gene in yeast. 8195187
Finley KD et al., 2003 blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. 12598614
Meléndez A et al., 2003 Autophagy genes are essential for dauer development and life-span extension in C. elegans. 12958363
Hansen M et al., 2008 A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. 18282106
German J, 1969 Bloom's syndrome. I. Genetical and clinical observations in the first twenty-seven patients. 5770175
Burtner CR et al., 2011 A genomic analysis of chronological longevity factors in budding yeast. 21447998
Wang MC et al., 2003 JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. 14602080
Baker DJ et al., 2004 BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. 15208629
Chiu CH et al., 2004 Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. 15289464
Chen SS et al., 2000 C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. 10982846
Orr WC & Sohal RS, 1994 Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. 8108730
Sun J & Tower J, 1999 FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. 9858546
Kaeberlein M & Guarente L, 2002 Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. 11805047
Landis GN et al., 2003 A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. 12620118
Sinclair DA & Guarente L, 1997 Extrachromosomal rDNA circles--a cause of aging in yeast. 9428525
Bruschi CV et al., 1995 The genomic instability of yeast cdc6-1/cdc6-1 mutants involves chromosome structure and recombination. 8552037
Merker RJ & Klein HL, 2002 hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae. 11756539
Jazwinski SM et al., 1989 Replication control and cellular life span. 2698814
Axelrod A & Rine J, 1991 A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae. 1990268
Garigan D et al., 2002 Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. 12136014
Kawano T et al., 2000 Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. 10873623
Barzilai N et al., 2003 Unique lipoprotein phenotype and genotype associated with exceptional longevity. 14559957
Vowels JJ & Thomas JH, 1992 Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. 1732156
Perkins LA et al., 1986 Mutant sensory cilia in the nematode Caenorhabditis elegans. 2428682
Gönczy P et al., 1999 Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo. 10508861
Starich TA et al., 1995 Mutations affecting the chemosensory neurons of Caenorhabditis elegans. 7705621
Liao XS et al., 1991 Intramitochondrial functions regulate nonmitochondrial citrate synthase (CIT2) expression in Saccharomyces cerevisiae. 1986232
Higginbottom MC et al., 1979 The Cockayne syndrome: an evaluation of hypertension and studies of renal pathology. 514720
Ewbank JJ et al., 1997 Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. 9020081
Jonassen T et al., 2001 A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants. 11136229
Lakowski B & Hekimi S, 1998 The genetics of caloric restriction in Caenorhabditis elegans. 9789046
Wong A et al., 1995 Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. 7768437
Gorbunova V & Seluanov A, 2002 CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA. 11959146
Felkai S et al., 1999 CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. 10202142
Begel O et al., 1999 Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina. 10330149
Koll F et al., 1985 A 1100-bp sequence of mitochondrial DNA is involved in senescence process in Podospora: study of senescent and mutant cultures. 2999848
Dufour E et al., 2000 A causal link between respiration and senescence in Podospora anserina. 10759557
Harris N et al., 2001 Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of nondividing cells. 11361336
Hoopes LL et al., 2002 Mutations in DNA replication genes reduce yeast life span. 12024027
Taub J et al., 1999 A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. 10335847
Taub J et al., 2003 A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. 12610632
Lin SJ et al., 2002 Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. 12124627
Kaeberlein M et al., 2005 Increased life span due to calorie restriction in respiratory-deficient yeast. 16311627
Sun X et al., 2012 Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. 22672579
Brown-Borg HM et al., 1996 Dwarf mice and the ageing process. 8900272
Steger RW et al., 1993 Premature ageing in transgenic mice expressing different growth hormone genes. 8100276
Bartke A, 2003 Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. 14583653
Flurkey K et al., 2002 The Snell dwarf mutation Pit1(dw) can increase life span in mice. 11718806
Flurkey K et al., 2001 Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. 11371619
Coschigano KT et al., 2000 Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. 10875265
Holzenberger M et al., 2003 IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. 12483226
Blüher M et al., 2003 Extended longevity in mice lacking the insulin receptor in adipose tissue. 12543978
Kuro-o M et al., 1997 Mutation of the mouse klotho gene leads to a syndrome resembling ageing. 9363890
Kurosu H et al., 2005 Suppression of aging in mice by the hormone Klotho. 16123266
Lu MH et al., 2002 Dietary restriction alters cell proliferation in rats: an immunohistochemical study by labeling proliferating cell nuclear antigen. 11744049
De Guzman JM et al., 2012 Chronic caloric restriction partially protects against age-related alteration in serum metabolome. 22661299
Larsen PL et al., 1995 Genes that regulate both development and longevity in Caenorhabditis elegans. 7789761
Hsin H & Kenyon C, 1999 Signals from the reproductive system regulate the lifespan of C. elegans. 10360574
Malone EA et al., 1996 Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. 8807293
Riddle DL et al., 1981 Interacting genes in nematode dauer larva formation. 7219552
Albani D et al., 2009 A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study. 19460140
Henderson ST & Johnson TE, 2001 daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. 11747825
Henderson ST et al., 2006 daf-16 protects the nematode Caenorhabditis elegans during food deprivation. 16720740
Chiang WC et al., 2012 HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity. 22265419
Masse I et al., 2005 Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18. 16153634
Dorman JB et al., 1995 The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. 8601482
Collet J et al., 1998 Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans. 9475731
Honda Y & Honda S, 1999 The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. 10428762
Tissenbaum HA & Ruvkun G, 1998 An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. 9504918
Malone EA & Thomas JH, 1994 A screen for nonconditional dauer-constitutive mutations in Caenorhabditis elegans. 8005442
Jia K et al., 2002 DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. 11782415
Gerisch B et al., 2001 A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. 11740945
Albert PS & Riddle DL, 1988 Mutants of Caenorhabditis elegans that form dauer-like larvae. 3350212
Lee JH et al., 2003 In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. 12935877
Kaeberlein M et al., 1999 The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. 10521401
Wisniewski KE et al., 1985 Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. 3158266
Seong KH et al., 2001 Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies. 11868902
Simon AF et al., 2003 Steroid control of longevity in Drosophila melanogaster. 12610309
Avery L, 1993 The genetics of feeding in Caenorhabditis elegans. 8462849
Shepherd JC et al., 1989 Fruit flies with additional expression of the elongation factor EF-1 alpha live longer. 2508089
Hirose T et al., 2003 Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans. 12571101
Lin MJ et al., 2005 DNA methyltransferase gene dDnmt2 and longevity of Drosophila. 15533947
Lin YJ et al., 1998 Extended life-span and stress resistance in the Drosophila mutant methuselah. 9794765
Rogina B & Helfand SL, 1995 Regulation of gene expression is linked to life span in adult Drosophila. 8582611
Hu Q et al., 1998 The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type. 9799084
Lambert JC et al., 2000 A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains. 11065130
Larsen PL & Clarke CF, 2002 Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q. 11778046
Defossez PA et al., 1999 Elimination of replication block protein Fob1 extends the life span of yeast mother cells. 10230397
Barton MK & Kimble J, 1990 fog-1, a regulatory gene required for specification of spermatogenesis in the germ line of Caenorhabditis elegans. 2341035
Gems D & Riddle DL, 2000 Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. 10747056
Clifford R et al., 2000 FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline. 11076749
Ellis RE & Kimble J, 1995 The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans. 7713418
Masferrer A et al., 2002 Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. 12000449
Ashrafi K et al., 2000 Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. 10921902
Shimokawa I et al., 2002 Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model. 12057928
Besson A et al., 2003 Reduced longevity in untreated patients with isolated growth hormone deficiency. 12915652
Walker DW et al., 2006 Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. 16581512
Sanchez D et al., 2006 Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. 16581513
Kaeberlein M et al., 2002 High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. 12391171
Osiewacz HD & Nuber U, 1996 GRISEA, a putative copper-activated transcription factor from Podospora anserina involved in differentiation and senescence. 8804410
Sinclair DA et al., 1997 Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. 9271578
Jiang JC et al., 2002 Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast. 12213553
Kim S et al., 1999 Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. 10512855
Rundlett SE et al., 1996 HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. 8962081
Milne GT et al., 1996 Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. 8754818
Laroche T et al., 1998 Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. 9635192
Boulton SJ & Jackson SP, 1998 Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. 9501103
Mankouri HW et al., 2002 SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases. 11861900
McVey M et al., 2001 The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. 11290710
Morley JF & Morimoto RI, 2004 Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. 14668486
Spindler SR et al., 2012 Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. 22737247
Walker GA & Lithgow GJ, 2003 Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. 12882326
Yokoyama K et al., 2002 Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. 11959102
Erjavec N et al., 2007 Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. 17908928
Lindquist S & Kim G, 1996 Heat-shock protein 104 expression is sufficient for thermotolerance in yeast. 8643570
Shama S et al., 1998 Heat stress-induced life span extension in yeast. 9851879
Wang HD et al., 2004 Multiple-stress analysis for isolation of Drosophila longevity genes. 15308776
Bodnar AG et al., 1998 Extension of life-span by introduction of telomerase into normal human cells. 9454332
Huang TT et al., 2000 Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. 10719757
Tu PH et al., 1996 Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. 8610185
Kinouchi H et al., 1991 Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. 1763030
Wittmann CW et al., 2001 Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. 11408621
Mitsui A et al., 2002 Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. 12230882
Managbanag JR et al., 2008 Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. 19030232
Tatar M et al., 2001 A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. 11292875
Pierce SB et al., 2001 Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. 11274053
Feng J et al., 2001 Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. 11709184
Kato Y et al., 2000 Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. 10631108
Utsugi T et al., 2000 Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. 11016890
Barz WP & Walter P, 1999 Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins. 10198056
Jiang JC et al., 1998 Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. 9872981
Childress AM et al., 1996 LAG2, a gene that determines yeast longevity. 8760941
Vellai T et al., 2003 Genetics: influence of TOR kinase on lifespan in C. elegans. 14668850
Nanji M et al., 2005 LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans. 16164423
Vergnes B et al., 2002 Cytoplasmic SIR2 homologue overexpression promotes survival of Leishmania parasites by preventing programmed cell death. 12383511
Puca AA et al., 2001 A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. 11526246
Perls TT et al., 1998 Siblings of centenarians live longer. 10326548
Heude M & Fabre F, 1993 a/alpha-control of DNA repair in the yeast Saccharomyces cerevisiae: genetic and physiological aspects. 8454201
Lundquist EA et al., 1996 The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts. 8625846
Capowski EE et al., 1991 Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans. 1783292
Ishii N et al., 1998 A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. 9716135
Ishii N et al., 1990 A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans. 2233820
Schriner SE et al., 2005 Extension of murine life span by overexpression of catalase targeted to mitochondria. 15879174
Bertram MJ et al., 1999 Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. 9891081
Pereira-Smith OM & Smith JR, 1983 Evidence for the recessive nature of cellular immortality. 6879195
Pereira-Smith OM & Smith JR, 1988 Genetic analysis of indefinite division in human cells: identification of four complementation groups. 3413074
Kaula SC et al., 2000 Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2. 10838077
Wadhwa R et al., 1993 Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype. 8454632
Stewart MS et al., 2007 Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. 17172436
Kikuchi Y et al., 1994 A new yeast gene, HTR1, required for growth at high temperature, is needed for recovery from mating pheromone-induced G1 arrest. 7845352
Sinclair DA et al., 1998 Molecular mechanisms of yeast aging. 9584615
Kennedy BK et al., 1995 Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. 7859289
Kennedy BK et al., 1997 Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. 9150138
Hata H et al., 1998 Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae. 9504907
Fabrizio P et al., 2004 Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. 14741356
Wei M et al., 2008 Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. 18225956
Ruan H et al., 2002 High-quality life extension by the enzyme peptide methionine sulfoxide reductase. 11867705
Beekman M et al., 2006 Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. 16611701
Nebel A et al., 2005 No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans. 15911777
Austriaco NR Jr, 1996 Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces. 8810036
Pélissier P et al., 1995 NCA3, a nuclear gene involved in the mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase of S. cerevisiae. 7586026
Lim DH et al., 2012 Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila. 22310715
Scheckhuber CQ et al., 2007 Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. 17173038
Van Gilst MR et al., 2005 Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. 15719061
Duronio RJ et al., 1990 Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. 2406721
Anderson RM et al., 2003 Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. 12736687
Ha CW & Huh WK, 2011 Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae. 20947565
Belenky P et al., 2007 Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. 17482543
Tahara EB et al., 2007 Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging. 17110466
Smith JS et al., 2000 A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. 10841563
Anderson RM et al., 2002 Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. 11884393
Michalkiewicz M et al., 2003 Hypotension and reduced catecholamines in neuropeptide Y transgenic rats. 12668588
van Rossum EF et al., 2004 Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. 15276593
Rinaldo C et al., 2002 Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development. 11861554
Tabish M et al., 1995 Exclusive expression of C. elegans osm-3 kinesin gene in chemosensory neurons open to the external environment. 7714894
Bargmann CI et al., 1993 Odorant-selective genes and neurons mediate olfaction in C. elegans. 8348618
Culotti JG & Russell RL, 1978 Osmotic avoidance defective mutants of the nematode Caenorhabditis elegans. 730048
Sgrò CM & Partridge L, 1999 A delayed wave of death from reproduction in Drosophila. 10617470
Migliaccio E et al., 1999 The p66shc adaptor protein controls oxidative stress response and life span in mammals. 10580504
Yamamura Y et al., 1973 Paralysis agitans of early onset with marked diurnal fluctuation of symptoms. 4735177
Sun LQ et al., 2004 Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. 15105378
Chavous DA et al., 2001 Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase. 11742076
Wilson RB & Tatchell K, 1988 SRA5 encodes the low-Km cyclic AMP phosphodiesterase of Saccharomyces cerevisiae. 2827010
Charizanis C et al., 1999 The oxidative stress response mediated via Pos9/Skn7 is negatively regulated by the Ras/PKA pathway in Saccharomyces cerevisiae. 10394911
Paradis S et al., 1999 A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. 10364160
Meissner B et al., 2004 Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans. 15155758
Kawasaki I et al., 1998 PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans. 9741628
Coates PJ et al., 1997 The prohibitin family of mitochondrial proteins regulate replicative lifespan. 9259555
Miskin R & Masos T, 1997 Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity. 9060969
Fan L et al., 1997 Antisense suppression of phospholipase D alpha retards abscisic acid- and ethylene-promoted senescence of postharvest Arabidopsis leaves. 9437863
Van Gassen G & Van Broeckhoven C, 2000 Molecular genetics of Alzheimer's disease: what have we learned? 10934557
Sun J et al., 1994 Divergent roles of RAS1 and RAS2 in yeast longevity. 8034612
Jang YC et al., 2009 Overexpression of Mn superoxide dismutase does not increase life span in mice. 19633237
Unal E et al., 2011 Gametogenesis eliminates age-induced cellular damage and resets life span in yeast. 21700873
Feser J et al., 2010 Elevated histone expression promotes life span extension. 20832724
Fabrizio P et al., 2001 Regulation of longevity and stress resistance by Sch9 in yeast. 11292860
Nakaya S et al., 2012 New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound. 22790951
Sebastiani P et al., 2012 Genetic signatures of exceptional longevity in humans. 22279548
Atzmon G et al., 2009 Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. 19837933
Atzmon G et al., 2010 Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. 19915151
Barzilai N et al., 2006 A genotype of exceptional longevity is associated with preservation of cognitive function. 17190939
Simonsen A et al., 2008 Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. 18059160
Hernández-Corbacho MJ et al., 2011 Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. 21687659
Tacutu R et al., 2012 Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. 23144747
Zuo Y et al., 2012 Black rice extract extends the lifespan of fruit flies. 22930061
Funakoshi M et al., 2011 A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila. 21281604
Paik D et al., 2012 Misexpression screen delineates novel genes controlling Drosophila lifespan. 22366109
Palermo V et al., 2012 Apple can act as anti-aging on yeast cells. 22970337
Chiang WC et al., 2012 C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. 23028355
Searls DB, 2012 Ten simple rules for online learning. 23028268
Howitz KT et al., 2003 Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. 12939617
Wood JG et al., 2004 Sirtuin activators mimic caloric restriction and delay ageing in metazoans. 15254550
Gruber J et al., 2007 Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans. 17460219
Bass TM et al., 2007 Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. 17875315
Baur JA et al., 2006 Resveratrol improves health and survival of mice on a high-calorie diet. 17086191
Pearson KJ et al., 2008 Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. 18599363
Miller RA et al., 2007 An Aging Interventions Testing Program: study design and interim report. 17578509
Miller RA et al., 2011 Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. 20974732
de Voer G et al., 2005 Deletion of the Caenorhabditis elegans homologues of the CLN3 gene, involved in human juvenile neuronal ceroid lipofuscinosis, causes a mild progeric phenotype. 16435200
Desmyter L et al., 2004 Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death. 15130665
Aerts AM et al., 2006 Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast. 16527275
Roy N & Runge KW, 2000 Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. 10662670
Gebre S et al., 2012 Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion. 22622083
Zhang Y et al., 2012 The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. 23066506
Antosh M et al., 2011 Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. 21325893
Meiklejohn CD et al., 2011 Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. 21857805
Oxenkrug G et al., 2001 Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models. 11462771
Karasek M, 2007 Does melatonin play a role in aging processes? 18212404
Pan Y et al., 2011 Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. 21641548
Tong JJ et al., 2007 Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. 17369827
Allikian MJ et al., 2007 Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. 17855453
Bodai L et al., 2007 Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level. 17933869
Svensson MJ & Larsson J, 2007 Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. 17567437
Simonsen A et al., 2007 Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. 17435236
Umeda-Kameyama Y et al., 2007 Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila. 17301052
Katewa SD et al., 2012 Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. 22768842
Bauer J et al., 2010 Comparative transcriptional profiling identifies takeout as a gene that regulates life span. 20519778
Flatt T et al., 2008 Drosophila germ-line modulation of insulin signaling and lifespan. 18434551
Kim HJ et al., 2010 Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22. 20036725
Morrow G et al., 2004 Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress. 14734639
Lavara-Culebras E & Paricio N, 2007 Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits. 17651920
Simonsen A et al., 2007 Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila. 17617737
Piper PW et al., 2002 The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. 12882345
Piper, Peter W & Bringloe, David, 2001 Loss of prohibitins, though it shortens the replicative life span of yeast cells undergoing division, does not shorten the chronological life span of G0-arrested cells. 11744041
Harris, Nicholas et al., 2003 Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells. 12788479
Bitterman KJ et al., 2002 Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. 12297502
Kruegel U et al., 2011 Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. 21931558
Lamming, Dudley W et al., 2005 HST2 mediates SIR2-independent life-span extension by calorie restriction. 16051752
Tsuchiya M et al., 2006 Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. 17129213
Postnikoff SD et al., 2012 The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex. 22438832
Murakami CJ et al., 2011 Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast. 21949725
Kaeberlein, Matt et al., 2004 Sir2-independent life span extension by calorie restriction in yeast. 15328540
Fabrizio P et al., 2005 Sir2 blocks extreme life-span extension. 16286010
Huang X et al., 2012 Down-regulating sphingolipid synthesis increases yeast lifespan. 22319457
Wanke V et al., 2008 Caffeine extends yeast lifespan by targeting TORC1. 18513215
Smith DL Jr et al., 2007 Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. 17711561
Li B et al., 2011 Identification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels. 21584246
Sharma PK et al., 2011 Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae. 20640543
Oliveira GA et al., 2008 Increased aerobic metabolism is essential for the beneficial effects of caloric restriction on yeast life span. 18704665
Bonawitz ND et al., 2007 Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. 17403371
Bonawitz ND et al., 2006 Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span. 16782871
Unlu ES & Koc A, 2007 Effects of deleting mitochondrial antioxidant genes on life span. 17460215
Demir AB & Koc A, 2010 Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes. 20707985
Kharade SV et al., 2005 Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence. 16336970
Dai J et al., 2010 Yin and Yang of histone H2B roles in silencing and longevity: a tale of two arginines. 20713692
Borklu Yucel, Esra & Ulgen, Kutlu O, 2012 A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae. 22216232
Powers, R Wilson 3rd et al., 2006 Extension of chronological life span in yeast by decreased TOR pathway signaling. 16418483
Wang C et al., 2009 Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response. 19805817
Wei M et al., 2009 Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. 19424415
Lavoie, Hugo & Whiteway, Malcolm, 2008 Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span. 18469137
Kaeberlein, Matt et al., 2005 Genes determining yeast replicative life span in a long-lived genetic background. 15722108
Tan, Yuanyou et al., 2009 Identification of longevity genes with systems biology approaches. 21918615
Matecic M et al., 2010 A microarray-based genetic screen for yeast chronological aging factors. 20421943
Alvers AL et al., 2009 Autophagy is required for extension of yeast chronological life span by rapamycin. 19458476
Kwan EX et al., 2011 Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. 21901113
Santos J et al., 2012 Ammonium is toxic for aging yeast cells, inducing death and shortening of the chronological lifespan. 22615903
Gomes P et al., 2007 Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span. 17544056
Jiang JC et al., 2000 An intervention resembling caloric restriction prolongs life span and retards aging in yeast. 11024000
Miceli MV et al., 2011 Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan. 22303396
Goldberg, Alexander A et al., 2010 Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. 20622262
Weinberger M et al., 2007 DNA replication stress is a determinant of chronological lifespan in budding yeast. 17710147
Longo, Valter D, 2003 The Ras and Sch9 pathways regulate stress resistance and longevity. 12855292
Easlon E et al., 2008 The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. 18381895
Easlon E et al., 2007 The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension. 17200108
Pan Y & Shadel GS, 2009 Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density. 20157595
Malc E et al., 2009 Inactivation of the 20S proteasome maturase, Ump1p, leads to the instability of mtDNA in Saccharomyces cerevisiae. 19467248
Madia, Federica et al., 2008 Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. 18195102
Heo SJ et al., 1999 Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast. 10620009
Parrella E & Longo VD, 2008 The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. 18930829
Qin H et al., 2008 Genomic instability is associated with natural life span variation in Saccharomyces cerevisiae. 18628831
Borghouts, Corina et al., 2004 Rtg2 protein links metabolism and genome stability in yeast longevity. 15020466
Kim S et al., 2004 The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity. 15547318
Gallo CM et al., 2004 Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. 14729974
Kaeberlein M et al., 2006 Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". 16741098
Delaney JR et al., 2011 Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. 21191185
Burtner, Christopher R et al., 2009 A molecular mechanism of chronological aging in yeast. 19305133
Shama, S et al., 1998 Role of RAS2 in recovery from chronic stress: effect on yeast life span. 9851878
Yang, Jingye et al., 2011 Cell size and growth rate are major determinants of replicative lifespan. 21248481
Lin SS et al., 2003 Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing. 12562756
Lin YY et al., 2009 Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. 19303850
Rizzetto L et al., 2012 Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60. 22675632
Ashrafi K et al., 1999 Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. 10430902
D'Mello NP & Jazwinski SM, 1991 Telomere length constancy during aging of Saccharomyces cerevisiae. 1938877
Park PU et al., 1999 Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae. 10207108
Kennedy BK et al., 1994 Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. 7806576
Zhu X et al., 2011 Mediator influences telomeric silencing and cellular life span. 21482672
Egilmez NK & Jazwinski SM, 1989 Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae. 2644196
Austriaco NR Jr & Guarente LP, 1997 Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae. 9275199
Chen, Xiao-Fen et al., 2009 Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae. 19557187
Jazwinski SM et al., 1998 Epigenetic stratification: the role of individual change in the biological aging process. 9789734
Jazwinski SM & Wawryn J, 2001 Profiles of random change during aging contain hidden information about longevity and the aging process. 11742528
Mankouri, H W & Morgan, A, 2001 The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors. 11389927
Ray A et al., 2003 Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan. 12640455
Longo VD et al., 1996 Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. 8647826
Longo VD et al., 1997 Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. 9199172
Longo VD et al., 1999 Mitochondrial superoxide decreases yeast survival in stationary phase. 10222047
Wawryn J et al., 2002 Effect of superoxide dismutase deficiency on the life span of the yeast Saccharomyces cerevisiae. An oxygen-independent role of Cu,Zn-superoxide dismutase. 12020810
Krzepiłko A et al., 2004 Ascorbate restores lifespan of superoxide-dismutase deficient yeast. 15621721
Parkes TL et al., 1998 Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. 9620775
Li L et al., 2009 Budding yeast SSD1-V regulates transcript levels of many longevity genes and extends chronological life span in purified quiescent cells. 19570907
Kaeberlein M et al., 2004 Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. 15126388
Delaney JR et al., 2011 Sir2 deletion prevents lifespan extension in 32 long-lived mutants. 21902802
Kamei Y et al., 2011 GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae. 21371425
Yoshida R et al., 2010 Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants. 20550517
Xiang L et al., 2011 Anti-aging effects of phloridzin, an apple polyphenol, on yeast via the SOD and Sir2 genes. 21597195
Weng, Yufang et al., 2010 Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene. 20093034
Jarolim, Stefanie et al., 2004 A novel assay for replicative lifespan in Saccharomyces cerevisiae. 15489200
Timmermann B et al., 2010 A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging. 20729566
Lu JY et al., 2011 Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. 21906795
Francis BR et al., 2007 Mutations in the Atp1p and Atp3p subunits of yeast ATP synthase differentially affect respiration and fermentation in Saccharomyces cerevisiae. 17492370
Kitanovic A & Wölfl S, 2006 Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae. 16199065
Rosaleny LE et al., 2005 Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes. 16023114
Barbosa AD et al., 2011 Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. 21707788
Almeida T et al., 2008 Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis. 18162582
Barbosa AD et al., 2012 Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging. 22445853
Li W et al., 2006 Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. 16436509
Chiocchetti A et al., 2007 Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. 17174052
Rinnerthaler M et al., 2006 MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria. 16806052
Aerts AM et al., 2009 Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast. 19059240
Aerts AM et al., 2008 Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast. 18500447
Kaya A et al., 2010 Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast. 20799725
Lorenz DR et al., 2009 A network biology approach to aging in yeast. 19164565
Savory FR et al., 2011 DAF-16 and Δ9 desaturase genes promote cold tolerance in long-lived Caenorhabditis elegans age-1 mutants. 21931751
Van Raamsdonk JM & Hekimi S, 2009 Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. 19197346
Honda Y et al., 2008 Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans. 18406553
Van Raamsdonk JM et al., 2010 Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage. 20382831
Yang W et al., 2007 A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans. 18073424
Yanase S et al., 2002 Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span. 12470895
Ren Y et al., 2012 Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans. 22253756
Vazquez-Manrique, Rafael P et al., 2005 Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant. 16293572
Ventura, Natascia et al., 2005 Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans. 15771615
Torgovnick, Alessandro et al., 2010 A role for p53 in mitochondrial stress response control of longevity in C. elegans. 20172019
Ventura, Natascia et al., 2009 p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. 19416129
Yang W & Hekimi S, 2010 Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. 20346072
Curran SP et al., 2009 A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. 19506556
Berman JR & Kenyon C, 2006 Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. 16530050
Wollam J et al., 2012 A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. 22505847
Wollam J et al., 2011 The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. 21749634
Rottiers V et al., 2006 Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. 16563875
Gerisch B et al., 2007 A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. 17360327
Rizki G et al., 2011 The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. 21909281
Araiz C et al., 2008 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. 18423931
Ghazi A et al., 2009 A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. 19749979
Goudeau, Jerome et al., 2011 Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. 21423649
Yamawaki TM et al., 2010 The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. 20824162
Lin, K et al., 2001 Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. 11381260
Walter, Ludivine et al., 2011 The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans. 21713031
Shen L et al., 2010 Regulation of longevity by genes required for the functions of AIY interneuron in nematode Caenorhabditis elegans. 21055415
Shen, Lu-Lu et al., 2010 Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion. 20332814
Rea, Shane L et al., 2007 Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. 17914900
Gallo, Marco et al., 2011 Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway. 21884719
Wang J et al., 2010 RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. 20700440
Yazaki K et al., 2011 Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans. 22013497
Zhang L et al., 2009 Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress. 19061950
Abbas S & Wink M, 2009 Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. 19085685
Honda Y et al., 2011 Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. 21858156
Petriv OI & Rachubinski RA, 2004 Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans. 14996832
Portal-Celhay C et al., 2012 Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans. 22452899
Alper S et al., 2010 The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity. 19923212
Troemel, Emily R et al., 2006 p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. 17096597
Pietsch, Kerstin et al., 2011 Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans. 21503726
Kampkotter, Andreas et al., 2007 Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. 18024103
Saul N et al., 2008 Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved? 18692520
Evans, Eric A et al., 2008 The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans. 18782349
Li X et al., 2011 Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. 21695230
Banfield KL et al., 2008 Protein-repair and hormone-signaling pathways specify dauer and adult longevity and dauer development in Caenorhabditis elegans. 18772467
Ogg, S et al., 1997 The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. 9353126
Rahman MM et al., 2010 Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans. 20952811
Honda, Yoko et al., 2010 Redox regulation, gene expression and longevity. 20590843
Lapierre LR et al., 2011 Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. 21906946
Hashimoto Y et al., 2009 Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans. 19469880
Hars, Eszter S et al., 2007 Autophagy regulates ageing in C. elegans. 17204841
Fisher AL & Lithgow GJ, 2006 The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms. 16626392
Halaschek-Wiener J et al., 2005 Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. 15837805
Curtis R et al., 2006 Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways. 16626391
Greer, Eric L et al., 2007 An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. 17900900
Williams DS et al., 2009 Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. 19793063
Hahm JH et al., 2009 Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans. 19489741
Lans H & Jansen G, 2007 Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. 17187771
Bishop, Nicholas A & Guarente, Leonard, 2007 Two neurons mediate diet-restriction-induced longevity in C. elegans. 17538612
Vertino, Anthony et al., 2012 A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat. 22303358
Ebert RH 2nd et al., 1996 Defining genes that govern longevity in Caenorhabditis elegans. 8934875
Ebert RH 2nd et al., 1993 Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci. 8307318
Ayyadevara S et al., 2009 Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan. 19764929
Tazearslan C et al., 2009 Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance. 19360094
Ayyadevara S et al., 2005 Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2. 16300482
Ayyadevara S et al., 2005 Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. 16164425
Ayyadevara S et al., 2007 Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. 17157356
Ayyadevara S et al., 2003 Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms. 12618395
Sánchez-Blanco A & Kim SK, 2011 Variable pathogenicity determines individual lifespan in Caenorhabditis elegans. 21533182
Xiang L et al., 2011 Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor. 22156377
Lehtinen MK et al., 2006 A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. 16751106
Wang MC et al., 2005 JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. 15820683
Dwivedi, Meenakshi et al., 2009 Autophagy genes mediate the effect of calcineurin on life span in C. elegans. 19279398
Mair W et al., 2011 Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. 21331044
Spanier B et al., 2010 Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity. 20550516
Zarse K & Ristow M, 2008 Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans. 19112515
Crawford D et al., 2007 Caenorhabditis elegans integrates food and reproductive signals in lifespan determination. 17711560
Zarse K et al., 2011 The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans. 21264793
Schmeisser S et al., 2011 Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species. 21932172
Zarse K et al., 2012 L: -Theanine extends lifespan of adult Caenorhabditis elegans. 22422488
Zarse K et al., 2010 Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans. 20925017
Yu YB et al., 2010 Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways. 20179756
Petrascheck, Michael et al., 2007 An antidepressant that extends lifespan in adult Caenorhabditis elegans. 18033297
Wang, Meng C et al., 2008 Fat metabolism links germline stem cells and longevity in C. elegans. 18988854
Khare S et al., 2011 The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans. 21695191
Gomez TA et al., 2007 The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy. 17187774
Castro PV et al., 2012 Caenorhabditis elegans battling starvation stress: low levels of ethanol prolong lifespan in L1 larvae. 22279556
Chen CS et al., 2010 WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans. 20209166
Kagan RM et al., 1997 Targeted gene disruption of the Caenorhabditis elegans L-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes. 9434744
Wang Y & Tissenbaum HA, 2006 Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. 16280150
Berdichevsky A et al., 2006 C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. 16777605
Viswanathan M et al., 2005 A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. 16256736
Burnett, Camilla et al., 2011 Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. 21938067
Heidler T et al., 2010 Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1. 19597959
Wang X et al., 2010 Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16. 20828537
Guan S et al., 2010 A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans. 20528576
Wiegant, F A C et al., 2008 Plant adaptogens increase lifespan and stress resistance in C. elegans. 18536978
Hunt, Piper R et al., 2011 Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms. 21765926
Zhu C et al., 2010 The lin-4 Gene Controls Fat Accumulation and Longevity in Caenorhabditis elegans. 21614175
Samuelson AV et al., 2007 Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. 18419309
Samuelson AV et al., 2007 Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. 18006689
Lee, Siu Sylvia et al., 2003 DAF-16 target genes that control C. elegans life-span and metabolism. 12690206
Bonilla E et al., 2002 Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin. 11909680
Le Bourg, Eric, 2007 Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster. 17318365
Le Bourg E & Minois N, 1997 Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity. 9183440
Takahashi M et al., 2001 Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans. 11511092
Morris JZ et al., 1996 A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. 8700226
Friedman DB & Johnson TE, 1988 A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. 8608934
Wu D et al., 2009 Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans. 19580861
Olsen A et al., 2006 Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments. 16826446
Wu D et al., 2008 The U-shaped response of initial mortality in Caenorhabditis elegans to mild heat shock: does it explain recent trends in human mortality? 18693219
Yashin AI et al., 2001 Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans. 11470134
Friedman DB & Johnson TE, 1988 Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. 3385139
Johnson TE, 1990 Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. 2392681
Johnson TE, 1987 Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans. 3473482
Wu D et al., 2009 Mortality shifts in Caenorhabditis elegans: remembrance of conditions past. 19747231
Johnson TE et al., 2001 Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects. 11487591
Cheong MC et al., 2011 A potential biochemical mechanism underlying the influence of sterol deprivation stress on Caenorhabditis elegans longevity. 21186286
Choi SS, 2011 High glucose diets shorten lifespan of Caenorhabditis elegans via ectopic apoptosis induction. 21779524
Gems D et al., 1998 Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. 9725835
Fei YJ et al., 2003 Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span. 12480943
Fei YJ et al., 2004 Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans. 14678010
Thyagarajan B et al., 2010 ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans. 20862312
Sutphin GL & Kaeberlein M, 2008 Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. 18083317
Smith ED et al., 2008 Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. 18457595
Houthoofd K et al., 2003 Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans. 12954481
Papp D et al., 2012 A role for SKN-1/Nrf in pathogen resistance and immunosenescence in Caenorhabditis elegans. 22577361
Narasimhan SD et al., 2011 PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism. 21533078
Zhang Y et al., 2008 Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. 18241854
Alam H et al., 2010 EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. 20620993
Dumas KJ et al., 2010 Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. 20178781
Gami, Minaxi S et al., 2006 Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling. 17020605
Meister P et al., 2011 Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism. 22185090
Masse I et al., 2008 A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans. 18836529
Park, Sang-Kyu et al., 2009 Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. 19627265
Chen J et al., 2007 A demographic analysis of the fitness cost of extended longevity in Caenorhabditis elegans. 17339638
Chen D et al., 2007 Longevity determined by developmental arrest genes in Caenorhabditis elegans. 17521386
van der Horst A et al., 2007 The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival. 17335870
Klass MR, 1983 A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. 6632998
Yang Y & Wilson DL, 2000 Isolating aging mutants: a novel method yields three strains of the nematode Caenorhabditis elegans with extended life spans. 10708258
Johnson TE & Hutchinson EW, 1993 Absence of strong heterosis for life span and other life history traits in Caenorhabditis elegans. 8325483
Yen K & Mobbs CV, 2010 Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. 19662517
Klass MR, 1977 Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. 926867
McCulloch D & Gems D, 2007 Sex-specific effects of the DAF-12 steroid receptor on aging in Caenorhabditis elegans. 18056973
Gems D & Riddle DL, 2000 Defining wild-type life span in Caenorhabditis elegans. 10819307
Pinkston JM et al., 2006 Mutations that increase the life span of C. elegans inhibit tumor growth. 16917064
Volovik Y et al., 2012 Temporal requirements of heat shock factor-1 for longevity assurance. 22360389
Hsu AL et al., 2003 Regulation of aging and age-related disease by DAF-16 and heat-shock factor. 12750521
Song HO et al., 2009 C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response. 19467242
Walker, G A et al., 2001 Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans. 11445592
Galbadage, Thushara & Hartman, Phil S, 2008 Repeated temperature fluctuation extends the life span of Caenorhabditis elegans in a daf-16-dependent fashion. 18538371
Arum O & Johnson TE, 2007 Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity. 17895432
Tavernarakis N et al., 2008 The effects of p53 on whole organism longevity are mediated by autophagy. 18728385
Amrit FR et al., 2010 Phenotypic covariance of longevity, immunity and stress resistance in the caenorhabditis nematodes. 20369008
Kimura K et al., 2007 Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans. 17189267
Boehm, Michelle & Slack, Frank, 2005 A developmental timing microRNA and its target regulate life span in C. elegans. 16373574
Angelo, Giana & Van Gilst, Marc R, 2009 Starvation protects germline stem cells and extends reproductive longevity in C. elegans. 19713489
Ishii N et al., 1994 The effects of temperature on the longevity of a radiation-sensitive mutant rad-8 of the nematode Caenorhabditis elegans. 8169328
Ishi N et al., 1993 The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development. 8350650
Hosokawa, H et al., 1994 Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans. 7934213
Ookuma S et al., 2003 Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. 12620193
Hertweck M et al., 2004 C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. 15068796
Cypser JR & Johnson TE, 1999 The spe-10 mutant has longer life and increased stress resistance. 10638523
Murakami S & Johnson TE, 1996 A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. 8807294
Fujii M et al., 2005 Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans. 16244463
Mukhopadhyay A et al., 2005 C. elegans tubby regulates life span and fat storage by two independent mechanisms. 16054097
Ailion, M et al., 1999 Neurosecretory control of aging in Caenorhabditis elegans. 10377425
Ailion, M & Thomas, J H, 2000 Dauer formation induced by high temperatures in Caenorhabditis elegans. 11063684
Shen, Lu-Lu et al., 2007 Involvement of genes required for synaptic function in aging control in C. elegans. 17592521
Mockett RJ et al., 1999 Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster. 10545213
Pinkston-Gosse J & Kenyon C, 2007 DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. 17934462
Ha MK et al., 2006 Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis. 16673436
Greer EL et al., 2011 Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. 22012258
Greer, Eric L et al., 2010 Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. 20555324
Vandamme, Julien et al., 2012 The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity. 22570628
Maures, Travis J et al., 2011 The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner. 21834846
Jin C et al., 2011 Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. 21803287
Oh SW et al., 2006 Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. 16380712
de Lencastre, Alexandre et al., 2010 MicroRNAs both promote and antagonize longevity in C. elegans. 21129974
Li W et al., 2007 RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. 17276341
Le DT et al., 2009 Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. 19049972
Dong, Meng-Qiu et al., 2007 Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. 17673661
Vaccaro A et al., 2012 TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans. 22792076
Honda S et al., 1993 Oxygen-dependent perturbation of life span and aging rate in the nematode. 8473689
Adachi H et al., 1998 Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans. 18314552
Kawano T et al., 2005 Lifespan extending activity of substances secreted by the nematode Caenorhabditis elegans that include the dauer-inducing pheromone. 16377915
Morselli E et al., 2011 Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. 21339330
McColl, Gawain et al., 2005 The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span. 16099946
Luo S et al., 2010 TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance. 20946987
Orr, W C & Sohal, R S, 1993 Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster. 8442664
Orr, W C & Sohal, R S, 1992 The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster. 1379030
Mockett, Robin J et al., 2003 Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity. 12521602
Bauer JH et al., 2004 An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. 15328413
Zheng J et al., 2005 Calorie restriction delays lipid oxidative damage in Drosophila melanogaster. 16026335
Vermeulen CJ et al., 2005 Resistance to oxidative stress induced by paraquat correlates well with both decreased and increased lifespan in Drosophila melanogaster. 16518700
Harshman LG & Haberer BA, 2000 Oxidative stress resistance: a robust correlated response to selection in extended longevity lines of Drosophila melanogaster? 10995037
Harshman, L G et al., 2000 Stress resistance and longevity in selected lines of Drosophila melanogaster. 10638525
Magwire MM et al., 2010 Quantitative and molecular genetic analyses of mutations increasing Drosophila life span. 20686706
Geiger-Thornsberry, Gretchen L & Mackay, Trudy F C, 2004 Quantitative trait loci affecting natural variation in Drosophila longevity. 15013662
Pasyukova EG et al., 2004 Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan. 15379853
Pasyukova, E G et al., 2000 Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster. 11063689
Wilson RH et al., 2006 High-resolution mapping of quantitative trait loci affecting increased life span in Drosophila melanogaster. 16702433
Nuzhdin SV et al., 2005 Survival analysis of life span quantitative trait loci in Drosophila melanogaster. 15834144
Shen J et al., 2009 Identifying sexual differentiation genes that affect Drosophila life span. 20003237
Shen J et al., 2009 A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila. 20157509
Ford, Daniel et al., 2007 Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone. 17349761
Sun J et al., 2004 Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span. 15130751
Sun J et al., 2002 Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. 12072463
Hoe N et al., 2011 Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster. 21415465
Alic N et al., 2011 Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. 21108726
Broughton S et al., 2008 Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. 19005568
Humphrey DM et al., 2009 Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan. 19385039
Giannakou ME et al., 2007 Dynamics of the action of dFOXO on adult mortality in Drosophila. 17465980
Min KJ et al., 2008 Drosophila lifespan control by dietary restriction independent of insulin-like signaling. 18221413
Waskar M et al., 2009 Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. 20157574
Shen J & Tower J, 2010 Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects. 19840842
Rybina OY & Pasyukova EG, 2010 A naturally occurring polymorphism at Drosophila melanogaster Lim3 Locus, a homolog of human LHX3/4, affects Lim3 transcription and fly lifespan. 20838645
Sepulveda S et al., 2008 Interactions between injury, stress resistance, reproduction, and aging in Drosophila melanogaster. 18053668
Nghiem, D et al., 2000 Postponed aging and desiccation resistance in Drosophila melanogaster. 11121683
Khazaeli AA & Curtsinger JW, 2000 Genetic analysis of extended lifespan in Drosophila melanogaster III. On the relationship between artificially selected and wild stocks. 11430488
Khazaeli AA et al., 2005 Longevity and metabolism in Drosophila melanogaster: genetic correlations between life span and age-specific metabolic rate in populations artificially selected for long life. 15466435
Sanz A et al., 2010 Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. 20435911
Bahadorani S et al., 2010 Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan. 20089120
Krishnan N et al., 2009 The circadian clock gene period extends healthspan in aging Drosophila melanogaster. 20157575
Krishnan N et al., 2012 Loss of circadian clock accelerates aging in neurodegeneration-prone mutants. 22227001
Bedoukian MA et al., 2009 Neuronal susceptibility to GRIM in Drosophila melanogaster measures the rate of genetic changes that scale to lifespan. 19428445
Liao PC et al., 2008 The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila. 18796296
Bhole D et al., 2004 Doxycycline-regulated over-expression of hsp22 has negative effects on stress resistance and life span in adult Drosophila melanogaster. 15491684
Yang J & Tower J, 2009 Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions. 19420297
Lee KS et al., 2009 JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span. 19720829
Spindler SR et al., 2012 Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. 22363408
Larson K et al., 2012 Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. 22291607
Rera, Michael et al., 2010 Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster. 20096722
Piacentini L et al., 2009 Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila. 19798443
Min, Kyung-Jin et al., 2006 Counting calories in Drosophila diet restriction. 17125951
Min KJ & Tatar M, 2006 Drosophila diet restriction in practice: do flies consume fewer nutrients? 16256171
Vigne P & Frelin C, 2010 Food presentation modifies longevity and the beneficial action of dietary restriction in Drosophila. 19895881
Yamamoto R & Tatar M, 2011 Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan. 21518241
Slack, Cathy et al., 2011 dFOXO-independent effects of reduced insulin-like signaling in Drosophila. 21443682
Slack C et al., 2010 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. 20333234
Bhandari, Poonam et al., 2007 Dietary restriction alters demographic but not behavioral aging in Drosophila. 17874997
Hulbert, A J et al., 2004 Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. 15288688
Mockett RJ et al., 2001 Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster. 11250117
Arking, R, 1987 Successful selection for increased longevity in Drosophila: analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity. 3113991
Mair, William et al., 2004 Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity. 15236760
Lee KP et al., 2008 Lifespan and reproduction in Drosophila: New insights from nutritional geometry. 18268352
Lushchak OV et al., 2012 Balance between macronutrients affects life span and functional senescence in fruit fly Drosophila melanogaster. 22042724
Landenberger A et al., 2004 Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster. 15542350
Smith EM et al., 2007 Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patterns. 17709434
Camporeale G et al., 2006 Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance. 17056793
Anisimov VN et al., 1997 Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster. 9226628
Ja WW et al., 2009 Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan. 19841272
Boyd O et al., 2011 Nectarine promotes longevity in Drosophila melanogaster. 21406223
Bahadorani S et al., 2008 The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress. 18245758
Huang SF et al., 2010 Cerium caused life span shortening and oxidative stress resistance in Drosophila melanogaster. 19828196
Zhang L et al., 2009 [Changes of the life span and certain biochemical indexes on Drosophila melanogaster by ethanol exposure]. 19408653
Cui X et al., 2004 D-galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress. 15547319
Le Rohellec M & Le Bourg E, 2009 Contrasted effects of suppressing live yeast from food on longevity, aging and resistance to several stresses in Drosophila melanogaster. 19666103
Le Bourg E, 2010 Combined effects of suppressing live yeast and of a cold pretreatment on longevity, aging and resistance to several stresses in Drosophila melanogaster. 19823937
Burger JM et al., 2007 The functional costs and benefits of dietary restriction in Drosophila. 17266676
Bass TM et al., 2007 Optimization of dietary restriction protocols in Drosophila. 17921418
Bross TG et al., 2005 Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction. 16300483
Tu MP et al., 2002 The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico. 12882356
Frankel, Stewart & Rogina, Blanka, 2005 Drosophila longevity is not affected by heterochromatin-mediated gene silencing. 15659213
Sanz, Alberto et al., 2010 Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. 20453260
Bayne AC et al., 2005 Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila. 15954861
Zhang H et al., 2010 Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster. 20600782
Landis G et al., 2001 High-frequency generation of conditional mutations affecting Drosophila melanogaster development and life span. 11454765
Poon PC et al., 2010 Carbon dioxide sensing modulates lifespan and physiology in Drosophila. 20422037
Broughton SJ et al., 2005 Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. 15708981
Shikama, N et al., 1994 Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster. 8183891
Ruiz M et al., 2011 Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz. 21376794
Muffat J et al., 2008 Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila. 18458334
Shchedrina VA et al., 2009 Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging. 19409408
Chung H et al., 2010 The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO. 20655917
Phillips, J P et al., 2000 Targeted neuronal gene expression and longevity in Drosophila. 11113599
Kirby K et al., 2002 RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress. 12456885
Mockett, R J et al., 1999 Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia. 10506576
Rebrin I & Sohal RS, 2006 Comparison between the effects of aging and hyperoxia on glutathione redox state and protein mixed disulfides in Drosophila melanogaster. 17011021
Linford NJ et al., 2012 Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality. 22570630
Mair, William et al., 2003 Demography of dietary restriction and death in Drosophila. 14500985
Jacobson, Jake et al., 2010 Biomarkers of aging in Drosophila. 20367621
Tu MP & Tatar M, 2003 Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster. 14677635
Peng C et al., 2012 Blueberry extract prolongs lifespan of Drosophila melanogaster. 22197903
Peng C et al., 2011 Apple polyphenols extend the mean lifespan of Drosophila melanogaster. 21319854
Benguría A et al., 1996 Microgravity effects on Drosophila melanogaster behavior and aging. Implications of the IML-2 experiment. 8987567
Tatar, M et al., 1997 Chaperoning extended life. 9363888
Juhász G et al., 2007 Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. 18056421
Juhasz, Gabor & Neufeld, Thomas P, 2008 Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis. 18216496
Ren C et al., 2009 Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity. 18955126
Connell-Crowley L et al., 2007 Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. 17368005
Rao RP et al., 2007 Ceramide transfer protein function is essential for normal oxidative stress response and lifespan. 17592126
Morrow G et al., 2004 Decreased lifespan in the absence of expression of the mitochondrial small heat shock protein Hsp22 in Drosophila. 15331597
Yang Q et al., 2010 Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity. 20112046
Wu D et al., 2012 Fertility/longevity trade-offs under limiting-male conditions in mating populations of Caenorhabditis elegans. 22771817
Mair W et al., 2005 Calories do not explain extension of life span by dietary restriction in Drosophila. 16000018
Mével-Ninio M et al., 1991 The ovo gene of Drosophila encodes a zinc finger protein required for female germ line development. 1712294
Sun X et al., 2010 Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. 20080168
Bruckbauer, Antje & Zemel, Michael B, 2009 Dietary calcium and dairy modulation of oxidative stress and mortality in aP2-agouti and wild-type mice. 22253967
Reilly SM et al., 2010 Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. 21109196
Lamming DW et al., 2012 Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. 22461615
Singh SP et al., 2010 Disruption of the mGsta4 gene increases life span of C57BL mice. 19880816
Smith DL Jr et al., 2011 No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight. 21079617
Al-Regaiey KA et al., 2005 Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. 15498882
Hughes BG & Hekimi S, 2011 A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice. 22028811
Chen YF et al., 2009 Cisd2 mediates mitochondrial integrity and life span in mammals. 19717971
Borrás C et al., 2011 RasGrf1 deficiency delays aging in mice. 21422498
Selman, Colin et al., 2009 Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. 19797661
Moskovitz J et al., 2001 Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. 11606777
Salmon, Adam B et al., 2009 Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span. 19487311
Miskin, R et al., 2000 AlphaMUPA mice: a transgenic model for increased life span. 10638529
Zhang Y et al., 2009 Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. 19776219
Van Remmen, Holly et al., 2003 Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. 14679299
Li, Y et al., 1995 Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. 7493016
Rudolph KL et al., 1999 Longevity, stress response, and cancer in aging telomerase-deficient mice. 10089885
Kwan KY & Wang JC, 2001 Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. 11331780
Speakman JR et al., 2004 Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. 15153176
Choi CS et al., 2007 Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. 17923673
Harrison DE et al., 1984 Effects of food restriction on aging: separation of food intake and adiposity. 6608731
Li Q & Ren J, 2007 Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression. 17973971
Liu X et al., 2005 Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. 16195414
Kanfi Y et al., 2012 The sirtuin SIRT6 regulates lifespan in male mice. 22367546
Shimokawa I et al., 2003 Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction. 12692087
Zha Y et al., 2008 Genetic suppression of GH-IGF-1 activity, combined with lifelong caloric restriction, prevents age-related renal damage and prolongs the life span in rats. 18434714
Hellmann JK et al., 2010 Synergistic and additive effects of epigallocatechin gallate and digitonin on Plasmodium sporozoite survival and motility. 20072627
Saastamoinen M et al., 2009 Significant effects of Pgi genotype and body reserves on lifespan in the Glanville fritillary butterfly. 19129143
Hatle, John D et al., 2008 Protein accumulation underlying lifespan extension via ovariectomy in grasshoppers is consistent with the disposable soma hypothesis but is not due to dietary restriction. 18761078
Drewry MD et al., 2011 Life-extending dietary restriction and ovariectomy result in similar feeding rates but different physiologic responses in grasshoppers. 21742024
Fanson, Benjamin G et al., 2009 Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni). 19558564
Fanson BG & Taylor PW, 2012 Protein:carbohydrate ratios explain life span patterns found in Queensland fruit fly on diets varying in yeast:sugar ratios. 21904823
Fanson BG & Taylor PW, 2012 Additive and interactive effects of nutrient classes on longevity, reproduction, and diet consumption in the Queensland fruit fly (Bactrocera tryoni). 22094291
Reynolds OL & Orchard BA, 2011 Effect of adult chill treatments on recovery, longevity and flight ability of Queensland fruit fly, Bactrocera tryoni (Froggatt) (Diptera: Tephritidae). 20609276
Molleman F et al., 2008 Adult diet affects lifespan and reproduction of the fruit-feeding butterfly Charaxes fulvescens. 19774093
Kulminski AM et al., 2009 Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens. 19716408
Carey JR et al., 2008 Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients. 18346215
Zou, Sige et al., 2009 The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. 19264118
Zou S et al., 2010 Prolongevity effects of an oregano and cranberry extract are diet dependent in the Mexican fruit fly (Anastrepha ludens). 19906819
Zou S et al., 2012 Prolongevity effects of a botanical with oregano and cranberry extracts in Mexican fruit flies: examining interactions of diet restriction and age. 21455602
Yan LJ & Sohal RS, 2000 Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins. 11121722
Bayne AC & Sohal RS, 2002 Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica. 12031907
Mai S et al., 2012 Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan. 22170153
Leontieva OV & Blagosklonny MV, 2011 Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. 22156391
Roux, Antoine E et al., 2009 Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast. 19266076
Zuin A et al., 2010 Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. 20075862
Honda Y et al., 2012 Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans. 22768380
Yuan, Yiyuan et al., 2012 Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. 22810224
Cañuelo A et al., 2012 Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. 22824366
Wuttke D et al., 2012 Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes. 22912585
Kyryakov P et al., 2012 Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration. 22783207
Koc A et al., 2004 Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. 15141092
Tsang WY et al., 2001 Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span. 11410594
Honda Y et al., 2010 Trehalose extends longevity in the nematode Caenorhabditis elegans. 20477758
Shore DE et al., 2012 Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. 22829775
Liu HP et al., 2012 The Yang-Tonifying Herbal Medicine Cynomorium songaricum Extends Lifespan and Delays Aging in Drosophila. 22844336
Hada, Binika et al., 2012 D-chiro-Inositol and Pinitol Extend the Life * Span of Drosophila melanogaster. 22843669
Ruiz M et al., 2012 Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz. 22846641
Orlandi I et al., 2012 Lack of Ach1 CoA-Transferase Triggers Apoptosis and Decreases Chronological Lifespan in Yeast. 22754872
Das SP & Sinha P, 2005 The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging. 16182251
Herbert AP et al., 2012 NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast. 22848679
Sagi, Dror & Kim, Stuart K, 2012 An engineering approach to extending lifespan in C. elegans. 22737090
Yamawaki TM et al., 2008 Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. 18202391
Honnen SJ et al., 2012 C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling. 22359667
Broué F et al., 2007 A steroid hormone that extends the lifespan of Caenorhabditis elegans. 17266678
Oh, Seung Wook et al., 2005 JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. 15767565
Château MT et al., 2010 Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans. 20844315
Szewczyk, Nathaniel J et al., 2006 Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction. 17023606
Carrano AC et al., 2009 A conserved ubiquitination pathway determines longevity in response to diet restriction. 19553937
Yanase, Sumino & Ishii, Naoaki, 2008 Hyperoxia exposure induced hormesis decreases mitochondrial superoxide radical levels via Ins/IGF-1 signaling pathway in a long-lived age-1 mutant of Caenorhabditis elegans. 18285659
Spencer CC et al., 2003 Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background. 12882325
Curtis C et al., 2007 Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. 18067683
Todd AM & Staveley BE, 2012 Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan. 22653599
Tettweiler G et al., 2005 Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. 16055649
Bauer, Johannes H et al., 2009 dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster. 19851477
Chen D et al., 2009 HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. 19461873
Mockett, Robin J et al., 2010 Expression of multiple copies of mitochondrially targeted catalase or genomic Mn superoxide dismutase transgenes does not extend the life span of Drosophila melanogaster. 20923705
Orr WC et al., 2003 Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster. 12743125
Kabil H et al., 2007 Superoxide dismutase activities in long-lived Drosophila melanogaster females: chico1 genotypes and dietary dilution. 17103233
Shimizu, Takahiko et al., 2011 Lifespan and glucose metabolism in insulin receptor mutant mice. 21876806
Simonsen A et al., 2004 Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. 15292400
Mourikis P et al., 2006 Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila. 16434470
Lee SH et al., 2012 Overexpression of Fatty-Acid-β-Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster. 22997544
Gimenez LE et al., 2012 Modulation of Methuselah Expression Targeted to Drosophila Insulin-producing Cells Extends Life and Enhances Oxidative Stress Resistance. 23121290
Downs JA et al., 2003 Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. 12820979
Kumar S et al., 2012 Extension of yeast chronological lifespan by methylamine. 23133668
Fabrizio P & Longo VD, 2007 The chronological life span of Saccharomyces cerevisiae. 17634576
Malick LE & Kidwell JF, 1966 The effect of mating status, sex and genotype on longevity in Drosophila melanogaster. 5961480
Carmona-Gutiérrez D et al., 2011 The propeptide of yeast cathepsin D inhibits programmed necrosis. 21593793
de Cabo R et al., 2003 An in vitro model of caloric restriction. 12814798
Soltow QA et al., 2010 A network perspective on metabolism and aging. 21031036
Xu M et al., 2008 An integrative approach to characterize disease-specific pathways and their coordination: a case study in cancer. 18366601
Zhang S et al., 2011 A novel computational framework for simultaneous integration of multiple types of genomic data to identify microRNA-gene regulatory modules. 21685098
Mete M et al., 2008 A structural approach for finding functional modules from large biological networks. 18793464
Janes KA et al., 2005 A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. 16339439
Pe'er D, 2005 Bayesian network analysis of signaling networks: a primer. 15855409
Kovács IA et al., 2010 Community landscapes: an integrative approach to determine overlapping network module hierarchy, identify key nodes and predict network dynamics. 20824084
Hahn MW & Kern AD, 2005 Comparative genomics of centrality and essentiality in three eukaryotic protein-interaction networks. 15616139
Raza S et al., 2010 Construction of a large scale integrated map of macrophage pathogen recognition and effector systems. 20470404
Freeman TC et al., 2007 Construction, visualisation, and clustering of transcription networks from microarray expression data. 17967053
Wang J et al., 2009 Disease-aging network reveals significant roles of aging genes in connecting genetic diseases. 19779549
Fraser, Hunter B et al., 2002 Evolutionary rate in the protein interaction network. 11976460
Batada, Nizar N et al., 2006 Evolutionary and physiological importance of hub proteins. 16839197
Boone, Charles et al., 2007 Exploring genetic interactions and networks with yeast. 17510664
Glaab E et al., 2010 Extending pathways and processes using molecular interaction networks to analyse cancer genome data. 21144022
Emilsson, Valur et al., 2008 Genetics of gene expression and its effect on disease. 18344981
Gillis J & Pavlidis P, 2012 "Guilt by association" is the exception rather than the rule in gene networks. 22479173
Merico D et al., 2009 How to visually interpret biological data using networks. 19816451
Gu J et al., 2010 Identification of responsive gene modules by network-based gene clustering and extending: application to inflammation and angiogenesis. 20406493
Maucher M et al., 2011 Inferring Boolean network structure via correlation. 21471013
Fortney K et al., 2010 Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging. 20128910
Zhu J et al., 2008 Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. 18552845
Wang, Yu-Chao & Chen, Bor-Sen, 2010 Integrated cellular network of transcription regulations and protein-protein interactions. 20211003
Chautard E et al., 2010 Interaction networks as a tool to investigate the mechanisms of aging. 20213321
Soler-López M et al., 2011 Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. 21163940
Budovsky A et al., 2007 Longevity network: construction and implications. 17116322
Emmert-Streib, Frank & Glazko, Galina V, 2011 Network biology: a direct approach to study biological function. 21197659
Barabasi, Albert-Laszlo & Oltvai, Zoltan N, 2004 Network biology: understanding the cell's functional organization. 14735121
Lecca P et al., 2011 Network inference from time-dependent Omics data. 21370096
Behrends, Christian et al., 2010 Network organization of the human autophagy system. 20562859
Theocharidis A et al., 2009 Network visualization and analysis of gene expression data using BioLayout Express(3D). 19798086
Emmert-Streib F & Glazko GV, 2011 Pathway analysis of expression data: deciphering functional building blocks of complex diseases. 21637797
Promislow DE, 2004 Protein networks, pleiotropy and the evolution of senescence. 15306346
Barabasi, Albert-Laszlo, 2009 Scale-free networks: a decade and beyond. 19628854
Ciaccio MF et al., 2010 Systems analysis of EGF receptor signaling dynamics with microwestern arrays. 20101245
De Smet R & Marchal K, 2010 Advantages and limitations of current network inference methods. 20805835
Jiao QJ et al., 2011 BinTree seeking: a novel approach to mine both bi-sparse and cohesive modules in protein interaction networks. 22140454
Vallabhajosyula, Ravishankar R & Raval, Alpan, 2010 Computational modeling in systems biology. 20824468
Sneddon MW et al., 2011 Efficient modeling, simulation and coarse-graining of biological complexity with NFsim. 21186362
Hartwell, L H et al., 1999 From molecular to modular cell biology. 10591225
Wang, Jianxin et al., 2010 A fast hierarchical clustering algorithm for functional modules discovery in protein interaction networks. 20733244
Shou C et al., 2011 Measuring the evolutionary rewiring of biological networks. 21253555
Rives AW & Galitski T, 2003 Modular organization of cellular networks. 12538875
Michaut M & Bader GD, 2012 Multiple genetic interaction experiments provide complementary information useful for gene function prediction. 22737063
Murali TM & Rivera CG, 2008 Network legos: building blocks of cellular wiring diagrams. 18707557
Barabasi, Albert-Laszlo et al., 2010 Network medicine: a network-based approach to human disease. 21164525
Bachman, John A & Sorger, Peter, 2011 New approaches to modeling complex biochemistry. 21278724
Ahmed SS et al., 2011 Systems biological approach on neurological disorders: a novel molecular connectivity to aging and psychiatric diseases. 21226925
Stumpf MP et al., 2008 Estimating the size of the human interactome. 18474861
Cho SC et al., 2010 DDS, 4,4'-diaminodiphenylsulfone, extends organismic lifespan. 20974969
Lee, Inhwan et al., 2012 Metabolic rate regulates L1 longevity in C. elegans. 22970296
Shimokawa I et al., 2009 Japan-Korea joint seminar: Asian aging core for longevity 2008 in Nagasaki - toward the establishment of an Asian aging research and education center - September 4th to 6th, 2008 at Huis ten Bosch, Nagasaki, Japan. 19084552
Lehrbach NJ et al., 2012 Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans. 23097426
Boulias K & Horvitz HR, 2012 The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO. 22482727
Lehner B et al., 2006 Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. 16845399
Ewing, Rob M et al., 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. 17353931
Sarup P et al., 2011 Flies selected for longevity retain a young gene expression profile. 20607427
Bonafè M et al., 2001 A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. 11500818
Lai CQ et al., 2007 Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. 17196240
Boutros M et al., 2002 Sequential activation of signaling pathways during innate immune responses in Drosophila. 12431377
Tanji T et al., 2006 Participation of a galactose-specific C-type lectin in Drosophila immunity. 16475980
Zhang C & Cuervo AM, 2008 Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. 18690243
Saftig P & Eskelinen EL, 2008 Live longer with LAMP-2. 18776878
Guachalla LM & Rudolph KL, 2009 Improve organ health by chewing up old proteins? 19115216
Jones MA et al., 2009 A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment. 19481596
Zou, S et al., 2000 Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. 11095759
Munier AI et al., 2004 graal: a Drosophila gene coding for several mosaic serine proteases. 15475297
Karsten SL et al., 2006 A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. 16950154
Paaby AB et al., 2010 Identification of a candidate adaptive polymorphism for Drosophila life history by parallel independent clines on two continents. 20074316
Delaney1 2 JR et al., 2012 Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. 23167605
Hughes AL & Gottschling DE, 2012 An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. 23172144
López-Andrés N et al., 2012 Absence of Cardiotrophin 1 Is Associated With Decreased Age-Dependent Arterial Stiffness and Increased Longevity in Mice. 23172930
Butler, Jeffrey A et al., 2010 Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism. 20732954
Butler JA et al., 2012 A metabolic signature for long-life in the c. Elegans mit mutants. 23173729
Matheu A et al., 2007 Delayed ageing through damage protection by the Arf/p53 pathway. 17637672
Guevara-Aguirre J et al., 2011 Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. 21325617
Oxenkrug G et al., 2012 Minocycline effect on life and health span of Drosophila melanogaster. 23185716
Anisimov VN et al., 2011 Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. 22107964
McColl, Gawain et al., 2010 Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. 20816092
Zhan M et al., 2007 Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster. 17623811
Dillin, Andrew et al., 2002 Timing requirements for insulin/IGF-1 signaling in C. elegans. 12399591
Giannakou, Maria E et al., 2004 Long-lived Drosophila with overexpressed dFOXO in adult fat body. 15192154
Walker DW et al., 2006 Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant. 17056719
Kato, Masaomi et al., 2011 Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. 21810936
Lim DH et al., 2011 The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. 21889502
Xu P et al., 2003 The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. 12725740
Conover CA et al., 2010 Longevity is not influenced by prenatal programming of body size. 20550518
Baati, Tarek et al., 2012 The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene. 22498298
Ali SS et al., 2004 A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties. 15451059
Quick KL et al., 2008 A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice. 17079053
Gao J et al., 2011 Polyhydroxy fullerenes (fullerols or fullerenols): beneficial effects on growth and lifespan in diverse biological models. 21637768
Kubota R et al., 2011 Time-dependent variation in the biodistribution of C₆₀ in rats determined by liquid chromatography-tandem mass spectrometry. 21787853
Gharbi N et al., 2005 [60]fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity. 16351219
Owen RW et al., 2000 Olive-oil consumption and health: the possible role of antioxidants. 11905662
Jacomelli M et al., 2010 Dietary extra-virgin olive oil rich in phenolic antioxidants and the aging process: long-term effects in the rat. 19369055
Inukai S et al., 2012 Novel microRNAs differentially expressed during aging in the mouse brain. 22844398
Ibanez-Ventoso, Carolina et al., 2006 Modulated microRNA expression during adult lifespan in Caenorhabditis elegans. 16842496
Dallaire A et al., 2012 Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging. 23075628
Lee, Se-Jin et al., 2004 A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint. 15115755
Lebel M et al., 2003 Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. 12707040
Massip L et al., 2010 Vitamin C restores healthy aging in a mouse model for Werner syndrome. 19741171
Takahashi M et al., 2012 Reduction of Type IV Collagen by Upregulated miR-29 in Normal Elderly Mouse and klotho-Deficient, Senescence-Model Mouse. 23139829
Anisimov VN et al., 2005 Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. 16125352
Anisimov VN et al., 2008 Metformin slows down aging and extends life span of female SHR mice. 18728386
Onken B & Driscoll M, 2010 Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. 20090912
Anisimov VN et al., 2011 If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. 21386129
Anisimov VN et al., 2005 Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice. 16224592
Anisimov VN et al., 2010 Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice. 21164223
Smith DL Jr et al., 2010 Metformin supplementation and life span in Fischer-344 rats. 20304770
Slack C et al., 2012 Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila. 23077661
Popovich IG et al., 2004 [Effect of antidiabetic drug diabenol on parameters of biological age, life span and tumor development in NMRI and HER-2/neu mice]. 15754958
Hannum G et al., 2012 Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates. 23177740
Saito T et al., 2005 Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. 15778722
Kim EJ et al., 2010 Skin aging and photoaging alter fatty acids composition, including 11,14,17-eicosatrienoic acid, in the epidermis of human skin. 20514327
Krechowec SO et al., 2012 Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice. 22253771
Hayasaka N et al., 2011 Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice. 21408016
Hirota T et al., 2010 Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork. 20070857
Chua KF et al., 2005 Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. 16054100
Asher G et al., 2008 SIRT1 regulates circadian clock gene expression through PER2 deacetylation. 18662546
Lamia KA et al., 2009 AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. 19833968
Miller BH et al., 2007 Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. 17360649
Koyanagi S et al., 2003 A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells. 14612524
Sebastián C et al., 2012 The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism. 23217706
Mostoslavsky R et al., 2006 Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. 16439206
Kusama S et al., 2006 Involvement of Drosophila Sir2-like genes in the regulation of life span. 17159295
Bai H et al., 2012 Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain. 22935001
Olivieri F et al., 2012 Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging. 23041385
Baker DJ et al., 2012 Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. 23242215
Hanks S et al., 2004 Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. 15475955
Matsumoto T et al., 2007 Aging-associated vascular phenotype in mutant mice with low levels of BubR1. 17272762
Hartman TK et al., 2007 Mutant mice with small amounts of BubR1 display accelerated age-related gliosis. 16781018
Baker DJ et al., 2008 Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. 18516091
Matsuura S et al., 2006 Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome. 16411201
Burtner CR & Kennedy BK, 2010 Progeria syndromes and ageing: what is the connection? 20651707
Villeda SA et al., 2011 The ageing systemic milieu negatively regulates neurogenesis and cognitive function. 21886162
Conboy IM et al., 2005 Rejuvenation of aged progenitor cells by exposure to a young systemic environment. 15716955
Jacob, H J, 1999 Functional genomics and rat models. 10568741
Lu T et al., 2004 Gene regulation and DNA damage in the ageing human brain. 15190254
Kastman EK et al., 2012 A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. 23082321
Bendlin BB et al., 2011 Effects of aging and calorie restriction on white matter in rhesus macaques. 20541839
Witte, A V et al., 2009 Caloric restriction improves memory in elderly humans. 19171901
Merry, Brian J et al., 2008 Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span. 18486188
Dashwood, Roderick H & Ho, Emily, 2007 Dietary histone deacetylase inhibitors: from cells to mice to man. 17555985
van de Mark K et al., 2003 Alpha-lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines. 12548552
Stoll S et al., 1993 The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits. 8309958
Poon HF et al., 2005 Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders. 15627516
Mattson, Mark P et al., 2002 Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. 12087131
Zhang, L et al., 2001 Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway. 11602326
Chung KW et al., 2012 Recent advances in calorie restriction research on aging. 23201549
Shay KP et al., 2009 Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. 19664690
Wood SH et al., 2012 Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome. 22555619
Masoro, Edward J, 2005 Overview of caloric restriction and ageing. 15885745
Fok WC et al., 2012 Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice. 22570137
Fumagalli M & d'Adda di Fagagna F, 2009 SASPense and DDRama in cancer and ageing. 19648977
Zhang G et al., 2012 Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity. 23258410
Papatheodorou I et al., 2012 Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing. 23251396
Umezaki Y et al., 2012 Pigment-Dispersing Factor Is Involved in Age-Dependent Rhythm Changes in Drosophila melanogaster. 23223368
Pagani L et al., 2011 Serum factors in older individuals change cellular clock properties. 21482780
Duffy JF et al., 1998 Later endogenous circadian temperature nadir relative to an earlier wake time in older people. 9791064
Duffy JF et al., 1999 Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people. 10198570
Biello SM, 2009 Circadian clock resetting in the mouse changes with age. 19557547
Dijk DJ et al., 2000 Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep. 10841208
Gitter A et al., 2012 Linking the signaling cascades and dynamic regulatory networks controlling stress responses. 23064748
Chung, Sangwoon et al., 2010 Regulation of SIRT1 in cellular functions: role of polyphenols. 20450879
Palacios JA et al., 2010 SIRT1 contributes to telomere maintenance and augments global homologous recombination. 21187328
Shen Y et al., 2012 A steroid receptor-microRNA switch regulates life span in response to signals from the gonad. 23239738
Schiavi A et al., 2012 Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans. 23247094
Xu X & Kim SK, 2012 The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegans. 23271974
Sinclair D & Verdin E, 2012 The longevity of sirtuins. 23273894
Banerjee, Kushal Kr et al., 2012 dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner. 23246004
Jordens, R G et al., 1999 Prolongation of life in an experimental model of aging in Drosophila melanogaster. 9972869
Heidrick ML et al., 1984 Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice. 6334792
Wang L et al., 2007 Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. 17227869
Kondratov RV et al., 2006 Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. 16847346
Harman, D, 1968 Free radical theory of aging: effect of free radical reaction inhibitors on the mortality rate of male LAF mice. 5723482
Harris SB et al., 1990 Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice. 2394907
Harman D, 2001 Aging: overview. 11795501
Xu Y et al., 1996 Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. 8843194
Elson A et al., 1996 Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. 8917548
Wong KK et al., 2003 Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. 12540856
Barlow C et al., 1996 Atm-deficient mice: a paradigm of ataxia telangiectasia. 8689683
Murga M et al., 2009 A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. 19620979
Ruzankina Y et al., 2007 Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. 18371340
Perez GI et al., 2007 Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice. 17360389
Jeng YM et al., 2007 Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation. 17420720
Cao L et al., 2003 Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. 12533509
Baker DJ et al., 2006 Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. 16476774
Zhang Y et al., 2007 Caspase-2 deficiency enhances aging-related traits in mice. 17188333
Cutler RG, 2005 Oxidative stress and aging: catalase is a longevity determinant enzyme. 16144468
Park DS et al., 2003 Caveolin-1 null (-/-) mice show dramatic reductions in life span. 14690422
Choudhury AR et al., 2007 Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. 17143283
Bedelbaeva K et al., 2010 Lack of p21 expression links cell cycle control and appendage regeneration in mice. 20231440
Arthur LM & Heber-Katz E, 2011 The role of p21 in regulating mammalian regeneration. 21722344
Cao L et al., 2006 ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. 16675955
McLaughlin PJ et al., 2007 Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice. 17872905
de Boer J et al., 2002 Premature aging in mice deficient in DNA repair and transcription. 11950998
Niedernhofer LJ et al., 2006 A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. 17183314
Razzaque MS et al., 2006 Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. 16436465
DeLuca S et al., 2008 Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23. 18729070
Krupczak-Hollis K et al., 2003 Growth hormone stimulates proliferation of old-aged regenerating liver through forkhead box m1b. 14647066
Thierbach R et al., 2005 Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. 16278235
Xie S et al., 2012 Upregulation of TRB2 induced by miR-98 in the early lesions of large artery of type-2 diabetic rat. 22012613
Watanabe T et al., 2006 Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. 16766679
Grady DL et al., 2013 DRD4 Genotype Predicts Longevity in Mouse and Human. 23283341
Yan, Jun et al., 2008 Analysis of gene regulatory networks in the mammalian circadian rhythm. 18846204
Spindler SR, 2012 Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span. 21424790
Delaney JR et al., 2012 Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. 23235143
Murakami C et al., 2012 pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. 22871733
Piper PW et al., 2006 Preadaptation to efficient respiratory maintenance is essential both for maximal longevity and the retention of replicative potential in chronologically ageing yeast. 16784770
Ringvoll J et al., 2007 Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol. 17506834
Komura T et al., 2013 Mechanism underlying prolongevity induced by bifidobacteria in Caenorhabditis elegans. 23291976
Zuo Y et al., 2013 Sesamin extends the mean lifespan of fruit flies. 23291977
Wilson MA et al., 2006 Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. 16441844
Wolkow, C A et al., 2000 Regulation of C. elegans life-span by insulinlike signaling in the nervous system. 11021802
Grompone G et al., 2012 Anti-Inflammatory Lactobacillus rhamnosus CNCM I-3690 Strain Protects against Oxidative Stress and Increases Lifespan in Caenorhabditis elegans. 23300685
Wijshake T et al., 2012 Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation. 23300461
Longo, Valter D et al., 2012 Replicative and chronological aging in Saccharomyces cerevisiae. 22768836
Blokh D et al., 2007 Breast cancer detection by Michaelis-Menten constants via linear programming. 17188399
Blokh D et al., 2007 The information-theory analysis of Michaelis-Menten constants for detection of breast cancer. 18061365
Blokh D et al., 2009 Comparative analysis of cell parameter groups for breast cancer detection. 19231022
Ng DS et al., 2013 HDL-is it too big to fail? 23318230
Beekman, Marian et al., 2013 Genome-wide linkage analysis for human longevity: Genetics of Healthy Ageing Study. 23286790
Blokh D et al., 2008 An information-theoretical model for breast cancer detection. 18690365
Montgomery MK et al., 2012 Metabolic rate and membrane fatty acid composition in birds: a comparison between long-living parrots and short-living fowl. 21766191
Reavill, Drury R & Dorrestein, Gerry M, 2010 Pathology of aging psittacines. 20159547
Herrero A & Barja G, 1999 8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging. 10631878
Ogburn CE et al., 2001 Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression. 11682567
Viña J et al., 2007 Theories of ageing. 17505961
Collins CJ & Sedivy JM, 2003 Involvement of the INK4a/Arf gene locus in senescence. 12882406
Krishnamurthy J et al., 2004 Ink4a/Arf expression is a biomarker of aging. 15520862
Krimpenfort P et al., 2001 Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. 11544530
Hood I et al., 1988 Fatality from illicit phendimetrazine use. 2901497
Rando TA & Chang HY, 2012 Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. 22265401
González-Beltrán A et al., 2012 Federated ontology-based queries over cancer data. 22373043
McCusker JP et al., 2009 Semantic web data warehousing for caGrid. 19796399
Horvath S et al., 2012 Aging effects on DNA methylation modules in human brain and blood tissue. 23034122
Vera E et al., 2013 Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. 23349740
Bala, Kiran et al., 2006 Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions. 16802111
Shen LR et al., 2013 Curcumin and aging. 23325575
Kitani K et al., 2007 The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice. 17516143
Dimmeler S & Nicotera P, 2013 MicroRNAs in age-related diseases. 23339066
Durieux J et al., 2011 The cell-non-autonomous nature of electron transport chain-mediated longevity. 21215371
Nebel A et al., 2009 A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians. 19698732
Soerensen M, 2012 Genetic variation and human longevity. 22549493
Mander BA et al., 2013 Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging. 23354332
Halicka HD et al., 2012 Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. 23363784
Bollheimer LC et al., 2012 [Reversal of aging and lifespan elongation : Current biomedical key publications and the implications for geriatrics.] 23242337
Liu M et al., 2013 Resveratrol protects against age-associated infertility in mice. 23293221
Yu X & Li G, 2012 Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri. 22960591
Morris BJ, 2012 Seven sirtuins for seven deadly diseases of aging. 23104101
Park HR et al., 2012 Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis. 23105098
Ito K et al., 2012 Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease. 23055713
Cheung TM et al., 2012 Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. 23023872
Liu GS et al., 2012 Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice. 22982350
Guarente, Leonard, 2005 NO link between calorie restriction and mitochondria. 16370369
Zhang Y et al., 2013 Hydrogen Sulfide: Next Potent Preventive and Therapeutic Agent in Aging and Age-associated Diseases. 23297346
Powolny AA et al., 2011 The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation. 21296648
De Cecco M et al., 2013 Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. 23360310
Brown K et al., 2013 SIRT3 Reverses Aging-Associated Degeneration. 23375372
Gerber A et al., 2013 Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity. 23374345
Warr MR et al., 2013 FOXO3A directs a protective autophagy program in haematopoietic stem cells. 23389440
Mizwicki MT et al., 2013 1α,25-Dihydroxyvitamin D3 and Resolvin D1 Retune the Balance between Amyloid-β Phagocytosis and Inflammation in Alzheimer's Disease Patients. 23186989
Tapia N et al., 2012 Restoring stem cell function in aged tissues by direct reprogramming? 22704502
Zwi-Dantsis L et al., 2012 Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients. 22621821
Glessner JT et al., 2013 Copy number variations in alternative splicing gene networks impact lifespan. 23382853
Orr WC et al., 2005 Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster. 16148000
Biteau B et al., 2010 Lifespan extension by preserving proliferative homeostasis in Drosophila. 20976250
Ivey KN et al., 2008 MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. 18371447
Moskalev AA & Shaposhnikov MV, 2010 Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster. 20017609
Barabási AL, 2013 Network science. 23419844
Philipp EE et al., 2012 Gene expression and physiological changes of different populations of the long-lived bivalve Arctica islandica under low oxygen conditions. 23028566
Lutz PL et al., 2003 Is turtle longevity linked to enhanced mechanisms for surviving brain anoxia and reoxygenation? 12855290
Krivoruchko A & Storey KB, 2010 Forever young: mechanisms of natural anoxia tolerance and potential links to longevity. 20716943
Belleau F et al., 2008 Bio2RDF: towards a mashup to build bioinformatics knowledge systems. 18472304
Ziv Y et al., 2013 Long-term dynamics of CA1 hippocampal place codes. 23396101
Jiang, Jianhua et al., 2013 Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease. 23426728
Pan Y et al., 2012 Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review. 22947849
Zimmerman, Laura M et al., 2013 Humoral immune responses are maintained with age in a long-lived ectotherm, the red-eared slider turtle. 23077164
Plot, Virginie et al., 2012 Telomeres, age and reproduction in a long-lived reptile. 22808278
Deweerdt S, 2012 Comparative biology: Looking for a master switch. 23222666
Van Nostrand EL et al., 2013 Roles of the Developmental Regulator unc-62/Homothorax in Limiting Longevity in Caenorhabditis elegans. 23468654
Ortega-Molina A & Serrano M, 2012 PTEN in cancer, metabolism, and aging. 23245767
Trindade, Lucas S et al., 2013 A novel classification system for evolutionary aging theories. 23508239
Callahan A et al., 2011 HyQue: evaluating hypotheses using Semantic Web technologies. 21624158
Attwood TK et al., 2009 Calling International Rescue: knowledge lost in literature and data landslide! 19929850
Othersen OG et al., 2012 Application of information theory to feature selection in protein docking. 21748327
Freitas, Alex A et al., 2011 A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related. 21226956
de Magalhães JP et al., 2009 The Human Ageing Genomic Resources: online databases and tools for biogerontologists. 18986374
Tacutu R et al., 2013 Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing. 23193293
Dhahbi JM et al., 2013 Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction. 23470454
Bhaumik D et al., 2009 MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. 20148189
Voorhoeve PM et al., 2006 A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. 16564011
Wagner W et al., 2008 Replicative senescence of mesenchymal stem cells: a continuous and organized process. 18493317
Maeda T et al., 2005 Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. 15662416
Pomerantz J et al., 1998 The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. 9529248
Poliseno L et al., 2008 The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence. 18596985
Bommer GT et al., 2007 p53-mediated activation of miRNA34 candidate tumor-suppressor genes. 17656095
He L et al., 2007 A microRNA component of the p53 tumour suppressor network. 17554337
Tazawa H et al., 2007 Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. 17875987
Kumamoto K et al., 2008 Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. 18451145
Braconi C et al., 2011 microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. 21625215
Peeper DS, 2011 Ageing: Old cells under attack. 22071762
Cheung TH et al., 2012 Maintenance of muscle stem-cell quiescence by microRNA-489. 22358842
Garofalo M et al., 2009 miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. 19962668
Chun-Zhi Z et al., 2010 MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN. 20618998
Grillari J et al., 2010 miR-17-92 cluster: ups and downs in cancer and aging. 20437201
Hackl M et al., 2010 miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. 20089119
Gavrilova NS et al., 2012 Testing predictions of the programmed and stochastic theories of aging: comparison of variation in age at death, menopause, and sexual maturation. 22817539
Bates DJ et al., 2010 MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging. 19878148
Li N et al., 2011 Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1. 21216258
Chen LH et al., 2010 MicroRNA and aging: a novel modulator in regulating the aging network. 20708718
Smith-Vikos T & Slack FJ, 2012 MicroRNAs and their roles in aging. 22294612
Antezana, Erick et al., 2013 The emergence of Semantic Systems Biology. 23165099
Maes OC et al., 2008 Murine microRNAs implicated in liver functions and aging process. 18561983
Zhang G et al., 2013 Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. 23636330
Martins AC, 2011 Change and aging senescence as an adaptation. 21949706
Jung, Hwa Jin & Suh, Yousin, 2012 MicroRNA in Aging: From Discovery to Biology. 23633914
Wongchitrat P et al., 2012 The expression of Per1 and Aa-nat genes in the pineal gland of postnatal rats. 23513468
Somel M et al., 2010 MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. 20647238
Skulachev VP, 1999 Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms. 10626278
Skulachev, V P, 2001 The programmed death phenomena, aging, and the Samurai law of biology. 11404047
Bradley AJ et al., 1980 Stress and mortality in a small marsupial (Antechinus stuartii, Macleay). 6245013
Skulachev, V P, 1997 Aging is a specific biological function rather than the result of a disorder in complex living systems: biochemical evidence in support of Weismann's hypothesis. 9467841
Skulachev, V P, 1999 Phenoptosis: programmed death of an organism. 10648966
Raff M, 1998 Cell suicide for beginners. 9823889
Lewis K, 2000 Programmed death in bacteria. 10974124
Dan I et al., 2001 The Ste20 group kinases as regulators of MAP kinase cascades. 11316611
Goldsmith TC, 2004 Aging as an evolved characteristic - Weismann's theory reconsidered. 14962645
Ruckenstuhl C et al., 2010 The sweet taste of death: glucose triggers apoptosis during yeast chronological aging. 21076182
Fabrizio P et al., 2004 Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. 15452146
Mattison JA et al., 2012 Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. 22932268
de Magalhães JP & Toussaint O, 2004 How bioinformatics can help reverse engineer human aging. 15177050
Epstein CJ et al., 1966 Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. 5327241
De Luca G et al., 2013 Prolonged Lifespan with Enhanced Exploratory Behavior in Mice Overexpressing the Oxidized Nucleoside Triphosphatase hMTH1. 23648059
Tatar M et al., 2003 The endocrine regulation of aging by insulin-like signals. 12610294
Knauf F et al., 2002 Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. 12391301
Loo LW et al., 2005 The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster. 16055719
Goddeeris MM et al., 2003 Delayed behavioural aging and altered mortality in Drosophila beta integrin mutants. 14570233
Bauer JH et al., 2007 Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling. 17686972
McQuibban GA et al., 2006 Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. 16713954
Tsuda M et al., 2007 A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila. 17854771
Phillips JP et al., 1989 Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. 2539600
Cvejic S et al., 2004 The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila. 15133470
Zordan MA et al., 2006 Post-transcriptional silencing and functional characterization of the Drosophila melanogaster homolog of human Surf1. 16172499
Fridell YW et al., 2005 Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly. 16054055
Nielsen, Mette Damgaard et al., 2008 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. 18665908
Liu YL et al., 2009 Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. 19302370
Martínez-Azorín F et al., 2008 Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion. 17999718
Taghli-Lamallem O et al., 2008 Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype. 18221418
Siebold AP et al., 2010 Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance. 20018689
Toba G et al., 2010 Life-span phenotypes of elav and Rbp9 in Drosophila suggest functional cooperation of the two ELAV-family protein genes. 20589912
Runko AP et al., 2008 Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila. 18258192
Li Y & Tower J, 2009 Adult-specific over-expression of the Drosophila genes magu and hebe increases life span and modulates late-age female fecundity. 19011900
Wadhwa R et al., 2010 Proproliferative functions of Drosophila small mitochondrial heat shock protein 22 in human cells. 19948727
Tao D et al., 2004 Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression. 15346199
Liu, Zhiyan et al., 2008 Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance. 18275960
Kim J et al., 2010 dGIPC is required for the locomotive activity and longevity in Drosophila. 21029723
Brandt A et al., 2008 The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies. 18494863
Lin YR et al., 2011 Loco signaling pathway in longevity. 21776417
Reenan RA & Rogina B, 2008 Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila. 18208580
Mery A et al., 2008 The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function. 18083727
Bahadorani S et al., 2010 Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity. 18775584
Balan V et al., 2008 Life span extension and neuronal cell protection by Drosophila nicotinamidase. 18678867
Nakayama M et al., 2011 Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes. 21826223
Demontis F & Perrimon N, 2010 FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. 21111239
Suh JM et al., 2008 An RGS-containing sorting nexin controls Drosophila lifespan. 18478054
Gáliková M & Flatt T, 2010 Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout. 20622267
Sone M et al., 2009 Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening. 19209226
Legan, Susan K et al., 2008 Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster. 18809674
Zhao Y et al., 2005 Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. 15695762
Rera M et al., 2011 Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. 22055505
Esslinger SM et al., 2013 Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. 23669073
Calin GA et al., 2002 Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. 12434020
Cimmino A et al., 2005 miR-15 and miR-16 induce apoptosis by targeting BCL2. 16166262
Musumeci M et al., 2011 Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer. 21532615
Bottoni A et al., 2005 miR-15a and miR-16-1 down-regulation in pituitary adenomas. 15648093
Shi B et al., 2007 Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. 17827156
La Rocca G et al., 2009 Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway. 19391107
Lee HK et al., 2013 MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor. 23390502
Haapa-Paananen S et al., 2013 Functional Profiling of Precursor MicroRNAs Identifies MicroRNAs Essential for Glioma Proliferation. 23577178
Chang TC et al., 2007 Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. 17540599
Tarasov V et al., 2007 Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. 17554199
Cole KA et al., 2008 A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. 18505919
Choi YH et al., 2003 Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians. 12634288
Arai Y et al., 2003 Deficiency of choresteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity. 12601526
Zuo B et al., 2012 Influences of lamin A levels on induction of pluripotent stem cells. 23213392
Speakman JR & Król E, 2010 The heat dissipation limit theory and evolution of life histories in endotherms--time to dispose of the disposable soma theory? 21558242
Nussey DH et al., 2013 Senescence in natural populations of animals: widespread evidence and its implications for bio-gerontology. 22884974
Froy O & Miskin R, 2010 Effect of feeding regimens on circadian rhythms: implications for aging and longevity. 20228939
Gutman, Roee et al., 2011 Long-lived mice exhibit 24 h locomotor circadian rhythms at young and old age. 21376793
Garaulet M & Madrid JA, 2010 Chronobiological aspects of nutrition, metabolic syndrome and obesity. 20580916
Omodei, Daniela & Fontana, Luigi, 2011 Calorie restriction and prevention of age-associated chronic disease. 21402069
Trepanowski JF et al., 2011 Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings. 21981968
Fontana L et al., 2010 Extending healthy life span--from yeast to humans. 20395504
Hatori M et al., 2012 Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. 22608008
Sherman H et al., 2012 Timed high-fat diet resets circadian metabolism and prevents obesity. 22593546
Kuroda H et al., 2012 Meal frequency patterns determine the phase of mouse peripheral circadian clocks. 23050095
Rakshit, Kuntol et al., 2012 Effects of aging on the molecular circadian oscillations in Drosophila. 22217096
Kondratova AA & Kondratov RV, 2012 The circadian clock and pathology of the ageing brain. 22395806
Zhdanova, I V et al., 2011 Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta. 21454295
Yamazaki, Shin et al., 2002 Effects of aging on central and peripheral mammalian clocks. 12149444
Luo W et al., 2012 Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations. 22268765
Corbalán-Tutau D et al., 2012 Daily profile in two circadian markers "melatonin and cortisol" and associations with metabolic syndrome components. 22705307
Bähr I et al., 2012 Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways. 22672634
Froy O, 2010 Metabolism and circadian rhythms--implications for obesity. 19854863
Wu Z et al., 2013 Dietary Restriction Depends on Nutrient Composition to Extend Chronological Lifespan in Budding Yeast Saccharomyces cerevisiae. 23691220
Houtkooper RH et al., 2013 Mitonuclear protein imbalance as a conserved longevity mechanism. 23698443
Paaby AB & Schmidt PS, 2009 Dissecting the genetics of longevity in Drosophila melanogaster. 19182541
Tatar M et al., 2001 Negligible Senescence during Reproductive Dormancy in Drosophila melanogaster. 18707322
Williams KD et al., 2006 Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase. 17043223
Sheeba, V et al., 2000 The effect of different light regimes on adult life span in Drosophila melanogaster is partly mediated through reproductive output. 11039916
Zhu Y et al., 2011 Lentiviral vector-mediated upregulation of let-7a inhibits gastric carcinoma cell growth in vitro and in vivo. 20809749
Yang Q et al., 2011 Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C. 21349817
Hu X et al., 2013 The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer. 23339187
Bhutia YD et al., 2013 Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein. 23335963
Nishi M et al., 2013 Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements. 22918121
Schultz J et al., 2008 MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. 18379589
Nadiminty N et al., 2012 MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. 22479342
Nadiminty N et al., 2012 MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. 22128178
Prainsack B, 2011 Voting with their mice: personal genome testing and the "participatory turn" in disease research. 21574070
de Magalhães JP et al., 2012 Genome-environment interactions that modulate aging: powerful targets for drug discovery. 22090473
Plank M et al., 2012 A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms. 22327899
Johnson AA et al., 2012 The role of DNA methylation in aging, rejuvenation, and age-related disease. 23098078
Pishel I et al., 2012 Accelerated aging versus rejuvenation of the immune system in heterochronic parabiosis. 22533440
Hughes KA et al., 2002 A test of evolutionary theories of aging. 12386342
Rose M & Charlesworth B, 1980 A test of evolutionary theories of senescence. 6776406
Shmookler Reis RJ et al., 2009 Extreme-longevity mutations orchestrate silencing of multiple signaling pathways. 19465083
Nebel A et al., 2011 A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. 21740922
Zheng B et al., 2011 MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. 21994419
Liffers ST et al., 2011 MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B. 21709669
Song YX et al., 2011 MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation. 21205300
Zhao G et al., 2013 miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKα1. 23171948
Xiang Y et al., 2013 MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine. 23318422
Zhou X et al., 2012 Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation. 21971665
Cardelli M et al., 2006 A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity. 16799135
Wang X et al., 2001 Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang. 11780357
Bessenyei B et al., 2004 Single nucleotide polymorphisms: aging and diseases. 15547317
Louhija J et al., 1994 Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians. 8018664
Anisimov SV et al., 2001 Age-associated accumulation of the apolipoprotein C-III gene T-455C polymorphism C allele in a Russian population. 11193221
Atzmon G et al., 2006 Lipoprotein genotype and conserved pathway for exceptional longevity in humans. 16602826
Van Voorhies, Wayne A et al., 2005 The longevity of Caenorhabditis elegans in soil. 17148178
Klapper, W et al., 1998 Longevity of lobsters is linked to ubiquitous telomerase expression. 9849895
Klapper W et al., 1998 Telomerase activity in 'immortal' fish. 9742964
Anselmi CV et al., 2009 Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. 19415983
Kolovou G et al., 2013 The Frequency of 4 Common Gene Polymorphisms in Nonagenarians, Centenarians, and Average Life Span Individuals. 23389097
Lee P et al., 2003 Polymorphisms in the human homologue of the drosophila Indy (I'm not dead yet) gene. 14499494
Terry DF et al., 2006 Serum heat shock protein 70 level as a biomarker of exceptional longevity. 17027907
Lao JI et al., 2005 Genetic contribution to aging: deleterious and helpful genes define life expectancy. 16399887
Kerber RA et al., 2012 A genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci. 22506048
Khabour OF & Barnawi JM, 2010 Association of longevity with IL-10 -1082 G/A and TNF-alpha-308 G/A polymorphisms. 20518833
Malaguarnera L et al., 2010 Human chitotriosidase polymorphism is associated with human longevity in Mediterranean nonagenarians and centenarians. 19881466
Kokaze A, 2005 Genetic epidemiological studies of longevity-associated mitochondrial DNA 5178 C/A polymorphism. 21432114
Middleton D et al., 2000 Immunogenetics and Life-Span : HLA. 22351285
Grimaldi MP et al., 2006 Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population. 16387839
Beaver LM et al., 2003 Noncircadian regulation and function of clock genes period and timeless in oogenesis of Drosophila melanogaster. 14667147
Bruce C et al., 1998 Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia. 9610775
Boekholdt SM et al., 2004 CETP gene variation: relation to lipid parameters and cardiovascular risk. 15243211
Siest, G et al., 1995 Apolipoprotein E: an important gene and protein to follow in laboratory medicine. 7628082
Weintraub MS et al., 1987 Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. 3479440
Hanis CL et al., 1991 Effects of the apolipoprotein E polymorphism on levels of lipids, lipoproteins, and apolipoproteins among Mexican-Americans in Starr County, Texas. 1998654
Davignon J et al., 1988 Apolipoprotein E polymorphism and atherosclerosis. 3277611
Kataoka S et al., 1996 Apolipoprotein E polymorphism in American Indians and its relation to plasma lipoproteins and diabetes. The Strong Heart Study. 8696954
Schaefer EJ et al., 1994 Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study. 8018666
Hallman DM et al., 1991 The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. 1867194
Lenzen HJ et al., 1986 Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease. 3698268
Eichner JE et al., 2002 Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. 11882522
Hu P et al., 2006 Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging. 16799145
Candore G et al., 2006 Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4. 16803999
De Benedictis G et al., 1998 Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). 9887369
Tan Q et al., 2004 Assessing genetic association with human survival at multi-allelic loci. 15105583
Maekawa M et al., 2005 Pilot study of arbitrarily primed PCR-single stranded DNA conformation polymorphism analysis for screening genetic polymorphisms related to specific phenotypes. 15820493
DeVry CG & Clarke S, 1999 Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins. 10496068
Faure-Delanef L et al., 1998 Plasma concentration, kinetic constants, and gene polymorphism of angiotensin I-converting enzyme in centenarians. 9761238
Rahmutula D et al., 2002 Angiotensin-converting enzyme gene and longevity in the Xin Jiang Uighur autonomous region of China: an association study. 11773214
Tan Q et al., 2001 Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity. 11602206
Garasto S et al., 2003 The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. 12556235
Pepe G et al., 1998 In search of a biological pattern for human longevity: impact of apo A-IV genetic polymorphisms on lipoproteins and the hyper-Lp(a) in centenarians. 9622284
De Benedictis G et al., 1997 DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus. 9050915
Kammerer S et al., 2003 Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. 12646697
Reiner AP et al., 2005 Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study. 15939070
Taioli E et al., 2001 Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus. 11162685
Lio D et al., 2002 Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population. 11857056
Akisaka M et al., 1997 Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity. 9389323
Yamaya M et al., 2003 Relationship between microsatellite polymorphism in the haem oxygenase-1 gene promoter and longevity of the normal Japanese population. 12566526
Altomare K et al., 2003 The allele (A)(-110) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women. 14501185
Singh R et al., 2006 Heat-shock protein 70 genes and human longevity: a view from Denmark. 16804002
Ross OA et al., 2003 Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population. 12742533
Lio D et al., 2002 Allele frequencies of +874T-->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians. 11772518
Bonafè M et al., 2003 Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. 12843179
Lio D et al., 2002 Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. 11857058
Kojima T et al., 2004 Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. 15582274
Kim DJ et al., 2006 Association between the MLH1 gene and longevity. 16474933
Linnebank M et al., 2005 The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity. 16142417
Xia Y et al., 2003 Effect of six candidate genes on early aging in a French population. 12889841
Barbieri M et al., 2004 Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity. 15236769
Gondo Y et al., 2005 Contribution of an affect-associated gene to human longevity: prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians. 16095668
Carrieri G et al., 2004 The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. 15569360
Soto-Vega E et al., 2005 Human leukocyte antigen class I, class II, and tumor necrosis factor-alpha polymorphisms in a healthy elder Mexican Mestizo population. 16269080
Jazwinski SM et al., 2010 HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging. 20569235
Berryman DE et al., 2013 A Dwarf Mouse Model With Decreased GH/IGF-1 Activity That Does Not Experience Life-Span Extension: Potential Impact of Increased Adiposity, Leptin, and Insulin With Advancing Age. 23695394
Scheibner KA et al., 2012 MiR-27a functions as a tumor suppressor in acute leukemia by regulating 14-3-3θ. 23236401
Liu T et al., 2009 MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin. 18789835
Jahid S et al., 2012 miR-23a promotes the transition from indolent to invasive colorectal cancer. 22628407
Deng S et al., 2008 Mechanisms of microRNA deregulation in human cancer. 18719391
Vincent JL, 1991 Advances in the concepts of intensive care. 2035418
Zang YS et al., 2012 MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression. 22996741
Kleine-Vehn J et al., 2011 Recycling, clustering, and endocytosis jointly maintain PIN auxin carrier polarity at the plasma membrane. 22027551
Jiang S et al., 2010 MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. 20354188
Babar IA et al., 2011 Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells. 22027557
Brus, M et al., 2013 Dynamics of olfactory and hippocampal neurogenesis in adult sheep. 22700217
Jin K et al., 2003 Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice. 12882410
Di Pietro F et al., 2013 TP53*P72 allele influences negatively female life expectancy in a population of central Italy: cross-sectional study and genetic-demographic approach analysis. 23125046
Olivieri F et al., 2002 The -174 C/G locus affects in vitro/in vivo IL-6 production during aging. 11772517
Lio D et al., 2004 Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. 15466015
Lescai F et al., 2009 Human longevity and 11p15.5: a study in 1321 centenarians. 19367319
Naumova E et al., 2011 'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop. 21299522
Heijmans BT et al., 2000 Common gene variants, mortality and extreme longevity in humans. 11053677
Ivanova R et al., 1998 HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity. 9425225
Cortopassi GA, 2002 Fixation of deleterious alleles, evolution and human aging. 12044933
Panza F et al., 2003 Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe. 12954489
Trougakos IP et al., 2006 Reduced expression levels of the senescence biomarker clusterin/apolipoprotein j in lymphocytes from healthy centenarians. 16804001
Piaceri I et al., 2013 Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians. 22960875
Pesch B et al., 2004 Polymorphic metabolic susceptibility genes and longevity: a study in octogonarians. 15177664
Kuznetsova SM, 1987 Polymorphism of heterochromatin areas on chromosomes 1, 9, 16 and Y in long-lived subjects and persons of different ages in two regions of the Soviet Union. 3632129
Sebastiani P et al., 2011 Whole genome sequences of a male and female supercentenarian, ages greater than 114 years. 22303384
Nebel A et al., 2007 Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men. 17493663
Meiklejohn DJ et al., 2000 The contribution of factor VII gene polymorphisms to longevity in Scottish nonagenarians. 10744171
Listì F et al., 2010 HLA and KIR frequencies in Sicilian Centenarians. 20426625
Naumova E et al., 2004 Immunological markers contributing to successful aging in Bulgarians. 15050300
Pan SL et al., 2012 Cholesteryl ester transfer protein TaqIB polymorphism and its association with serum lipid levels and longevity in Chinese Bama Zhuang population. 22336474
Adler G et al., 2010 An age-related decrease in factor V Leiden frequency among Polish subjects. 20720309
Tan Q et al., 2008 Power for genetic association study of human longevity using the case-control design. 18756013
Flachsbart F et al., 2011 Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population. 21798861
Bilal E et al., 2008 Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan. 18545700
Flachsbart F et al., 2006 Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity. 16257164
Naumova E et al., 2007 14th International HLA and Immunogenetics Workshop: report on the immunogenetics of aging. 17445222
Walston JD et al., 2009 Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. 19249341
Frederiksen H et al., 2003 Angiotensin I-converting enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival--a follow-up study of elderly Danish twins. 12547486
Deelen J et al., 2013 Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways. 22113349
Atzmon G et al., 2005 Biological evidence for inheritance of exceptional longevity. 15621216
Pan SL et al., 2012 Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China. 23273182
Wilding CS et al., 2006 Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity. 16518718
Woo J et al., 2012 The Alu polymorphism of angiotensin I converting enzyme (ACE) and atherosclerosis, incident chronic diseases and mortality in an elderly Chinese population. 22456784
Jylhävä J & Hurme M, 2010 Gene variants as determinants of longevity: focus on the inflammatory factors. 19763607
Yashin AI et al., 2010 Joint influence of small-effect genetic variants on human longevity. 20834067
Jiang W et al., 2007 Correlation between haplotype of apolipoprotein B gene and natural longevity persons in Uygur nationality. 17393087
Melzer D, 2008 Genetic polymorphisms and human aging: association studies deliver. 18341427
Han J et al., 2013 Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing. 23376243
Kleindorp R et al., 2011 Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans. 21388494
Bellavia D et al., 1999 C4, BF, C3 allele distribution and complement activity in healthy aged people and centenarians. 10219002
Kamei H et al., 2003 Association analysis of the SHC1 gene locus with longevity in the Japanese population. 14530863
Hurme M et al., 2005 Interleukin-6 -174G/C polymorphism and longevity: a follow-up study. 15664628
Edwards DR et al., 2012 Linkage and association of successful aging to the 6q25 region in large Amish kindreds. 22773346
Fuzikawa AK et al., 2007 Apolipoprotein E polymorphism distribution in an elderly Brazilian population: the Bambuí Health and Aging Study. 17934638
Newman AB & Murabito JM, 2013 The Epidemiology of Longevity and Exceptional Survival. 23372024
Capurso C et al., 2007 Interleukin 6 variable number of tandem repeats (VNTR) gene polymorphism in centenarians. 17506774
Kuningas M et al., 2006 Impact of genetic variations in the WRN gene on age related pathologies and mortality. 16405962
de Jongh RT et al., 2011 Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals. 21051524
Singh R et al., 2010 Anti-inflammatory heat shock protein 70 genes are positively associated with human survival. 20388090
Invidia L et al., 2010 The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect. 19421891
Ewbank DC, 2002 Mortality differences by APOE genotype estimated from demographic synthesis. 11788960
Lottermoser K et al., 2001 The plasminogen activator inhibitor 1 4G/5G polymorphism is not associated with longevity: a study in octogenarians. 11485022
Napolioni V et al., 2011 APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism. 21703254
Deelen J et al., 2011 Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. 21418511
Wuttke D & de Magalhães JP, 2012 Osh6 links yeast vacuolar functions to lifespan extension and TOR. 22722495
Hamilton LK et al., 2013 Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here. 23773067
Schriner SE et al., 2013 Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction. 23704949
Demars MP et al., 2013 Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation. 23683827
Noren Hooten N et al., 2010 microRNA expression patterns reveal differential expression of target genes with age. 20505758
Harry GJ, 2013 Microglia during development and aging. 23644076
Bellizzi D et al., 2005 A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. 15676284
Bonafe, Massimiliano et al., 2002 An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity. 11943467
De Luca M et al., 2001 Sex-specific longevity associations defined by Tyrosine Hydroxylase-Insulin-Insulin Growth Factor 2 haplotypes on the 11p15.5 chromosomal region. 11672987
Gaunt TR et al., 2001 Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. 11448941
Rose, G et al., 2003 Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. 14580859
Tan Q et al., 2002 The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach. 12297342
Lee YN et al., 2012 Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster. 22465014
Gerdes LU et al., 2000 Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a "frailty gene," not a "longevity gene". 11015124
De Benedictis G et al., 1999 Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. 10463944
Mooijaart SP et al., 2004 Variation in the SHC1 gene and longevity in humans. 15036421
Tanaka M et al., 2000 Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis. 10996007
Hong MG et al., 2008 Evidence that the gene encoding insulin degrading enzyme influences human lifespan. 18448515
Yang X et al., 2012 Mitochondrial DNA polymorphisms are associated with the longevity in the Guangxi Bama population of China. 22729909
Vaccarino L et al., 2011 Role of prothrombotic polymorphisms in successful or unsuccessful aging. 21424155
Zeng Y et al., 2010 Effects of FOXO genotypes on longevity: a biodemographic analysis. 20884733
Seripa D et al., 2006 Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy. 16960022
Napolioni V et al., 2011 PTPN22 1858C>T (R620W) functional polymorphism and human longevity. 21113673
Emanuele E et al., 2010 Preliminary evidence of a genetic association between chromosome 9p21.3 and human longevity. 20230275
Todesco L et al., 1999 Methylenetetrahydrofolate reductase polymorphism, plasma homocysteine and age. 10583447
Garasto S et al., 2004 A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians. 15028112
Garatachea N et al., 2013 Association of the K153R polymorphism in the myostatin gene and extreme longevity. 23354683
Cellini E et al., 2005 Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians. 15888337
Atzmon G et al., 2008 Adiponectin levels and genotype: a potential regulator of life span in humans. 18511746
Cipriano C et al., 2006 Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population. 16955215
Naumova E et al., 2011 Immunogenetics of ageing. 21726414
Vijg J et al., 2001 BRCA1 gene sequence variation in centenarians. 11795532
Yang JK et al., 2009 Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population. 19502260
Gonos ES, 2000 Genetics of aging: lessons from centenarians. 10705035
Rea IM et al., 2004 Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis. 15050299
Soerensen M et al., 2013 Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. 22234866
Noordam R et al., 2012 Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study. 23128285
Listì F et al., 2007 Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity. 17048073
Ross OA et al., 2004 Hypothetical soluble KIR2DS4 natural killer cell receptor molecule does not associate with successful ageing in the Irish. 15130674
Santiago C et al., 2013 Mitochondriogenesis genes and extreme longevity. 23186209
Bonafè M et al., 1999 P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia. 10577935
Tan Q et al., 2002 A centenarian-only approach for assessing gene-gene interaction in human longevity. 11938442
Kim S et al., 2012 Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity. 21972126
Benn M et al., 2008 Mitochondrial haplogroups: ischemic cardiovascular disease, other diseases, mortality, and longevity in the general population. 18458168
Perls T & Terry D, 2003 Understanding the determinants of exceptional longevity. 12965974
Schoenmaker M et al., 2006 Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. 16251894
Kerber RA et al., 2009 Gene expression profiles associated with aging and mortality in humans. 19245677
Khabour OF et al., 2009 Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population. 20003469
Conneely KN et al., 2012 Human longevity and common variations in the LMNA gene: a meta-analysis. 22340368
Bojesen SE & Nordestgaard BG, 2008 The common germline Arg72Pro polymorphism of p53 and increased longevity in humans. 18256523
Kuningas M et al., 2011 The relationship between fertility and lifespan in humans. 21222045
Melzer D et al., 2007 Genetic variation and human aging: progress and prospects. 17389728
Castro E et al., 1999 Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians. 10069711
Corbo RM et al., 2011 Association of CYP19 and ESR1 pleiotropic genes with human longevity. 20819792
Albani D et al., 2009 Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism. 19377912
Stakias N et al., 2006 Lower prevalence of epsilon 4 allele of apolipoprotein E gene in healthy, longer-lived individuals of Hellenic origin. 17234815
Mishto M et al., 2002 Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells. 11772516
Polosak J et al., 2011 Aging is accompanied by a progressive decrease of expression of the WRN gene in human blood mononuclear cells. 20855428
Kulminski AM et al., 2011 Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan. 21332925
Niemi AK et al., 2003 Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. 12483296
Dato S et al., 2012 UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts. 22743239
Lunetta KL et al., 2007 Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. 17903295
Matsubara M et al., 2001 Decreased longevity in Japanese men, associated with low-molecular-weight apolipoprotein(a) phenotypes. 11269751
Holsinger RM et al., 2012 Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians. 22985157
Frisoni GB et al., 2001 Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study. 11213279
Barbieri M et al., 2012 A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity. 21340542
Maxwell LD et al., 2004 Investigation of KIR diversity in immunosenescence and longevity within the Irish population. 15288696
Napolioni V & Lucarini N, 2010 Gender-specific association of ADA genetic polymorphism with human longevity. 20174870
Malovini A et al., 2011 Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins. 21612516
Ulybina YM et al., 2010 Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects. 20434535
Cardelli M et al., 2008 A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism. 18511747
Okayama N et al., 2005 Association of interleukin-10 promoter single nucleotide polymorphisms -819 T/C and -592 A/C with aging. 16424284
Kulminski AM & Culminskaya I, 2013 Genomics of human health and aging. 22174011
Lio D et al., 2003 Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP. 12676903
Huffman DM et al., 2012 Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene. 22496539
Flesch BK et al., 2006 The FCGR2A--Arg131 variant is no major mortality factor in the elderly--evidence from a German centenarian study. 16893392
Ma YX et al., 1997 HLA and longevity or aging among Shanghai Chinese. 9147371
Scola L et al., 2005 Study of the association with -330T/G IL-2 in a population of centenarians from centre and south Italy. 16518704
Barbieri M et al., 2010 The IRS2 Gly1057Asp variant is associated with human longevity. 19887537
Da Cruz IB et al., 2003 Angiotensin I-converting enzyme gene polymorphism in two ethnic groups living in Brazil's southern region: association with age. 14528043
Rose G et al., 2011 Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity. 21827845
Nuzzo D et al., 2006 Role of proinflammatory alleles in longevity and atherosclerosis: results of studies performed on -1562C/T MMP-9 in centenarians and myocardial infarction patients from Sicily. 17261792
Soerensen M et al., 2012 Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. 22406557
Rontu R et al., 2006 Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians. 16487435
Pawlikowska L et al., 2009 Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. 19489743
Ren WH et al., 2008 Mitochondrial DNA haplogroups in a Chinese Uygur population and their potential association with longevity. 18759861
Boyden SE & Kunkel LM, 2010 High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. 20824210
Benigni A et al., 2013 Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity. 22569962
Scola L et al., 2008 Analysis of HLA-DRB1, DQA1, DQB1 haplotypes in Sardinian centenarians. 17714903
Carru C et al., 2003 Association between the HFE mutations and longevity: a study in Sardinian population. 12714263
Faure-Delanef L et al., 1997 Methylenetetrahydrofolate reductase thermolabile variant and human longevity. 9106548
Pan H et al., 2011 Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population. 21262335
Bathum L et al., 2005 No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians. 16015282
Rea IM et al., 2001 Apolipoprotein E alleles in nonagenarian subjects in the Belfast Elderly Longitudinal Free-living Ageing Study (BELFAST). 11470126
Bonafè M et al., 2002 Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. 12082503
Muiras ML et al., 1998 Lack of association between human longevity and genetic polymorphisms in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci. 9654200
Mooijaart SP et al., 2007 Liver X receptor alpha associates with human life span. 17452725
Chen T et al., 2010 A functional single nucleotide polymorphism in promoter of ATM is associated with longevity. 20816691
Xie L et al., 2010 A microsatellite polymorphism in IGF1 gene promoter and longevity in a Han Chinese population. 20199671
Hui L et al., 2011 Variations in short tandem repeats deduced on the basis of the number of repeats and the relationship of these variations with longevity. 20582731
Muiras ML et al., 1998 Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians. 9587069
Marchegiani F et al., 2006 Paraoxonase activity and genotype predispose to successful aging. 16799134
Neville MJ et al., 2007 Absence of relationship between MTTP haplotypes and longevity. 17339647
von Wurmb-Schwark N et al., 2011 Association of TH01 with human longevity revisited. 21407269
Feng J et al., 2011 Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China. 21945877
Ross OA et al., 2003 HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish. 12714268
Campa D et al., 2012 Bitter taste receptor polymorphisms and human aging. 23133589
Christiansen L et al., 2006 A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival. 16574194
Jian-Gang Z et al., 1998 Apolipoprotein E and longevity among Han Chinese population. 9792194
Xie L et al., 2008 Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population. 18761080
Li Y et al., 2009 Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. 19793722
Zajc Petranović M et al., 2012 Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans. 21614448
Roszkowska-Gancarz M et al., 2010 The -351A/G polymorphism of ESR1 is associated with risk of myocardial infarction but not with extreme longevity. 20599431
Gravina S et al., 2009 Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. 20126416
Nygaard M et al., 2013 AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians. 22929028
Courtenay MD et al., 2012 Mitochondrial haplogroup X is associated with successful aging in the Amish. 21750925
van Heemst D et al., 2005 Reduced insulin/IGF-1 signalling and human longevity. 15771611
Cavallone L et al., 2003 The role of IL-1 gene cluster in longevity: a study in Italian population. 12714264
Shi H et al., 2012 Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). 22445811
Fiuza-Luces C et al., 2011 Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort. 21330423
Domínguez-Garrido E et al., 2009 Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations. 18931934
Wang XY et al., 2001 Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians. 11640949
Polosak J et al., 2010 Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity. 19707883
Tazearslan C et al., 2012 Discovery of functional gene variants associated with human longevity: opportunities and challenges. 22156437
Lio D et al., 2003 Association between the HLA-DR alleles and longevity: a study in Sardinian population. 12581796
Franceschi C et al., 2005 Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. 15621218
Napolioni V et al., 2011 Haptoglobin (HP) polymorphisms and human longevity: A cross-sectional association study in a Central Italy population. 21147083
Li J et al., 2009 Interactive association of heat shock protein 70 genes variants with natural longevity in Xinjiang Hetian Uygur ethnicity. 19840767
Roszkowska-Gancarz M et al., 2012 Total and high molecular weight adiponectin and level-modifying polymorphisms of ADIPOQ in centenarians. 23339001
Lelashvili NG & Dalakishvili SM, 1984 Genetic study of high longevity index populations. 6240576
Proust J et al., 1982 HLA and longevity. 7089955
Merched A et al., 1998 Apolipoprotein AIV codon 360 mutation increases with human aging and is not associated with Alzheimer's disease. 9533408
Toupance B et al., 1998 A model for antagonistic pleiotropic gene action for mortality and advanced age. 9585593
Bathum L et al., 1998 Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevitY. Role of CYP2D6 and CYP2C19 in longevity. 9754988
De Benedictis G et al., 1998 Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts. 9759473
Coughtrie MW et al., 1999 Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. 9854023
Panza F et al., 1999 Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians. 10643896
De Benedictis G et al., 2000 Does a retrograde response in human aging and longevity exist? 11053670
Blanché H et al., 2001 A study of French centenarians: are ACE and APOE associated with longevity? 11280044
Caruso C et al., 2001 Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data. 11292511
Ross OA et al., 2001 Mitochondrial DNA polymorphism: its role in longevity of the Irish population. 11404057
Varcasia O et al., 2001 Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus. 11592926
Pinti M et al., 2002 Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: studies on centenarians. 11965496
Perls T et al., 2002 The genetics of aging. 12076681
Yao YG et al., 2002 Mitochondrial DNA 5178A polymorphism and longevity. 12384792
Christiansen L et al., 2004 Modest implication of interleukin-6 promoter polymorphisms in longevity. 15130757
Gaspari L et al., 2003 Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls. 15195682
Capurso C et al., 2004 Interleukin 6-174 G/C promoter gene polymorphism in centenarians: no evidence of association with human longevity or interaction with apolipoprotein E alleles. 15236771
Christiansen L et al., 2004 Paraoxonase 1 polymorphisms and survival. 15241482
Christiansen L et al., 2004 The catalase -262C/T promoter polymorphism and aging phenotypes. 15472150
Sorkin J et al., 2005 Exploring the genetics of longevity in the Old Order Amish. 15621217
Arking DE et al., 2005 Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. 15677572
Tan Q et al., 2005 Haplotype effects on human survival: logistic regression models applied to unphased genotype data. 15720298
Capri M et al., 2006 The genetics of human longevity. 16803995
Kaeberlein M, 2006 Genome-wide approaches to understanding human ageing. 16848980
Au WY et al., 2006 Glucose-6-phosphate dehydrogenase deficiency in female octogenarians, nanogenarians, and centenarians. 17077204
Salvioli S et al., 2006 Genes, ageing and longevity in humans: problems, advantages and perspectives. 17090420
Shao J et al., 2007 SOD2 polymorphisms: unmasking the effect of polymorphism on splicing. 17331249
Liu H et al., 2007 Molecular genetic studies on relationships among longevity, diseases, and HLA-DRB1/DQB1 allelic polymorphism. 17364902
Del Bo R et al., 2008 Role of VEGF gene variability in longevity: a lesson from the Italian population. 17574707
Bergman A et al., 2007 Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. 17784782
Mari D et al., 2008 Hemostasis factors and aging. 17869046
De Rango F et al., 2008 A novel sampling design to explore gene-longevity associations: the ECHA study. 17989723
Balistreri CR et al., 2008 Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity. 18379014
Ralser M et al., 2008 Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans. 18510744
Willcox BJ et al., 2008 FOXO3A genotype is strongly associated with human longevity. 18765803
Jylhävä J et al., 2009 Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study. 19000922
Flachsbart F et al., 2009 Association of FOXO3A variation with human longevity confirmed in German centenarians. 19196970
Soerensen M et al., 2009 The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. 19428448
Balistreri CR et al., 2009 TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases. 19459036
Cai XY et al., 2009 Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population. 19641616
Li H et al., 2009 The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese population. 20003397
Sebastiani P et al., 2009 RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. 20011587
Khabour OF et al., 2010 Associations of polymorphisms in adiponectin and leptin genes with men's longevity. 20201642
Caliebe A et al., 2010 No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis. 20362697
Laplana M et al., 2010 Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes. 20407924
Candore G et al., 2010 Inflammation, genetic background and longevity. 20549353
Sebastiani P et al., 2010 Genetic signatures of exceptional longevity in humans. 20595579
Zhang WG et al., 2010 SIRT1 variants are associated with aging in a healthy Han Chinese population. 20633545
Flachsbart F et al., 2010 Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. 20800603
Soerensen M et al., 2010 Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. 20849522
Slagboom PE et al., 2011 Genomics of human longevity. 21115528
Fiuza-Luces C et al., 2011 Are 'endurance' alleles 'survival' alleles? Insights from the ACTN3 R577X polymorphism. 21407828
Mocchegiani E et al., 2011 Zinc, metallothioneins and immunosenescence: effect of zinc supply as nutrigenomic approach. 21503725
Napolioni V et al., 2011 Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy. 21865054
Soerensen M et al., 2012 Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis. 22136229
Laplana M & Fibla J, 2012 Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals. 22265023
Ferrario A et al., 2012 The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations. 22524405
Heckman MG et al., 2012 Evaluation of the role of SNCA variants in survival without neurological disease. 22912757
Corbo RM et al., 2013 Gender-specific association between FSHR and PPARG common variants and human longevity. 22985084
Zhao L et al., 2012 Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. 23020224
Reiner AP et al., 2013 Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults. 23162014
Park JW et al., 2009 Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans. 19641380
Yashin AI et al., 2012 Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality. 22533364
Geesaman BJ et al., 2003 Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan. 14615589
Ueland PM et al., 2001 Biological and clinical implications of the MTHFR C677T polymorphism. 11282420
Bonafè M & Olivieri F, 2009 Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity. 19027825
Schupf N et al., 2013 Apolipoprotein E and familial longevity. 23040522
Dato S et al., 2007 Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case-control approach (APOE and HSP70.1 loci). 16896546
Perls T & Terry D, 2003 Genetics of exceptional longevity. 12855277
Scola L et al., 2006 Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians. 16608414
Erickson RP et al., 2008 Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population. 18834923
Wheeler HE & Kim SK, 2011 Genetics and genomics of human ageing. 21115529
Listì F et al., 2007 Connexin37 1019 gene polymorphism in myocardial infarction patients and centenarians. 16970956
Walter S et al., 2011 A genome-wide association study of aging. 21782286
Novelli V et al., 2008 Lack of replication of genetic associations with human longevity. 18034366
Yashin AI et al., 2012 How genes influence life span: the biodemography of human survival. 22607627
Hindorff LA et al., 2008 Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study. 17888441
Tanaka M, 2002 Mitochondrial genotypes and cytochrome b variants associated with longevity or Parkinson's disease. 12375058
Suh Y et al., 2008 Functionally significant insulin-like growth factor I receptor mutations in centenarians. 18316725
Glasper ER & Gould E, 2013 Sexual experience restores age-related decline in adult neurogenesis and hippocampal function. 23460298
Bizon JL & Gallagher M, 2003 Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline. 12859354
Boily, Gino et al., 2008 SirT1 regulates energy metabolism and response to caloric restriction in mice. 18335035
Huang T et al., 2012 Deciphering the effects of gene deletion on yeast longevity using network and machine learning approaches. 22239951
Tanaka, M et al., 1988 Extensive defects of mitochondrial electron-transfer chain in muscular cytochrome c oxidase deficiency. 2845344
Tanaka, M et al., 1998 Mitochondrial genotype associated with longevity. 9449878
Arking DE et al., 2002 Association of human aging with a functional variant of klotho. 11792841
Goto M et al., 1981 Family analysis of Werner's syndrome: a survey of 42 Japanese families with a review of the literature. 7460386
Faragher RG et al., 1993 The gene responsible for Werner syndrome may be a cell division "counting" gene. 8265666
Prince PR et al., 2001 Loss of Werner syndrome protein function promotes aberrant mitotic recombination. 11316787
Arslan-Ergul A et al., 2013 Aging, neurogenesis, and caloric restriction in different model organisms. 23936746
Kim J et al., 2013 Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis. 23891729
Kitamura T et al., 2006 Dietary restriction increases hippocampal neurogenesis by molecular mechanisms independent of NMDA receptors. 16356642
Huang X et al., 2011 The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans. 21471153
Johannsen TH et al., 2012 Genetic inhibition of CETP, ischemic vascular disease and mortality, and possible adverse effects. 23083790
Wootton JC et al., 1975 The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides. 1000
Numano F, 1979 [Symposium on major histocompatibility antigens (HLA) and diseases. Supplement: genetic factor in Takayasu disease (author's transl)]. 42663
Simplicio J et al., 1975 Kinetics of cyanate and imidazole binding to hemin in micelles. 437
Lübek J, 1976 [Bacterial flora in patients with prostatic adenoma]. 56000
Slichter SJ & Harker LA, 1976 Preparation and storage of platelet concentrates. 3000
Martin TM et al., 2008 A hierarchical clustering methodology for the estimation of toxicity. 20020919
Drozhdeniuk AP et al., 1976 [DNA degradation during standard alkaline of thermal denaturation]. 999984
Hori K et al., 1991 Fluctuations in tumor blood flow under normotension and the effect of angiotensin II-induced hypertension. 1752787
Sticker LS et al., 1991 Effect of supplemental lysocellin and tetronasin on growth, ruminal and blood metabolites, and ruminal proteolytic activity in steers grazing ryegrass. 1752803
Bishop MD et al., 1991 Divergent selection for postweaning feed conversion in Angus beef cattle: II. Genetic and phenotypic correlations and realized heritability estimate. 1752811
Wang CT & Dickerson GE, 1991 Simulation of life-cycle efficiency of lamb and wool production for genetic levels of component traits and alternative management options. 1752808
Palladino DE et al., 1992 Measurement of amino acid compositions of glycoprotein systems by gas-phase hydrolysis and reversed-phase high-performance liquid chromatography. 1352306
Bishop MD et al., 1991 Divergent selection for postweaning feed conversion in Angus beef cattle: I. Mean comparisons. 1752810
Miles A & Miller DJ, 1992 Genomes of diploblastic organisms contain homeoboxes: sequence of eveC, an even-skipped homologue from the cnidarian Acropora formosa. 1352890
Goding GS Jr, 1991 Nerve-muscle pedicle reinnervation of the paralyzed vocal cord. 1754223
Składzień J et al., 1991 [Non-epithelial malignant neoplasms of the larynx]. 1754230
Murlewska A, 1991 [Use of ultrasonography in the diagnosis of laryngeal cancer]. 1754243
Koufman JA & Isaacson G, 1991 The spectrum of vocal dysfunction. 1754226
Carter JH et al., 1992 Quantitative image cytometry of hepatocytes expressing gamma-glutamyl transpeptidase and glutathione S-transferase in diethylnitrosamine-initiated rats treated with phenobarbital and/or phthalate esters. 1352315
Johnson DW et al., 1991 Exogenous opioids increase plasma prolactin in Holstein calves primarily via a dopaminergic mechanism. 1752829
Pazin GJ, 1991 Counseling to avoid AIDS. 1754272
Dowton SB et al., 1991 Developmental regulation of expression of C-reactive protein and serum amyloid A in Syrian hamsters. 1754300
Kirby KC et al., 1991 Reactivity in self-recording: obtrusiveness of recording procedure and peer comments. 1752838
Azmitia EC & Whitaker-Azmitia PM, 1991 Awakening the sleeping giant: anatomy and plasticity of the brain serotonergic system. 1752858
Yamaguchi S et al., 1991 Prenatal diagnosis and neonatal monitoring of a fetus with glutaric aciduria type II due to electron transfer flavoprotein (beta-subunit) deficiency. 1754299
Zeigler V, 1991 Adenosine in the pediatric population: nursing implications. 1754289
Schadewaldt P et al., 1991 Oral L-alloisoleucine loading studies in healthy subjects and in patients with maple syrup urine disease. 1754297
Wennberg RP et al., 1991 Bilirubin-induced changes in brain energy metabolism after osmotic opening of the blood-brain barrier. 1754304
Bengtsson C et al., 1992 Diabetes incidence in users and non-users of antihypertensive drugs in relation to serum insulin, glucose tolerance and degree of adiposity: a 12-year prospective population study of women in Gothenburg, Sweden. 1352324
Makovetskaia GA et al., 1991 [Structure of interstitial nephritis in children]. 1754325
Greenleaf G et al., 1991 Microbial contamination in allografted wound beds in patients with burns. 1752879
Lu CS et al., 1992 Pseudoathetosis as a presenting symptom of spinal multiple sclerosis. 1352326
Ting KS et al., 1992 Brachial plexus neuropathy associated with scrub typhus: report of a case. 1352327
Valdes AM et al., 2013 Omics technologies and the study of human ageing. 23938363
Lopez-Otin, Carlos et al., 2013 The hallmarks of aging. 23746838
Berger B et al., 2013 Computational solutions for omics data. 23594911
Rhinn H et al., 2013 Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease. 23883936
Ilamanov M & Naumova VI, 1991 [Results of the treatment of glomerulonephritis in children with hepatitis B]. 1754336
Heggers JP et al., 1991 Bactericidal and wound-healing properties of sodium hypochlorite solutions: the 1991 Lindberg Award. 1752875
Volodin NN, 1991 [Crigler-Najjar syndrome in an infant during the 1st year of life]. 1754338
Aksenov V et al., 2010 Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. 20404021
Serbanesco F et al., 1991 Epilepsy and cardiac surgery. 1752905
Sheĭbak MP & Evets LV, 1991 [Clinical syndromes and treatment tactics in cow's milk intolerance in young children]. 1754356
Wang CS et al., 1992 Localization of obscure gastrointestinal bleeding by technetium 99m-labeled red blood cell scintigraphy. 1352337
Hsu WH et al., 1992 Detection of mass lesions in the collapsed lung by ultrasonography. 1352336
Sasso MP et al., 1991 Molecular cloning of the gene encoding the bovine brain ribonuclease and its expression in different regions of the brain. 1754384
Reese JC & Katzenellenbogen BS, 1991 Differential DNA-binding abilities of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells. 1754396
Navab M et al., 1991 Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. 1752961
Phillips HA et al., 1991 Dinucleotide repeat polymorphism at D16S287. 1754417
Horikoshi S et al., 1991 Water deprivation stimulates transforming growth factor-beta 2 accumulation in the juxtaglomerular apparatus of mouse kidney. 1752966
Shiratsuchi Y et al., 1991 Evaluation of masticatory function following orthognathic surgical correction of mandibular prognathism. 1752969
Freihofer HP, 1991 Restricted opening of the mouth with an extra-articular cause in children. 1752968
Higgins CM et al., 1992 Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis. 1352961
Volpe A et al., 1991 Clinical use of growth hormone-releasing factor for induction of superovulation. 1752922
Erlen JA et al., 1991 Professional oaths--pharmacy can lead the way. 1752910
Drake J et al., 1991 Comparative pharmacokinetics of temazepam Gelthix and liquid-filled soft gelatin capsules. 1752914
Edwards JG, 1992 Medicolegal aspects of benzodiazepine dependence. Duties and responsibilities of doctors. 1352373
, 1991 Guidelines on testing for the lupus anticoagulant. Lupus Anticoagulant Working Party on behalf of the BCSH Haemostasis and Thrombosis Task Force. 1752976
Lewis SM et al., 1991 Current concerns in haematology. 3: Blood count calibration. 1752975
Thomas JS et al., 1991 Prospective study of quantitative aspects of audit in a large general histopathology laboratory. 1752984
Löscher W & Hönack D, 1992 Withdrawal precipitation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil. 1352384
Onali P & Olianas MC, 1992 B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity. 1352980
Smith JP, 1991 Meeting the challenge of cancer care and prevention in Europe. 1753022
De Wals P et al., 1991 Association between holoprosencephaly and exposure to topical retinoids: results of the EUROCAT Survey. 1754503
Good BM & Su AI, 2013 Crowdsourcing for bioinformatics. 23782614
Landreth A & Silva AJ, 2013 The need for research maps to navigate published work and inform experiment planning. 23931992
de Saint-Jean M et al., 2011 Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers. 22162133
Takahashi K & Yamanaka S, 2006 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. 16904174
Hayamizu TF et al., 2013 EMAP/EMAPA ontology of mouse developmental anatomy: 2013 update. 23972281
Bard J, 2012 A new ontology (structured hierarchy) of human developmental anatomy for the first 7 weeks (Carnegie stages 1-20). 22973865
Fuellen G et al., 2010 Bioinformatics in aging research: a workshop report. 21204651
Budovsky A et al., 2013 LongevityMap: a database of human genetic variants associated with longevity. 23998809
Koch CM & Wagner W, 2011 Epigenetic-aging-signature to determine age in different tissues. 22067257
Walker RF et al., 2009 A case study of "disorganized development" and its possible relevance to genetic determinants of aging. 19428454
Miller RA, 2001 Biomarkers of aging: prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, genetically heterogeneous mouse population. 11283189
Wu JJ et al., 2013 Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression. 23994476
Horvath S, 2013 DNA methylation age of human tissues and cell types. 24138928
Fuellen G et al., 2013 In-Silico-Approaches and the Role of Ontologies in Aging Research. 24188080
Groza T et al., 2013 State of the art and open challenges in community-driven knowledge curation. 23219718
Hughes KA & Reynolds RM, 2005 Evolutionary and mechanistic theories of aging. 15355246
Partridge L & Gems D, 2002 Mechanisms of ageing: public or private? 11972154
Hayflick L, 2007 Biological aging is no longer an unsolved problem. 17460161
Anderson WF et al., 2009 Qualitative age interactions in breast cancer studies: mind the gap. 19826117
Jatoi I et al., 2008 Qualitative age-interactions in breast cancer: a tale of two diseases? 18838890
Thomas GA & Leonard RC, 2009 How age affects the biology of breast cancer. 19071000
Traniello IM et al., 2013 Age-related changes in stem cell dynamics, neurogenesis, apoptosis, and gliosis in the adult brain: A novel teleost fish model of negligible senescence. 24293183
Zhang J et al., 2004 Enhancing HMM-based biomedical named entity recognition by studying special phenomena. 15542015
Zhu, Fei et al., 2013 Biomedical text mining and its applications in cancer research. 23159498
Maruszak A et al., 2014 Hippocampal neurogenesis in Alzheimer's disease: is there a role for dietary modulation? 23948932
Bao JM et al., 2014 Association between <i>FOXO3A</i> gene polymorphisms and human longevity: a meta-analysis. 25038186
Garatachea N et al., 2014 PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. 24930376
Lu F et al., 2014 Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population. 24924924
Guney O et al., 2014 Mitochondrial DNA polymorphisms associated with longevity in the Turkish population. 24792352
Deelen J et al., 2014 Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. 24688116
Roszkowska-Gancarz M et al., 2014 Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus. 24549597
Garatachea N et al., 2014 ApoE gene and exceptional longevity: Insights from three independent cohorts. 24534555
Li Q et al., 2014 Association between the CETP polymorphisms and the risk of Alzheimer's disease, carotid atherosclerosis, longevity, and the efficacy of statin therapy. 24468472
Flachsbart F et al., 2014 Investigation of complement component C4 copy number variation in human longevity. 24465950
Falcone C et al., 2013 Possible role of -374T/A polymorphism of RAGE gene in longevity. 24284407
Sebastiani P et al., 2013 Meta‐analysis of genetic variants associated with human exceptional longevity. 24244950
Di Bona D et al., 2014 Association of Klotho polymorphisms with healthy aging: a systematic review and meta-analysis. 24164579
Pinós T et al., 2014 The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. 24163049
Tindale LC et al., 2014 Rare and common variants in the Apolipoprotein E gene in healthy oldest old. 24126160
Albani D et al., 2014 Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)". 23839864
Morris BJ et al., 2014 Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry. 23770741
Zheĭkova TV et al., 2013 [Association between 242C &gt; T polymorphism of NADPH oxidase p22phox gene (CYBA) and longevity in Russian population]. 23755540
Garatachea N et al., 2013 The ACE DD genotype and D-allele are associated with exceptional longevity: a meta-analysis. 23623925
Tan Q et al., 2013 A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family. 23607278
Montesanto A et al., 2013 Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans. 23572278
Concetti F et al., 2013 The functional VNTR MNS16A of the TERT gene is associated with human longevity in a population of Central Italy. 23562826
Figarska SM et al., 2013 SIRT1 polymorphism, long-term survival and glucose tolerance in the general population. 23505545
Huang J et al., 2013 [Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi]. 23450480
Golanska E et al., 2013 The prion protein M129V polymorphism: longevity and cognitive impairment among Polish centenarians. 23406923

Add reference

Comment on This Data Unit

Please log in for making a comment without the need to specify any credentials.