We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o


  • Species: + -
  • Types: + -
  • symbol name observation species
    Mir489 microRNA 489 Mir489 is maintaining adult stem cells in quiescence phase. Inhibition of miR489 is sufficient to make murine satellite muscle cells exit the quiescence phase and enter the cell cycle through downregulation of the oncogene Dek [22358842]. House mouse
    Mir133 miR-133 is associated with stem cell differentiation in mouse and human ESCs [18371447]. House mouse
    Mir1 miR-1 is associated with stem cell differentiation in mouse and human ESCs [18371447]. House mouse
    • 3 factors
    Factors are an extension of GenAge and GenDR.

    Comment on This Data Unit

    Please log in for making a comment without the need to specify any credentials.