|mir-277 ||— ||Constitutive miR-277 expression shortens lifespan and synthetically lethal with reduced insulin signaling, indicating that metabolic control underlies this phenotype. Transgenic inhibition with a miRNA sponge construct also shortens lifespan .
miR-277 is downregulated during adult life .
mir-277 controls branched-chain amino acid catabolism and as a result it can modulate the activity of TOR kinase . ||Fruit fly |
|Spargel ||— ||Tissue-specific overexpression of dPGC-1 in stem and progenitor cells within the digestive tract of females flies extends the mean and maximum lifespan of females by up to 33% and 37%. Those mutants display a delay in the onset of aging-related changes in the intestine, leading to improved tissue homoeostasis in old flies . ||Fruit fly |
|Hsp70Ba ||Heat-shock-protein-70Ba ||Hsp70Ba overexpression reduces mean and maximum lifespan up to 30% .
hsp70 and hsp22 RNA levels are higher in long-lived than in short-lived fly lines. The HDAC inhibitor TSA causes a higher expression of hsp22 and hsp70, and strikingly influences the lifespan in both long and short-lived lines, with variable degrees (up to 25%) . ||Fruit fly |
|Zw ||Zwischenferment ||Mean lifespan of G6PD overexpressor flies is extended in comparison with driver and responder controls, armadillo-GAL4 (up to 38%), Tubulin-GAL4 (up to 29%), C23-GAL4 (up to 27%), da-GAL4 (up to 24%), D42-GAL4 (up to 18%) and Appl-GAL4 (up to 16%). The maximum lifespan is also increased .
G6PD enzymatic activity as well as levels of NADPH, NADH, and the GSH/GSSG ration are increased . ||Fruit fly |
|yata ||— ||yata mutation shortens the maximum lifespan by 68% and results in progressive deterioration of the nervous tissues and aberrant accumulation of Sec23 . ||Fruit fly |
|snz ||snazarus ||Mutation in snz increases maximum lifespan of both sexes by up to 66%, while the median female lifespan is approximately 85% higher and that of males around 72% . ||Fruit fly |
|SNF4Agamma ||SNF4/AMP-activated protein kinase gamma subunit ||Deletion of SNF4Agamma from the first day of the imaginal stage shortens mean lifespan by 23% and causes morphological and behavioural features of premature aging . ||Fruit fly |
|Rbp9 ||RNA-binding protein 9 ||Rbp9 mutation significantly decreases longevity with a 33% reduction in median lifespan of males . ||Fruit fly |
|Pten ||— ||Increased Pten and 4E-BP activity in muscles is extends the lifespan . ||Fruit fly |
|Prx5 ||Peroxiredoxin 5 ||Prx5 overexpression causes an increase in mean and median lifespan under normal conditions. It also leads to a small increase in maximum lifespan.
dprx5(-/-) null mutants are comparatively more susceptible to oxidative stress, have higher incidence of apoptosis, and a shortened mean lifespan, but thee is no significant difference in maximum lifespan (10% survival) . ||Fruit fly |
|pex16 ||peroxin 16 ||pex16 mutation lead to a reduced mean lifespan of one-third in females and on-fourth in males. The short lifespan can be rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons .
Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects in the development of the nervous system . ||Fruit fly |
|Nlaz ||Neural Lazarillo ||Absence of Nlaz, which is homologous to ApoD, results in a reduced lifespan in both sexes. Median lifespan is 30.8% and 22.5% lower in females and males, respectively. Maximum lifespan is reduced by 12% and 30% in females and males . ||Fruit fly |
|Naam ||Nicotinamide amidase ||Naam overexpression increases mean and maximum lifespan by 30% in both females and males. The lifespan extension is reversed by Sir2 mutants, indicating the it is dependent on Sir2 . ||Fruit fly |
|MTF-1 ||Metal response element-binding Transcription Factor-1 ||MTF-1 overexpression in either the peripheral nervous system or motorneurons extends both mean and maximum lifespan by 40% in males . ||Fruit fly |
|Mlp84B ||Muscle LIM protein at 84B ||RNA interference of Mlp84B specifically in the heart results in bradycardia and heart rthym abnormalities as well as a shorter mean lifespan in males but not in females . ||Fruit fly |
|mle ||maleless ||Homozygous mutant animals (mle napts) display a shortened median lifespan and increased frailty in both males and females . ||Fruit fly |
|magu ||— ||Adult-specific overexpression of magu increases lifespan by 5-30% and modulates late-age fecundity . ||Fruit fly |
|Loco ||locomotion defects ||Reduced expression of Loco due to hetero-deficient results in a 17-20% longer mean lifespan for both male and females, besides the fact that the homozygous deficiency of loco is lethal. Several of these long-lived mutants are more resistant to stresses such as starvation, oxidation and heat. Additionally, mutants have higher Manganese-containing superoxide dismutase (MnSOD) activity, increased fat content an diminished cAMP levels. Loco's RGS domain is required for the regulation of longevity as deletion analysis suggest . ||Fruit fly |
|Lnk ||— ||Loss of Lnk function results in increased median (14% in females and 17.5 in males) and maximum lifespan, reduced female fecundity and improves survival under conditions of oxidative stress and starvation. Heterozygousity does not result in any significant differences in lifespan in either males or females. Moreover, lifespan extension in one of the female homozygous mutant is fully rescued by the introduction of a Lnk genomic rescue construct . ||Fruit fly |
|LBR ||Lamin B receptor ||Overexpression of Lamin B receptor in the adult muscle and in the abdominal fat body results in a 54% and 46% reduction of mean lifespan, respectively . ||Fruit fly |
|kuk ||kugelkern ||Overexpression of kugelkern in the adult muscle results in a 60% reduction of mean lifespan . ||Fruit fly |
|kermit ||— ||The disruption of kermit (alias dGIPC) function results in premature loss of locomotor activity and reduced mean lifespan . ||Fruit fly |
|CG3776 ||— ||Both overexpression and underexpression of CG3776 (alias Jhebp29) reduces the mean lifespan, where the reduction in males is slightly higher.
The lifespan of male flies with under- and overexpressed CG3776 is reduced by 38.8 and 42.6%, respectively when compared with Oregon R flies.The lifespan of female flies with under- and overexpressed CG3776 is reduced by 31.6 and 35%, respectively when compared to Oregon R flies.
Among the males and females, relatively to Oregon R and EP835/CyO, the age-specific survival of EP835/EP835 and EP835/Gal4 is reduced in both log-rank and Wilcoxon tests (P < 0.001); survival of EP835/EP835 and EP835/Gal4 differed using the log-rank-test (male: P<0.001; female: P=0.027) .
||Fruit fly |
|Hsc70-3 ||Heat shock protein cognate 3 ||Overexpression of Hsc70-3 increases average female lifespan by 27% . ||Fruit fly |
|hebe ||— ||Adult-specific overexpression of hebe increases the lifespan by 5-30% and modulates late-age female fecundity. Female and male mean lifespan is up to 11% and 24% higher . ||Fruit fly |