|nhr-62 ||Nuclear Hormone Receptor family ||NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. *nhr-62* mediates the longevity response of *eat-2* mutants and blunts the longevity by bacterial food dilution [Heestand, et al. 2012].
Mutation in *nhr-62* suppresses the lifespan extension of eat-2(ad465) animals (p<0.001) [Heestand et al. 2013].
Wild-type (N2) worms with extrachromosomal array dhEx627 (carrying a wild-type nhr-62) exhibit a significant increase in lifespan compared to wild-type (p<0.001) [Heestand et al. 2013]. ||Nematode |
|mir-277 ||— ||Constitutive miR-277 expression shortens lifespan and synthetically lethal with reduced insulin signaling, indicating that metabolic control underlies this phenotype. Transgenic inhibition with a miRNA sponge construct also shortens lifespan .
miR-277 is downregulated during adult life .
mir-277 controls branched-chain amino acid catabolism and as a result it can modulate the activity of TOR kinase . ||Fruit fly |
|Spargel ||— ||Tissue-specific overexpression of dPGC-1 in stem and progenitor cells within the digestive tract of females flies extends the mean and maximum lifespan of females by up to 33% and 37%. Those mutants display a delay in the onset of aging-related changes in the intestine, leading to improved tissue homoeostasis in old flies . ||Fruit fly |
|Zw ||Zwischenferment ||Mean lifespan of G6PD overexpressor flies is extended in comparison with driver and responder controls, armadillo-GAL4 (up to 38%), Tubulin-GAL4 (up to 29%), C23-GAL4 (up to 27%), da-GAL4 (up to 24%), D42-GAL4 (up to 18%) and Appl-GAL4 (up to 16%). The maximum lifespan is also increased .
G6PD enzymatic activity as well as levels of NADPH, NADH, and the GSH/GSSG ration are increased . ||Fruit fly |
|yata ||— ||yata mutation shortens the maximum lifespan by 68% and results in progressive deterioration of the nervous tissues and aberrant accumulation of Sec23 . ||Fruit fly |
|SNF4Agamma ||SNF4/AMP-activated protein kinase gamma subunit ||Deletion of SNF4Agamma from the first day of the imaginal stage shortens mean lifespan by 23% and causes morphological and behavioural features of premature aging . ||Fruit fly |
|Rbp9 ||RNA-binding protein 9 ||Rbp9 mutation significantly decreases longevity with a 33% reduction in median lifespan of males . ||Fruit fly |
|Pten ||— ||Increased Pten and 4E-BP activity in muscles is extends the lifespan . ||Fruit fly |
|Prx5 ||Peroxiredoxin 5 ||Prx5 overexpression causes an increase in mean and median lifespan under normal conditions. It also leads to a small increase in maximum lifespan.
dprx5(-/-) null mutants are comparatively more susceptible to oxidative stress, have higher incidence of apoptosis, and a shortened mean lifespan, but thee is no significant difference in maximum lifespan (10% survival) . ||Fruit fly |
|pex16 ||peroxin 16 ||pex16 mutation lead to a reduced mean lifespan of one-third in females and on-fourth in males. The short lifespan can be rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons .
Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects in the development of the nervous system . ||Fruit fly |
|Nlaz ||Neural Lazarillo ||Absence of Nlaz, which is homologous to ApoD, results in a reduced lifespan in both sexes. Median lifespan is 30.8% and 22.5% lower in females and males, respectively. Maximum lifespan is reduced by 12% and 30% in females and males . ||Fruit fly |
|Naam ||Nicotinamide amidase ||Naam overexpression increases mean and maximum lifespan by 30% in both females and males. The lifespan extension is reversed by Sir2 mutants, indicating the it is dependent on Sir2 . ||Fruit fly |
|MTF-1 ||Metal response element-binding Transcription Factor-1 ||MTF-1 overexpression in either the peripheral nervous system or motorneurons extends both mean and maximum lifespan by 40% in males . ||Fruit fly |
|Mlp84B ||Muscle LIM protein at 84B ||RNA interference of Mlp84B specifically in the heart results in bradycardia and heart rthym abnormalities as well as a shorter mean lifespan in males but not in females . ||Fruit fly |
|mle ||maleless ||Homozygous mutant animals (mle napts) display a shortened median lifespan and increased frailty in both males and females . ||Fruit fly |
|magu ||— ||Adult-specific overexpression of magu increases lifespan by 5-30% and modulates late-age fecundity . ||Fruit fly |
|kermit ||— ||The disruption of kermit (alias dGIPC) function results in premature loss of locomotor activity and reduced mean lifespan . ||Fruit fly |
|CG3776 ||— ||Both overexpression and underexpression of CG3776 (alias Jhebp29) reduces the mean lifespan, where the reduction in males is slightly higher.
The lifespan of male flies with under- and overexpressed CG3776 is reduced by 38.8 and 42.6%, respectively when compared with Oregon R flies.The lifespan of female flies with under- and overexpressed CG3776 is reduced by 31.6 and 35%, respectively when compared to Oregon R flies.
Among the males and females, relatively to Oregon R and EP835/CyO, the age-specific survival of EP835/EP835 and EP835/Gal4 is reduced in both log-rank and Wilcoxon tests (P < 0.001); survival of EP835/EP835 and EP835/Gal4 differed using the log-rank-test (male: P<0.001; female: P=0.027) .
||Fruit fly |
|Hsc70-3 ||Heat shock protein cognate 3 ||Overexpression of Hsc70-3 increases average female lifespan by 27% . ||Fruit fly |
|hebe ||— ||Adult-specific overexpression of hebe increases the lifespan by 5-30% and modulates late-age female fecundity. Female and male mean lifespan is up to 11% and 24% higher . ||Fruit fly |
|GstS1 ||Glutathione S transferase S1 ||GstS1 overexpression increases the mean lifespan by 33% . ||Fruit fly |
|fh ||frataxin homolog ||Overexpression of fh in the mitochondria of female transgenic animals increases antioxidant capability, resistance to oxidative stress insults, and longevity . ||Fruit fly |
|elav ||embryonic lethal abnormal vision ||elav mutation significantly decreases the lifespan. Median lifespan in males is 66% lower . ||Fruit fly |
|Dys ||Dystroglycan ||Loss of dys function in the heart leads to an age-dependent disruption of the myofibrillar organization within the myocardium as well as to alterations in cardiac performance. dys RNAi-mediated knockdown in the mesoderm also shortens lifespan. Mesodermal dys knockout results in a morderate maximum lifespan reduction (13%), but not when exclusively targeted to the heart. In contrast, half of the transheteozygous DysExel618/Dyskx43 deficiency flies die at 29 days compared to 63 days in controls. This indicates that a moderate dye loss-of-function in all muscles, but not in just the heart, reduces the normal lifespan . ||Fruit fly |
|bsk ||basket ||RNA interference of bsk in intestinal stem cells, results in short lived mutants with impaired intestinal homeostasis and tissue regeneration. The mean lifespan of males is 16.4% lower and those of female is reduced by 10.2% . ||Fruit fly |