Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    NOS3 NOS3 was not found to be associated with longevity [23572278]. Human
    NOS1 NOS1 was not found to be associated with longevity [23572278]. Human
    JUN JUN was not found to be associated with longevity [23770741]. Human
    CBL CBL was not found to be associated with longevity [23770741]. Human
    ATF4 ATF4 was not found to be associated with longevity [23770741]. Human
    SOD3 SOD3 was not found to be associated with longevity [24163049]. Human
    PVRL2 PVRL2 was found to be associated with longevity [24924924]. PVRL2 was not found to be associated with longevity [24924924]. Human
    PTK2 PTK2 was found to be associated with longevity [24930376]. PTK2 was not found to be associated with longevity [24930376]. Human
    LPLUNC4 chromosome 20 open reading frame 186 LPLUNC4 was not found to be associated with longevity [21612516]. Human
    PRKCA protein kinase C, alpha PRKCA was not found to be associated with longevity [21612516]. Human
    MAMDC1 MAM domain containing glycosylphosphatidylinositol anchor 2 MAMDC1 was not found to be associated with longevity [21612516]. Human
    MADMC1 breast cancer 1, early onset MADMC1 was not found to be associated with longevity [21612516]. Human
    RNF113B ring finger protein 113B RNF113B was not found to be associated with longevity [21612516]. Human
    DCAMKL1 doublecortin-like kinase 1 DCAMKL1 was not found to be associated with longevity [21612516]. Human
    PTPRO protein tyrosine phosphatase, receptor type, O PTPRO was not found to be associated with longevity [21612516]. Human
    ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 ABCC8 was not found to be associated with longevity [21612516]. Human
    CDH23 cadherin-related 23 CDH23 was not found to be associated with longevity [21612516]. Human
    MSRB2 methionine sulfoxide reductase B2 MSRB2 was not found to be associated with longevity [21612516]. Human
    ANKRD19 ankyrin repeat domain 19, pseudogene ANKRD19 was not found to be associated with longevity [21612516]. Human
    FAM49B family with sequence similarity 49, member B FAM49B was not found to be associated with longevity [21612516]. Human
    ATXN1 ataxin 1 ATXN1 was not found to be associated with longevity [21612516]. Human
    RHOBTB3 Rho-related BTB domain containing 3 RHOBTB3 was not found to be associated with longevity [21612516]. Human
    MGST2 microsomal glutathione S-transferase 2 MGST2 was not found to be associated with longevity [21612516]. Human
    IMPG2 interphotoreceptor matrix proteoglycan 2 IMPG2 was not found to be associated with longevity [21612516]. Human
    GRM7 glutamate receptor, metabotropic 7 GRM7 was not found to be associated with longevity [21612516]. Human
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    • 25 of 288 factors
    Factors are an extension of GenAge and GenDR.

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