Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Age‑Related Disease Associated (2740)   ‑1 OR 2+17‑17‑1=0+0+0+1 ‑‑  (342)   Oxidative Stress (344)   Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (3428)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (3998)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    1 aak-2 1.00 -1.0 1 1 African European 20 1 1 GWAS 1
    1 aat-8 1.00 -1.0 1 1 African European 20 1 1 GWAS 1
    1 aak-2 1.00 -1.0 1 1 African European 20 1 1 GWAS 1
    1 aak-2 1.00 -1.0 1 1 Australian 20 1 1 GWAS 1
    1 aak-2 1.00 -1.0 1 1 African European 20 1 1 GWAS 1
    1 aak-2 1.00 -1.0 1 1 African European 20 1 1 GWAS 1
    1 aak-2 1.00 -1.0 1 1 African European 20 1 1 GWAS 1
    1 aak-2 1.00 -1.0 1 1 African European 20 1 1 GWAS 1
    1 aak-2 1.00 -1.0 1 1 African European 20 1 1 GWAS 1
    1 aak-2 1.00 -1.0 1 1 (select(0)from(select(sleep(15)))v)/*'+(select(0)from(select(sleep(15)))v)+'"+(select(0)from(select(sleep(15)))v)+"*/ 20 1 1 GWAS 1
    rs5491 ICAM1 — 5e-66 5036 — American 28-70 TT, AT AA Genome-Wide Association Study 22174011
    rs9330200 TUBB4B — 6e-53 5036 — American 28-70 AA, AT TT Genome-Wide Association Study 22174011
    rs2292664 RIMBP2 — 1.4e-37 5036 — American 28-70 CC, CG GG Genome-Wide Association Study 22174011
    rs4420638 APOE 0.72 3.4e-36 7729 vs 16121 13060 vs 61156 European 90+ — — GWAS 24688116
    rs4537545 IL6R — 3e-18 308 — American, European, Ashkenazi Jewish 75.7 — — Candidate Region/Gene 19249341
    rs2075650 APOE 0.71 3.39e-17 403 vs 1670 4149 vs 7582 Dutch mean 94 e4 — Genome-Wide Association Study 21418511
    rs2075650 APOE 0.53 4.44e-16 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs4420638 APOC1 0.53 1.8e-10 763 vs 1085 754 vs 850 German Mean age 99.7 G — Genome-Wide Association Study 21740922
    rs2075650 TOMM40 2.07 2.36e-10 801 vs 914 253 vs 341 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    HRAS1 LASS1 (CGT) APOE — 1.06e-09 68 vs 68 — American — — — Candidate Region/Gene 20569235
    E2 / E3 / E4 APOE — 1.2e-08 560 vs 560 — French centenarians 100th year or beyond, mean age 103.1 E4 — Candidate Region/Gene 11280044
    rs2149954 — 1.10 1.74e-08 7729 vs 16121 13060 vs 61156 European 90+ — — GWAS 24688116
    DRD4 7R allele DRD4 — 3.5e-08 310 vs 2909 — European mean age 95.2 years — — Candidate Region/Gene 23283341
    rs1528753 — — 8.1e-08 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
    rs4420638 APOE — 9.6e-08 4445 total (each a part of sibship of 2-5 siblings) — Caucasian, European 90 — — Genome-Wide Association Study 23286790
    • Page 1 of 203
    • 25 of 5061 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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