Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs5491 ICAM1 — 5e-66 5036 — American 28-70 TT, AT AA Genome-Wide Association Study 22174011
    rs2075650 APOE 0.71 3.39e-17 403 vs 1670 4149 vs 7582 Dutch mean 94 e4 — Genome-Wide Association Study 21418511
    rs4420638 APOC1 0.53 1.8e-10 763 vs 1085 754 vs 850 German Mean age 99.7 G — Genome-Wide Association Study 21740922
    rs2075650 TOMM40 2.07 2.36e-10 801 vs 914 253 vs 341 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    E2 / E3 / E4 APOE — 1.2e-08 560 vs 560 — French centenarians 100th year or beyond, mean age 103.1 E4 — Candidate Region/Gene 11280044
    rs4420638 APOE — 9.6e-08 4445 total (each a part of sibship of 2-5 siblings) — Caucasian, European 90 — — Genome-Wide Association Study 23286790
    rs2075650 TOMM40 0.53 2.65e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 G — Genome-Wide Association Study 21418511
    rs10412199 ATCAY 0.91 3.02e-06 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American — — A Genome-Wide Association Study 21782286
    rs4802234 CEACAM16 1.36 9.22e-06 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs2708754 ZNF331 0.94 5.79e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American — — A Genome-Wide Association Study 21782286
    rs2302951 GRWD1 1.51 7.59e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    APOE polymorphism APOE — 0.0001 291 vs 589 — Finn Mean age 97.5 e4 e2 Candidate Region/Gene 16487435
    APOE haplotype - rs1346044 APOE — 0.0001 175 vs 178 — Finn 100.8 e4 e2 Candidate Region/Gene 10069711
    rs7246865 MYO9B 1.25 0.000164604 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs11086106 PGPEP1 1.77 0.000263101 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs3220637 XRCC1 — 0.0005 430 (case) vs 290 — British Mean age 70 16 — Candidate Region/Gene 16518718
    rs429358, rs7412 APOE — 0.0005 318 vs 350 376 vs 506 American, Caucasian Mean age 100,8 e4 e2 Candidate Region/Gene 18034366
    rs1674159 NDUFA11 1.41 0.000520159 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs2075650 APOE — 0.000527 1364 — American, British Age range 50-108; mean age at death 80.2 C T Candidate Region/Gene 22445811
    rs429358, rs7412 APOE 0.43 0.0006 114 vs 2071 — Irish >90 e4 e2 Candidate Region/Gene 11470126
    APOE polymorphism APOE 3.26 0.001 64 vs 1344 — Italian 100+ e4 e2 Candidate Region/Gene 16960022
    APOE e2/e4 APOE 2.00 0.001 300 vs 160 — French 100+ e4 e2 Candidate Region/Gene 8136829
    rs429358, rs7412 APOE — 0.001 179 vs 615 — Finn Mean age 100 e4 e2, e3 Candidate Region/Gene 8018664
    APOE polymorphism APOE 0.38 0.002 200 (cases) vs 539 — Italian >88 e4 e2 Candidate Region/Gene 21703254
    rs2075650 TOMM40 0.70 0.002 2307 vs 764 — American, Danish Mean age 60.2 G A Candidate Region/Gene 23040522
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    • 25 of 67 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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