Longevity Variant Database

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  • Variant type: + -

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs12446736 CES3 (upstream) 0.77 1.63e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American T Genome-Wide Association Study 21782286
    rs3743518 FOPNL 0.93 2.52e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American T Genome-Wide Association Study 21782286
    rs8052394 MT1a 2.16 0.0002 151 vs 100 Italian Mean age 91.4 +/- 4.1 A Candidate Region/Gene 16955215
    rs4785393 PAPD5 1.36 0.000253223 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs2738679 WWOX 1.22 0.000869114 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs5882 CETP 3.56 0.001 213 vs 258 Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
    rs9923854 CETP 1.95 0.001 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German A 22234866
    rs41383 NLRC5 0.00455 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
    rs3211994 NTHL1 1.99 0.0056 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) G Candidate Region/Gene 22406557
    Arg 213 ->His SULT1A1 0.017 Total 165 Nigerian, Caucasian range 17- 90 SULT1A1*2 9854023
    rs9282861 SULT1A1 0.017 68 vs 49 American, Caucasian 70-99 GG Candidate Region/Gene 9854023
    HP 1/2 HP 1.27 0.0194 1072 total Italian >88 HP*2 HP*1 Candidate Region/Gene 21147083
    rs1800775 CETP 0.02 10261 Danish 20-93, followed for up to 34 years CC non-CC Candidate Region/Gene 23083790
    rs708272 CETP 0.02 10261 Danish 20-93, followed for up to 34 years GG non-GG Candidate Region/Gene 23083790
    rs5882 CETP 1.30 0.041 318 vs 350 376 vs 506 American, Caucasian Mean age 100.8 non-GG GG Candidate Region/Gene 18034366
    rs5882 CETP 0.05 300 vs 320 vs 258 Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
    rs708272 CETP 0.068 523 vs 498 Chinese Mean age 93.4 Candidate Region/Gene 22336474
    rs5882 CETP 0.069 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish Mean age 98.2 A 16602826
    rs5882 CETP 0.318 175 vs 189 Italian 99.6 Candidate Region/Gene 15888337
    HP*1 F/S HP 0.82 0.33 1072 total Italian >88 Candidate Region/Gene 21147083
    rs11074359 COQ7 0.43 213 vs 402 Japanese minimum 95; mean 97.9 Candidate Region/Gene 18765803
    rs708272 CETP 0.439 175 vs 189 Italian 99.6 Candidate Region/Gene 15888337
    rs7192898 COQ7 0.73 213 vs 402 Japanese minimum 95; mean 97.9 Candidate Region/Gene 18765803
    rs8051232 COQ7 0.9 213 vs 402 Japanese minimum 95; mean 97.9 Candidate Region/Gene 18765803
    rs708272 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
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    • 25 of 26 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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