Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    mtDNA haplotype — — 0.0052 212 vs 275 — Italian 100+ non-J haplogroups — Mitochondrial Haplogroup 10463944
    Met410Val SHC1 — 0.192 730 563 Human 85+ Met — Candidate Region/Gene 15036421
    rs2251101 IDE 1.88 0.0011 829 vs 1033 — Australian, Caucasian Mixed — — Candidate Region/Gene 18448515
    rs4646994 ACE — 0.04 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals — Chinese Old: 59-70, Very old 90-113 I (insertion) — Candidate Region/Gene 11773214
    K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 Italian, Spaniard 100–111 K — Candidate Region/Gene 23354683
    55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years — — Candidate Region/Gene 15050299
    192 (Q/R) PON1 1.30 0.007 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years Q — Candidate Region/Gene 15050299
    rs9923854 CETP 1.95 0.001 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German A — — 22234866
    rs12770830 HSPA14 1.35 0.011 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German — — — 22234866
    rs7896005 SIRT1 2.38 0.003 224 vs 293 170 vs 220 Caucasian, European 90-103, 98+ (replication) G — Candidate Region/Gene 21972126
    apoE haplotypes — — 0.02 80 vs 391 — Greek 80+ Apo e4 — Candidate Region/Gene 17234815
    ?60H LMP2 — 0.756 157 vs 311 — Italian 88+ H — Candidate Region/Gene 11772516
    ?145K LMP7 — 0.849 157 vs 311 — Italian 88+ K — Candidate Region/Gene 11772516
    apoE haplotypes — — 0.0042 3924 — American 5-70 Apo e4 — Candidate Region/Gene 21332925
    rs11235972 UCP3 — 0.029 908 vs 708 — Danish 93 A — Candidate Region/Gene 22743239
    rs1685354 UCP3 — 0.762 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
    rs3781907 UCP3 — 0.05 908 vs 708 — Danish 93 G — Candidate Region/Gene 22743239
    rs647126 UCP3 — 0.447 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
    82133 G>A — — 0.0189 33 vs 39 — Japanese 90+ A — Candidate Region/Gene 15820493
    SV-6 CLU — 1.0 49 vs 27 vs 20 — Greek, Italian 99–107 — — Candidate Region/Gene 16804001
    rs1800629 TNF — 1.0 119 vs 118 — Jordanian Mean age 90.2 — — Candidate Region/Gene 20518833
    rs1043618 HSP70-A1A — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
    rs6457452 HSP70-A1B — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
    rs708272 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    rs5882 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    • Page 1 of 66
    • 25 of 1635 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue