Longevity Variant Database

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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs12629971 EIF4E3 1.61 1.9e-06 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs513154 IMPG2 0.52 4.65e-06 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs9868286 CCDC50 1.48 7.4e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 C Genome-Wide Association Study 21418511
    rs6801173 EIF4E3 1.52 8.16e-06 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs3210458 ACPL2 1.52e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs7622678 BDH1 1.93e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs571391 IMPG2 0.55 2.67e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs17047650 FAM19A1 3.19e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs10433502 FAM19A1 3.49e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs4686837 ST6GAL1 4.6e-05 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs964403 SUMF1 2.07 4.91e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs3864051 SUMF1 2.07 5.49e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs14576 GALNTL2 0.93 6.54e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
    rs4681554 C3orf16 0.64 9.82e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 A Genome-Wide Association Study 21418511
    rs712773 GRM7 0.66 9.99e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs6443429 TBL1XR1 1.13 0.000251569 801 vs 914 Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs10510828 FHIT 1.24 0.000311601 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs1377843 DZIP3 1.36 0.000414112 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs12634249 SUMF1 1.18 0.000686245 801 vs 914 Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs2243115 IL12A 1.11 0.001736813 801 vs 914 Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs10511330 ZBTB20 1.15 0.002831841 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs13320360 MLH1 3.13 0.0036 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A Candidate Region/Gene 22406557
    rs572169 GHSR 0.72 0.0045 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs572169 GHSR 0.72 0.0045 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 A Candidate Region/Gene 22406557
    rs422858 AGTR1 3.57 0.007 173 vs 376 Italian 99-106 (mean 100.9±1.7) AG CC Candidate Region/Gene 22569962
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    • 25 of 53 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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