Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    APOE4 APOE — 0.013 35 vs 125 — Chinese 90 years or over High E4 frequency — Candidate Region/Gene 11780357
    rs2542052 APOC3 — 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish Mean age 98.2 A — — 16602826
    rs5882 CETP — 0.069 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish Mean age 98.2 A — — 16602826
    APOE4 APOE — 0.71 106 vs 349 — American 70-79 (duration of study - 7 years) e4 — Candidate Region/Gene 16799145
    ASP299GLY TLR4 — 0.04 8 vs 8 — Italian 25-50 — — — 16803999
    82133GNA PLXNA1 — 0.0189 26 vs 27 — Japanese 60-69, 90-99, >100 — — — 15820493
    DR7 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — — 9425225
    DR11 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — — 9425225
    DR13 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — — 9425225
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90+ apoE4 — Candidate Region/Gene 11780357
    mtDNA haplotype — — 0.0052 212 vs 275 — Italian 100+ non-J haplogroups — Mitochondrial Haplogroup 10463944
    Met410Val SHC1 — 0.192 730 563 Human 85+ Met — Candidate Region/Gene 15036421
    Apo C-I 1>2 Apo C-I — 0.05 282 vs 200 — British 84+ Apo C-I 2 — Candidate Region/Gene 9105559
    mt146 C>T — — 0.005 113 (cases) vs 200 — Chinese 90-110 mt146T mt146C Complete Mitochondrial Genome 22729909
    2437 T>C HSPA1L — 0.01 129 vs 100 — Irish 80–97 2437C — Candidate Region/Gene 12742533
    rs4646994 ACE — 0.04 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals — Chinese Old: 59-70, Very old 90-113 I (insertion) — Candidate Region/Gene 11773214
    rs2542052 APOC3 — 0.0001 213 old vs 216 offspring vs 258 controls — Ashkenazi Jewish 100+ A — Candidate Region/Gene 16602826
    rs2476601 PTPN22 — 0.663 225 vs 278 — Italian Mean age 93 — — Candidate Region/Gene 21113673
    rs1801133 MTHFR — 0.01 108 (patients with CVD) vs 118 — Swiss >65 C — Candidate Region/Gene 10583447
    rs5882 CETP — 0.318 175 vs 189 — Italian 99.6 — — Candidate Region/Gene 15888337
    (+)2019 del ADIPOQ10 — 0.05 118 centenarians vs 78 unrelated young — Ashkenazi Jewish 95-105 A Del/Del Candidate Region/Gene 18511746
    rs2069827 IL6 — 0.064 1,089 vs 736 563 (longtitudinal study) Danish, Dutch 92+ Danish, 85+ Dutch A — — 22234866
    rs2060793 CYP2R1 — 0.04 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) A — Candidate Region/Gene 23128285
    rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
    rs3829251 NADSYN1 — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
    • Page 1 of 66
    • 25 of 1635 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue