It enables to store, organize, and more effectively search annotated data of biomedical literature on aging-related topics.
Author(s), Year |
Title |
PMID |
Laun P et al., 2001 |
Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. |
11251834
|
Schlotterer A et al., 2010 |
Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans. |
20346071
|
Wijeyesekera A et al., 2012 |
Metabotyping of long-lived mice using 1H NMR spectroscopy. |
22225495
|
Fontana L et al., 2004 |
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. |
15096581
|
Apfeld J et al., 2004 |
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. |
15574588
|
Petersen KF et al., 2003 |
Mitochondrial dysfunction in the elderly: possible role in insulin resistance. |
12750520
|
Shmookler Reis RJ et al., 2011 |
Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. |
21386131
|
Hillyard SL & German JB, 2009 |
Quantitative lipid analysis and life span of the fat-3 mutant of Caenorhabditis elegans. |
19301819
|
Steffen KK et al., 2008 |
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. |
18423200
|
Barros MH et al., 2004 |
Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. |
15383542
|
Kirchman PA et al., 1999 |
Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. |
10224252
|
Eisenberg T et al., 2009 |
Induction of autophagy by spermidine promotes longevity. |
19801973
|
Basso A et al., 2010 |
Noninvasive neonatal thymus graft into the axillary cavity extends the lifespan of old mice. |
19954334
|
Minois N, 2000 |
Longevity and aging: beneficial effects of exposure to mild stress. |
11707916
|
Yang Y & Wilson DL, 1999 |
Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans. |
10219000
|
Sun K et al., 2012 |
Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression. |
22484922
|
Willcox BJ et al., 2007 |
Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span. |
17986602
|
Igwebuike, Ada et al., 2008 |
Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women. |
18029465
|
Hinson JP & Raven PW, 1999 |
DHEA deficiency syndrome: a new term for old age? |
10495400
|
Lane MA et al., 1997 |
Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restriction. |
9215277
|
Mesquita A et al., 2010 |
Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity. |
20696905
|
Weinberger M et al., 2010 |
Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence. |
21076178
|
Fabrizio P et al., 2003 |
SOD2 functions downstream of Sch9 to extend longevity in yeast. |
12586694
|
Petrascheck M et al., 2009 |
A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans. |
19686215
|
Samanez-Larkin GR et al., 2012 |
Frontostriatal white matter integrity mediates adult age differences in probabilistic reward learning. |
22496578
|
Zarse K et al., 2012 |
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. |
22482728
|
Roorda S et al., 1991 |
Structural relaxation and defect annihilation in pure amorphous silicon. |
9999999
|
Curran SP & Ruvkun G, 2007 |
Lifespan regulation by evolutionarily conserved genes essential for viability. |
17411345
|
Olsen A et al., 2006 |
Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. |
16741121
|
Kim Y & Sun H, 2007 |
Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan. |
17608836
|
Schächter F et al., 1994 |
Genetic associations with human longevity at the APOE and ACE loci. |
8136829
|
Alafuzoff I et al., 2000 |
Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia. |
10818513
|
Corder EH et al., 1996 |
Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition. |
8624216
|
Ruiu G et al., 1995 |
Apolipoprotein E allele frequencies in an Italian population: relation to age and lipid profile. |
8541369
|
Galinsky D et al., 1997 |
Analysis of the apo E/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity. |
9105559
|
Schwanke CH et al., 2002 |
Analysis of the association between apolipoprotein E polymorphism and cardiovascular risk factors in an elderly population with longevity. |
12185856
|
Stessman J et al., 2005 |
Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. |
15621215
|
Forero DA et al., 2006 |
Analysis of common polymorphisms in angiotensin-converting enzyme and apolipoprotein e genes and human longevity in Colombia. |
16971231
|
, 1985 |
Ataxia-telangiectasia: genetics, neuropathology, and immunology of a degenerative disease of childhood. Proceedings of a conference. Solvang, California, January 16-20, 1984. |
3864931
|
Hansen M et al., 2005 |
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. |
16103914
|
Dillin A et al., 2002 |
Rates of behavior and aging specified by mitochondrial function during development. |
12471266
|
Hamilton B et al., 2005 |
A systematic RNAi screen for longevity genes in C. elegans. |
15998808
|
Lai CY et al., 2002 |
A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae. |
12242224
|
Smith ED et al., 2008 |
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. |
18340043
|
Stein JL et al., 2012 |
Identification of common variants associated with human hippocampal and intracranial volumes. |
22504417
|
Bis JC et al., 2012 |
Common variants at 12q14 and 12q24 are associated with hippocampal volume. |
22504421
|
Zhou B et al., 2012 |
Midlife gene expressions identify modulators of aging through dietary interventions. |
22509016
|
Xue H et al., 2007 |
A modular network model of aging. |
18059442
|
Lee SS et al., 2003 |
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. |
12447374
|
Lakowski B & Hekimi S, 1996 |
Determination of life-span in Caenorhabditis elegans by four clock genes. |
8638122
|
Lin SJ et al., 2000 |
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. |
11000115
|
Suthammarak W et al., 2009 |
Complex I function is defective in complex IV-deficient Caenorhabditis elegans. |
19074434
|
Kenyon C et al., 1993 |
A C. elegans mutant that lives twice as long as wild type. |
8247153
|
Van Voorhies WA, 1992 |
Production of sperm reduces nematode lifespan. |
1448167
|
Reis-Rodrigues P et al., 2012 |
Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan. |
22103665
|
Ghazi A et al., 2007 |
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. |
17392428
|
Jia K & Levine B, 2007 |
Autophagy is required for dietary restriction-mediated life span extension in C. elegans. |
17912023
|
Luo S et al., 2009 |
TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. |
20041217
|
Riddle DL et al., 1997 |
Genetic and Environmental Regulation of Dauer Larva Development |
21413222
|
Shaw WM et al., 2007 |
The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. |
17900898
|
Fabrizio P et al., 2010 |
Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. |
20657825
|
List EO et al., 2011 |
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. |
21123740
|
Zhou Y et al., 1997 |
A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). |
9371826
|
Coschigano KT et al., 2003 |
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. |
12933651
|
GarcÃa-Cao I et al., 2002 |
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. |
12426394
|
Tyner SD et al., 2002 |
p53 mutant mice that display early ageing-associated phenotypes. |
11780111
|
Matheu A et al., 2004 |
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. |
15520276
|
Fuellen, Georg et al., 2012 |
Systems Biology and Bioinformatics in Aging Research: A Workshop Report. |
22950424
|
Ortega-Molina A et al., 2012 |
Pten positively regulates brown adipose function, energy expenditure, and longevity. |
22405073
|
Price NL et al., 2012 |
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. |
22560220
|
Li J et al., 2008 |
Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. |
18828672
|
Harrison DE et al., 2009 |
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. |
19587680
|
Robida-Stubbs S et al., 2012 |
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. |
22560223
|
Tullet JM et al., 2008 |
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. |
18358814
|
Honjoh S et al., 2009 |
Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. |
19079239
|
Jia K et al., 2004 |
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. |
15253933
|
Hansen M et al., 2007 |
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. |
17266679
|
Scott RC et al., 2004 |
Role and regulation of starvation-induced autophagy in the Drosophila fat body. |
15296714
|
Kumsta C & Hansen M, 2012 |
C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline. |
22574120
|
Wysocka J & Herr W, 2003 |
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. |
12826401
|
Wang Y et al., 2006 |
C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. |
16860373
|
Tissenbaum HA & Guarente L, 2001 |
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. |
11242085
|
Wolff S et al., 2006 |
SMK-1, an essential regulator of DAF-16-mediated longevity. |
16530049
|
Panowski SH et al., 2007 |
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. |
17476212
|
Essers MA et al., 2005 |
Functional interaction between beta-catenin and FOXO in oxidative stress signaling. |
15905404
|
Arantes-Oliveira N et al., 2002 |
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. |
11799246
|
Julien E & Herr W, 2003 |
Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1. |
12743030
|
Julien E & Herr W, 2004 |
A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1. |
15200950
|
Tyagi S et al., 2007 |
E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases. |
17612494
|
Lee S et al., 2007 |
Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells. |
18043729
|
Alvers AL et al., 2009 |
Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. |
19302372
|
Longo VD et al., 2010 |
Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. |
20953148
|
Di Cianni F et al., 2012 |
MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping. |
22576335
|
Tomás-Loba A et al., 2008 |
Telomerase reverse transcriptase delays aging in cancer-resistant mice. |
19013273
|
González-Suárez E et al., 2005 |
Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice. |
15688016
|
Jaskelioff M et al., 2011 |
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. |
21113150
|
Bernardes de Jesus B et al., 2012 |
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. |
22585399
|
Ferguson VL et al., 2003 |
Bone development and age-related bone loss in male C57BL/6J mice. |
13678781
|
Shimokata H et al., 1989 |
Studies in the distribution of body fat: I. Effects of age, sex, and obesity. |
2921472
|
Hammerman MR, 1987 |
Insulin-like growth factors and aging. |
3322823
|
Krishnamurthy J et al., 2006 |
p16INK4a induces an age-dependent decline in islet regenerative potential. |
16957737
|
Molofsky AV et al., 2006 |
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. |
16957738
|
Chien KR & Karsenty G, 2005 |
Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. |
15734685
|
Geiger H & Van Zant G, 2002 |
The aging of lympho-hematopoietic stem cells. |
11919569
|
Flores I et al., 2008 |
The longest telomeres: a general signature of adult stem cell compartments. |
18283121
|
GarcÃa-Cao I et al., 2006 |
Increased p53 activity does not accelerate telomere-driven ageing. |
16582880
|
Shulman GI & Helfand SL, 2011 |
Indy knockdown in mice mimics elements of dietary restriction. |
21937764
|
Vartiainen S et al., 2006 |
Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein. |
16782295
|
Steinkraus KA et al., 2008 |
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. |
18331616
|
Greer EL & Brunet A, 2009 |
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. |
19239417
|
Mair W et al., 2009 |
Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. |
19229346
|
Apfeld J & Kenyon C, 1999 |
Regulation of lifespan by sensory perception in Caenorhabditis elegans. |
10617200
|
Bell R et al., 2009 |
A human protein interaction network shows conservation of aging processes between human and invertebrate species. |
19293945
|
Murakami S & Johnson TE, 1998 |
Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene. |
9768365
|
Murakami S & Johnson TE, 2001 |
The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. |
11591319
|
Murphy CT et al., 2003 |
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. |
12845331
|
Arum O et al., 2009 |
The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet. |
19747233
|
Lindstrom DL et al., 2011 |
Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae. |
21436897
|
Tang F et al., 2008 |
A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery. |
18690010
|
Kaeberlein M et al., 2005 |
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. |
16293764
|
Waaijer ME et al., 2012 |
The number of p16INK4a positive cells in human skin reflects biological age. |
22612594
|
Doroszuk A et al., 2012 |
Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. |
22559237
|
Yan L et al., 2007 |
Type 5 adenylyl cyclase disruption increases longevity and protects against stress. |
17662940
|
Enns LC et al., 2009 |
Disruption of protein kinase A in mice enhances healthy aging. |
19536287
|
Steffen KK et al., 2012 |
Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. |
22377630
|
Yang W & Hekimi S, 2010 |
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. |
21151885
|
Neumann-Haefelin E et al., 2008 |
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans. |
18832074
|
Cai WJ et al., 2011 |
Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. |
22216122
|
Shen LR et al., 2012 |
Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. |
22653297
|
Liao VH et al., 2011 |
Curcumin-mediated lifespan extension in Caenorhabditis elegans. |
21855561
|
Caesar I et al., 2012 |
Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. |
22348084
|
Pietsch K et al., 2009 |
Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43. |
19043800
|
Hashimoto T et al., 2010 |
Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16. |
19370397
|
Bonkowski MS et al., 2006 |
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. |
16682650
|
Kabil H et al., 2011 |
Increased transsulfuration mediates longevity and dietary restriction in Drosophila. |
21930912
|
Grönke S et al., 2010 |
Molecular evolution and functional characterization of Drosophila insulin-like peptides. |
20195512
|
Zid BM et al., 2009 |
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. |
19804760
|
Bahadorani S et al., 2010 |
Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila. |
19968629
|
Copeland JM et al., 2009 |
Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. |
19747824
|
Bauer JH et al., 2005 |
Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. |
16303568
|
van Heemst D et al., 2005 |
Variation in the human TP53 gene affects old age survival and cancer mortality. |
15732191
|
Hwangbo DS et al., 2004 |
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. |
15175753
|
Giannakou ME et al., 2008 |
Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. |
18241326
|
Wang PY et al., 2009 |
Long-lived Indy and calorie restriction interact to extend life span. |
19470468
|
Rogina B et al., 2000 |
Extended life-span conferred by cotransporter gene mutations in Drosophila. |
11118146
|
Marden JH et al., 2003 |
Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. |
12626742
|
Toivonen JM et al., 2007 |
No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. |
17571923
|
Rogina B & Helfand SL, 2004 |
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. |
15520384
|
Kapahi P et al., 2004 |
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. |
15186745
|
Clancy DJ et al., 2001 |
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. |
11292874
|
Clancy DJ et al., 2002 |
Dietary restriction in long-lived dwarf flies. |
11951037
|
Libert S et al., 2007 |
Regulation of Drosophila life span by olfaction and food-derived odors. |
17272684
|
Rogina B et al., 2002 |
Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. |
12459580
|
Sánchez-Blanco A et al., 2006 |
Involvement of Drosophila uncoupling protein 5 in metabolism and aging. |
16387864
|
Budovskaya YV et al., 2008 |
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. |
18662544
|
Lucanic M et al., 2011 |
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. |
21562563
|
Schleit J et al., 2011 |
The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans. |
22132200
|
Kaeberlein TL et al., 2006 |
Lifespan extension in Caenorhabditis elegans by complete removal of food. |
17081160
|
Lee GD et al., 2006 |
Dietary deprivation extends lifespan in Caenorhabditis elegans. |
17096674
|
Miranda-Vizuete A et al., 2006 |
Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons. |
16387300
|
Fierro-González JC et al., 2011 |
The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans. |
21334311
|
Mouchiroud L et al., 2011 |
Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. |
21040400
|
Park SK et al., 2010 |
Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. |
19783783
|
Artal-Sanz M & Tavernarakis N, 2009 |
Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. |
19812672
|
Zhang M et al., 2009 |
Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. |
19924292
|
Lee SJ et al., 2009 |
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. |
19883616
|
Tóth ML et al., 2008 |
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. |
18219227
|
Streeper RS et al., 2012 |
Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. |
22291164
|
Sunagawa T et al., 2011 |
Procyanidins from apples (Malus pumila Mill.) extend the lifespan of Caenorhabditis elegans. |
20717869
|
Chen S et al., 2009 |
The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. |
19164523
|
Iser WB & Wolkow CA, 2007 |
DAF-2/insulin-like signaling in C. elegans modifies effects of dietary restriction and nutrient stress on aging, stress and growth. |
18043747
|
Wu CY et al., 2012 |
A persistent level of Cisd2 extends healthy lifespan and delays aging in mice. |
22661501
|
Chen YF et al., 2009 |
Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. |
19451219
|
Anisimov VN et al., 2012 |
The second international conference "genetics of aging and longevity". |
22661237
|
D'mello NP et al., 1994 |
Cloning and characterization of LAG1, a longevity-assurance gene in yeast. |
8195187
|
Finley KD et al., 2003 |
blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. |
12598614
|
Meléndez A et al., 2003 |
Autophagy genes are essential for dauer development and life-span extension in C. elegans. |
12958363
|
Hansen M et al., 2008 |
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. |
18282106
|
German J, 1969 |
Bloom's syndrome. I. Genetical and clinical observations in the first twenty-seven patients. |
5770175
|
Burtner CR et al., 2011 |
A genomic analysis of chronological longevity factors in budding yeast. |
21447998
|
Wang MC et al., 2003 |
JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. |
14602080
|
Baker DJ et al., 2004 |
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. |
15208629
|
Chiu CH et al., 2004 |
Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. |
15289464
|
Chen SS et al., 2000 |
C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. |
10982846
|
Orr WC & Sohal RS, 1994 |
Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. |
8108730
|
Sun J & Tower J, 1999 |
FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. |
9858546
|
Kaeberlein M & Guarente L, 2002 |
Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. |
11805047
|
Landis GN et al., 2003 |
A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. |
12620118
|
Sinclair DA & Guarente L, 1997 |
Extrachromosomal rDNA circles--a cause of aging in yeast. |
9428525
|
Bruschi CV et al., 1995 |
The genomic instability of yeast cdc6-1/cdc6-1 mutants involves chromosome structure and recombination. |
8552037
|
Merker RJ & Klein HL, 2002 |
hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae. |
11756539
|
Jazwinski SM et al., 1989 |
Replication control and cellular life span. |
2698814
|
Axelrod A & Rine J, 1991 |
A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae. |
1990268
|
Garigan D et al., 2002 |
Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. |
12136014
|
Kawano T et al., 2000 |
Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. |
10873623
|
Barzilai N et al., 2003 |
Unique lipoprotein phenotype and genotype associated with exceptional longevity. |
14559957
|
Vowels JJ & Thomas JH, 1992 |
Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. |
1732156
|
Perkins LA et al., 1986 |
Mutant sensory cilia in the nematode Caenorhabditis elegans. |
2428682
|
Gönczy P et al., 1999 |
Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo. |
10508861
|
Starich TA et al., 1995 |
Mutations affecting the chemosensory neurons of Caenorhabditis elegans. |
7705621
|
Liao XS et al., 1991 |
Intramitochondrial functions regulate nonmitochondrial citrate synthase (CIT2) expression in Saccharomyces cerevisiae. |
1986232
|
PADDISON RM et al., 1963 |
COCKAYNE'S SYNDROME. A REPORT OF FIVE NEW CASES WITH BIOCHEMICAL, CHROMOSOMAL, DERMATOLOGIC, GENETIC AND NEUROPATHOLOGIC OBSERVATIONS. |
14156156
|
Higginbottom MC et al., 1979 |
The Cockayne syndrome: an evaluation of hypertension and studies of renal pathology. |
514720
|
Ewbank JJ et al., 1997 |
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. |
9020081
|
Jonassen T et al., 2001 |
A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants. |
11136229
|
Lakowski B & Hekimi S, 1998 |
The genetics of caloric restriction in Caenorhabditis elegans. |
9789046
|
Wong A et al., 1995 |
Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. |
7768437
|
Gorbunova V & Seluanov A, 2002 |
CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA. |
11959146
|
Felkai S et al., 1999 |
CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. |
10202142
|
Begel O et al., 1999 |
Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina. |
10330149
|
Koll F et al., 1985 |
A 1100-bp sequence of mitochondrial DNA is involved in senescence process in Podospora: study of senescent and mutant cultures. |
2999848
|
Dufour E et al., 2000 |
A causal link between respiration and senescence in Podospora anserina. |
10759557
|
Harris N et al., 2001 |
Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of nondividing cells. |
11361336
|
Hoopes LL et al., 2002 |
Mutations in DNA replication genes reduce yeast life span. |
12024027
|
Taub J et al., 1999 |
A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. |
10335847
|
Taub J et al., 2003 |
A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. |
12610632
|
Lin SJ et al., 2002 |
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. |
12124627
|
Kaeberlein M et al., 2005 |
Increased life span due to calorie restriction in respiratory-deficient yeast. |
16311627
|
Sun X et al., 2012 |
Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. |
22672579
|
Brown-Borg HM et al., 1996 |
Dwarf mice and the ageing process. |
8900272
|
Steger RW et al., 1993 |
Premature ageing in transgenic mice expressing different growth hormone genes. |
8100276
|
Bartke A, 2003 |
Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. |
14583653
|
Flurkey K et al., 2002 |
The Snell dwarf mutation Pit1(dw) can increase life span in mice. |
11718806
|
Flurkey K et al., 2001 |
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. |
11371619
|
Coschigano KT et al., 2000 |
Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. |
10875265
|
Holzenberger M et al., 2003 |
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. |
12483226
|
Blüher M et al., 2003 |
Extended longevity in mice lacking the insulin receptor in adipose tissue. |
12543978
|
Kuro-o M et al., 1997 |
Mutation of the mouse klotho gene leads to a syndrome resembling ageing. |
9363890
|
Kurosu H et al., 2005 |
Suppression of aging in mice by the hormone Klotho. |
16123266
|
Lu MH et al., 2002 |
Dietary restriction alters cell proliferation in rats: an immunohistochemical study by labeling proliferating cell nuclear antigen. |
11744049
|
De Guzman JM et al., 2012 |
Chronic caloric restriction partially protects against age-related alteration in serum metabolome. |
22661299
|
Larsen PL et al., 1995 |
Genes that regulate both development and longevity in Caenorhabditis elegans. |
7789761
|
Hsin H & Kenyon C, 1999 |
Signals from the reproductive system regulate the lifespan of C. elegans. |
10360574
|
Malone EA et al., 1996 |
Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. |
8807293
|
Riddle DL et al., 1981 |
Interacting genes in nematode dauer larva formation. |
7219552
|
Albani D et al., 2009 |
A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study. |
19460140
|
Henderson ST & Johnson TE, 2001 |
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. |
11747825
|
Henderson ST et al., 2006 |
daf-16 protects the nematode Caenorhabditis elegans during food deprivation. |
16720740
|
Chiang WC et al., 2012 |
HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity. |
22265419
|
Masse I et al., 2005 |
Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18. |
16153634
|
Dorman JB et al., 1995 |
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. |
8601482
|
Collet J et al., 1998 |
Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans. |
9475731
|
Honda Y & Honda S, 1999 |
The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. |
10428762
|
Tissenbaum HA & Ruvkun G, 1998 |
An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. |
9504918
|
Malone EA & Thomas JH, 1994 |
A screen for nonconditional dauer-constitutive mutations in Caenorhabditis elegans. |
8005442
|
Jia K et al., 2002 |
DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. |
11782415
|
Gerisch B et al., 2001 |
A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. |
11740945
|
Albert PS & Riddle DL, 1988 |
Mutants of Caenorhabditis elegans that form dauer-like larvae. |
3350212
|
Lee JH et al., 2003 |
In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. |
12935877
|
Kaeberlein M et al., 1999 |
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. |
10521401
|
Wisniewski KE et al., 1985 |
Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. |
3158266
|
Seong KH et al., 2001 |
Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies. |
11868902
|
Simon AF et al., 2003 |
Steroid control of longevity in Drosophila melanogaster. |
12610309
|
Avery L, 1993 |
The genetics of feeding in Caenorhabditis elegans. |
8462849
|
Shepherd JC et al., 1989 |
Fruit flies with additional expression of the elongation factor EF-1 alpha live longer. |
2508089
|
Hirose T et al., 2003 |
Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans. |
12571101
|
Lin MJ et al., 2005 |
DNA methyltransferase gene dDnmt2 and longevity of Drosophila. |
15533947
|
Lin YJ et al., 1998 |
Extended life-span and stress resistance in the Drosophila mutant methuselah. |
9794765
|
Rogina B & Helfand SL, 1995 |
Regulation of gene expression is linked to life span in adult Drosophila. |
8582611
|
Hu Q et al., 1998 |
The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type. |
9799084
|
Lambert JC et al., 2000 |
A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains. |
11065130
|
Larsen PL & Clarke CF, 2002 |
Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q. |
11778046
|
Defossez PA et al., 1999 |
Elimination of replication block protein Fob1 extends the life span of yeast mother cells. |
10230397
|
Barton MK & Kimble J, 1990 |
fog-1, a regulatory gene required for specification of spermatogenesis in the germ line of Caenorhabditis elegans. |
2341035
|
Gems D & Riddle DL, 2000 |
Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. |
10747056
|
Clifford R et al., 2000 |
FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline. |
11076749
|
Ellis RE & Kimble J, 1995 |
The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans. |
7713418
|
Masferrer A et al., 2002 |
Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. |
12000449
|
Ashrafi K et al., 2000 |
Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. |
10921902
|
Shimokawa I et al., 2002 |
Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model. |
12057928
|
Besson A et al., 2003 |
Reduced longevity in untreated patients with isolated growth hormone deficiency. |
12915652
|
Walker DW et al., 2006 |
Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. |
16581512
|
Sanchez D et al., 2006 |
Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. |
16581513
|
Kaeberlein M et al., 2002 |
High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. |
12391171
|
Osiewacz HD & Nuber U, 1996 |
GRISEA, a putative copper-activated transcription factor from Podospora anserina involved in differentiation and senescence. |
8804410
|
Sinclair DA et al., 1997 |
Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. |
9271578
|
Jiang JC et al., 2002 |
Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast. |
12213553
|
Kim S et al., 1999 |
Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. |
10512855
|
Rundlett SE et al., 1996 |
HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. |
8962081
|
Milne GT et al., 1996 |
Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. |
8754818
|
Laroche T et al., 1998 |
Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. |
9635192
|
Boulton SJ & Jackson SP, 1998 |
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. |
9501103
|
Mankouri HW et al., 2002 |
SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases. |
11861900
|
McVey M et al., 2001 |
The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. |
11290710
|
Morley JF & Morimoto RI, 2004 |
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. |
14668486
|
Spindler SR et al., 2012 |
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. |
22737247
|
Walker GA & Lithgow GJ, 2003 |
Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. |
12882326
|
Yokoyama K et al., 2002 |
Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. |
11959102
|
Erjavec N et al., 2007 |
Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. |
17908928
|
Lindquist S & Kim G, 1996 |
Heat-shock protein 104 expression is sufficient for thermotolerance in yeast. |
8643570
|
Shama S et al., 1998 |
Heat stress-induced life span extension in yeast. |
9851879
|
Wang HD et al., 2004 |
Multiple-stress analysis for isolation of Drosophila longevity genes. |
15308776
|
Bodnar AG et al., 1998 |
Extension of life-span by introduction of telomerase into normal human cells. |
9454332
|
Huang TT et al., 2000 |
Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. |
10719757
|
Tu PH et al., 1996 |
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. |
8610185
|
Kinouchi H et al., 1991 |
Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. |
1763030
|
Wittmann CW et al., 2001 |
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. |
11408621
|
Mitsui A et al., 2002 |
Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. |
12230882
|
Managbanag JR et al., 2008 |
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. |
19030232
|
Tatar M et al., 2001 |
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. |
11292875
|
Pierce SB et al., 2001 |
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. |
11274053
|
Feng J et al., 2001 |
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. |
11709184
|
Kato Y et al., 2000 |
Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. |
10631108
|
Utsugi T et al., 2000 |
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. |
11016890
|
Barz WP & Walter P, 1999 |
Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins. |
10198056
|
Jiang JC et al., 1998 |
Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. |
9872981
|
Childress AM et al., 1996 |
LAG2, a gene that determines yeast longevity. |
8760941
|
Vellai T et al., 2003 |
Genetics: influence of TOR kinase on lifespan in C. elegans. |
14668850
|
Nanji M et al., 2005 |
LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans. |
16164423
|
Vergnes B et al., 2002 |
Cytoplasmic SIR2 homologue overexpression promotes survival of Leishmania parasites by preventing programmed cell death. |
12383511
|
Puca AA et al., 2001 |
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. |
11526246
|
Perls TT et al., 1998 |
Siblings of centenarians live longer. |
10326548
|
Heude M & Fabre F, 1993 |
a/alpha-control of DNA repair in the yeast Saccharomyces cerevisiae: genetic and physiological aspects. |
8454201
|
Lundquist EA et al., 1996 |
The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts. |
8625846
|
Capowski EE et al., 1991 |
Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans. |
1783292
|
Ishii N et al., 1998 |
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. |
9716135
|
Ishii N et al., 1990 |
A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans. |
2233820
|
Schriner SE et al., 2005 |
Extension of murine life span by overexpression of catalase targeted to mitochondria. |
15879174
|
Bertram MJ et al., 1999 |
Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. |
9891081
|
Pereira-Smith OM & Smith JR, 1983 |
Evidence for the recessive nature of cellular immortality. |
6879195
|
Pereira-Smith OM & Smith JR, 1988 |
Genetic analysis of indefinite division in human cells: identification of four complementation groups. |
3413074
|
Kaula SC et al., 2000 |
Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2. |
10838077
|
Wadhwa R et al., 1993 |
Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype. |
8454632
|
Stewart MS et al., 2007 |
Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. |
17172436
|
Kikuchi Y et al., 1994 |
A new yeast gene, HTR1, required for growth at high temperature, is needed for recovery from mating pheromone-induced G1 arrest. |
7845352
|
Sinclair DA et al., 1998 |
Molecular mechanisms of yeast aging. |
9584615
|
Kennedy BK et al., 1995 |
Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. |
7859289
|
Kennedy BK et al., 1997 |
Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. |
9150138
|
Hata H et al., 1998 |
Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae. |
9504907
|
Fabrizio P et al., 2004 |
Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. |
14741356
|
Wei M et al., 2008 |
Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. |
18225956
|
Ruan H et al., 2002 |
High-quality life extension by the enzyme peptide methionine sulfoxide reductase. |
11867705
|
Beekman M et al., 2006 |
Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. |
16611701
|
Nebel A et al., 2005 |
No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans. |
15911777
|
Austriaco NR Jr, 1996 |
Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces. |
8810036
|
Pélissier P et al., 1995 |
NCA3, a nuclear gene involved in the mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase of S. cerevisiae. |
7586026
|
Lim DH et al., 2012 |
Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila. |
22310715
|
Scheckhuber CQ et al., 2007 |
Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. |
17173038
|
Van Gilst MR et al., 2005 |
Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. |
15719061
|
Duronio RJ et al., 1990 |
Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. |
2406721
|
Anderson RM et al., 2003 |
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. |
12736687
|
Ha CW & Huh WK, 2011 |
Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae. |
20947565
|
Belenky P et al., 2007 |
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. |
17482543
|
Tahara EB et al., 2007 |
Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging. |
17110466
|
Smith JS et al., 2000 |
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. |
10841563
|
Anderson RM et al., 2002 |
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. |
11884393
|
Michalkiewicz M et al., 2003 |
Hypotension and reduced catecholamines in neuropeptide Y transgenic rats. |
12668588
|
van Rossum EF et al., 2004 |
Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. |
15276593
|
Rinaldo C et al., 2002 |
Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development. |
11861554
|
Tabish M et al., 1995 |
Exclusive expression of C. elegans osm-3 kinesin gene in chemosensory neurons open to the external environment. |
7714894
|
Bargmann CI et al., 1993 |
Odorant-selective genes and neurons mediate olfaction in C. elegans. |
8348618
|
Culotti JG & Russell RL, 1978 |
Osmotic avoidance defective mutants of the nematode Caenorhabditis elegans. |
730048
|
Sgrò CM & Partridge L, 1999 |
A delayed wave of death from reproduction in Drosophila. |
10617470
|
Migliaccio E et al., 1999 |
The p66shc adaptor protein controls oxidative stress response and life span in mammals. |
10580504
|
Yamamura Y et al., 1973 |
Paralysis agitans of early onset with marked diurnal fluctuation of symptoms. |
4735177
|
Sun LQ et al., 2004 |
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. |
15105378
|
Chavous DA et al., 2001 |
Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase. |
11742076
|
Wilson RB & Tatchell K, 1988 |
SRA5 encodes the low-Km cyclic AMP phosphodiesterase of Saccharomyces cerevisiae. |
2827010
|
Charizanis C et al., 1999 |
The oxidative stress response mediated via Pos9/Skn7 is negatively regulated by the Ras/PKA pathway in Saccharomyces cerevisiae. |
10394911
|
Paradis S et al., 1999 |
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. |
10364160
|
Meissner B et al., 2004 |
Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans. |
15155758
|
Kawasaki I et al., 1998 |
PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans. |
9741628
|
Coates PJ et al., 1997 |
The prohibitin family of mitochondrial proteins regulate replicative lifespan. |
9259555
|
Miskin R & Masos T, 1997 |
Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity. |
9060969
|
Fan L et al., 1997 |
Antisense suppression of phospholipase D alpha retards abscisic acid- and ethylene-promoted senescence of postharvest Arabidopsis leaves. |
9437863
|
Van Gassen G & Van Broeckhoven C, 2000 |
Molecular genetics of Alzheimer's disease: what have we learned? |
10934557
|
Sun J et al., 1994 |
Divergent roles of RAS1 and RAS2 in yeast longevity. |
8034612
|
Jang YC et al., 2009 |
Overexpression of Mn superoxide dismutase does not increase life span in mice. |
19633237
|
Unal E et al., 2011 |
Gametogenesis eliminates age-induced cellular damage and resets life span in yeast. |
21700873
|
Feser J et al., 2010 |
Elevated histone expression promotes life span extension. |
20832724
|
Fabrizio P et al., 2001 |
Regulation of longevity and stress resistance by Sch9 in yeast. |
11292860
|
Nakaya S et al., 2012 |
New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound. |
22790951
|
Sebastiani P et al., 2012 |
Genetic signatures of exceptional longevity in humans. |
22279548
|
Atzmon G et al., 2009 |
Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. |
19837933
|
Atzmon G et al., 2010 |
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. |
19915151
|
Barzilai N et al., 2006 |
A genotype of exceptional longevity is associated with preservation of cognitive function. |
17190939
|
Simonsen A et al., 2008 |
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. |
18059160
|
Hernández-Corbacho MJ et al., 2011 |
Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. |
21687659
|
Tacutu R et al., 2012 |
Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. |
23144747
|
Zuo Y et al., 2012 |
Black rice extract extends the lifespan of fruit flies. |
22930061
|
Funakoshi M et al., 2011 |
A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila. |
21281604
|
Paik D et al., 2012 |
Misexpression screen delineates novel genes controlling Drosophila lifespan. |
22366109
|
Palermo V et al., 2012 |
Apple can act as anti-aging on yeast cells. |
22970337
|
Chiang WC et al., 2012 |
C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. |
23028355
|
Searls DB, 2012 |
Ten simple rules for online learning. |
23028268
|
Howitz KT et al., 2003 |
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. |
12939617
|
Wood JG et al., 2004 |
Sirtuin activators mimic caloric restriction and delay ageing in metazoans. |
15254550
|
Gruber J et al., 2007 |
Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans. |
17460219
|
Bass TM et al., 2007 |
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. |
17875315
|
Baur JA et al., 2006 |
Resveratrol improves health and survival of mice on a high-calorie diet. |
17086191
|
Pearson KJ et al., 2008 |
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. |
18599363
|
Miller RA et al., 2007 |
An Aging Interventions Testing Program: study design and interim report. |
17578509
|
Miller RA et al., 2011 |
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. |
20974732
|
de Voer G et al., 2005 |
Deletion of the Caenorhabditis elegans homologues of the CLN3 gene, involved in human juvenile neuronal ceroid lipofuscinosis, causes a mild progeric phenotype. |
16435200
|
Desmyter L et al., 2004 |
Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death. |
15130665
|
Aerts AM et al., 2006 |
Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast. |
16527275
|
Roy N & Runge KW, 2000 |
Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. |
10662670
|
Gebre S et al., 2012 |
Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion. |
22622083
|
Zhang Y et al., 2012 |
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. |
23066506
|
Antosh M et al., 2011 |
Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. |
21325893
|
Meiklejohn CD et al., 2011 |
Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. |
21857805
|
Oxenkrug G et al., 2001 |
Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models. |
11462771
|
Karasek M, 2007 |
Does melatonin play a role in aging processes? |
18212404
|
Pan Y et al., 2011 |
Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. |
21641548
|
Tong JJ et al., 2007 |
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. |
17369827
|
Allikian MJ et al., 2007 |
Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. |
17855453
|
Bodai L et al., 2007 |
Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level. |
17933869
|
Svensson MJ & Larsson J, 2007 |
Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. |
17567437
|
Simonsen A et al., 2007 |
Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. |
17435236
|
Umeda-Kameyama Y et al., 2007 |
Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila. |
17301052
|
Katewa SD et al., 2012 |
Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. |
22768842
|
Bauer J et al., 2010 |
Comparative transcriptional profiling identifies takeout as a gene that regulates life span. |
20519778
|
Flatt T et al., 2008 |
Drosophila germ-line modulation of insulin signaling and lifespan. |
18434551
|
Kim HJ et al., 2010 |
Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22. |
20036725
|
Morrow G et al., 2004 |
Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress. |
14734639
|
Lavara-Culebras E & Paricio N, 2007 |
Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits. |
17651920
|
Simonsen A et al., 2007 |
Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila. |
17617737
|
Piper PW et al., 2002 |
The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. |
12882345
|
Piper, Peter W & Bringloe, David, 2001 |
Loss of prohibitins, though it shortens the replicative life span of yeast cells undergoing division, does not shorten the chronological life span of G0-arrested cells. |
11744041
|
Harris, Nicholas et al., 2003 |
Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells. |
12788479
|
Bitterman KJ et al., 2002 |
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. |
12297502
|
Kruegel U et al., 2011 |
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. |
21931558
|
Lamming, Dudley W et al., 2005 |
HST2 mediates SIR2-independent life-span extension by calorie restriction. |
16051752
|
Tsuchiya M et al., 2006 |
Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. |
17129213
|
Postnikoff SD et al., 2012 |
The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex. |
22438832
|
Murakami CJ et al., 2011 |
Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast. |
21949725
|
Kaeberlein, Matt et al., 2004 |
Sir2-independent life span extension by calorie restriction in yeast. |
15328540
|
Fabrizio P et al., 2005 |
Sir2 blocks extreme life-span extension. |
16286010
|
Huang X et al., 2012 |
Down-regulating sphingolipid synthesis increases yeast lifespan. |
22319457
|
Wanke V et al., 2008 |
Caffeine extends yeast lifespan by targeting TORC1. |
18513215
|
Smith DL Jr et al., 2007 |
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. |
17711561
|
Li B et al., 2011 |
Identification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels. |
21584246
|
Sharma PK et al., 2011 |
Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae. |
20640543
|
Oliveira GA et al., 2008 |
Increased aerobic metabolism is essential for the beneficial effects of caloric restriction on yeast life span. |
18704665
|
Bonawitz ND et al., 2007 |
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. |
17403371
|
Bonawitz ND et al., 2006 |
Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span. |
16782871
|
Unlu ES & Koc A, 2007 |
Effects of deleting mitochondrial antioxidant genes on life span. |
17460215
|
Demir AB & Koc A, 2010 |
Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes. |
20707985
|
Kharade SV et al., 2005 |
Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence. |
16336970
|
Dai J et al., 2010 |
Yin and Yang of histone H2B roles in silencing and longevity: a tale of two arginines. |
20713692
|
Borklu Yucel, Esra & Ulgen, Kutlu O, 2012 |
A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae. |
22216232
|
Powers, R Wilson 3rd et al., 2006 |
Extension of chronological life span in yeast by decreased TOR pathway signaling. |
16418483
|
Wang C et al., 2009 |
Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response. |
19805817
|
Wei M et al., 2009 |
Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. |
19424415
|
Lavoie, Hugo & Whiteway, Malcolm, 2008 |
Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span. |
18469137
|
Kaeberlein, Matt et al., 2005 |
Genes determining yeast replicative life span in a long-lived genetic background. |
15722108
|
Tan, Yuanyou et al., 2009 |
Identification of longevity genes with systems biology approaches. |
21918615
|
Matecic M et al., 2010 |
A microarray-based genetic screen for yeast chronological aging factors. |
20421943
|
Alvers AL et al., 2009 |
Autophagy is required for extension of yeast chronological life span by rapamycin. |
19458476
|
Kwan EX et al., 2011 |
Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. |
21901113
|
Santos J et al., 2012 |
Ammonium is toxic for aging yeast cells, inducing death and shortening of the chronological lifespan. |
22615903
|
Gomes P et al., 2007 |
Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span. |
17544056
|
Jiang JC et al., 2000 |
An intervention resembling caloric restriction prolongs life span and retards aging in yeast. |
11024000
|
Miceli MV et al., 2011 |
Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan. |
22303396
|
Goldberg, Alexander A et al., 2010 |
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. |
20622262
|
Weinberger M et al., 2007 |
DNA replication stress is a determinant of chronological lifespan in budding yeast. |
17710147
|
Longo, Valter D, 2003 |
The Ras and Sch9 pathways regulate stress resistance and longevity. |
12855292
|
Easlon E et al., 2008 |
The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. |
18381895
|
Easlon E et al., 2007 |
The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension. |
17200108
|
Pan Y & Shadel GS, 2009 |
Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density. |
20157595
|
Malc E et al., 2009 |
Inactivation of the 20S proteasome maturase, Ump1p, leads to the instability of mtDNA in Saccharomyces cerevisiae. |
19467248
|
Madia, Federica et al., 2008 |
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. |
18195102
|
Heo SJ et al., 1999 |
Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast. |
10620009
|
Parrella E & Longo VD, 2008 |
The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. |
18930829
|
Qin H et al., 2008 |
Genomic instability is associated with natural life span variation in Saccharomyces cerevisiae. |
18628831
|
Borghouts, Corina et al., 2004 |
Rtg2 protein links metabolism and genome stability in yeast longevity. |
15020466
|
Kim S et al., 2004 |
The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity. |
15547318
|
Gallo CM et al., 2004 |
Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. |
14729974
|
Kaeberlein M et al., 2006 |
Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". |
16741098
|
Delaney JR et al., 2011 |
Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. |
21191185
|
Burtner, Christopher R et al., 2009 |
A molecular mechanism of chronological aging in yeast. |
19305133
|
Shama, S et al., 1998 |
Role of RAS2 in recovery from chronic stress: effect on yeast life span. |
9851878
|
Yang, Jingye et al., 2011 |
Cell size and growth rate are major determinants of replicative lifespan. |
21248481
|
Lin SS et al., 2003 |
Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing. |
12562756
|
Lin YY et al., 2009 |
Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. |
19303850
|
Rizzetto L et al., 2012 |
Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60. |
22675632
|
Ashrafi K et al., 1999 |
Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. |
10430902
|
D'Mello NP & Jazwinski SM, 1991 |
Telomere length constancy during aging of Saccharomyces cerevisiae. |
1938877
|
Park PU et al., 1999 |
Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae. |
10207108
|
Kennedy BK et al., 1994 |
Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. |
7806576
|
Zhu X et al., 2011 |
Mediator influences telomeric silencing and cellular life span. |
21482672
|
Egilmez NK & Jazwinski SM, 1989 |
Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae. |
2644196
|
Austriaco NR Jr & Guarente LP, 1997 |
Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae. |
9275199
|
Chen, Xiao-Fen et al., 2009 |
Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae. |
19557187
|
Jazwinski SM et al., 1998 |
Epigenetic stratification: the role of individual change in the biological aging process. |
9789734
|
Jazwinski SM & Wawryn J, 2001 |
Profiles of random change during aging contain hidden information about longevity and the aging process. |
11742528
|
Mankouri, H W & Morgan, A, 2001 |
The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors. |
11389927
|
Ray A et al., 2003 |
Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan. |
12640455
|
Longo VD et al., 1996 |
Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. |
8647826
|
Longo VD et al., 1997 |
Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. |
9199172
|
Longo VD et al., 1999 |
Mitochondrial superoxide decreases yeast survival in stationary phase. |
10222047
|
Wawryn J et al., 2002 |
Effect of superoxide dismutase deficiency on the life span of the yeast Saccharomyces cerevisiae. An oxygen-independent role of Cu,Zn-superoxide dismutase. |
12020810
|
Krzepiłko A et al., 2004 |
Ascorbate restores lifespan of superoxide-dismutase deficient yeast. |
15621721
|
Parkes TL et al., 1998 |
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. |
9620775
|
Li L et al., 2009 |
Budding yeast SSD1-V regulates transcript levels of many longevity genes and extends chronological life span in purified quiescent cells. |
19570907
|
Kaeberlein M et al., 2004 |
Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. |
15126388
|
Delaney JR et al., 2011 |
Sir2 deletion prevents lifespan extension in 32 long-lived mutants. |
21902802
|
Kamei Y et al., 2011 |
GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae. |
21371425
|
Yoshida R et al., 2010 |
Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants. |
20550517
|
Xiang L et al., 2011 |
Anti-aging effects of phloridzin, an apple polyphenol, on yeast via the SOD and Sir2 genes. |
21597195
|
Weng, Yufang et al., 2010 |
Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene. |
20093034
|
Jarolim, Stefanie et al., 2004 |
A novel assay for replicative lifespan in Saccharomyces cerevisiae. |
15489200
|
Timmermann B et al., 2010 |
A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging. |
20729566
|
Lu JY et al., 2011 |
Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. |
21906795
|
Francis BR et al., 2007 |
Mutations in the Atp1p and Atp3p subunits of yeast ATP synthase differentially affect respiration and fermentation in Saccharomyces cerevisiae. |
17492370
|
Kitanovic A & Wölfl S, 2006 |
Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae. |
16199065
|
Rosaleny LE et al., 2005 |
Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes. |
16023114
|
Barbosa AD et al., 2011 |
Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. |
21707788
|
Almeida T et al., 2008 |
Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis. |
18162582
|
Barbosa AD et al., 2012 |
Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging. |
22445853
|
Li W et al., 2006 |
Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. |
16436509
|
Chiocchetti A et al., 2007 |
Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. |
17174052
|
Rinnerthaler M et al., 2006 |
MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria. |
16806052
|
Aerts AM et al., 2009 |
Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast. |
19059240
|
Aerts AM et al., 2008 |
Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast. |
18500447
|
Kaya A et al., 2010 |
Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast. |
20799725
|
Lorenz DR et al., 2009 |
A network biology approach to aging in yeast. |
19164565
|
Savory FR et al., 2011 |
DAF-16 and Δ9 desaturase genes promote cold tolerance in long-lived Caenorhabditis elegans age-1 mutants. |
21931751
|
Van Raamsdonk JM & Hekimi S, 2009 |
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. |
19197346
|
Honda Y et al., 2008 |
Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans. |
18406553
|
Van Raamsdonk JM et al., 2010 |
Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage. |
20382831
|
Yang W et al., 2007 |
A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans. |
18073424
|
Yanase S et al., 2002 |
Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span. |
12470895
|
Ren Y et al., 2012 |
Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans. |
22253756
|
Vazquez-Manrique, Rafael P et al., 2005 |
Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant. |
16293572
|
Ventura, Natascia et al., 2005 |
Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans. |
15771615
|
Torgovnick, Alessandro et al., 2010 |
A role for p53 in mitochondrial stress response control of longevity in C. elegans. |
20172019
|
Ventura, Natascia et al., 2009 |
p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. |
19416129
|
Yang W & Hekimi S, 2010 |
Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. |
20346072
|
Curran SP et al., 2009 |
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. |
19506556
|
Berman JR & Kenyon C, 2006 |
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. |
16530050
|
Wollam J et al., 2012 |
A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. |
22505847
|
Wollam J et al., 2011 |
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. |
21749634
|
Rottiers V et al., 2006 |
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. |
16563875
|
Gerisch B et al., 2007 |
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. |
17360327
|
Rizki G et al., 2011 |
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. |
21909281
|
Araiz C et al., 2008 |
14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. |
18423931
|
Ghazi A et al., 2009 |
A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. |
19749979
|
Goudeau, Jerome et al., 2011 |
Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. |
21423649
|
Yamawaki TM et al., 2010 |
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. |
20824162
|
Lin, K et al., 2001 |
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. |
11381260
|
Walter, Ludivine et al., 2011 |
The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans. |
21713031
|
Shen L et al., 2010 |
Regulation of longevity by genes required for the functions of AIY interneuron in nematode Caenorhabditis elegans. |
21055415
|
Shen, Lu-Lu et al., 2010 |
Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion. |
20332814
|
Rea, Shane L et al., 2007 |
Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. |
17914900
|
Gallo, Marco et al., 2011 |
Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway. |
21884719
|
Wang J et al., 2010 |
RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. |
20700440
|
Yazaki K et al., 2011 |
Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans. |
22013497
|
Zhang L et al., 2009 |
Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress. |
19061950
|
Abbas S & Wink M, 2009 |
Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. |
19085685
|
Honda Y et al., 2011 |
Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. |
21858156
|
Petriv OI & Rachubinski RA, 2004 |
Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans. |
14996832
|
Portal-Celhay C et al., 2012 |
Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans. |
22452899
|
Alper S et al., 2010 |
The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity. |
19923212
|
Troemel, Emily R et al., 2006 |
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. |
17096597
|
Pietsch, Kerstin et al., 2011 |
Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans. |
21503726
|
Kampkotter, Andreas et al., 2007 |
Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. |
18024103
|
Saul N et al., 2008 |
Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved? |
18692520
|
Evans, Eric A et al., 2008 |
The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans. |
18782349
|
Li X et al., 2011 |
Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. |
21695230
|
Banfield KL et al., 2008 |
Protein-repair and hormone-signaling pathways specify dauer and adult longevity and dauer development in Caenorhabditis elegans. |
18772467
|
Ogg, S et al., 1997 |
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. |
9353126
|
Rahman MM et al., 2010 |
Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans. |
20952811
|
Honda, Yoko et al., 2010 |
Redox regulation, gene expression and longevity. |
20590843
|
Lapierre LR et al., 2011 |
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. |
21906946
|
Hashimoto Y et al., 2009 |
Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans. |
19469880
|
Hars, Eszter S et al., 2007 |
Autophagy regulates ageing in C. elegans. |
17204841
|
Fisher AL & Lithgow GJ, 2006 |
The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms. |
16626392
|
Halaschek-Wiener J et al., 2005 |
Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. |
15837805
|
Curtis R et al., 2006 |
Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways. |
16626391
|
Greer, Eric L et al., 2007 |
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. |
17900900
|
Williams DS et al., 2009 |
Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. |
19793063
|
Hahm JH et al., 2009 |
Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans. |
19489741
|
Lans H & Jansen G, 2007 |
Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. |
17187771
|
Bishop, Nicholas A & Guarente, Leonard, 2007 |
Two neurons mediate diet-restriction-induced longevity in C. elegans. |
17538612
|
Vertino, Anthony et al., 2012 |
A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat. |
22303358
|
Ebert RH 2nd et al., 1996 |
Defining genes that govern longevity in Caenorhabditis elegans. |
8934875
|
Ebert RH 2nd et al., 1993 |
Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci. |
8307318
|
Ayyadevara S et al., 2009 |
Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan. |
19764929
|
Tazearslan C et al., 2009 |
Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance. |
19360094
|
Ayyadevara S et al., 2005 |
Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2. |
16300482
|
Ayyadevara S et al., 2005 |
Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. |
16164425
|
Ayyadevara S et al., 2007 |
Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. |
17157356
|
Ayyadevara S et al., 2003 |
Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms. |
12618395
|
Sánchez-Blanco A & Kim SK, 2011 |
Variable pathogenicity determines individual lifespan in Caenorhabditis elegans. |
21533182
|
Xiang L et al., 2011 |
Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor. |
22156377
|
Lehtinen MK et al., 2006 |
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. |
16751106
|
Wang MC et al., 2005 |
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. |
15820683
|
Dwivedi, Meenakshi et al., 2009 |
Autophagy genes mediate the effect of calcineurin on life span in C. elegans. |
19279398
|
Mair W et al., 2011 |
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. |
21331044
|
Spanier B et al., 2010 |
Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity. |
20550516
|
Zarse K & Ristow M, 2008 |
Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans. |
19112515
|
Crawford D et al., 2007 |
Caenorhabditis elegans integrates food and reproductive signals in lifespan determination. |
17711560
|
Zarse K et al., 2011 |
The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans. |
21264793
|
Schmeisser S et al., 2011 |
Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species. |
21932172
|
Zarse K et al., 2012 |
L: -Theanine extends lifespan of adult Caenorhabditis elegans. |
22422488
|
Zarse K et al., 2010 |
Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans. |
20925017
|
Yu YB et al., 2010 |
Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways. |
20179756
|
Petrascheck, Michael et al., 2007 |
An antidepressant that extends lifespan in adult Caenorhabditis elegans. |
18033297
|
Wang, Meng C et al., 2008 |
Fat metabolism links germline stem cells and longevity in C. elegans. |
18988854
|
Khare S et al., 2011 |
The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans. |
21695191
|
Gomez TA et al., 2007 |
The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy. |
17187774
|
Castro PV et al., 2012 |
Caenorhabditis elegans battling starvation stress: low levels of ethanol prolong lifespan in L1 larvae. |
22279556
|
Chen CS et al., 2010 |
WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans. |
20209166
|
Kagan RM et al., 1997 |
Targeted gene disruption of the Caenorhabditis elegans L-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes. |
9434744
|
Wang Y & Tissenbaum HA, 2006 |
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. |
16280150
|
Berdichevsky A et al., 2006 |
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. |
16777605
|
Viswanathan M et al., 2005 |
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. |
16256736
|
Burnett, Camilla et al., 2011 |
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. |
21938067
|
Heidler T et al., 2010 |
Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1. |
19597959
|
Wang X et al., 2010 |
Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16. |
20828537
|
Guan S et al., 2010 |
A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans. |
20528576
|
Wiegant, F A C et al., 2008 |
Plant adaptogens increase lifespan and stress resistance in C. elegans. |
18536978
|
Hunt, Piper R et al., 2011 |
Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms. |
21765926
|
Zhu C et al., 2010 |
The lin-4 Gene Controls Fat Accumulation and Longevity in Caenorhabditis elegans. |
21614175
|
Samuelson AV et al., 2007 |
Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. |
18419309
|
Samuelson AV et al., 2007 |
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. |
18006689
|
Lee, Siu Sylvia et al., 2003 |
DAF-16 target genes that control C. elegans life-span and metabolism. |
12690206
|
Bonilla E et al., 2002 |
Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin. |
11909680
|
Le Bourg, Eric, 2007 |
Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster. |
17318365
|
Le Bourg E & Minois N, 1997 |
Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity. |
9183440
|
Takahashi M et al., 2001 |
Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans. |
11511092
|
Morris JZ et al., 1996 |
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. |
8700226
|
Friedman DB & Johnson TE, 1988 |
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. |
8608934
|
Wu D et al., 2009 |
Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans. |
19580861
|
Olsen A et al., 2006 |
Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments. |
16826446
|
Wu D et al., 2008 |
The U-shaped response of initial mortality in Caenorhabditis elegans to mild heat shock: does it explain recent trends in human mortality? |
18693219
|
Yashin AI et al., 2001 |
Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans. |
11470134
|
Friedman DB & Johnson TE, 1988 |
Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. |
3385139
|
Johnson TE, 1990 |
Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. |
2392681
|
Johnson TE, 1987 |
Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans. |
3473482
|
Wu D et al., 2009 |
Mortality shifts in Caenorhabditis elegans: remembrance of conditions past. |
19747231
|
Johnson TE et al., 2001 |
Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects. |
11487591
|
Cheong MC et al., 2011 |
A potential biochemical mechanism underlying the influence of sterol deprivation stress on Caenorhabditis elegans longevity. |
21186286
|
Choi SS, 2011 |
High glucose diets shorten lifespan of Caenorhabditis elegans via ectopic apoptosis induction. |
21779524
|
Gems D et al., 1998 |
Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. |
9725835
|
Fei YJ et al., 2003 |
Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span. |
12480943
|
Fei YJ et al., 2004 |
Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans. |
14678010
|
Thyagarajan B et al., 2010 |
ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans. |
20862312
|
Sutphin GL & Kaeberlein M, 2008 |
Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. |
18083317
|
Smith ED et al., 2008 |
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. |
18457595
|
Houthoofd K et al., 2003 |
Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans. |
12954481
|
Papp D et al., 2012 |
A role for SKN-1/Nrf in pathogen resistance and immunosenescence in Caenorhabditis elegans. |
22577361
|
Narasimhan SD et al., 2011 |
PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism. |
21533078
|
Zhang Y et al., 2008 |
Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. |
18241854
|
Alam H et al., 2010 |
EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. |
20620993
|
Dumas KJ et al., 2010 |
Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. |
20178781
|
Gami, Minaxi S et al., 2006 |
Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling. |
17020605
|
Meister P et al., 2011 |
Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism. |
22185090
|
Masse I et al., 2008 |
A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans. |
18836529
|
Park, Sang-Kyu et al., 2009 |
Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. |
19627265
|
Chen J et al., 2007 |
A demographic analysis of the fitness cost of extended longevity in Caenorhabditis elegans. |
17339638
|
Chen D et al., 2007 |
Longevity determined by developmental arrest genes in Caenorhabditis elegans. |
17521386
|
van der Horst A et al., 2007 |
The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival. |
17335870
|
Klass MR, 1983 |
A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. |
6632998
|
Yang Y & Wilson DL, 2000 |
Isolating aging mutants: a novel method yields three strains of the nematode Caenorhabditis elegans with extended life spans. |
10708258
|
Johnson TE & Hutchinson EW, 1993 |
Absence of strong heterosis for life span and other life history traits in Caenorhabditis elegans. |
8325483
|
Yen K & Mobbs CV, 2010 |
Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. |
19662517
|
Klass MR, 1977 |
Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. |
926867
|
McCulloch D & Gems D, 2007 |
Sex-specific effects of the DAF-12 steroid receptor on aging in Caenorhabditis elegans. |
18056973
|
Gems D & Riddle DL, 2000 |
Defining wild-type life span in Caenorhabditis elegans. |
10819307
|
Pinkston JM et al., 2006 |
Mutations that increase the life span of C. elegans inhibit tumor growth. |
16917064
|
Volovik Y et al., 2012 |
Temporal requirements of heat shock factor-1 for longevity assurance. |
22360389
|
Hsu AL et al., 2003 |
Regulation of aging and age-related disease by DAF-16 and heat-shock factor. |
12750521
|
Song HO et al., 2009 |
C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response. |
19467242
|
Walker, G A et al., 2001 |
Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans. |
11445592
|
Galbadage, Thushara & Hartman, Phil S, 2008 |
Repeated temperature fluctuation extends the life span of Caenorhabditis elegans in a daf-16-dependent fashion. |
18538371
|
Arum O & Johnson TE, 2007 |
Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity. |
17895432
|
Tavernarakis N et al., 2008 |
The effects of p53 on whole organism longevity are mediated by autophagy. |
18728385
|
Amrit FR et al., 2010 |
Phenotypic covariance of longevity, immunity and stress resistance in the caenorhabditis nematodes. |
20369008
|
Kimura K et al., 2007 |
Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans. |
17189267
|
Boehm, Michelle & Slack, Frank, 2005 |
A developmental timing microRNA and its target regulate life span in C. elegans. |
16373574
|
Angelo, Giana & Van Gilst, Marc R, 2009 |
Starvation protects germline stem cells and extends reproductive longevity in C. elegans. |
19713489
|
Ishii N et al., 1994 |
The effects of temperature on the longevity of a radiation-sensitive mutant rad-8 of the nematode Caenorhabditis elegans. |
8169328
|
Ishi N et al., 1993 |
The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development. |
8350650
|
Hosokawa, H et al., 1994 |
Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans. |
7934213
|
Ookuma S et al., 2003 |
Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. |
12620193
|
Hertweck M et al., 2004 |
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. |
15068796
|
Cypser JR & Johnson TE, 1999 |
The spe-10 mutant has longer life and increased stress resistance. |
10638523
|
Murakami S & Johnson TE, 1996 |
A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. |
8807294
|
Fujii M et al., 2005 |
Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans. |
16244463
|
Mukhopadhyay A et al., 2005 |
C. elegans tubby regulates life span and fat storage by two independent mechanisms. |
16054097
|
Ailion, M et al., 1999 |
Neurosecretory control of aging in Caenorhabditis elegans. |
10377425
|
Ailion, M & Thomas, J H, 2000 |
Dauer formation induced by high temperatures in Caenorhabditis elegans. |
11063684
|
Shen, Lu-Lu et al., 2007 |
Involvement of genes required for synaptic function in aging control in C. elegans. |
17592521
|
Mockett RJ et al., 1999 |
Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster. |
10545213
|
Pinkston-Gosse J & Kenyon C, 2007 |
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. |
17934462
|
Ha MK et al., 2006 |
Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis. |
16673436
|
Greer EL et al., 2011 |
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. |
22012258
|
Greer, Eric L et al., 2010 |
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. |
20555324
|
Vandamme, Julien et al., 2012 |
The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity. |
22570628
|
Maures, Travis J et al., 2011 |
The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner. |
21834846
|
Jin C et al., 2011 |
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. |
21803287
|
Oh SW et al., 2006 |
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. |
16380712
|
de Lencastre, Alexandre et al., 2010 |
MicroRNAs both promote and antagonize longevity in C. elegans. |
21129974
|
Li W et al., 2007 |
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. |
17276341
|
Le DT et al., 2009 |
Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. |
19049972
|
Dong, Meng-Qiu et al., 2007 |
Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. |
17673661
|
Vaccaro A et al., 2012 |
TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans. |
22792076
|
Honda S et al., 1993 |
Oxygen-dependent perturbation of life span and aging rate in the nematode. |
8473689
|
Adachi H et al., 1998 |
Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans. |
18314552
|
Kawano T et al., 2005 |
Lifespan extending activity of substances secreted by the nematode Caenorhabditis elegans that include the dauer-inducing pheromone. |
16377915
|
Morselli E et al., 2011 |
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. |
21339330
|
McColl, Gawain et al., 2005 |
The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span. |
16099946
|
Luo S et al., 2010 |
TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance. |
20946987
|
Orr, W C & Sohal, R S, 1993 |
Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster. |
8442664
|
Orr, W C & Sohal, R S, 1992 |
The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster. |
1379030
|
Mockett, Robin J et al., 2003 |
Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity. |
12521602
|
Bauer JH et al., 2004 |
An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. |
15328413
|
Zheng J et al., 2005 |
Calorie restriction delays lipid oxidative damage in Drosophila melanogaster. |
16026335
|
Vermeulen CJ et al., 2005 |
Resistance to oxidative stress induced by paraquat correlates well with both decreased and increased lifespan in Drosophila melanogaster. |
16518700
|
Harshman LG & Haberer BA, 2000 |
Oxidative stress resistance: a robust correlated response to selection in extended longevity lines of Drosophila melanogaster? |
10995037
|
Harshman, L G et al., 2000 |
Stress resistance and longevity in selected lines of Drosophila melanogaster. |
10638525
|
Magwire MM et al., 2010 |
Quantitative and molecular genetic analyses of mutations increasing Drosophila life span. |
20686706
|
Geiger-Thornsberry, Gretchen L & Mackay, Trudy F C, 2004 |
Quantitative trait loci affecting natural variation in Drosophila longevity. |
15013662
|
Pasyukova EG et al., 2004 |
Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan. |
15379853
|
Pasyukova, E G et al., 2000 |
Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster. |
11063689
|
Wilson RH et al., 2006 |
High-resolution mapping of quantitative trait loci affecting increased life span in Drosophila melanogaster. |
16702433
|
Nuzhdin SV et al., 2005 |
Survival analysis of life span quantitative trait loci in Drosophila melanogaster. |
15834144
|
Shen J et al., 2009 |
Identifying sexual differentiation genes that affect Drosophila life span. |
20003237
|
Shen J et al., 2009 |
A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila. |
20157509
|
Ford, Daniel et al., 2007 |
Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone. |
17349761
|
Sun J et al., 2004 |
Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span. |
15130751
|
Sun J et al., 2002 |
Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. |
12072463
|
Hoe N et al., 2011 |
Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster. |
21415465
|
Alic N et al., 2011 |
Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. |
21108726
|
Broughton S et al., 2008 |
Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. |
19005568
|
Humphrey DM et al., 2009 |
Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan. |
19385039
|
Giannakou ME et al., 2007 |
Dynamics of the action of dFOXO on adult mortality in Drosophila. |
17465980
|
Min KJ et al., 2008 |
Drosophila lifespan control by dietary restriction independent of insulin-like signaling. |
18221413
|
Waskar M et al., 2009 |
Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. |
20157574
|
Shen J & Tower J, 2010 |
Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects. |
19840842
|
Rybina OY & Pasyukova EG, 2010 |
A naturally occurring polymorphism at Drosophila melanogaster Lim3 Locus, a homolog of human LHX3/4, affects Lim3 transcription and fly lifespan. |
20838645
|
Sepulveda S et al., 2008 |
Interactions between injury, stress resistance, reproduction, and aging in Drosophila melanogaster. |
18053668
|
Nghiem, D et al., 2000 |
Postponed aging and desiccation resistance in Drosophila melanogaster. |
11121683
|
Khazaeli AA & Curtsinger JW, 2000 |
Genetic analysis of extended lifespan in Drosophila melanogaster III. On the relationship between artificially selected and wild stocks. |
11430488
|
Khazaeli AA et al., 2005 |
Longevity and metabolism in Drosophila melanogaster: genetic correlations between life span and age-specific metabolic rate in populations artificially selected for long life. |
15466435
|
Sanz A et al., 2010 |
Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. |
20435911
|
Bahadorani S et al., 2010 |
Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan. |
20089120
|
Krishnan N et al., 2009 |
The circadian clock gene period extends healthspan in aging Drosophila melanogaster. |
20157575
|
Krishnan N et al., 2012 |
Loss of circadian clock accelerates aging in neurodegeneration-prone mutants. |
22227001
|
Bedoukian MA et al., 2009 |
Neuronal susceptibility to GRIM in Drosophila melanogaster measures the rate of genetic changes that scale to lifespan. |
19428445
|
Liao PC et al., 2008 |
The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila. |
18796296
|
Bhole D et al., 2004 |
Doxycycline-regulated over-expression of hsp22 has negative effects on stress resistance and life span in adult Drosophila melanogaster. |
15491684
|
Yang J & Tower J, 2009 |
Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions. |
19420297
|
Lee KS et al., 2009 |
JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span. |
19720829
|
Spindler SR et al., 2012 |
Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. |
22363408
|
Larson K et al., 2012 |
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. |
22291607
|
Rera, Michael et al., 2010 |
Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster. |
20096722
|
Piacentini L et al., 2009 |
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila. |
19798443
|
Min, Kyung-Jin et al., 2006 |
Counting calories in Drosophila diet restriction. |
17125951
|
Min KJ & Tatar M, 2006 |
Drosophila diet restriction in practice: do flies consume fewer nutrients? |
16256171
|
Vigne P & Frelin C, 2010 |
Food presentation modifies longevity and the beneficial action of dietary restriction in Drosophila. |
19895881
|
Yamamoto R & Tatar M, 2011 |
Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan. |
21518241
|
Slack, Cathy et al., 2011 |
dFOXO-independent effects of reduced insulin-like signaling in Drosophila. |
21443682
|
Slack C et al., 2010 |
Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. |
20333234
|
Bhandari, Poonam et al., 2007 |
Dietary restriction alters demographic but not behavioral aging in Drosophila. |
17874997
|
Hulbert, A J et al., 2004 |
Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. |
15288688
|
Mockett RJ et al., 2001 |
Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster. |
11250117
|
Arking, R, 1987 |
Successful selection for increased longevity in Drosophila: analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity. |
3113991
|
Mair, William et al., 2004 |
Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity. |
15236760
|
Lee KP et al., 2008 |
Lifespan and reproduction in Drosophila: New insights from nutritional geometry. |
18268352
|
Lushchak OV et al., 2012 |
Balance between macronutrients affects life span and functional senescence in fruit fly Drosophila melanogaster. |
22042724
|
Landenberger A et al., 2004 |
Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster. |
15542350
|
Smith EM et al., 2007 |
Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patterns. |
17709434
|
Camporeale G et al., 2006 |
Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance. |
17056793
|
Anisimov VN et al., 1997 |
Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster. |
9226628
|
Ja WW et al., 2009 |
Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan. |
19841272
|
Boyd O et al., 2011 |
Nectarine promotes longevity in Drosophila melanogaster. |
21406223
|
Bahadorani S et al., 2008 |
The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress. |
18245758
|
Huang SF et al., 2010 |
Cerium caused life span shortening and oxidative stress resistance in Drosophila melanogaster. |
19828196
|
Zhang L et al., 2009 |
[Changes of the life span and certain biochemical indexes on Drosophila melanogaster by ethanol exposure]. |
19408653
|
Cui X et al., 2004 |
D-galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress. |
15547319
|
Le Rohellec M & Le Bourg E, 2009 |
Contrasted effects of suppressing live yeast from food on longevity, aging and resistance to several stresses in Drosophila melanogaster. |
19666103
|
Le Bourg E, 2010 |
Combined effects of suppressing live yeast and of a cold pretreatment on longevity, aging and resistance to several stresses in Drosophila melanogaster. |
19823937
|
Burger JM et al., 2007 |
The functional costs and benefits of dietary restriction in Drosophila. |
17266676
|
Bass TM et al., 2007 |
Optimization of dietary restriction protocols in Drosophila. |
17921418
|
Bross TG et al., 2005 |
Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction. |
16300483
|
Tu MP et al., 2002 |
The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico. |
12882356
|
Frankel, Stewart & Rogina, Blanka, 2005 |
Drosophila longevity is not affected by heterochromatin-mediated gene silencing. |
15659213
|
Sanz, Alberto et al., 2010 |
Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. |
20453260
|
Bayne AC et al., 2005 |
Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila. |
15954861
|
Zhang H et al., 2010 |
Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster. |
20600782
|
Landis G et al., 2001 |
High-frequency generation of conditional mutations affecting Drosophila melanogaster development and life span. |
11454765
|
Poon PC et al., 2010 |
Carbon dioxide sensing modulates lifespan and physiology in Drosophila. |
20422037
|
Broughton SJ et al., 2005 |
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. |
15708981
|
Shikama, N et al., 1994 |
Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster. |
8183891
|
Ruiz M et al., 2011 |
Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz. |
21376794
|
Muffat J et al., 2008 |
Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila. |
18458334
|
Shchedrina VA et al., 2009 |
Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging. |
19409408
|
Chung H et al., 2010 |
The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO. |
20655917
|
Phillips, J P et al., 2000 |
Targeted neuronal gene expression and longevity in Drosophila. |
11113599
|
Kirby K et al., 2002 |
RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress. |
12456885
|
Mockett, R J et al., 1999 |
Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia. |
10506576
|
Rebrin I & Sohal RS, 2006 |
Comparison between the effects of aging and hyperoxia on glutathione redox state and protein mixed disulfides in Drosophila melanogaster. |
17011021
|
Linford NJ et al., 2012 |
Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality. |
22570630
|
Mair, William et al., 2003 |
Demography of dietary restriction and death in Drosophila. |
14500985
|
Jacobson, Jake et al., 2010 |
Biomarkers of aging in Drosophila. |
20367621
|
Tu MP & Tatar M, 2003 |
Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster. |
14677635
|
Peng C et al., 2012 |
Blueberry extract prolongs lifespan of Drosophila melanogaster. |
22197903
|
Peng C et al., 2011 |
Apple polyphenols extend the mean lifespan of Drosophila melanogaster. |
21319854
|
Benguría A et al., 1996 |
Microgravity effects on Drosophila melanogaster behavior and aging. Implications of the IML-2 experiment. |
8987567
|
Tatar, M et al., 1997 |
Chaperoning extended life. |
9363888
|
Juhász G et al., 2007 |
Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. |
18056421
|
Juhasz, Gabor & Neufeld, Thomas P, 2008 |
Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis. |
18216496
|
Ren C et al., 2009 |
Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity. |
18955126
|
Connell-Crowley L et al., 2007 |
Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. |
17368005
|
Rao RP et al., 2007 |
Ceramide transfer protein function is essential for normal oxidative stress response and lifespan. |
17592126
|
Morrow G et al., 2004 |
Decreased lifespan in the absence of expression of the mitochondrial small heat shock protein Hsp22 in Drosophila. |
15331597
|
Yang Q et al., 2010 |
Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity. |
20112046
|
Wu D et al., 2012 |
Fertility/longevity trade-offs under limiting-male conditions in mating populations of Caenorhabditis elegans. |
22771817
|
Mair W et al., 2005 |
Calories do not explain extension of life span by dietary restriction in Drosophila. |
16000018
|
Mével-Ninio M et al., 1991 |
The ovo gene of Drosophila encodes a zinc finger protein required for female germ line development. |
1712294
|
Sun X et al., 2010 |
Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. |
20080168
|
Bruckbauer, Antje & Zemel, Michael B, 2009 |
Dietary calcium and dairy modulation of oxidative stress and mortality in aP2-agouti and wild-type mice. |
22253967
|
Reilly SM et al., 2010 |
Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. |
21109196
|
Lamming DW et al., 2012 |
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. |
22461615
|
Singh SP et al., 2010 |
Disruption of the mGsta4 gene increases life span of C57BL mice. |
19880816
|
Smith DL Jr et al., 2011 |
No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight. |
21079617
|
Al-Regaiey KA et al., 2005 |
Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. |
15498882
|
Hughes BG & Hekimi S, 2011 |
A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice. |
22028811
|
Chen YF et al., 2009 |
Cisd2 mediates mitochondrial integrity and life span in mammals. |
19717971
|
Borrás C et al., 2011 |
RasGrf1 deficiency delays aging in mice. |
21422498
|
Selman, Colin et al., 2009 |
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. |
19797661
|
Moskovitz J et al., 2001 |
Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. |
11606777
|
Salmon, Adam B et al., 2009 |
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span. |
19487311
|
Miskin, R et al., 2000 |
AlphaMUPA mice: a transgenic model for increased life span. |
10638529
|
Zhang Y et al., 2009 |
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. |
19776219
|
Van Remmen, Holly et al., 2003 |
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. |
14679299
|
Li, Y et al., 1995 |
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. |
7493016
|
Rudolph KL et al., 1999 |
Longevity, stress response, and cancer in aging telomerase-deficient mice. |
10089885
|
Kwan KY & Wang JC, 2001 |
Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. |
11331780
|
Speakman JR et al., 2004 |
Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. |
15153176
|
Choi CS et al., 2007 |
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. |
17923673
|
Harrison DE et al., 1984 |
Effects of food restriction on aging: separation of food intake and adiposity. |
6608731
|
Li Q & Ren J, 2007 |
Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression. |
17973971
|
Liu X et al., 2005 |
Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. |
16195414
|
Kanfi Y et al., 2012 |
The sirtuin SIRT6 regulates lifespan in male mice. |
22367546
|
Shimokawa I et al., 2003 |
Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction. |
12692087
|
Zha Y et al., 2008 |
Genetic suppression of GH-IGF-1 activity, combined with lifelong caloric restriction, prevents age-related renal damage and prolongs the life span in rats. |
18434714
|
Hellmann JK et al., 2010 |
Synergistic and additive effects of epigallocatechin gallate and digitonin on Plasmodium sporozoite survival and motility. |
20072627
|
Saastamoinen M et al., 2009 |
Significant effects of Pgi genotype and body reserves on lifespan in the Glanville fritillary butterfly. |
19129143
|
Hatle, John D et al., 2008 |
Protein accumulation underlying lifespan extension via ovariectomy in grasshoppers is consistent with the disposable soma hypothesis but is not due to dietary restriction. |
18761078
|
Drewry MD et al., 2011 |
Life-extending dietary restriction and ovariectomy result in similar feeding rates but different physiologic responses in grasshoppers. |
21742024
|
Fanson, Benjamin G et al., 2009 |
Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni). |
19558564
|
Fanson BG & Taylor PW, 2012 |
Protein:carbohydrate ratios explain life span patterns found in Queensland fruit fly on diets varying in yeast:sugar ratios. |
21904823
|
Fanson BG & Taylor PW, 2012 |
Additive and interactive effects of nutrient classes on longevity, reproduction, and diet consumption in the Queensland fruit fly (Bactrocera tryoni). |
22094291
|
Reynolds OL & Orchard BA, 2011 |
Effect of adult chill treatments on recovery, longevity and flight ability of Queensland fruit fly, Bactrocera tryoni (Froggatt) (Diptera: Tephritidae). |
20609276
|
Molleman F et al., 2008 |
Adult diet affects lifespan and reproduction of the fruit-feeding butterfly Charaxes fulvescens. |
19774093
|
Kulminski AM et al., 2009 |
Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens. |
19716408
|
Carey JR et al., 2008 |
Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients. |
18346215
|
Zou, Sige et al., 2009 |
The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. |
19264118
|
Zou S et al., 2010 |
Prolongevity effects of an oregano and cranberry extract are diet dependent in the Mexican fruit fly (Anastrepha ludens). |
19906819
|
Zou S et al., 2012 |
Prolongevity effects of a botanical with oregano and cranberry extracts in Mexican fruit flies: examining interactions of diet restriction and age. |
21455602
|
Yan LJ & Sohal RS, 2000 |
Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins. |
11121722
|
Bayne AC & Sohal RS, 2002 |
Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica. |
12031907
|
Mai S et al., 2012 |
Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan. |
22170153
|
Leontieva OV & Blagosklonny MV, 2011 |
Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. |
22156391
|
Roux, Antoine E et al., 2009 |
Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast. |
19266076
|
Zuin A et al., 2010 |
Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. |
20075862
|
Honda Y et al., 2012 |
Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans. |
22768380
|
Yuan, Yiyuan et al., 2012 |
Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. |
22810224
|
Cañuelo A et al., 2012 |
Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. |
22824366
|
Wuttke D et al., 2012 |
Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes. |
22912585
|
Kyryakov P et al., 2012 |
Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration. |
22783207
|
Koc A et al., 2004 |
Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. |
15141092
|
Tsang WY et al., 2001 |
Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span. |
11410594
|
Honda Y et al., 2010 |
Trehalose extends longevity in the nematode Caenorhabditis elegans. |
20477758
|
Shore DE et al., 2012 |
Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. |
22829775
|
Liu HP et al., 2012 |
The Yang-Tonifying Herbal Medicine Cynomorium songaricum Extends Lifespan and Delays Aging in Drosophila. |
22844336
|
Hada, Binika et al., 2012 |
D-chiro-Inositol and Pinitol Extend the Life * Span of Drosophila melanogaster. |
22843669
|
Ruiz M et al., 2012 |
Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz. |
22846641
|
Orlandi I et al., 2012 |
Lack of Ach1 CoA-Transferase Triggers Apoptosis and Decreases Chronological Lifespan in Yeast. |
22754872
|
Das SP & Sinha P, 2005 |
The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging. |
16182251
|
Herbert AP et al., 2012 |
NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast. |
22848679
|
Sagi, Dror & Kim, Stuart K, 2012 |
An engineering approach to extending lifespan in C. elegans. |
22737090
|
Yamawaki TM et al., 2008 |
Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. |
18202391
|
Honnen SJ et al., 2012 |
C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling. |
22359667
|
Broué F et al., 2007 |
A steroid hormone that extends the lifespan of Caenorhabditis elegans. |
17266678
|
Oh, Seung Wook et al., 2005 |
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. |
15767565
|
Château MT et al., 2010 |
Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans. |
20844315
|
Szewczyk, Nathaniel J et al., 2006 |
Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction. |
17023606
|
Carrano AC et al., 2009 |
A conserved ubiquitination pathway determines longevity in response to diet restriction. |
19553937
|
Yanase, Sumino & Ishii, Naoaki, 2008 |
Hyperoxia exposure induced hormesis decreases mitochondrial superoxide radical levels via Ins/IGF-1 signaling pathway in a long-lived age-1 mutant of Caenorhabditis elegans. |
18285659
|
Spencer CC et al., 2003 |
Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background. |
12882325
|
Curtis C et al., 2007 |
Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. |
18067683
|
Todd AM & Staveley BE, 2012 |
Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan. |
22653599
|
Tettweiler G et al., 2005 |
Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. |
16055649
|
Bauer, Johannes H et al., 2009 |
dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster. |
19851477
|
Chen D et al., 2009 |
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. |
19461873
|
Mockett, Robin J et al., 2010 |
Expression of multiple copies of mitochondrially targeted catalase or genomic Mn superoxide dismutase transgenes does not extend the life span of Drosophila melanogaster. |
20923705
|
Orr WC et al., 2003 |
Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster. |
12743125
|
Kabil H et al., 2007 |
Superoxide dismutase activities in long-lived Drosophila melanogaster females: chico1 genotypes and dietary dilution. |
17103233
|
Shimizu, Takahiko et al., 2011 |
Lifespan and glucose metabolism in insulin receptor mutant mice. |
21876806
|
Simonsen A et al., 2004 |
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. |
15292400
|
Mourikis P et al., 2006 |
Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila. |
16434470
|
Lee SH et al., 2012 |
Overexpression of Fatty-Acid-β-Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster. |
22997544
|
Gimenez LE et al., 2012 |
Modulation of Methuselah Expression Targeted to Drosophila Insulin-producing Cells Extends Life and Enhances Oxidative Stress Resistance. |
23121290
|
Downs JA et al., 2003 |
Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. |
12820979
|
Kumar S et al., 2012 |
Extension of yeast chronological lifespan by methylamine. |
23133668
|
Fabrizio P & Longo VD, 2007 |
The chronological life span of Saccharomyces cerevisiae. |
17634576
|
Malick LE & Kidwell JF, 1966 |
The effect of mating status, sex and genotype on longevity in Drosophila melanogaster. |
5961480
|
Carmona-Gutiérrez D et al., 2011 |
The propeptide of yeast cathepsin D inhibits programmed necrosis. |
21593793
|
de Cabo R et al., 2003 |
An in vitro model of caloric restriction. |
12814798
|
Soltow QA et al., 2010 |
A network perspective on metabolism and aging. |
21031036
|
Xu M et al., 2008 |
An integrative approach to characterize disease-specific pathways and their coordination: a case study in cancer. |
18366601
|
Zhang S et al., 2011 |
A novel computational framework for simultaneous integration of multiple types of genomic data to identify microRNA-gene regulatory modules. |
21685098
|
Mete M et al., 2008 |
A structural approach for finding functional modules from large biological networks. |
18793464
|
Janes KA et al., 2005 |
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. |
16339439
|
Pe'er D, 2005 |
Bayesian network analysis of signaling networks: a primer. |
15855409
|
Kovács IA et al., 2010 |
Community landscapes: an integrative approach to determine overlapping network module hierarchy, identify key nodes and predict network dynamics. |
20824084
|
Hahn MW & Kern AD, 2005 |
Comparative genomics of centrality and essentiality in three eukaryotic protein-interaction networks. |
15616139
|
Raza S et al., 2010 |
Construction of a large scale integrated map of macrophage pathogen recognition and effector systems. |
20470404
|
Freeman TC et al., 2007 |
Construction, visualisation, and clustering of transcription networks from microarray expression data. |
17967053
|
Wang J et al., 2009 |
Disease-aging network reveals significant roles of aging genes in connecting genetic diseases. |
19779549
|
Fraser, Hunter B et al., 2002 |
Evolutionary rate in the protein interaction network. |
11976460
|
Batada, Nizar N et al., 2006 |
Evolutionary and physiological importance of hub proteins. |
16839197
|
Boone, Charles et al., 2007 |
Exploring genetic interactions and networks with yeast. |
17510664
|
Glaab E et al., 2010 |
Extending pathways and processes using molecular interaction networks to analyse cancer genome data. |
21144022
|
Emilsson, Valur et al., 2008 |
Genetics of gene expression and its effect on disease. |
18344981
|
Gillis J & Pavlidis P, 2012 |
"Guilt by association" is the exception rather than the rule in gene networks. |
22479173
|
Merico D et al., 2009 |
How to visually interpret biological data using networks. |
19816451
|
Gu J et al., 2010 |
Identification of responsive gene modules by network-based gene clustering and extending: application to inflammation and angiogenesis. |
20406493
|
Maucher M et al., 2011 |
Inferring Boolean network structure via correlation. |
21471013
|
Fortney K et al., 2010 |
Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging. |
20128910
|
Zhu J et al., 2008 |
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. |
18552845
|
Wang, Yu-Chao & Chen, Bor-Sen, 2010 |
Integrated cellular network of transcription regulations and protein-protein interactions. |
20211003
|
Chautard E et al., 2010 |
Interaction networks as a tool to investigate the mechanisms of aging. |
20213321
|
Soler-López M et al., 2011 |
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. |
21163940
|
Budovsky A et al., 2007 |
Longevity network: construction and implications. |
17116322
|
Emmert-Streib, Frank & Glazko, Galina V, 2011 |
Network biology: a direct approach to study biological function. |
21197659
|
Barabasi, Albert-Laszlo & Oltvai, Zoltan N, 2004 |
Network biology: understanding the cell's functional organization. |
14735121
|
Lecca P et al., 2011 |
Network inference from time-dependent Omics data. |
21370096
|
Behrends, Christian et al., 2010 |
Network organization of the human autophagy system. |
20562859
|
Theocharidis A et al., 2009 |
Network visualization and analysis of gene expression data using BioLayout Express(3D). |
19798086
|
Emmert-Streib F & Glazko GV, 2011 |
Pathway analysis of expression data: deciphering functional building blocks of complex diseases. |
21637797
|
Promislow DE, 2004 |
Protein networks, pleiotropy and the evolution of senescence. |
15306346
|
Barabasi, Albert-Laszlo, 2009 |
Scale-free networks: a decade and beyond. |
19628854
|
Ciaccio MF et al., 2010 |
Systems analysis of EGF receptor signaling dynamics with microwestern arrays. |
20101245
|
De Smet R & Marchal K, 2010 |
Advantages and limitations of current network inference methods. |
20805835
|
Jiao QJ et al., 2011 |
BinTree seeking: a novel approach to mine both bi-sparse and cohesive modules in protein interaction networks. |
22140454
|
Vallabhajosyula, Ravishankar R & Raval, Alpan, 2010 |
Computational modeling in systems biology. |
20824468
|
Sneddon MW et al., 2011 |
Efficient modeling, simulation and coarse-graining of biological complexity with NFsim. |
21186362
|
Hartwell, L H et al., 1999 |
From molecular to modular cell biology. |
10591225
|
Wang, Jianxin et al., 2010 |
A fast hierarchical clustering algorithm for functional modules discovery in protein interaction networks. |
20733244
|
Shou C et al., 2011 |
Measuring the evolutionary rewiring of biological networks. |
21253555
|
Rives AW & Galitski T, 2003 |
Modular organization of cellular networks. |
12538875
|
Michaut M & Bader GD, 2012 |
Multiple genetic interaction experiments provide complementary information useful for gene function prediction. |
22737063
|
Murali TM & Rivera CG, 2008 |
Network legos: building blocks of cellular wiring diagrams. |
18707557
|
Barabasi, Albert-Laszlo et al., 2010 |
Network medicine: a network-based approach to human disease. |
21164525
|
Bachman, John A & Sorger, Peter, 2011 |
New approaches to modeling complex biochemistry. |
21278724
|
Ahmed SS et al., 2011 |
Systems biological approach on neurological disorders: a novel molecular connectivity to aging and psychiatric diseases. |
21226925
|
Stumpf MP et al., 2008 |
Estimating the size of the human interactome. |
18474861
|
Cho SC et al., 2010 |
DDS, 4,4'-diaminodiphenylsulfone, extends organismic lifespan. |
20974969
|
Lee, Inhwan et al., 2012 |
Metabolic rate regulates L1 longevity in C. elegans. |
22970296
|
Shimokawa I et al., 2009 |
Japan-Korea joint seminar: Asian aging core for longevity 2008 in Nagasaki - toward the establishment of an Asian aging research and education center - September 4th to 6th, 2008 at Huis ten Bosch, Nagasaki, Japan. |
19084552
|
Lehrbach NJ et al., 2012 |
Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans. |
23097426
|
Boulias K & Horvitz HR, 2012 |
The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO. |
22482727
|
Remolina, Silvia C et al., 2012 |
GENOMIC BASIS OF AGING AND LIFE-HISTORY EVOLUTION IN DROSOPHILA MELANOGASTER. |
23106705
|
Lehner B et al., 2006 |
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. |
16845399
|
Ewing, Rob M et al., 2007 |
Large-scale mapping of human protein-protein interactions by mass spectrometry. |
17353931
|
Sarup P et al., 2011 |
Flies selected for longevity retain a young gene expression profile. |
20607427
|
Bonafè M et al., 2001 |
A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. |
11500818
|
Lai CQ et al., 2007 |
Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. |
17196240
|
Boutros M et al., 2002 |
Sequential activation of signaling pathways during innate immune responses in Drosophila. |
12431377
|
Tanji T et al., 2006 |
Participation of a galactose-specific C-type lectin in Drosophila immunity. |
16475980
|
Zhang C & Cuervo AM, 2008 |
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. |
18690243
|
Saftig P & Eskelinen EL, 2008 |
Live longer with LAMP-2. |
18776878
|
Guachalla LM & Rudolph KL, 2009 |
Improve organ health by chewing up old proteins? |
19115216
|
Jones MA et al., 2009 |
A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment. |
19481596
|
Zou, S et al., 2000 |
Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. |
11095759
|
Munier AI et al., 2004 |
graal: a Drosophila gene coding for several mosaic serine proteases. |
15475297
|
Karsten SL et al., 2006 |
A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. |
16950154
|
Paaby AB et al., 2010 |
Identification of a candidate adaptive polymorphism for Drosophila life history by parallel independent clines on two continents. |
20074316
|
Delaney1 2 JR et al., 2012 |
Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. |
23167605
|
Hughes AL & Gottschling DE, 2012 |
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. |
23172144
|
López-Andrés N et al., 2012 |
Absence of Cardiotrophin 1 Is Associated With Decreased Age-Dependent Arterial Stiffness and Increased Longevity in Mice. |
23172930
|
Butler, Jeffrey A et al., 2010 |
Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism. |
20732954
|
Butler JA et al., 2012 |
A metabolic signature for long-life in the c. Elegans mit mutants. |
23173729
|
Matheu A et al., 2007 |
Delayed ageing through damage protection by the Arf/p53 pathway. |
17637672
|
Guevara-Aguirre J et al., 2011 |
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. |
21325617
|
Oxenkrug G et al., 2012 |
Minocycline effect on life and health span of Drosophila melanogaster. |
23185716
|
Anisimov VN et al., 2011 |
Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. |
22107964
|
McColl, Gawain et al., 2010 |
Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. |
20816092
|
Zhan M et al., 2007 |
Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster. |
17623811
|
Dillin, Andrew et al., 2002 |
Timing requirements for insulin/IGF-1 signaling in C. elegans. |
12399591
|
Giannakou, Maria E et al., 2004 |
Long-lived Drosophila with overexpressed dFOXO in adult fat body. |
15192154
|
Walker DW et al., 2006 |
Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant. |
17056719
|
Kato, Masaomi et al., 2011 |
Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. |
21810936
|
Lim DH et al., 2011 |
The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. |
21889502
|
Xu P et al., 2003 |
The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. |
12725740
|
Conover CA et al., 2010 |
Longevity is not influenced by prenatal programming of body size. |
20550518
|
Baati, Tarek et al., 2012 |
The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene. |
22498298
|
Ali SS et al., 2004 |
A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties. |
15451059
|
Quick KL et al., 2008 |
A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice. |
17079053
|
Gao J et al., 2011 |
Polyhydroxy fullerenes (fullerols or fullerenols): beneficial effects on growth and lifespan in diverse biological models. |
21637768
|
Kubota R et al., 2011 |
Time-dependent variation in the biodistribution of C₆₀ in rats determined by liquid chromatography-tandem mass spectrometry. |
21787853
|
Gharbi N et al., 2005 |
[60]fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity. |
16351219
|
Owen RW et al., 2000 |
Olive-oil consumption and health: the possible role of antioxidants. |
11905662
|
Jacomelli M et al., 2010 |
Dietary extra-virgin olive oil rich in phenolic antioxidants and the aging process: long-term effects in the rat. |
19369055
|
Inukai S et al., 2012 |
Novel microRNAs differentially expressed during aging in the mouse brain. |
22844398
|
Ibanez-Ventoso, Carolina et al., 2006 |
Modulated microRNA expression during adult lifespan in Caenorhabditis elegans. |
16842496
|
Dallaire A et al., 2012 |
Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging. |
23075628
|
Lee, Se-Jin et al., 2004 |
A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint. |
15115755
|
Lebel M et al., 2003 |
Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. |
12707040
|
Massip L et al., 2010 |
Vitamin C restores healthy aging in a mouse model for Werner syndrome. |
19741171
|
Takahashi M et al., 2012 |
Reduction of Type IV Collagen by Upregulated miR-29 in Normal Elderly Mouse and klotho-Deficient, Senescence-Model Mouse. |
23139829
|
Anisimov VN et al., 2005 |
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. |
16125352
|
Anisimov VN et al., 2008 |
Metformin slows down aging and extends life span of female SHR mice. |
18728386
|
Onken B & Driscoll M, 2010 |
Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. |
20090912
|
Anisimov VN et al., 2011 |
If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. |
21386129
|
Anisimov VN et al., 2005 |
Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice. |
16224592
|
Anisimov VN et al., 2010 |
Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice. |
21164223
|
Smith DL Jr et al., 2010 |
Metformin supplementation and life span in Fischer-344 rats. |
20304770
|
Slack C et al., 2012 |
Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila. |
23077661
|
Popovich IG et al., 2004 |
[Effect of antidiabetic drug diabenol on parameters of biological age, life span and tumor development in NMRI and HER-2/neu mice]. |
15754958
|
Hannum G et al., 2012 |
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates. |
23177740
|
Saito T et al., 2005 |
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. |
15778722
|
Kim EJ et al., 2010 |
Skin aging and photoaging alter fatty acids composition, including 11,14,17-eicosatrienoic acid, in the epidermis of human skin. |
20514327
|
Krechowec SO et al., 2012 |
Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice. |
22253771
|
Hayasaka N et al., 2011 |
Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice. |
21408016
|
Hirota T et al., 2010 |
Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork. |
20070857
|
Chua KF et al., 2005 |
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. |
16054100
|
Asher G et al., 2008 |
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. |
18662546
|
Lamia KA et al., 2009 |
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. |
19833968
|
Miller BH et al., 2007 |
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. |
17360649
|
Koyanagi S et al., 2003 |
A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells. |
14612524
|
Sebastián C et al., 2012 |
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism. |
23217706
|
Mostoslavsky R et al., 2006 |
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. |
16439206
|
Kusama S et al., 2006 |
Involvement of Drosophila Sir2-like genes in the regulation of life span. |
17159295
|
Bai H et al., 2012 |
Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain. |
22935001
|
Olivieri F et al., 2012 |
Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging. |
23041385
|
Baker DJ et al., 2012 |
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. |
23242215
|
Hanks S et al., 2004 |
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. |
15475955
|
Matsumoto T et al., 2007 |
Aging-associated vascular phenotype in mutant mice with low levels of BubR1. |
17272762
|
Hartman TK et al., 2007 |
Mutant mice with small amounts of BubR1 display accelerated age-related gliosis. |
16781018
|
Baker DJ et al., 2008 |
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. |
18516091
|
Matsuura S et al., 2006 |
Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome. |
16411201
|
Burtner CR & Kennedy BK, 2010 |
Progeria syndromes and ageing: what is the connection? |
20651707
|
Villeda SA et al., 2011 |
The ageing systemic milieu negatively regulates neurogenesis and cognitive function. |
21886162
|
Conboy IM et al., 2005 |
Rejuvenation of aged progenitor cells by exposure to a young systemic environment. |
15716955
|
Jacob, H J, 1999 |
Functional genomics and rat models. |
10568741
|
Lu T et al., 2004 |
Gene regulation and DNA damage in the ageing human brain. |
15190254
|
Kastman EK et al., 2012 |
A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. |
23082321
|
Bendlin BB et al., 2011 |
Effects of aging and calorie restriction on white matter in rhesus macaques. |
20541839
|
Witte, A V et al., 2009 |
Caloric restriction improves memory in elderly humans. |
19171901
|
Merry, Brian J et al., 2008 |
Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span. |
18486188
|
Dashwood, Roderick H & Ho, Emily, 2007 |
Dietary histone deacetylase inhibitors: from cells to mice to man. |
17555985
|
van de Mark K et al., 2003 |
Alpha-lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines. |
12548552
|
Stoll S et al., 1993 |
The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits. |
8309958
|
Poon HF et al., 2005 |
Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders. |
15627516
|
Mattson, Mark P et al., 2002 |
Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. |
12087131
|
Zhang, L et al., 2001 |
Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway. |
11602326
|
Chung KW et al., 2012 |
Recent advances in calorie restriction research on aging. |
23201549
|
Shay KP et al., 2009 |
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. |
19664690
|
Wood SH et al., 2012 |
Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome. |
22555619
|
Masoro, Edward J, 2005 |
Overview of caloric restriction and ageing. |
15885745
|
Fok WC et al., 2012 |
Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice. |
22570137
|
Fumagalli M & d'Adda di Fagagna F, 2009 |
SASPense and DDRama in cancer and ageing. |
19648977
|
Zhang G et al., 2012 |
Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity. |
23258410
|
Papatheodorou I et al., 2012 |
Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing. |
23251396
|
Umezaki Y et al., 2012 |
Pigment-Dispersing Factor Is Involved in Age-Dependent Rhythm Changes in Drosophila melanogaster. |
23223368
|
Pagani L et al., 2011 |
Serum factors in older individuals change cellular clock properties. |
21482780
|
Duffy JF et al., 1998 |
Later endogenous circadian temperature nadir relative to an earlier wake time in older people. |
9791064
|
Duffy JF et al., 1999 |
Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people. |
10198570
|
Biello SM, 2009 |
Circadian clock resetting in the mouse changes with age. |
19557547
|
Dijk DJ et al., 2000 |
Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep. |
10841208
|
Gitter A et al., 2012 |
Linking the signaling cascades and dynamic regulatory networks controlling stress responses. |
23064748
|
Chung, Sangwoon et al., 2010 |
Regulation of SIRT1 in cellular functions: role of polyphenols. |
20450879
|
Palacios JA et al., 2010 |
SIRT1 contributes to telomere maintenance and augments global homologous recombination. |
21187328
|
Shen Y et al., 2012 |
A steroid receptor-microRNA switch regulates life span in response to signals from the gonad. |
23239738
|
Schiavi A et al., 2012 |
Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans. |
23247094
|
Xu X & Kim SK, 2012 |
The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegans. |
23271974
|
Sinclair D & Verdin E, 2012 |
The longevity of sirtuins. |
23273894
|
Banerjee, Kushal Kr et al., 2012 |
dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner. |
23246004
|
Jordens, R G et al., 1999 |
Prolongation of life in an experimental model of aging in Drosophila melanogaster. |
9972869
|
Heidrick ML et al., 1984 |
Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice. |
6334792
|
Wang L et al., 2007 |
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. |
17227869
|
Kondratov RV et al., 2006 |
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. |
16847346
|
Harman, D, 1968 |
Free radical theory of aging: effect of free radical reaction inhibitors on the mortality rate of male LAF mice. |
5723482
|
Harris SB et al., 1990 |
Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice. |
2394907
|
Harman D, 2001 |
Aging: overview. |
11795501
|
Xu Y et al., 1996 |
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. |
8843194
|
Elson A et al., 1996 |
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. |
8917548
|
Wong KK et al., 2003 |
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. |
12540856
|
Barlow C et al., 1996 |
Atm-deficient mice: a paradigm of ataxia telangiectasia. |
8689683
|
Murga M et al., 2009 |
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. |
19620979
|
Ruzankina Y et al., 2007 |
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. |
18371340
|
Perez GI et al., 2007 |
Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice. |
17360389
|
Jeng YM et al., 2007 |
Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation. |
17420720
|
Cao L et al., 2003 |
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. |
12533509
|
Baker DJ et al., 2006 |
Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. |
16476774
|
Zhang Y et al., 2007 |
Caspase-2 deficiency enhances aging-related traits in mice. |
17188333
|
Cutler RG, 2005 |
Oxidative stress and aging: catalase is a longevity determinant enzyme. |
16144468
|
Park DS et al., 2003 |
Caveolin-1 null (-/-) mice show dramatic reductions in life span. |
14690422
|
Choudhury AR et al., 2007 |
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. |
17143283
|
Bedelbaeva K et al., 2010 |
Lack of p21 expression links cell cycle control and appendage regeneration in mice. |
20231440
|
Arthur LM & Heber-Katz E, 2011 |
The role of p21 in regulating mammalian regeneration. |
21722344
|
Cao L et al., 2006 |
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. |
16675955
|
McLaughlin PJ et al., 2007 |
Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice. |
17872905
|
de Boer J et al., 2002 |
Premature aging in mice deficient in DNA repair and transcription. |
11950998
|
Niedernhofer LJ et al., 2006 |
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. |
17183314
|
Razzaque MS et al., 2006 |
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. |
16436465
|
DeLuca S et al., 2008 |
Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23. |
18729070
|
Krupczak-Hollis K et al., 2003 |
Growth hormone stimulates proliferation of old-aged regenerating liver through forkhead box m1b. |
14647066
|
Thierbach R et al., 2005 |
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. |
16278235
|
Xie S et al., 2012 |
Upregulation of TRB2 induced by miR-98 in the early lesions of large artery of type-2 diabetic rat. |
22012613
|
Watanabe T et al., 2006 |
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. |
16766679
|
Grady DL et al., 2013 |
DRD4 Genotype Predicts Longevity in Mouse and Human. |
23283341
|
Yan, Jun et al., 2008 |
Analysis of gene regulatory networks in the mammalian circadian rhythm. |
18846204
|
Spindler SR, 2012 |
Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span. |
21424790
|
Delaney JR et al., 2012 |
Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. |
23235143
|
Murakami C et al., 2012 |
pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. |
22871733
|
Piper PW et al., 2006 |
Preadaptation to efficient respiratory maintenance is essential both for maximal longevity and the retention of replicative potential in chronologically ageing yeast. |
16784770
|
Ringvoll J et al., 2007 |
Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol. |
17506834
|
Komura T et al., 2013 |
Mechanism underlying prolongevity induced by bifidobacteria in Caenorhabditis elegans. |
23291976
|
Zuo Y et al., 2013 |
Sesamin extends the mean lifespan of fruit flies. |
23291977
|
Wilson MA et al., 2006 |
Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. |
16441844
|
Wolkow, C A et al., 2000 |
Regulation of C. elegans life-span by insulinlike signaling in the nervous system. |
11021802
|
Grompone G et al., 2012 |
Anti-Inflammatory Lactobacillus rhamnosus CNCM I-3690 Strain Protects against Oxidative Stress and Increases Lifespan in Caenorhabditis elegans. |
23300685
|
Wijshake T et al., 2012 |
Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation. |
23300461
|
Longo, Valter D et al., 2012 |
Replicative and chronological aging in Saccharomyces cerevisiae. |
22768836
|
Blokh D et al., 2007 |
Breast cancer detection by Michaelis-Menten constants via linear programming. |
17188399
|
Blokh D et al., 2007 |
The information-theory analysis of Michaelis-Menten constants for detection of breast cancer. |
18061365
|
Blokh D et al., 2009 |
Comparative analysis of cell parameter groups for breast cancer detection. |
19231022
|
Ng DS et al., 2013 |
HDL-is it too big to fail? |
23318230
|
Beekman, Marian et al., 2013 |
Genome-wide linkage analysis for human longevity: Genetics of Healthy Ageing Study. |
23286790
|
Blokh D et al., 2008 |
An information-theoretical model for breast cancer detection. |
18690365
|
Montgomery MK et al., 2012 |
Metabolic rate and membrane fatty acid composition in birds: a comparison between long-living parrots and short-living fowl. |
21766191
|
Reavill, Drury R & Dorrestein, Gerry M, 2010 |
Pathology of aging psittacines. |
20159547
|
Herrero A & Barja G, 1999 |
8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging. |
10631878
|
Ogburn CE et al., 2001 |
Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression. |
11682567
|
Viña J et al., 2007 |
Theories of ageing. |
17505961
|
Collins CJ & Sedivy JM, 2003 |
Involvement of the INK4a/Arf gene locus in senescence. |
12882406
|
Krishnamurthy J et al., 2004 |
Ink4a/Arf expression is a biomarker of aging. |
15520862
|
Krimpenfort P et al., 2001 |
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. |
11544530
|
Hood I et al., 1988 |
Fatality from illicit phendimetrazine use. |
2901497
|
Rando TA & Chang HY, 2012 |
Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. |
22265401
|
González-Beltrán A et al., 2012 |
Federated ontology-based queries over cancer data. |
22373043
|
McCusker JP et al., 2009 |
Semantic web data warehousing for caGrid. |
19796399
|
Horvath S et al., 2012 |
Aging effects on DNA methylation modules in human brain and blood tissue. |
23034122
|
Vera E et al., 2013 |
Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. |
23349740
|
Bala, Kiran et al., 2006 |
Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions. |
16802111
|
Shen LR et al., 2013 |
Curcumin and aging. |
23325575
|
Kitani K et al., 2007 |
The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice. |
17516143
|
Dimmeler S & Nicotera P, 2013 |
MicroRNAs in age-related diseases. |
23339066
|
Durieux J et al., 2011 |
The cell-non-autonomous nature of electron transport chain-mediated longevity. |
21215371
|
Nebel A et al., 2009 |
A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians. |
19698732
|
Soerensen M, 2012 |
Genetic variation and human longevity. |
22549493
|
Mander BA et al., 2013 |
Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging. |
23354332
|
Halicka HD et al., 2012 |
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. |
23363784
|
Bollheimer LC et al., 2012 |
[Reversal of aging and lifespan elongation : Current biomedical key publications and the implications for geriatrics.] |
23242337
|
Liu M et al., 2013 |
Resveratrol protects against age-associated infertility in mice. |
23293221
|
Yu X & Li G, 2012 |
Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri. |
22960591
|
Morris BJ, 2012 |
Seven sirtuins for seven deadly diseases of aging. |
23104101
|
Park HR et al., 2012 |
Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis. |
23105098
|
Ito K et al., 2012 |
Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease. |
23055713
|
Cheung TM et al., 2012 |
Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. |
23023872
|
Liu GS et al., 2012 |
Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice. |
22982350
|
Guarente, Leonard, 2005 |
NO link between calorie restriction and mitochondria. |
16370369
|
Zhang Y et al., 2013 |
Hydrogen Sulfide: Next Potent Preventive and Therapeutic Agent in Aging and Age-associated Diseases. |
23297346
|
Powolny AA et al., 2011 |
The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation. |
21296648
|
De Cecco M et al., 2013 |
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. |
23360310
|
Brown K et al., 2013 |
SIRT3 Reverses Aging-Associated Degeneration. |
23375372
|
Gerber A et al., 2013 |
Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity. |
23374345
|
Warr MR et al., 2013 |
FOXO3A directs a protective autophagy program in haematopoietic stem cells. |
23389440
|
Mizwicki MT et al., 2013 |
1α,25-Dihydroxyvitamin D3 and Resolvin D1 Retune the Balance between Amyloid-β Phagocytosis and Inflammation in Alzheimer's Disease Patients. |
23186989
|
Tapia N et al., 2012 |
Restoring stem cell function in aged tissues by direct reprogramming? |
22704502
|
Zwi-Dantsis L et al., 2012 |
Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients. |
22621821
|
Glessner JT et al., 2013 |
Copy number variations in alternative splicing gene networks impact lifespan. |
23382853
|
Orr WC et al., 2005 |
Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster. |
16148000
|
Biteau B et al., 2010 |
Lifespan extension by preserving proliferative homeostasis in Drosophila. |
20976250
|
Ivey KN et al., 2008 |
MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. |
18371447
|
Moskalev AA & Shaposhnikov MV, 2010 |
Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster. |
20017609
|
Barabási AL, 2013 |
Network science. |
23419844
|
Philipp EE et al., 2012 |
Gene expression and physiological changes of different populations of the long-lived bivalve Arctica islandica under low oxygen conditions. |
23028566
|
Lutz PL et al., 2003 |
Is turtle longevity linked to enhanced mechanisms for surviving brain anoxia and reoxygenation? |
12855290
|
Krivoruchko A & Storey KB, 2010 |
Forever young: mechanisms of natural anoxia tolerance and potential links to longevity. |
20716943
|
Belleau F et al., 2008 |
Bio2RDF: towards a mashup to build bioinformatics knowledge systems. |
18472304
|
Ziv Y et al., 2013 |
Long-term dynamics of CA1 hippocampal place codes. |
23396101
|
Jiang, Jianhua et al., 2013 |
Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease. |
23426728
|
Pan Y et al., 2012 |
Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review. |
22947849
|
Zimmerman, Laura M et al., 2013 |
Humoral immune responses are maintained with age in a long-lived ectotherm, the red-eared slider turtle. |
23077164
|
Plot, Virginie et al., 2012 |
Telomeres, age and reproduction in a long-lived reptile. |
22808278
|
Deweerdt S, 2012 |
Comparative biology: Looking for a master switch. |
23222666
|
Van Nostrand EL et al., 2013 |
Roles of the Developmental Regulator unc-62/Homothorax in Limiting Longevity in Caenorhabditis elegans. |
23468654
|
Ortega-Molina A & Serrano M, 2012 |
PTEN in cancer, metabolism, and aging. |
23245767
|
Trindade, Lucas S et al., 2013 |
A novel classification system for evolutionary aging theories. |
23508239
|
Callahan A et al., 2011 |
HyQue: evaluating hypotheses using Semantic Web technologies. |
21624158
|
Attwood TK et al., 2009 |
Calling International Rescue: knowledge lost in literature and data landslide! |
19929850
|
Othersen OG et al., 2012 |
Application of information theory to feature selection in protein docking. |
21748327
|
Freitas, Alex A et al., 2011 |
A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related. |
21226956
|
de Magalhães JP et al., 2009 |
The Human Ageing Genomic Resources: online databases and tools for biogerontologists. |
18986374
|
Tacutu R et al., 2013 |
Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing. |
23193293
|
Dhahbi JM et al., 2013 |
Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction. |
23470454
|
Bhaumik D et al., 2009 |
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. |
20148189
|
Voorhoeve PM et al., 2006 |
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. |
16564011
|
Wagner W et al., 2008 |
Replicative senescence of mesenchymal stem cells: a continuous and organized process. |
18493317
|
Maeda T et al., 2005 |
Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. |
15662416
|
Pomerantz J et al., 1998 |
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. |
9529248
|
Poliseno L et al., 2008 |
The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence. |
18596985
|
Bommer GT et al., 2007 |
p53-mediated activation of miRNA34 candidate tumor-suppressor genes. |
17656095
|
He L et al., 2007 |
A microRNA component of the p53 tumour suppressor network. |
17554337
|
Tazawa H et al., 2007 |
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. |
17875987
|
Kumamoto K et al., 2008 |
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. |
18451145
|
Braconi C et al., 2011 |
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. |
21625215
|
Peeper DS, 2011 |
Ageing: Old cells under attack. |
22071762
|
Cheung TH et al., 2012 |
Maintenance of muscle stem-cell quiescence by microRNA-489. |
22358842
|
Garofalo M et al., 2009 |
miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. |
19962668
|
Chun-Zhi Z et al., 2010 |
MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN. |
20618998
|
Grillari J et al., 2010 |
miR-17-92 cluster: ups and downs in cancer and aging. |
20437201
|
Hackl M et al., 2010 |
miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. |
20089119
|
Gavrilova NS et al., 2012 |
Testing predictions of the programmed and stochastic theories of aging: comparison of variation in age at death, menopause, and sexual maturation. |
22817539
|
Bates DJ et al., 2010 |
MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging. |
19878148
|
Li N et al., 2011 |
Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1. |
21216258
|
Chen LH et al., 2010 |
MicroRNA and aging: a novel modulator in regulating the aging network. |
20708718
|
Smith-Vikos T & Slack FJ, 2012 |
MicroRNAs and their roles in aging. |
22294612
|
Antezana, Erick et al., 2013 |
The emergence of Semantic Systems Biology. |
23165099
|
Maes OC et al., 2008 |
Murine microRNAs implicated in liver functions and aging process. |
18561983
|
Zhang G et al., 2013 |
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. |
23636330
|
Martins AC, 2011 |
Change and aging senescence as an adaptation. |
21949706
|
Jung, Hwa Jin & Suh, Yousin, 2012 |
MicroRNA in Aging: From Discovery to Biology. |
23633914
|
Wongchitrat P et al., 2012 |
The expression of Per1 and Aa-nat genes in the pineal gland of postnatal rats. |
23513468
|
Somel M et al., 2010 |
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. |
20647238
|
Skulachev VP, 1999 |
Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms. |
10626278
|
Skulachev, V P, 2001 |
The programmed death phenomena, aging, and the Samurai law of biology. |
11404047
|
Bradley AJ et al., 1980 |
Stress and mortality in a small marsupial (Antechinus stuartii, Macleay). |
6245013
|
Skulachev, V P, 1997 |
Aging is a specific biological function rather than the result of a disorder in complex living systems: biochemical evidence in support of Weismann's hypothesis. |
9467841
|
Skulachev, V P, 1999 |
Phenoptosis: programmed death of an organism. |
10648966
|
Raff M, 1998 |
Cell suicide for beginners. |
9823889
|
Lewis K, 2000 |
Programmed death in bacteria. |
10974124
|
Dan I et al., 2001 |
The Ste20 group kinases as regulators of MAP kinase cascades. |
11316611
|
Goldsmith TC, 2004 |
Aging as an evolved characteristic - Weismann's theory reconsidered. |
14962645
|
Ruckenstuhl C et al., 2010 |
The sweet taste of death: glucose triggers apoptosis during yeast chronological aging. |
21076182
|
Fabrizio P et al., 2004 |
Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. |
15452146
|
Mattison JA et al., 2012 |
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. |
22932268
|
de Magalhães JP & Toussaint O, 2004 |
How bioinformatics can help reverse engineer human aging. |
15177050
|
Epstein CJ et al., 1966 |
Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. |
5327241
|
De Luca G et al., 2013 |
Prolonged Lifespan with Enhanced Exploratory Behavior in Mice Overexpressing the Oxidized Nucleoside Triphosphatase hMTH1. |
23648059
|
Tatar M et al., 2003 |
The endocrine regulation of aging by insulin-like signals. |
12610294
|
Knauf F et al., 2002 |
Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. |
12391301
|
Loo LW et al., 2005 |
The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster. |
16055719
|
Goddeeris MM et al., 2003 |
Delayed behavioural aging and altered mortality in Drosophila beta integrin mutants. |
14570233
|
Bauer JH et al., 2007 |
Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling. |
17686972
|
McQuibban GA et al., 2006 |
Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. |
16713954
|
Tsuda M et al., 2007 |
A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila. |
17854771
|
Phillips JP et al., 1989 |
Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. |
2539600
|
Cvejic S et al., 2004 |
The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila. |
15133470
|
Zordan MA et al., 2006 |
Post-transcriptional silencing and functional characterization of the Drosophila melanogaster homolog of human Surf1. |
16172499
|
Fridell YW et al., 2005 |
Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly. |
16054055
|
Nielsen, Mette Damgaard et al., 2008 |
14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. |
18665908
|
Liu YL et al., 2009 |
Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. |
19302370
|
Martínez-Azorín F et al., 2008 |
Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion. |
17999718
|
Taghli-Lamallem O et al., 2008 |
Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype. |
18221418
|
Siebold AP et al., 2010 |
Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance. |
20018689
|
Toba G et al., 2010 |
Life-span phenotypes of elav and Rbp9 in Drosophila suggest functional cooperation of the two ELAV-family protein genes. |
20589912
|
Runko AP et al., 2008 |
Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila. |
18258192
|
Li Y & Tower J, 2009 |
Adult-specific over-expression of the Drosophila genes magu and hebe increases life span and modulates late-age female fecundity. |
19011900
|
Wadhwa R et al., 2010 |
Proproliferative functions of Drosophila small mitochondrial heat shock protein 22 in human cells. |
19948727
|
Tao D et al., 2004 |
Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression. |
15346199
|
Liu, Zhiyan et al., 2008 |
Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance. |
18275960
|
Kim J et al., 2010 |
dGIPC is required for the locomotive activity and longevity in Drosophila. |
21029723
|
Brandt A et al., 2008 |
The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies. |
18494863
|
Lin YR et al., 2011 |
Loco signaling pathway in longevity. |
21776417
|
Reenan RA & Rogina B, 2008 |
Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila. |
18208580
|
Mery A et al., 2008 |
The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function. |
18083727
|
Bahadorani S et al., 2010 |
Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity. |
18775584
|
Balan V et al., 2008 |
Life span extension and neuronal cell protection by Drosophila nicotinamidase. |
18678867
|
Nakayama M et al., 2011 |
Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes. |
21826223
|
Demontis F & Perrimon N, 2010 |
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. |
21111239
|
Suh JM et al., 2008 |
An RGS-containing sorting nexin controls Drosophila lifespan. |
18478054
|
Gáliková M & Flatt T, 2010 |
Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout. |
20622267
|
Sone M et al., 2009 |
Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening. |
19209226
|
Legan, Susan K et al., 2008 |
Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster. |
18809674
|
Zhao Y et al., 2005 |
Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. |
15695762
|
Rera M et al., 2011 |
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. |
22055505
|
Esslinger SM et al., 2013 |
Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. |
23669073
|
Calin GA et al., 2002 |
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. |
12434020
|
Cimmino A et al., 2005 |
miR-15 and miR-16 induce apoptosis by targeting BCL2. |
16166262
|
Musumeci M et al., 2011 |
Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer. |
21532615
|
Bottoni A et al., 2005 |
miR-15a and miR-16-1 down-regulation in pituitary adenomas. |
15648093
|
Shi B et al., 2007 |
Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. |
17827156
|
La Rocca G et al., 2009 |
Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway. |
19391107
|
Lee HK et al., 2013 |
MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor. |
23390502
|
Haapa-Paananen S et al., 2013 |
Functional Profiling of Precursor MicroRNAs Identifies MicroRNAs Essential for Glioma Proliferation. |
23577178
|
Chang TC et al., 2007 |
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. |
17540599
|
Tarasov V et al., 2007 |
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. |
17554199
|
Cole KA et al., 2008 |
A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. |
18505919
|
Choi YH et al., 2003 |
Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians. |
12634288
|
Arai Y et al., 2003 |
Deficiency of choresteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity. |
12601526
|
Zuo B et al., 2012 |
Influences of lamin A levels on induction of pluripotent stem cells. |
23213392
|
Speakman JR & Król E, 2010 |
The heat dissipation limit theory and evolution of life histories in endotherms--time to dispose of the disposable soma theory? |
21558242
|
Nussey DH et al., 2013 |
Senescence in natural populations of animals: widespread evidence and its implications for bio-gerontology. |
22884974
|
Froy O & Miskin R, 2010 |
Effect of feeding regimens on circadian rhythms: implications for aging and longevity. |
20228939
|
Gutman, Roee et al., 2011 |
Long-lived mice exhibit 24 h locomotor circadian rhythms at young and old age. |
21376793
|
Garaulet M & Madrid JA, 2010 |
Chronobiological aspects of nutrition, metabolic syndrome and obesity. |
20580916
|
Omodei, Daniela & Fontana, Luigi, 2011 |
Calorie restriction and prevention of age-associated chronic disease. |
21402069
|
Trepanowski JF et al., 2011 |
Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings. |
21981968
|
Fontana L et al., 2010 |
Extending healthy life span--from yeast to humans. |
20395504
|
Hatori M et al., 2012 |
Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. |
22608008
|
Sherman H et al., 2012 |
Timed high-fat diet resets circadian metabolism and prevents obesity. |
22593546
|
Kuroda H et al., 2012 |
Meal frequency patterns determine the phase of mouse peripheral circadian clocks. |
23050095
|
Rakshit, Kuntol et al., 2012 |
Effects of aging on the molecular circadian oscillations in Drosophila. |
22217096
|
Kondratova AA & Kondratov RV, 2012 |
The circadian clock and pathology of the ageing brain. |
22395806
|
Zhdanova, I V et al., 2011 |
Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta. |
21454295
|
Yamazaki, Shin et al., 2002 |
Effects of aging on central and peripheral mammalian clocks. |
12149444
|
Luo W et al., 2012 |
Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations. |
22268765
|
Corbalán-Tutau D et al., 2012 |
Daily profile in two circadian markers "melatonin and cortisol" and associations with metabolic syndrome components. |
22705307
|
Bähr I et al., 2012 |
Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways. |
22672634
|
Froy O, 2010 |
Metabolism and circadian rhythms--implications for obesity. |
19854863
|
Wu Z et al., 2013 |
Dietary Restriction Depends on Nutrient Composition to Extend Chronological Lifespan in Budding Yeast Saccharomyces cerevisiae. |
23691220
|
Houtkooper RH et al., 2013 |
Mitonuclear protein imbalance as a conserved longevity mechanism. |
23698443
|
Paaby AB & Schmidt PS, 2009 |
Dissecting the genetics of longevity in Drosophila melanogaster. |
19182541
|
Tatar M et al., 2001 |
Negligible Senescence during Reproductive Dormancy in Drosophila melanogaster. |
18707322
|
Williams KD et al., 2006 |
Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase. |
17043223
|
Sheeba, V et al., 2000 |
The effect of different light regimes on adult life span in Drosophila melanogaster is partly mediated through reproductive output. |
11039916
|
Zhu Y et al., 2011 |
Lentiviral vector-mediated upregulation of let-7a inhibits gastric carcinoma cell growth in vitro and in vivo. |
20809749
|
Yang Q et al., 2011 |
Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C. |
21349817
|
Hu X et al., 2013 |
The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer. |
23339187
|
Bhutia YD et al., 2013 |
Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein. |
23335963
|
Nishi M et al., 2013 |
Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements. |
22918121
|
Schultz J et al., 2008 |
MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. |
18379589
|
Nadiminty N et al., 2012 |
MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. |
22479342
|
Nadiminty N et al., 2012 |
MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. |
22128178
|
Prainsack B, 2011 |
Voting with their mice: personal genome testing and the "participatory turn" in disease research. |
21574070
|
de Magalhães JP et al., 2012 |
Genome-environment interactions that modulate aging: powerful targets for drug discovery. |
22090473
|
Plank M et al., 2012 |
A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms. |
22327899
|
Johnson AA et al., 2012 |
The role of DNA methylation in aging, rejuvenation, and age-related disease. |
23098078
|
Pishel I et al., 2012 |
Accelerated aging versus rejuvenation of the immune system in heterochronic parabiosis. |
22533440
|
Hughes KA et al., 2002 |
A test of evolutionary theories of aging. |
12386342
|
Rose M & Charlesworth B, 1980 |
A test of evolutionary theories of senescence. |
6776406
|
Shmookler Reis RJ et al., 2009 |
Extreme-longevity mutations orchestrate silencing of multiple signaling pathways. |
19465083
|
Nebel A et al., 2011 |
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. |
21740922
|
Zheng B et al., 2011 |
MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. |
21994419
|
Liffers ST et al., 2011 |
MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B. |
21709669
|
Song YX et al., 2011 |
MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation. |
21205300
|
Zhao G et al., 2013 |
miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKα1. |
23171948
|
Xiang Y et al., 2013 |
MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine. |
23318422
|
Zhou X et al., 2012 |
Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation. |
21971665
|
Cardelli M et al., 2006 |
A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity. |
16799135
|
Wang X et al., 2001 |
Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang. |
11780357
|
Bessenyei B et al., 2004 |
Single nucleotide polymorphisms: aging and diseases. |
15547317
|
Louhija J et al., 1994 |
Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians. |
8018664
|
Anisimov SV et al., 2001 |
Age-associated accumulation of the apolipoprotein C-III gene T-455C polymorphism C allele in a Russian population. |
11193221
|
Atzmon G et al., 2006 |
Lipoprotein genotype and conserved pathway for exceptional longevity in humans. |
16602826
|
Van Voorhies, Wayne A et al., 2005 |
The longevity of Caenorhabditis elegans in soil. |
17148178
|
Klapper, W et al., 1998 |
Longevity of lobsters is linked to ubiquitous telomerase expression. |
9849895
|
Klapper W et al., 1998 |
Telomerase activity in 'immortal' fish. |
9742964
|
Anselmi CV et al., 2009 |
Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. |
19415983
|
Kolovou G et al., 2013 |
The Frequency of 4 Common Gene Polymorphisms in Nonagenarians, Centenarians, and Average Life Span Individuals. |
23389097
|
Lee P et al., 2003 |
Polymorphisms in the human homologue of the drosophila Indy (I'm not dead yet) gene. |
14499494
|
Terry DF et al., 2006 |
Serum heat shock protein 70 level as a biomarker of exceptional longevity. |
17027907
|
Lao JI et al., 2005 |
Genetic contribution to aging: deleterious and helpful genes define life expectancy. |
16399887
|
Kerber RA et al., 2012 |
A genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci. |
22506048
|
Khabour OF & Barnawi JM, 2010 |
Association of longevity with IL-10 -1082 G/A and TNF-alpha-308 G/A polymorphisms. |
20518833
|
Malaguarnera L et al., 2010 |
Human chitotriosidase polymorphism is associated with human longevity in Mediterranean nonagenarians and centenarians. |
19881466
|
Kokaze A, 2005 |
Genetic epidemiological studies of longevity-associated mitochondrial DNA 5178 C/A polymorphism. |
21432114
|
Middleton D et al., 2000 |
Immunogenetics and Life-Span : HLA. |
22351285
|
Grimaldi MP et al., 2006 |
Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population. |
16387839
|
Beaver LM et al., 2003 |
Noncircadian regulation and function of clock genes period and timeless in oogenesis of Drosophila melanogaster. |
14667147
|
Bruce C et al., 1998 |
Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia. |
9610775
|
Boekholdt SM et al., 2004 |
CETP gene variation: relation to lipid parameters and cardiovascular risk. |
15243211
|
Siest, G et al., 1995 |
Apolipoprotein E: an important gene and protein to follow in laboratory medicine. |
7628082
|
Weintraub MS et al., 1987 |
Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. |
3479440
|
Hanis CL et al., 1991 |
Effects of the apolipoprotein E polymorphism on levels of lipids, lipoproteins, and apolipoproteins among Mexican-Americans in Starr County, Texas. |
1998654
|
Davignon J et al., 1988 |
Apolipoprotein E polymorphism and atherosclerosis. |
3277611
|
Kataoka S et al., 1996 |
Apolipoprotein E polymorphism in American Indians and its relation to plasma lipoproteins and diabetes. The Strong Heart Study. |
8696954
|
Schaefer EJ et al., 1994 |
Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study. |
8018666
|
Hallman DM et al., 1991 |
The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. |
1867194
|
Lenzen HJ et al., 1986 |
Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease. |
3698268
|
Eichner JE et al., 2002 |
Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. |
11882522
|
Hu P et al., 2006 |
Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging. |
16799145
|
Candore G et al., 2006 |
Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4. |
16803999
|
De Benedictis G et al., 1998 |
Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). |
9887369
|
Tan Q et al., 2004 |
Assessing genetic association with human survival at multi-allelic loci. |
15105583
|
Maekawa M et al., 2005 |
Pilot study of arbitrarily primed PCR-single stranded DNA conformation polymorphism analysis for screening genetic polymorphisms related to specific phenotypes. |
15820493
|
DeVry CG & Clarke S, 1999 |
Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins. |
10496068
|
Faure-Delanef L et al., 1998 |
Plasma concentration, kinetic constants, and gene polymorphism of angiotensin I-converting enzyme in centenarians. |
9761238
|
Rahmutula D et al., 2002 |
Angiotensin-converting enzyme gene and longevity in the Xin Jiang Uighur autonomous region of China: an association study. |
11773214
|
Tan Q et al., 2001 |
Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity. |
11602206
|
Garasto S et al., 2003 |
The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. |
12556235
|
Pepe G et al., 1998 |
In search of a biological pattern for human longevity: impact of apo A-IV genetic polymorphisms on lipoproteins and the hyper-Lp(a) in centenarians. |
9622284
|
De Benedictis G et al., 1997 |
DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus. |
9050915
|
Kammerer S et al., 2003 |
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. |
12646697
|
Reiner AP et al., 2005 |
Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study. |
15939070
|
Taioli E et al., 2001 |
Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus. |
11162685
|
Lio D et al., 2002 |
Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population. |
11857056
|
Akisaka M et al., 1997 |
Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity. |
9389323
|
Yamaya M et al., 2003 |
Relationship between microsatellite polymorphism in the haem oxygenase-1 gene promoter and longevity of the normal Japanese population. |
12566526
|
Altomare K et al., 2003 |
The allele (A)(-110) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women. |
14501185
|
Singh R et al., 2006 |
Heat-shock protein 70 genes and human longevity: a view from Denmark. |
16804002
|
Ross OA et al., 2003 |
Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population. |
12742533
|
Lio D et al., 2002 |
Allele frequencies of +874T-->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians. |
11772518
|
Bonafè M et al., 2003 |
Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. |
12843179
|
Lio D et al., 2002 |
Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. |
11857058
|
Kojima T et al., 2004 |
Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. |
15582274
|
Kim DJ et al., 2006 |
Association between the MLH1 gene and longevity. |
16474933
|
Linnebank M et al., 2005 |
The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity. |
16142417
|
Xia Y et al., 2003 |
Effect of six candidate genes on early aging in a French population. |
12889841
|
Barbieri M et al., 2004 |
Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity. |
15236769
|
Gondo Y et al., 2005 |
Contribution of an affect-associated gene to human longevity: prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians. |
16095668
|
Carrieri G et al., 2004 |
The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. |
15569360
|
Soto-Vega E et al., 2005 |
Human leukocyte antigen class I, class II, and tumor necrosis factor-alpha polymorphisms in a healthy elder Mexican Mestizo population. |
16269080
|
Jazwinski SM et al., 2010 |
HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging. |
20569235
|
Berryman DE et al., 2013 |
A Dwarf Mouse Model With Decreased GH/IGF-1 Activity That Does Not Experience Life-Span Extension: Potential Impact of Increased Adiposity, Leptin, and Insulin With Advancing Age. |
23695394
|
Scheibner KA et al., 2012 |
MiR-27a functions as a tumor suppressor in acute leukemia by regulating 14-3-3θ. |
23236401
|
Liu T et al., 2009 |
MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin. |
18789835
|
Jahid S et al., 2012 |
miR-23a promotes the transition from indolent to invasive colorectal cancer. |
22628407
|
Deng S et al., 2008 |
Mechanisms of microRNA deregulation in human cancer. |
18719391
|
Vincent JL, 1991 |
Advances in the concepts of intensive care. |
2035418
|
Zang YS et al., 2012 |
MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression. |
22996741
|
Kleine-Vehn J et al., 2011 |
Recycling, clustering, and endocytosis jointly maintain PIN auxin carrier polarity at the plasma membrane. |
22027551
|
Jiang S et al., 2010 |
MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. |
20354188
|
Babar IA et al., 2011 |
Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells. |
22027557
|
Brus, M et al., 2013 |
Dynamics of olfactory and hippocampal neurogenesis in adult sheep. |
22700217
|
Jin K et al., 2003 |
Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice. |
12882410
|
Di Pietro F et al., 2013 |
TP53*P72 allele influences negatively female life expectancy in a population of central Italy: cross-sectional study and genetic-demographic approach analysis. |
23125046
|
Olivieri F et al., 2002 |
The -174 C/G locus affects in vitro/in vivo IL-6 production during aging. |
11772517
|
Lio D et al., 2004 |
Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. |
15466015
|
Lescai F et al., 2009 |
Human longevity and 11p15.5: a study in 1321 centenarians. |
19367319
|
Naumova E et al., 2011 |
'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop. |
21299522
|
Heijmans BT et al., 2000 |
Common gene variants, mortality and extreme longevity in humans. |
11053677
|
Ivanova R et al., 1998 |
HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity. |
9425225
|
Cortopassi GA, 2002 |
Fixation of deleterious alleles, evolution and human aging. |
12044933
|
Panza F et al., 2003 |
Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe. |
12954489
|
Trougakos IP et al., 2006 |
Reduced expression levels of the senescence biomarker clusterin/apolipoprotein j in lymphocytes from healthy centenarians. |
16804001
|
Piaceri I et al., 2013 |
Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians. |
22960875
|
Pesch B et al., 2004 |
Polymorphic metabolic susceptibility genes and longevity: a study in octogonarians. |
15177664
|
Kuznetsova SM, 1987 |
Polymorphism of heterochromatin areas on chromosomes 1, 9, 16 and Y in long-lived subjects and persons of different ages in two regions of the Soviet Union. |
3632129
|
Sebastiani P et al., 2011 |
Whole genome sequences of a male and female supercentenarian, ages greater than 114 years. |
22303384
|
Nebel A et al., 2007 |
Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men. |
17493663
|
Meiklejohn DJ et al., 2000 |
The contribution of factor VII gene polymorphisms to longevity in Scottish nonagenarians. |
10744171
|
Listì F et al., 2010 |
HLA and KIR frequencies in Sicilian Centenarians. |
20426625
|
Naumova E et al., 2004 |
Immunological markers contributing to successful aging in Bulgarians. |
15050300
|
Pan SL et al., 2012 |
Cholesteryl ester transfer protein TaqIB polymorphism and its association with serum lipid levels and longevity in Chinese Bama Zhuang population. |
22336474
|
Adler G et al., 2010 |
An age-related decrease in factor V Leiden frequency among Polish subjects. |
20720309
|
Tan Q et al., 2008 |
Power for genetic association study of human longevity using the case-control design. |
18756013
|
Flachsbart F et al., 2011 |
Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population. |
21798861
|
Bilal E et al., 2008 |
Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan. |
18545700
|
Flachsbart F et al., 2006 |
Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity. |
16257164
|
Naumova E et al., 2007 |
14th International HLA and Immunogenetics Workshop: report on the immunogenetics of aging. |
17445222
|
Walston JD et al., 2009 |
Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. |
19249341
|
Frederiksen H et al., 2003 |
Angiotensin I-converting enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival--a follow-up study of elderly Danish twins. |
12547486
|
Deelen J et al., 2013 |
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways. |
22113349
|
Atzmon G et al., 2005 |
Biological evidence for inheritance of exceptional longevity. |
15621216
|
Pan SL et al., 2012 |
Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China. |
23273182
|
Wilding CS et al., 2006 |
Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity. |
16518718
|
Woo J et al., 2012 |
The Alu polymorphism of angiotensin I converting enzyme (ACE) and atherosclerosis, incident chronic diseases and mortality in an elderly Chinese population. |
22456784
|
Jylhävä J & Hurme M, 2010 |
Gene variants as determinants of longevity: focus on the inflammatory factors. |
19763607
|
Yashin AI et al., 2010 |
Joint influence of small-effect genetic variants on human longevity. |
20834067
|
Jiang W et al., 2007 |
Correlation between haplotype of apolipoprotein B gene and natural longevity persons in Uygur nationality. |
17393087
|
Melzer D, 2008 |
Genetic polymorphisms and human aging: association studies deliver. |
18341427
|
Han J et al., 2013 |
Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing. |
23376243
|
Kleindorp R et al., 2011 |
Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans. |
21388494
|
Bellavia D et al., 1999 |
C4, BF, C3 allele distribution and complement activity in healthy aged people and centenarians. |
10219002
|
Kamei H et al., 2003 |
Association analysis of the SHC1 gene locus with longevity in the Japanese population. |
14530863
|
Hurme M et al., 2005 |
Interleukin-6 -174G/C polymorphism and longevity: a follow-up study. |
15664628
|
Edwards DR et al., 2012 |
Linkage and association of successful aging to the 6q25 region in large Amish kindreds. |
22773346
|
Fuzikawa AK et al., 2007 |
Apolipoprotein E polymorphism distribution in an elderly Brazilian population: the Bambuí Health and Aging Study. |
17934638
|
Newman AB & Murabito JM, 2013 |
The Epidemiology of Longevity and Exceptional Survival. |
23372024
|
Capurso C et al., 2007 |
Interleukin 6 variable number of tandem repeats (VNTR) gene polymorphism in centenarians. |
17506774
|
Kuningas M et al., 2006 |
Impact of genetic variations in the WRN gene on age related pathologies and mortality. |
16405962
|
de Jongh RT et al., 2011 |
Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals. |
21051524
|
Singh R et al., 2010 |
Anti-inflammatory heat shock protein 70 genes are positively associated with human survival. |
20388090
|
Invidia L et al., 2010 |
The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect. |
19421891
|
Ewbank DC, 2002 |
Mortality differences by APOE genotype estimated from demographic synthesis. |
11788960
|
Lottermoser K et al., 2001 |
The plasminogen activator inhibitor 1 4G/5G polymorphism is not associated with longevity: a study in octogenarians. |
11485022
|
Napolioni V et al., 2011 |
APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism. |
21703254
|
Deelen J et al., 2011 |
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. |
21418511
|
Wuttke D & de Magalhães JP, 2012 |
Osh6 links yeast vacuolar functions to lifespan extension and TOR. |
22722495
|
Hamilton LK et al., 2013 |
Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here. |
23773067
|
Schriner SE et al., 2013 |
Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction. |
23704949
|
Demars MP et al., 2013 |
Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation. |
23683827
|
Noren Hooten N et al., 2010 |
microRNA expression patterns reveal differential expression of target genes with age. |
20505758
|
Harry GJ, 2013 |
Microglia during development and aging. |
23644076
|
Bellizzi D et al., 2005 |
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. |
15676284
|
Bonafe, Massimiliano et al., 2002 |
An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity. |
11943467
|
De Luca M et al., 2001 |
Sex-specific longevity associations defined by Tyrosine Hydroxylase-Insulin-Insulin Growth Factor 2 haplotypes on the 11p15.5 chromosomal region. |
11672987
|
Gaunt TR et al., 2001 |
Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. |
11448941
|
Rose, G et al., 2003 |
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. |
14580859
|
Tan Q et al., 2002 |
The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach. |
12297342
|
Lee YN et al., 2012 |
Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster. |
22465014
|
Gerdes LU et al., 2000 |
Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a "frailty gene," not a "longevity gene". |
11015124
|
De Benedictis G et al., 1999 |
Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. |
10463944
|
Mooijaart SP et al., 2004 |
Variation in the SHC1 gene and longevity in humans. |
15036421
|
Tanaka M et al., 2000 |
Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis. |
10996007
|
Hong MG et al., 2008 |
Evidence that the gene encoding insulin degrading enzyme influences human lifespan. |
18448515
|
Yang X et al., 2012 |
Mitochondrial DNA polymorphisms are associated with the longevity in the Guangxi Bama population of China. |
22729909
|
Vaccarino L et al., 2011 |
Role of prothrombotic polymorphisms in successful or unsuccessful aging. |
21424155
|
Zeng Y et al., 2010 |
Effects of FOXO genotypes on longevity: a biodemographic analysis. |
20884733
|
Seripa D et al., 2006 |
Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy. |
16960022
|
Napolioni V et al., 2011 |
PTPN22 1858C>T (R620W) functional polymorphism and human longevity. |
21113673
|
Emanuele E et al., 2010 |
Preliminary evidence of a genetic association between chromosome 9p21.3 and human longevity. |
20230275
|
Todesco L et al., 1999 |
Methylenetetrahydrofolate reductase polymorphism, plasma homocysteine and age. |
10583447
|
Garasto S et al., 2004 |
A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians. |
15028112
|
Garatachea N et al., 2013 |
Association of the K153R polymorphism in the myostatin gene and extreme longevity. |
23354683
|
Cellini E et al., 2005 |
Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians. |
15888337
|
Atzmon G et al., 2008 |
Adiponectin levels and genotype: a potential regulator of life span in humans. |
18511746
|
Cipriano C et al., 2006 |
Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population. |
16955215
|
Naumova E et al., 2011 |
Immunogenetics of ageing. |
21726414
|
Vijg J et al., 2001 |
BRCA1 gene sequence variation in centenarians. |
11795532
|
Yang JK et al., 2009 |
Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population. |
19502260
|
Gonos ES, 2000 |
Genetics of aging: lessons from centenarians. |
10705035
|
Rea IM et al., 2004 |
Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis. |
15050299
|
Soerensen M et al., 2013 |
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. |
22234866
|
Noordam R et al., 2012 |
Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study. |
23128285
|
Listì F et al., 2007 |
Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity. |
17048073
|
Ross OA et al., 2004 |
Hypothetical soluble KIR2DS4 natural killer cell receptor molecule does not associate with successful ageing in the Irish. |
15130674
|
Santiago C et al., 2013 |
Mitochondriogenesis genes and extreme longevity. |
23186209
|
Bonafè M et al., 1999 |
P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia. |
10577935
|
Tan Q et al., 2002 |
A centenarian-only approach for assessing gene-gene interaction in human longevity. |
11938442
|
Kim S et al., 2012 |
Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity. |
21972126
|
Benn M et al., 2008 |
Mitochondrial haplogroups: ischemic cardiovascular disease, other diseases, mortality, and longevity in the general population. |
18458168
|
Perls T & Terry D, 2003 |
Understanding the determinants of exceptional longevity. |
12965974
|
Schoenmaker M et al., 2006 |
Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. |
16251894
|
Kerber RA et al., 2009 |
Gene expression profiles associated with aging and mortality in humans. |
19245677
|
Khabour OF et al., 2009 |
Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population. |
20003469
|
Conneely KN et al., 2012 |
Human longevity and common variations in the LMNA gene: a meta-analysis. |
22340368
|
Bojesen SE & Nordestgaard BG, 2008 |
The common germline Arg72Pro polymorphism of p53 and increased longevity in humans. |
18256523
|
Kuningas M et al., 2011 |
The relationship between fertility and lifespan in humans. |
21222045
|
Melzer D et al., 2007 |
Genetic variation and human aging: progress and prospects. |
17389728
|
Castro E et al., 1999 |
Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians. |
10069711
|
Corbo RM et al., 2011 |
Association of CYP19 and ESR1 pleiotropic genes with human longevity. |
20819792
|
Albani D et al., 2009 |
Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism. |
19377912
|
Stakias N et al., 2006 |
Lower prevalence of epsilon 4 allele of apolipoprotein E gene in healthy, longer-lived individuals of Hellenic origin. |
17234815
|
Mishto M et al., 2002 |
Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells. |
11772516
|
Polosak J et al., 2011 |
Aging is accompanied by a progressive decrease of expression of the WRN gene in human blood mononuclear cells. |
20855428
|
Kulminski AM et al., 2011 |
Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan. |
21332925
|
Niemi AK et al., 2003 |
Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. |
12483296
|
Dato S et al., 2012 |
UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts. |
22743239
|
Lunetta KL et al., 2007 |
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. |
17903295
|
Matsubara M et al., 2001 |
Decreased longevity in Japanese men, associated with low-molecular-weight apolipoprotein(a) phenotypes. |
11269751
|
Holsinger RM et al., 2012 |
Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians. |
22985157
|
Frisoni GB et al., 2001 |
Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study. |
11213279
|
Barbieri M et al., 2012 |
A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity. |
21340542
|
Maxwell LD et al., 2004 |
Investigation of KIR diversity in immunosenescence and longevity within the Irish population. |
15288696
|
Napolioni V & Lucarini N, 2010 |
Gender-specific association of ADA genetic polymorphism with human longevity. |
20174870
|
Malovini A et al., 2011 |
Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins. |
21612516
|
Ulybina YM et al., 2010 |
Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects. |
20434535
|
Cardelli M et al., 2008 |
A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism. |
18511747
|
Okayama N et al., 2005 |
Association of interleukin-10 promoter single nucleotide polymorphisms -819 T/C and -592 A/C with aging. |
16424284
|
Kulminski AM & Culminskaya I, 2013 |
Genomics of human health and aging. |
22174011
|
Lio D et al., 2003 |
Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP. |
12676903
|
Huffman DM et al., 2012 |
Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene. |
22496539
|
Flesch BK et al., 2006 |
The FCGR2A--Arg131 variant is no major mortality factor in the elderly--evidence from a German centenarian study. |
16893392
|
Ma YX et al., 1997 |
HLA and longevity or aging among Shanghai Chinese. |
9147371
|
Scola L et al., 2005 |
Study of the association with -330T/G IL-2 in a population of centenarians from centre and south Italy. |
16518704
|
Barbieri M et al., 2010 |
The IRS2 Gly1057Asp variant is associated with human longevity. |
19887537
|
Da Cruz IB et al., 2003 |
Angiotensin I-converting enzyme gene polymorphism in two ethnic groups living in Brazil's southern region: association with age. |
14528043
|
Rose G et al., 2011 |
Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity. |
21827845
|
Nuzzo D et al., 2006 |
Role of proinflammatory alleles in longevity and atherosclerosis: results of studies performed on -1562C/T MMP-9 in centenarians and myocardial infarction patients from Sicily. |
17261792
|
Soerensen M et al., 2012 |
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. |
22406557
|
Rontu R et al., 2006 |
Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians. |
16487435
|
Pawlikowska L et al., 2009 |
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. |
19489743
|
Ren WH et al., 2008 |
Mitochondrial DNA haplogroups in a Chinese Uygur population and their potential association with longevity. |
18759861
|
Boyden SE & Kunkel LM, 2010 |
High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. |
20824210
|
Benigni A et al., 2013 |
Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity. |
22569962
|
Scola L et al., 2008 |
Analysis of HLA-DRB1, DQA1, DQB1 haplotypes in Sardinian centenarians. |
17714903
|
Carru C et al., 2003 |
Association between the HFE mutations and longevity: a study in Sardinian population. |
12714263
|
Faure-Delanef L et al., 1997 |
Methylenetetrahydrofolate reductase thermolabile variant and human longevity. |
9106548
|
Pan H et al., 2011 |
Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population. |
21262335
|
Bathum L et al., 2005 |
No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians. |
16015282
|
Rea IM et al., 2001 |
Apolipoprotein E alleles in nonagenarian subjects in the Belfast Elderly Longitudinal Free-living Ageing Study (BELFAST). |
11470126
|
Bonafè M et al., 2002 |
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. |
12082503
|
Muiras ML et al., 1998 |
Lack of association between human longevity and genetic polymorphisms in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci. |
9654200
|
Mooijaart SP et al., 2007 |
Liver X receptor alpha associates with human life span. |
17452725
|
Chen T et al., 2010 |
A functional single nucleotide polymorphism in promoter of ATM is associated with longevity. |
20816691
|
Xie L et al., 2010 |
A microsatellite polymorphism in IGF1 gene promoter and longevity in a Han Chinese population. |
20199671
|
Hui L et al., 2011 |
Variations in short tandem repeats deduced on the basis of the number of repeats and the relationship of these variations with longevity. |
20582731
|
Muiras ML et al., 1998 |
Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians. |
9587069
|
Marchegiani F et al., 2006 |
Paraoxonase activity and genotype predispose to successful aging. |
16799134
|
Neville MJ et al., 2007 |
Absence of relationship between MTTP haplotypes and longevity. |
17339647
|
von Wurmb-Schwark N et al., 2011 |
Association of TH01 with human longevity revisited. |
21407269
|
Feng J et al., 2011 |
Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China. |
21945877
|
Ross OA et al., 2003 |
HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish. |
12714268
|
Campa D et al., 2012 |
Bitter taste receptor polymorphisms and human aging. |
23133589
|
Christiansen L et al., 2006 |
A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival. |
16574194
|
Jian-Gang Z et al., 1998 |
Apolipoprotein E and longevity among Han Chinese population. |
9792194
|
Xie L et al., 2008 |
Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population. |
18761080
|
Li Y et al., 2009 |
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. |
19793722
|
Zajc Petranović M et al., 2012 |
Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans. |
21614448
|
Roszkowska-Gancarz M et al., 2010 |
The -351A/G polymorphism of ESR1 is associated with risk of myocardial infarction but not with extreme longevity. |
20599431
|
Gravina S et al., 2009 |
Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. |
20126416
|
Nygaard M et al., 2013 |
AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians. |
22929028
|
Courtenay MD et al., 2012 |
Mitochondrial haplogroup X is associated with successful aging in the Amish. |
21750925
|
van Heemst D et al., 2005 |
Reduced insulin/IGF-1 signalling and human longevity. |
15771611
|
Cavallone L et al., 2003 |
The role of IL-1 gene cluster in longevity: a study in Italian population. |
12714264
|
Shi H et al., 2012 |
Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). |
22445811
|
Fiuza-Luces C et al., 2011 |
Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort. |
21330423
|
Domínguez-Garrido E et al., 2009 |
Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations. |
18931934
|
Wang XY et al., 2001 |
Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians. |
11640949
|
Polosak J et al., 2010 |
Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity. |
19707883
|
Tazearslan C et al., 2012 |
Discovery of functional gene variants associated with human longevity: opportunities and challenges. |
22156437
|
Lio D et al., 2003 |
Association between the HLA-DR alleles and longevity: a study in Sardinian population. |
12581796
|
Franceschi C et al., 2005 |
Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. |
15621218
|
Napolioni V et al., 2011 |
Haptoglobin (HP) polymorphisms and human longevity: A cross-sectional association study in a Central Italy population. |
21147083
|
Li J et al., 2009 |
Interactive association of heat shock protein 70 genes variants with natural longevity in Xinjiang Hetian Uygur ethnicity. |
19840767
|
Roszkowska-Gancarz M et al., 2012 |
Total and high molecular weight adiponectin and level-modifying polymorphisms of ADIPOQ in centenarians. |
23339001
|
Lelashvili NG & Dalakishvili SM, 1984 |
Genetic study of high longevity index populations. |
6240576
|
Proust J et al., 1982 |
HLA and longevity. |
7089955
|
Merched A et al., 1998 |
Apolipoprotein AIV codon 360 mutation increases with human aging and is not associated with Alzheimer's disease. |
9533408
|
Toupance B et al., 1998 |
A model for antagonistic pleiotropic gene action for mortality and advanced age. |
9585593
|
Bathum L et al., 1998 |
Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevitY. Role of CYP2D6 and CYP2C19 in longevity. |
9754988
|
De Benedictis G et al., 1998 |
Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts. |
9759473
|
Coughtrie MW et al., 1999 |
Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. |
9854023
|
Panza F et al., 1999 |
Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians. |
10643896
|
De Benedictis G et al., 2000 |
Does a retrograde response in human aging and longevity exist? |
11053670
|
Blanché H et al., 2001 |
A study of French centenarians: are ACE and APOE associated with longevity? |
11280044
|
Caruso C et al., 2001 |
Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data. |
11292511
|
Ross OA et al., 2001 |
Mitochondrial DNA polymorphism: its role in longevity of the Irish population. |
11404057
|
Varcasia O et al., 2001 |
Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus. |
11592926
|
Pinti M et al., 2002 |
Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: studies on centenarians. |
11965496
|
Perls T et al., 2002 |
The genetics of aging. |
12076681
|
Yao YG et al., 2002 |
Mitochondrial DNA 5178A polymorphism and longevity. |
12384792
|
Christiansen L et al., 2004 |
Modest implication of interleukin-6 promoter polymorphisms in longevity. |
15130757
|
Gaspari L et al., 2003 |
Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls. |
15195682
|
Capurso C et al., 2004 |
Interleukin 6-174 G/C promoter gene polymorphism in centenarians: no evidence of association with human longevity or interaction with apolipoprotein E alleles. |
15236771
|
Christiansen L et al., 2004 |
Paraoxonase 1 polymorphisms and survival. |
15241482
|
Christiansen L et al., 2004 |
The catalase -262C/T promoter polymorphism and aging phenotypes. |
15472150
|
Sorkin J et al., 2005 |
Exploring the genetics of longevity in the Old Order Amish. |
15621217
|
Arking DE et al., 2005 |
Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. |
15677572
|
Tan Q et al., 2005 |
Haplotype effects on human survival: logistic regression models applied to unphased genotype data. |
15720298
|
Capri M et al., 2006 |
The genetics of human longevity. |
16803995
|
Kaeberlein M, 2006 |
Genome-wide approaches to understanding human ageing. |
16848980
|
Au WY et al., 2006 |
Glucose-6-phosphate dehydrogenase deficiency in female octogenarians, nanogenarians, and centenarians. |
17077204
|
Salvioli S et al., 2006 |
Genes, ageing and longevity in humans: problems, advantages and perspectives. |
17090420
|
Shao J et al., 2007 |
SOD2 polymorphisms: unmasking the effect of polymorphism on splicing. |
17331249
|
Liu H et al., 2007 |
Molecular genetic studies on relationships among longevity, diseases, and HLA-DRB1/DQB1 allelic polymorphism. |
17364902
|
Del Bo R et al., 2008 |
Role of VEGF gene variability in longevity: a lesson from the Italian population. |
17574707
|
Bergman A et al., 2007 |
Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. |
17784782
|
Mari D et al., 2008 |
Hemostasis factors and aging. |
17869046
|
De Rango F et al., 2008 |
A novel sampling design to explore gene-longevity associations: the ECHA study. |
17989723
|
Balistreri CR et al., 2008 |
Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity. |
18379014
|
Ralser M et al., 2008 |
Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans. |
18510744
|
Willcox BJ et al., 2008 |
FOXO3A genotype is strongly associated with human longevity. |
18765803
|
Jylhävä J et al., 2009 |
Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study. |
19000922
|
Flachsbart F et al., 2009 |
Association of FOXO3A variation with human longevity confirmed in German centenarians. |
19196970
|
Soerensen M et al., 2009 |
The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. |
19428448
|
Balistreri CR et al., 2009 |
TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases. |
19459036
|
Cai XY et al., 2009 |
Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population. |
19641616
|
Li H et al., 2009 |
The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese population. |
20003397
|
Sebastiani P et al., 2009 |
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. |
20011587
|
Khabour OF et al., 2010 |
Associations of polymorphisms in adiponectin and leptin genes with men's longevity. |
20201642
|
Caliebe A et al., 2010 |
No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis. |
20362697
|
Laplana M et al., 2010 |
Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes. |
20407924
|
Candore G et al., 2010 |
Inflammation, genetic background and longevity. |
20549353
|
Sebastiani P et al., 2010 |
Genetic signatures of exceptional longevity in humans. |
20595579
|
Zhang WG et al., 2010 |
SIRT1 variants are associated with aging in a healthy Han Chinese population. |
20633545
|
Flachsbart F et al., 2010 |
Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. |
20800603
|
Soerensen M et al., 2010 |
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. |
20849522
|
Slagboom PE et al., 2011 |
Genomics of human longevity. |
21115528
|
Fiuza-Luces C et al., 2011 |
Are 'endurance' alleles 'survival' alleles? Insights from the ACTN3 R577X polymorphism. |
21407828
|
Mocchegiani E et al., 2011 |
Zinc, metallothioneins and immunosenescence: effect of zinc supply as nutrigenomic approach. |
21503725
|
Napolioni V et al., 2011 |
Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy. |
21865054
|
Soerensen M et al., 2012 |
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis. |
22136229
|
Laplana M & Fibla J, 2012 |
Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals. |
22265023
|
Ferrario A et al., 2012 |
The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations. |
22524405
|
Heckman MG et al., 2012 |
Evaluation of the role of SNCA variants in survival without neurological disease. |
22912757
|
Corbo RM et al., 2013 |
Gender-specific association between FSHR and PPARG common variants and human longevity. |
22985084
|
Zhao L et al., 2012 |
Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. |
23020224
|
Reiner AP et al., 2013 |
Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults. |
23162014
|
Park JW et al., 2009 |
Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans. |
19641380
|
Yashin AI et al., 2012 |
Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality. |
22533364
|
Geesaman BJ et al., 2003 |
Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan. |
14615589
|
Ueland PM et al., 2001 |
Biological and clinical implications of the MTHFR C677T polymorphism. |
11282420
|
Bonafè M & Olivieri F, 2009 |
Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity. |
19027825
|
Schupf N et al., 2013 |
Apolipoprotein E and familial longevity. |
23040522
|
Dato S et al., 2007 |
Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case-control approach (APOE and HSP70.1 loci). |
16896546
|
Perls T & Terry D, 2003 |
Genetics of exceptional longevity. |
12855277
|
Scola L et al., 2006 |
Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians. |
16608414
|
Erickson RP et al., 2008 |
Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population. |
18834923
|
Wheeler HE & Kim SK, 2011 |
Genetics and genomics of human ageing. |
21115529
|
Listì F et al., 2007 |
Connexin37 1019 gene polymorphism in myocardial infarction patients and centenarians. |
16970956
|
Walter S et al., 2011 |
A genome-wide association study of aging. |
21782286
|
Novelli V et al., 2008 |
Lack of replication of genetic associations with human longevity. |
18034366
|
Yashin AI et al., 2012 |
How genes influence life span: the biodemography of human survival. |
22607627
|
Hindorff LA et al., 2008 |
Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study. |
17888441
|
Tanaka M, 2002 |
Mitochondrial genotypes and cytochrome b variants associated with longevity or Parkinson's disease. |
12375058
|
Suh Y et al., 2008 |
Functionally significant insulin-like growth factor I receptor mutations in centenarians. |
18316725
|
Glasper ER & Gould E, 2013 |
Sexual experience restores age-related decline in adult neurogenesis and hippocampal function. |
23460298
|
Bizon JL & Gallagher M, 2003 |
Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline. |
12859354
|
Boily, Gino et al., 2008 |
SirT1 regulates energy metabolism and response to caloric restriction in mice. |
18335035
|
Huang T et al., 2012 |
Deciphering the effects of gene deletion on yeast longevity using network and machine learning approaches. |
22239951
|
Tanaka, M et al., 1988 |
Extensive defects of mitochondrial electron-transfer chain in muscular cytochrome c oxidase deficiency. |
2845344
|
Tanaka, M et al., 1998 |
Mitochondrial genotype associated with longevity. |
9449878
|
Arking DE et al., 2002 |
Association of human aging with a functional variant of klotho. |
11792841
|
Goto M et al., 1981 |
Family analysis of Werner's syndrome: a survey of 42 Japanese families with a review of the literature. |
7460386
|
Faragher RG et al., 1993 |
The gene responsible for Werner syndrome may be a cell division "counting" gene. |
8265666
|
Prince PR et al., 2001 |
Loss of Werner syndrome protein function promotes aberrant mitotic recombination. |
11316787
|
Arslan-Ergul A et al., 2013 |
Aging, neurogenesis, and caloric restriction in different model organisms. |
23936746
|
Kim J et al., 2013 |
Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis. |
23891729
|
Kitamura T et al., 2006 |
Dietary restriction increases hippocampal neurogenesis by molecular mechanisms independent of NMDA receptors. |
16356642
|
Huang X et al., 2011 |
The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans. |
21471153
|
Johannsen TH et al., 2012 |
Genetic inhibition of CETP, ischemic vascular disease and mortality, and possible adverse effects. |
23083790
|
Wootton JC et al., 1975 |
The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides. |
1000
|
Numano F, 1979 |
[Symposium on major histocompatibility antigens (HLA) and diseases. Supplement: genetic factor in Takayasu disease (author's transl)]. |
42663
|
Simplicio J et al., 1975 |
Kinetics of cyanate and imidazole binding to hemin in micelles. |
437
|
Lübek J, 1976 |
[Bacterial flora in patients with prostatic adenoma]. |
56000
|
Slichter SJ & Harker LA, 1976 |
Preparation and storage of platelet concentrates. |
3000
|
Martin TM et al., 2008 |
A hierarchical clustering methodology for the estimation of toxicity. |
20020919
|
Drozhdeniuk AP et al., 1976 |
[DNA degradation during standard alkaline of thermal denaturation]. |
999984
|
Hori K et al., 1991 |
Fluctuations in tumor blood flow under normotension and the effect of angiotensin II-induced hypertension. |
1752787
|
Sticker LS et al., 1991 |
Effect of supplemental lysocellin and tetronasin on growth, ruminal and blood metabolites, and ruminal proteolytic activity in steers grazing ryegrass. |
1752803
|
Bishop MD et al., 1991 |
Divergent selection for postweaning feed conversion in Angus beef cattle: II. Genetic and phenotypic correlations and realized heritability estimate. |
1752811
|
Wang CT & Dickerson GE, 1991 |
Simulation of life-cycle efficiency of lamb and wool production for genetic levels of component traits and alternative management options. |
1752808
|
Palladino DE et al., 1992 |
Measurement of amino acid compositions of glycoprotein systems by gas-phase hydrolysis and reversed-phase high-performance liquid chromatography. |
1352306
|
Bishop MD et al., 1991 |
Divergent selection for postweaning feed conversion in Angus beef cattle: I. Mean comparisons. |
1752810
|
Miles A & Miller DJ, 1992 |
Genomes of diploblastic organisms contain homeoboxes: sequence of eveC, an even-skipped homologue from the cnidarian Acropora formosa. |
1352890
|
Goding GS Jr, 1991 |
Nerve-muscle pedicle reinnervation of the paralyzed vocal cord. |
1754223
|
Składzień J et al., 1991 |
[Non-epithelial malignant neoplasms of the larynx]. |
1754230
|
Murlewska A, 1991 |
[Use of ultrasonography in the diagnosis of laryngeal cancer]. |
1754243
|
Koufman JA & Isaacson G, 1991 |
The spectrum of vocal dysfunction. |
1754226
|
Carter JH et al., 1992 |
Quantitative image cytometry of hepatocytes expressing gamma-glutamyl transpeptidase and glutathione S-transferase in diethylnitrosamine-initiated rats treated with phenobarbital and/or phthalate esters. |
1352315
|
Johnson DW et al., 1991 |
Exogenous opioids increase plasma prolactin in Holstein calves primarily via a dopaminergic mechanism. |
1752829
|
Pazin GJ, 1991 |
Counseling to avoid AIDS. |
1754272
|
Dowton SB et al., 1991 |
Developmental regulation of expression of C-reactive protein and serum amyloid A in Syrian hamsters. |
1754300
|
Kirby KC et al., 1991 |
Reactivity in self-recording: obtrusiveness of recording procedure and peer comments. |
1752838
|
Azmitia EC & Whitaker-Azmitia PM, 1991 |
Awakening the sleeping giant: anatomy and plasticity of the brain serotonergic system. |
1752858
|
Yamaguchi S et al., 1991 |
Prenatal diagnosis and neonatal monitoring of a fetus with glutaric aciduria type II due to electron transfer flavoprotein (beta-subunit) deficiency. |
1754299
|
Zeigler V, 1991 |
Adenosine in the pediatric population: nursing implications. |
1754289
|
Schadewaldt P et al., 1991 |
Oral L-alloisoleucine loading studies in healthy subjects and in patients with maple syrup urine disease. |
1754297
|
Wennberg RP et al., 1991 |
Bilirubin-induced changes in brain energy metabolism after osmotic opening of the blood-brain barrier. |
1754304
|
Bengtsson C et al., 1992 |
Diabetes incidence in users and non-users of antihypertensive drugs in relation to serum insulin, glucose tolerance and degree of adiposity: a 12-year prospective population study of women in Gothenburg, Sweden. |
1352324
|
Makovetskaia GA et al., 1991 |
[Structure of interstitial nephritis in children]. |
1754325
|
Greenleaf G et al., 1991 |
Microbial contamination in allografted wound beds in patients with burns. |
1752879
|
Lu CS et al., 1992 |
Pseudoathetosis as a presenting symptom of spinal multiple sclerosis. |
1352326
|
Ting KS et al., 1992 |
Brachial plexus neuropathy associated with scrub typhus: report of a case. |
1352327
|
Valdes AM et al., 2013 |
Omics technologies and the study of human ageing. |
23938363
|
Lopez-Otin, Carlos et al., 2013 |
The hallmarks of aging. |
23746838
|
Berger B et al., 2013 |
Computational solutions for omics data. |
23594911
|
Rhinn H et al., 2013 |
Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease. |
23883936
|
Ilamanov M & Naumova VI, 1991 |
[Results of the treatment of glomerulonephritis in children with hepatitis B]. |
1754336
|
Heggers JP et al., 1991 |
Bactericidal and wound-healing properties of sodium hypochlorite solutions: the 1991 Lindberg Award. |
1752875
|
Volodin NN, 1991 |
[Crigler-Najjar syndrome in an infant during the 1st year of life]. |
1754338
|
Aksenov V et al., 2010 |
Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. |
20404021
|
Serbanesco F et al., 1991 |
Epilepsy and cardiac surgery. |
1752905
|
Sheĭbak MP & Evets LV, 1991 |
[Clinical syndromes and treatment tactics in cow's milk intolerance in young children]. |
1754356
|
Wang CS et al., 1992 |
Localization of obscure gastrointestinal bleeding by technetium 99m-labeled red blood cell scintigraphy. |
1352337
|
Hsu WH et al., 1992 |
Detection of mass lesions in the collapsed lung by ultrasonography. |
1352336
|
Sasso MP et al., 1991 |
Molecular cloning of the gene encoding the bovine brain ribonuclease and its expression in different regions of the brain. |
1754384
|
Reese JC & Katzenellenbogen BS, 1991 |
Differential DNA-binding abilities of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells. |
1754396
|
Navab M et al., 1991 |
Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. |
1752961
|
Phillips HA et al., 1991 |
Dinucleotide repeat polymorphism at D16S287. |
1754417
|
Horikoshi S et al., 1991 |
Water deprivation stimulates transforming growth factor-beta 2 accumulation in the juxtaglomerular apparatus of mouse kidney. |
1752966
|
Shiratsuchi Y et al., 1991 |
Evaluation of masticatory function following orthognathic surgical correction of mandibular prognathism. |
1752969
|
Freihofer HP, 1991 |
Restricted opening of the mouth with an extra-articular cause in children. |
1752968
|
Higgins CM et al., 1992 |
Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis. |
1352961
|
Volpe A et al., 1991 |
Clinical use of growth hormone-releasing factor for induction of superovulation. |
1752922
|
Erlen JA et al., 1991 |
Professional oaths--pharmacy can lead the way. |
1752910
|
Drake J et al., 1991 |
Comparative pharmacokinetics of temazepam Gelthix and liquid-filled soft gelatin capsules. |
1752914
|
Edwards JG, 1992 |
Medicolegal aspects of benzodiazepine dependence. Duties and responsibilities of doctors. |
1352373
|
, 1991 |
Guidelines on testing for the lupus anticoagulant. Lupus Anticoagulant Working Party on behalf of the BCSH Haemostasis and Thrombosis Task Force. |
1752976
|
Lewis SM et al., 1991 |
Current concerns in haematology. 3: Blood count calibration. |
1752975
|
Thomas JS et al., 1991 |
Prospective study of quantitative aspects of audit in a large general histopathology laboratory. |
1752984
|
Löscher W & Hönack D, 1992 |
Withdrawal precipitation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil. |
1352384
|
Onali P & Olianas MC, 1992 |
B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity. |
1352980
|
Smith JP, 1991 |
Meeting the challenge of cancer care and prevention in Europe. |
1753022
|
De Wals P et al., 1991 |
Association between holoprosencephaly and exposure to topical retinoids: results of the EUROCAT Survey. |
1754503
|
Good BM & Su AI, 2013 |
Crowdsourcing for bioinformatics. |
23782614
|
Landreth A & Silva AJ, 2013 |
The need for research maps to navigate published work and inform experiment planning. |
23931992
|
de Saint-Jean M et al., 2011 |
Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers. |
22162133
|
Takahashi K & Yamanaka S, 2006 |
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. |
16904174
|
Hayamizu TF et al., 2013 |
EMAP/EMAPA ontology of mouse developmental anatomy: 2013 update. |
23972281
|
Bard J, 2012 |
A new ontology (structured hierarchy) of human developmental anatomy for the first 7 weeks (Carnegie stages 1-20). |
22973865
|
Fuellen G et al., 2010 |
Bioinformatics in aging research: a workshop report. |
21204651
|
Budovsky A et al., 2013 |
LongevityMap: a database of human genetic variants associated with longevity. |
23998809
|
Koch CM & Wagner W, 2011 |
Epigenetic-aging-signature to determine age in different tissues. |
22067257
|
Walker RF et al., 2009 |
A case study of "disorganized development" and its possible relevance to genetic determinants of aging. |
19428454
|
Miller RA, 2001 |
Biomarkers of aging: prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, genetically heterogeneous mouse population. |
11283189
|
Wu JJ et al., 2013 |
Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression. |
23994476
|
Horvath S, 2013 |
DNA methylation age of human tissues and cell types. |
24138928
|
Fuellen G et al., 2013 |
In-Silico-Approaches and the Role of Ontologies in Aging Research. |
24188080
|
Groza T et al., 2013 |
State of the art and open challenges in community-driven knowledge curation. |
23219718
|
Hughes KA & Reynolds RM, 2005 |
Evolutionary and mechanistic theories of aging. |
15355246
|
Partridge L & Gems D, 2002 |
Mechanisms of ageing: public or private? |
11972154
|
Hayflick L, 2007 |
Biological aging is no longer an unsolved problem. |
17460161
|
Anderson WF et al., 2009 |
Qualitative age interactions in breast cancer studies: mind the gap. |
19826117
|
Jatoi I et al., 2008 |
Qualitative age-interactions in breast cancer: a tale of two diseases? |
18838890
|
Thomas GA & Leonard RC, 2009 |
How age affects the biology of breast cancer. |
19071000
|
Traniello IM et al., 2013 |
Age-related changes in stem cell dynamics, neurogenesis, apoptosis, and gliosis in the adult brain: A novel teleost fish model of negligible senescence. |
24293183
|
Zhang J et al., 2004 |
Enhancing HMM-based biomedical named entity recognition by studying special phenomena. |
15542015
|
Zhu, Fei et al., 2013 |
Biomedical text mining and its applications in cancer research. |
23159498
|
Maruszak A et al., 2014 |
Hippocampal neurogenesis in Alzheimer's disease: is there a role for dietary modulation? |
23948932
|
Bao JM et al., 2014 |
Association between <i>FOXO3A</i> gene polymorphisms and human longevity: a meta-analysis. |
25038186
|
Garatachea N et al., 2014 |
PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. |
24930376
|
Lu F et al., 2014 |
Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population. |
24924924
|
Guney O et al., 2014 |
Mitochondrial DNA polymorphisms associated with longevity in the Turkish population. |
24792352
|
Deelen J et al., 2014 |
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. |
24688116
|
Roszkowska-Gancarz M et al., 2014 |
Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus. |
24549597
|
Garatachea N et al., 2014 |
ApoE gene and exceptional longevity: Insights from three independent cohorts. |
24534555
|
Li Q et al., 2014 |
Association between the CETP polymorphisms and the risk of Alzheimer's disease, carotid atherosclerosis, longevity, and the efficacy of statin therapy. |
24468472
|
Flachsbart F et al., 2014 |
Investigation of complement component C4 copy number variation in human longevity. |
24465950
|
Falcone C et al., 2013 |
Possible role of -374T/A polymorphism of RAGE gene in longevity. |
24284407
|
Sebastiani P et al., 2013 |
Meta‐analysis of genetic variants associated with human exceptional longevity. |
24244950
|
Di Bona D et al., 2014 |
Association of Klotho polymorphisms with healthy aging: a systematic review and meta-analysis. |
24164579
|
Pinós T et al., 2014 |
The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. |
24163049
|
Tindale LC et al., 2014 |
Rare and common variants in the Apolipoprotein E gene in healthy oldest old. |
24126160
|
Albani D et al., 2014 |
Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)". |
23839864
|
Morris BJ et al., 2014 |
Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry. |
23770741
|
Zheĭkova TV et al., 2013 |
[Association between 242C > T polymorphism of NADPH oxidase p22phox gene (CYBA) and longevity in Russian population]. |
23755540
|
Garatachea N et al., 2013 |
The ACE DD genotype and D-allele are associated with exceptional longevity: a meta-analysis. |
23623925
|
Tan Q et al., 2013 |
A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family. |
23607278
|
Montesanto A et al., 2013 |
Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans. |
23572278
|
Concetti F et al., 2013 |
The functional VNTR MNS16A of the TERT gene is associated with human longevity in a population of Central Italy. |
23562826
|
Figarska SM et al., 2013 |
SIRT1 polymorphism, long-term survival and glucose tolerance in the general population. |
23505545
|
Huang J et al., 2013 |
[Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi]. |
23450480
|
Golanska E et al., 2013 |
The prion protein M129V polymorphism: longevity and cognitive impairment among Polish centenarians. |
23406923
|
Comment on This Data Unit