Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs519007 FOXO3 0.93 0.55 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs9486902 FOXO3 1.40 0.0118 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs12206094 FOXO3 1.38 0.0076 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs2802292 FOXO3 1.34 0.0078 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs13220810 FOXO3 0.75 0.0223 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs2764264 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs7762395 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 G — Candidate Region/Gene 20849522
    rs13217795 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs9400239 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs9398172 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 A — Candidate Region/Gene 20849522
    rs3800231 FOXO3 1.26 0.0495 1089 vs 736 — Danish 92–93 G — Candidate Region/Gene 20849522
    rs479744 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 (can't figure out using ensemble and NCBI) — Candidate Region/Gene 20849522
    rs3019435 PARK2 1.41 0.001006354 801 vs 914 — Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs4880 SOD2 — 0.009 224 vs 441 — Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
    rs5746098 SOD2 — 0.355 130 vs 135 — Jordanian Mean age 90.01 — — Candidate Region/Gene 20003469
    rs4880 SOD2 0.91 0.002 1650 — Danish All danes born in 1905 (Danish 1905 cohort) T — Candidate Region/Gene 19428448
    rs4880 SOD2 — 0.009 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — T Candidate Region/Gene 15621215
    rs2758331 SOD2 1.33 2.92563e-05 801 vs 914 — Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    Ile119Val PCMT1 — 0.049 40 vs 40 — Ashkenazi Jewish Mean age 87.2 — — Candidate Region/Gene 10496068
    H63D HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
    S65C HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
    HFE C282Y HFE — 7.2e-07 35 vs 106 — 91-105 (< 50 versus >90) C Y Candidate Region/Gene 11857056
    rs1799945 HFE — 0.008 57 vs 60 — Italian 100-105 — — Candidate Region/Gene 12714263
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 1.72 0.01 152 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR7 alleles DR7 Candidate Region/Gene 9425225
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 2.03 0.001 336 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR11 alleles DR11 Candidate Region/Gene 9425225

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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