There is a significant effect of HP 1/2 polymorphism on APOEε4 carriers (p=0.006); HP1/1 genotype protects APOEε4carriers from age-related negative selection, while the HP2 allele seems to enhance the deleterious effect of APOEε4"
APOE4 OR to live longer = 0.377
APOE2 OR to live longer = 1.479
APOE polymorphism includes haplotype combination of rs429358-rs7412 polymorphisms.
Ethnicity: Italian
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