Polymorphism: APOE polymorphism
Variant Type: Haplotype
Location: 19q13.2
Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203
Factors:
APOE
apolipoprotein E
(
348
/
ENSG00000130203
)
Description:
There is a significant effect of HP 1/2 polymorphism on APOEε4 carriers (p=0.006); HP1/1 genotype protects APOEε4carriers from age-related negative selection, while the HP2 allele seems to enhance the deleterious effect of APOEε4"
APOE4 OR to live longer = 0.377
APOE2 OR to live longer = 1.479
APOE polymorphism includes haplotype combination of rs429358-rs7412 polymorphisms.
Ethnicity:
Italian
Age of cases: >88
Shorter lived allele: e4
Longer lived allele: e2
Finding: Positive
Statistics
- Number of cases/controls: 200 (cases) vs 539 (initial)
- Odds ratio: 0.377
- Odds ratio type: Longer
- p-value:
0.002
[0.002 (e4), 0.037 (e2)]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR-RFLP
Reference:
21703254: APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism.
Choice: Clean
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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