Mutations in components of the âWnt/b-catenin wrm-1 or pop-1/TCF decreases expression levels of elt-5 and elt-6 GATA factors through live and increasing elt-3 expression. Inactivation of the âWnt/b-catenin asymmetry pathway starting at the first day of adulthood, extends lifespan by 40-50% [22661237].
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