E(z) mutation

Species: Fruit fly (Taxid: 7227)
Factor:
Manipulation: Loss-of-Function, Mutation
Effect:

Flies heterozygous for the protein null E(z)63 or the catalytically inactive E(z)731 mutation that are progeny of an out-cross to an Oregon-R (O-R) wild-type strain exhibit a substantially greater median lifespan than the O-R control (71% and 76%, respectively). When derived from an out-cross to a longer-lived Canton-S (C-S) wild-type strain, the median lifespan of E(z)63 heterozygous is 33% longer than the C-S control [20018689].

Median: +33 to +76

References:
  • 20018689: Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.




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