RNAi of pha-4 completely cancels out the lifespan extension of eat-2 mutation. Therefore, loss of pha-4 completely blocks the response to varying food concentration. sDR extends lifespan pha-4 RNAi knockdown, but not daf-16 RNAi [19239417]. RNAi of pha-4 decreases lifespan of wild-type worms, but not of daf-2 mutants or of animals with defective electron transport chains.
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