Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    CRP C-reactive protein, pentraxin-related CRP was not found to be associated with longevity [17888441]. Human
    IL6 + APOE IL6 + APOE was not found to be associated with longevity [15236771]. Human
    HLA-DQB major histocompatibility complex, class II, DQ beta 1 HLA-DQB was not found to be associated with longevity [16608414]. Human
    HLA-DQA major histocompatibility complex, class II, DQ alpha 1 HLA-DQA was not found to be associated with longevity [16608414]. Human
    PARP poly (ADP-ribose) polymerase 1 PARP was not found to be associated with longevity [9887369]. Human
    Downstream of FOXO3A Downstream of FOXO3A was found to be associated with longevity [19196970]. Downstream of FOXO3A was not found to be associated with longevity [19196970]. Human
    Downstream of LACE1 Downstream of LACE1 was not found to be associated with longevity [19196970]. Human
    LACE1 lactation elevated 1 LACE1 was not found to be associated with longevity [19196970]. Human
    B9D2 B9 protein domain 2 B9D2 was not found to be associated with longevity [15569360]. Human
    CCL5 chemokine (C-C motif) ligand 5 CCL5 was not found to be associated with longevity [22265023]. Human
    JAK2 (for males) Janus kinase 2 JAK2 (for males) was not found to be associated with longevity [19641380]. Human
    TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 TNFSF11 was not found to be associated with longevity [19641380]. Human
    MGP matrix Gla protein MGP was not found to be associated with longevity [19641380]. Human
    SERT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 SERT was not found to be associated with longevity [15621215]. Human
    CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase CAD was not found to be associated with longevity [15621215]. Human
    ND2 ND2 was not found to be associated with longevity [12384792]. Human
    APOE + TOMM40 APOE + TOMM40 was not found to be associated with longevity [21418511]. APOE + TOMM40 was not found to be associated with longevity [23040522]. Human
    ADCY5 adenylate cyclase 5 ADCY5 was not found to be associated with longevity [23020224]. Human
    ADRB2 adrenergic, beta-2-, receptor, surface ADRB2 was found to be associated with longevity [23020224]. ADRB2 was not found to be associated with longevity [23020224]. Human
    ADRB1 adrenergic, beta-1-, receptor ADRB1 was not found to be associated with longevity [23020224]. Human
    ERCC1 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) ERCC1 was not found to be associated with longevity [22576335]. Human
    POMC proopiomelanocortin POMC was not found to be associated with longevity [22576335]. Human
    PTPN11 protein tyrosine phosphatase, non-receptor type 11 PTPN11 was not found to be associated with longevity [22576335]. Human
    CCR5 chemokine (C-C motif) receptor 5 CCR5 was not found to be associated with longevity [22265023]. Human
    RANTES ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G RANTES was not found to be associated with longevity [22265023]. RANTES was found to be associated with longevity [22265023]. Human
    Factors are an extension of GenAge and GenDR.

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