Symbol: SOD2 Name: SuperOxide Dismutase 2 Entrez gene ID: 856399 Ensembl gene ID: YHR008C Species: Yeast (Taxid: 4932) Functional description: Sod2p; Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated [Source:SGD;Acc:S000001050] [Ensembl] Observation: SOD2 deletion decreases replicative lifespan by 72% [17460215]. SOD2 deletion decreases chronological lifespan [21076178]. Deletion of SOD2 decreases chronological lifespan in wild-type and abolishes chronological lifespan extension in sch9Delta mutants as well as decreases chronological lifespan in cyr1:mTn mutants [12586694]. Combined overexpression of SOD1 and SOD2 extends chronological lifespan by 30% in EG103 strain [12586694]. SOD2 deletion mutants are hypersensitive to oxygen and grow poorly in ethanol [10222047]. Interventions: Assays: Replicative Lifespan Chronological Lifespan Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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