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Symbol: RIM15 Name: Regulator of IME2 15 Alias: TAK1 Entrez gene ID: 850511 Ensembl gene ID: YFL033C Species: Yeast (Taxid: 4932) Functional description: Rim15p; Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase [Source:SGD;Acc:S000001861] [Ensembl] Observation: RIM15 deletion results in 50% reduction of maximal chronological lifespan [11292860] and consistently decreases chronological lifespan under AL [21076178]. Rim15 is required for chronological lifespan extension caused by deficiency in RAS2, TOR1, or SCH9, as well as by 0.5% glucose restriction, but not by water starvation [18225956]. Interventions: Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Note: This reference might not be adequate: and consistently decreases chronological lifespan under AL [21076178] Edit \ Update (Admin) | Delete |
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