Denigma: Factor

XRCC5

Symbol: XRCC5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Alias: KU80; KUB2; Ku86; NFIV; KARP1; KARP-1
Entrez gene ID: 7520
Ensembl gene ID: ENSG00000079246
Species: Human (Taxid: 9606)

Function:
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Observation:

XRCC5 was found to be associated with longevity [22406557; 16518718].

Assays: Organismal Lifespan

Longevity Associated Variants:

XRCC5 120 bp 5` (GAPyA)n STR 0.0005 [16518718]

rs705649 0.029 [22406557]

Classification:

Longevity-Associated

Type:

Gene

Protein coding

References:

16518718: Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity.

22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Aging Relevance Analysis/Source: