Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity.

Authors: Wilding CS; Rees GS; Relton CL; Tawn EJ

Abstract: The comparison of genotype frequencies between neonates and elderly populations can aid in the identification of loci, and polymorphisms within those loci, that affect longevity. Here we have compared genotype frequencies of seven polymorphisms at four loci involved in DNA repair between a cohort of newborns (n = 290) and a retired population (average age at sampling 70.02 years; n = 430) who have suffered a lifetime of DNA damage from normal, metabolic processes, and on whom selection on DNA repair gene variants may be expected to have acted. No differences in genotype frequencies at the four SNP loci were seen, indicating that there is no evidence of association with longevity in this population. Significant differences in frequency of certain repeat sizes at three microsatellite loci were detected. However, since there is no known functional consequence of these repeat lengths, the action of selection cannot yet be ascribed.

Keywords: Aged; Aging/*genetics/*metabolism; Alleles; Cohort Studies; DNA Damage/genetics; DNA Repair/genetics; DNA Repair Enzymes/*genetics; Female; Gene Frequency; Genotype; Great Britain; Humans; Infant, Newborn; Longevity/*genetics/*physiology; Male; Microsatellite Repeats; Polymorphism, Genetic; Polymorphism, Single Nucleotide
Journal: Biogerontology
Volume: 7
Issue: 1
Pages: 35-41
Date: March 7, 2006
PMID: 16518718
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Citation:

Wilding CS, Rees GS, Relton CL, Tawn EJ (2006) Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity. Biogerontology 7: 35-41.


Lifespan Factors:
  • XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
  • XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
  • XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
  • XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

  • Longevity Variant Associations (p-value):
  • rs1799782 (0.658)
  • rs25487 (0.51)
  • rs861539 (0.97)
  • rs28360135 (0.29)
  • rs3220637 (0.0005)
  • XRCC3 intron 3 STR (0.0005)
  • XRCC5 120 bp 5` (GAPyA)n STR (0.0005)

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