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Symbol: TLG2 Name: T-snare affecting a Late Golgi compartment 2 Entrez gene ID: 854142 Ensembl gene ID: YOL018C Species: Yeast (Taxid: 4932) Functional description: Tlg2p; Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammal /.../ARE protein syntaxin 16 (Sx16) [Source:SGD;Acc:S000005378] [Ensembl]; Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) [SGD] Observation: Deletion of TLG2 increases mean chronological lifespan by 28 - 111% (28, 32, 37, 91, 111) in diploid cells [21447998]. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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