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Symbol: TOM1 Name: Temperature dependent Organization in Mitotic nucleus 1 Entrez gene ID: 852068 Ensembl gene ID: YDR457W Species: Yeast (Taxid: 4932) Functional description: Tom1p; E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones [Source:SGD;Acc:S000002865] [Ensembl] Observation: Replicative lifespan increased by 20%-10% in the alpha and a strains [19030232]. Deletion of TOM1 causes a mean (+30%) and maximum (+11%) replicative lifespan extension independent of RPN4 [21931558]. Assays: Mean: +30 Maximum: +11 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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