Denigma

NMD4

Symbol: NMD4
Name: Nonsense-Mediated mRNA Decay 4
Entrez gene ID: 851077
Ensembl gene ID: YLR363C
Species: Yeast (Taxid: 4932)

Functional description:
Nmd4p; Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway [Source:SGD;Acc:S000004355] [Ensembl]

Observation:

Deletion of NMD4 increases replicative lifespan [16293764]. NMD4 deletion results in replicative lifespan increase by 25% in the alpha strain and decrease by 20% in a strain [19030232].



Interventions:
  • NMD4 deletion -20 to +25%

    • Assays: Replicative Lifespan

    Classification:
  • Aging Associated
  • Gerontogene
  • Positive Gerontogene


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • NMD4 (4932)
  • KLLA0B08107g (28985)

    • Note: SGD only states the increase

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