Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
131 Arterial walls stiffen with age — López-Andrés et al. 2012 23172930 — — — — — Age-associated changes in blood vessels include the increase in inflammatory response, cell loss, inability to repair DNA damage, oncogene activation and regulation of telomere-telomerase complex [9-11]. Several age-associated structural, functional, and molecular changes occur in the arterial system. Aging is accompanied with thickening and dilatation of large arteries, extracellular matrix accumulation, calcium deposits, increased vascular stiffness, and endothelial dysfunction [12,13]. These alterations may be attributable to age-related functional changes in vascular cells [12]. Age-related arterial inflammatory phenotype includes increased expression of monocyte chemoattractant protein 1, intercellular adhesion molecule 1, matrix metalloproteinase-2 activity, or transforming growth factor-β expression [14,15]. Age-associated changes in blood vessels include a decrease in compliance, and increase in arterial stiffness and arterial wall thickening as a result of increased vascular calcifications, increased collagen content and cross-linking, and decreased elastin content [16,18]. References =========== 9. Lakatta EG. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev. 1993;73:413–467. 10. Serrano M, Blasco MA. Putting the stress on senescence. Curr Opin Cell Biol. 2001;13:748–753. 11. Wei JY. Age and the cardiovascular system. N Engl J Med. 1992;327:1735–1739. 12. Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging. Circulation. 2003;107:490–497. 13. Lakatta EG, Wang M, Najjar SS. Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels. Med Clin North Am. 2009;93:583–604, Table of Contents. 14. Spinetti G, Wang M, Monticone R, Zhang J, Zhao D, Lakatta EG. Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler Thromb Vasc Biol. 2004;24:1397–1402. 15. Wang M, Zhao D, Spinetti G, Zhang J, Jiang LQ, Pintus G, Monticone R, Lakatta EG. Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall. Arterioscler Thromb Vasc Biol. 2006;26:1503–1509. 16. Lacolley P, Labat C, Pujol A, Delcayre C, Benetos A, Safar M. Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone. Circulation. 2002;106:2848–2853. 17. López-Andrés N, Martin-Fernandez B, Rossignol P, Zannad F, Lahera V, Fortuno MA, Cachofeiro V, Díez J. A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone. Am J Physiol Heart Circ Physiol. 2011;301:H2372–H2382. 18. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol.2005;25:932–943.
130 Melatonin decreases — — 18212404 — age old young — Melatonin level decrease with age [reviewed in 18212404].
129 Accumulation of long-chain glycosphingolipids 10090 — 21687659 brain age 17 months 3 months — Measurement of sphingolipid profiles in young (3 months), middle aged (9 moths) and old (17 months) C57BL/6 mice in brain reveals a dramatic elevations in long-chain hexosylceramides (HexCer) and lactosylceramides, with C14- and C16-lactosylcermaides (LacCers) elevated as much as 8 and 12-fold, respectively. Similar changes occur in kidney and liver [21687659].
128 Accumulation of long-chain glycosphingolipids 10090 — 21687659 liver age 17 months 3 months — Measurement of sphingolipid profiles in young (3 months), middle aged (9 moths) and old (17 months) C57BL/6 mice in liver reveals a dramatic elevations in long-chain hexosylceramides (HexCer) and lactosylceramides, with C14- and C16-lactosylcermaides (LacCers) elevated as much as 8 and 12-fold, respectively. Similar changes occur in kidney and brain [21687659].
127 Accumulation of long-chain glycosphingolipids 10090 — 21687659 kidney age 17 month 3 month — Measurement of sphingolipid profiles in young (3 months), middle aged (9 moths) and old (17 months) C57BL/6 mice in kidney reveals a dramatic elevations in long-chain hexosylceramides (HexCer) and lactosylceramides, with C14- and C16-lactosylcermaides (LacCers) elevated as much as 8 and 12-fold, respectively. Similar changes occur in liver and brain. DR prevents the decline in kidney function, inhibits the accumulation of long-chain HexCer/LacCers and and also prevents the age-associated elevation of enzymes involved in their synthesis [21687659].
126 Elevated long-chain lactosylceramides 9606 — 21687659 fibroblasts age old young — Long-chain lactosylceramides (LacCers) are significantly elevated in human fibroblasts isolated from elderly individuals [21687659].
125 Insoluble ubiquitinated proteins accumulate 7227 — 18059160 neuronal age old young — Insoluble ubiquitinated proteins, markers of neuronal aging and degeneration, accumulate with aging in concomitantly with the age-dependent suppression of autopagy [18059160].
124 Reduced expression of autophagy genes 7227 — 18059160 neural age old young — The expression of several autophagy genes is reduced in neural tissues as a normal part of aging [18059160].
123 Cellular liver sterol content increases 10116 [Fusheng Tang, personal communication — liver age old young — Overall the total cellular sterol content in liver increases with age [Fusheng Tang, personal communication].
122 Lysosomal cholesterol content decreases 10116 Fusheng Tang, personal communication — liver age young old — In rat liver cells, the content of cholesterol in the lysosomal membrane decreases with age in spite of the overall increase of total cellular sterols.
121 Smaller body size 6239 — 22810224 — mutation eat-2 wild-type — eat-2 mutants are noticeable smaller than wild-type [22810224].
120 Oye2 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Oye2 levels [Herbert et al. in press].
119 Rgi1 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Rgi1 levels [Herbert et al. in press].
118 Rtc3 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Rtc3 levels [Herbert et al. in press].
117 Lys9 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Lys9 levels [Herbert et al. in press].
116 Hsp31 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Hsp31 levels [Herbert et al. in press].
115 Hsp26 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Hsp26 levels [Herbert et al. in press].
114 Fba1 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Fba1 levels [Herbert et al. in press].
113 Fba1 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Fba1 levels [Herbert et al. in press].
112 Eno1 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Eno1 levels [Herbert et al. in press].
111 Ctt1 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Ctt1 levels [Herbert et al. in press].
110 Yef3 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — Moderate DR upregulates Yef3 levels [Herbert et al. in press].
109 Sbp1 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — Moderate DR upregulates Sbp1 levels [Herbert et al. in press].
108 Rgil induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — Moderate DR upregulates Eno1 levels [Herbert et al. in press].
107 Rtc3 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — Moderate DR upregulates Rtc3 levels [Herbert et al. in press].
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