Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
74 Reduced regenerative capacity Aging in mammals is associated with reduced regenerative capacity in tissues that contain stem cells [15734685;11919569].
77 Osh6 downregulation Gebre et al., unpublished age Total cellular Osh6 levels decrease in aged cells. Osh6 in mid-aged cells is less than half of the Osh6 levels in young cells [Gebre et al., unpublished].
80 Cisd2 expression declines 22661501 age Cisd2 expression decreases with age [22661501].
95 Ceramides increase age Sphingosine-linked fatty acids like ceramides serve as "damage-associated molecular patterns" (DAMPs) are increased in aged tissue and cause inflammatory damage via activation of Nlrp3 inflammasome [Vandanmagsar et al. 2011; Youm et al. 2012].
103 Decreased stem cell activity 20504968 age Advanced age is associated with decreased stem cell activity [20504968].
130 Melatonin decreases 18212404 age old young Melatonin level decrease with age [reviewed in 18212404].
131 Arterial walls stiffen with age López-Andrés et al. 2012 23172930 Age-associated changes in blood vessels include the increase in inflammatory response, cell loss, inability to repair DNA damage, oncogene activation and regulation of telomere-telomerase complex [9-11]. Several age-associated structural, functional, and molecular changes occur in the arterial system. Aging is accompanied with thickening and dilatation of large arteries, extracellular matrix accumulation, calcium deposits, increased vascular stiffness, and endothelial dysfunction [12,13]. These alterations may be attributable to age-related functional changes in vascular cells [12]. Age-related arterial inflammatory phenotype includes increased expression of monocyte chemoattractant protein 1, intercellular adhesion molecule 1, matrix metalloproteinase-2 activity, or transforming growth factor-β expression [14,15]. Age-associated changes in blood vessels include a decrease in compliance, and increase in arterial stiffness and arterial wall thickening as a result of increased vascular calcifications, increased collagen content and cross-linking, and decreased elastin content [16,18]. References =========== 9. Lakatta EG. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev. 1993;73:413–467. 10. Serrano M, Blasco MA. Putting the stress on senescence. Curr Opin Cell Biol. 2001;13:748–753. 11. Wei JY. Age and the cardiovascular system. N Engl J Med. 1992;327:1735–1739. 12. Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging. Circulation. 2003;107:490–497. 13. Lakatta EG, Wang M, Najjar SS. Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels. Med Clin North Am. 2009;93:583–604, Table of Contents. 14. Spinetti G, Wang M, Monticone R, Zhang J, Zhao D, Lakatta EG. Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler Thromb Vasc Biol. 2004;24:1397–1402. 15. Wang M, Zhao D, Spinetti G, Zhang J, Jiang LQ, Pintus G, Monticone R, Lakatta EG. Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall. Arterioscler Thromb Vasc Biol. 2006;26:1503–1509. 16. Lacolley P, Labat C, Pujol A, Delcayre C, Benetos A, Safar M. Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone. Circulation. 2002;106:2848–2853. 17. López-Andrés N, Martin-Fernandez B, Rossignol P, Zannad F, Lahera V, Fortuno MA, Cachofeiro V, Díez J. A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone. Am J Physiol Heart Circ Physiol. 2011;301:H2372–H2382. 18. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol.2005;25:932–943.
89 Chromosomal anomalies 969 age Chromosomal anomalies (rearrangements and aneuploidies) during cell division increases with age in cultured lymphocytes and fibroblasts [30,31 in Lauri et al. 2012].
84 Cell proliferation increases 1016 11744049 Diet 24 month DR in rats enhances cell proliferation in duodenum and forestomach mucosal tissue [11744049].
1 ROS production increases 4932 Laun et al., 2001 11251834 Age young old
65 Protein expression variation increases 4932 Levy et al., 2012 age Transcripts tha become over- or under-expressed in old cells tend to result in protein levels that are more variable across cells in exponential growth [Levy et al., 2012].
66 Tsl1 abundance increases 4932 Levy et al., 2012 age Replicative age correlates with a Tsl1-abundant cell state [Levy et al., 2012].
76 OSH5 upregulation 4932 Gebre et al. unpublished age OSH5 level is up-regulated during aging by about 3-15-fold [Gebre et al. unpublished].
78 Sir2 decline 4932 21436897 age Sir2 levels exhibit an age-related decline at an age of about one thir lifespan expectancies [21436897].
79 Vacuolar membrane deteriorates 4932 18690010 age The vacuolar membrane deteriorates as judged by Vac8 localisation at or before generations 6-7. At generation 6-7, cells begin to exhibit large round vacoules and vacoules with invaginated vacoular membranes [18690010].
96 Loss of histone proteins from the genome 4932 20832724 age Normal aging is accompanied by a profound loss of histone proteins from the genome [20832724].
104 Hsp12 induction 4932 Herbert et al. in press diet DR (0.5% glucose) AL (2% glucose) Moderate DR upregulates Hsp12 levels [Herbert et al. in press].
105 Eno1 induction 4932 Herbert et al. in press diet DR (0.5% glucose) AL (2% glucose) Moderate DR upregulates Eno1 levels [Herbert et al. in press].
106 Hxk1 induction 4932 Herbert et al. in press diet DR (0.5% glucose) AL (2% glucose) Moderate DR upregulates Hxk1 levels [Herbert et al. in press].
107 Rtc3 induction 4932 Herbert et al. in press diet DR (0.5% glucose) AL (2% glucose) Moderate DR upregulates Rtc3 levels [Herbert et al. in press].
108 Rgil induction 4932 Herbert et al. in press diet DR (0.5% glucose) AL (2% glucose) Moderate DR upregulates Eno1 levels [Herbert et al. in press].
109 Sbp1 induction 4932 Herbert et al. in press diet DR (0.5% glucose) AL (2% glucose) Moderate DR upregulates Sbp1 levels [Herbert et al. in press].
110 Yef3 induction 4932 Herbert et al. in press diet DR (0.5% glucose) AL (2% glucose) Moderate DR upregulates Yef3 levels [Herbert et al. in press].
111 Ctt1 induction 4932 Herbert et al. in press diet DR (0.5% glucose) AL (2% glucose) High osmolarity upregulates Ctt1 levels [Herbert et al. in press].
112 Eno1 induction 4932 Herbert et al. in press diet DR (0.5% glucose) AL (2% glucose) High osmolarity upregulates Eno1 levels [Herbert et al. in press].
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