Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.

Authors: Arantes-Oliveira N; Apfeld J; Dillin A; Kenyon C
Year: 2002
Journal: Science (New York, N.Y.)
Abstract: The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.
Reference

Integration:

Created on Nov. 5, 2012, 5:57 p.m.
Not linked
Integrated: False

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Species: Nematode

Experiments: 0
Interventions:

daz-1 mutation

fog-1 mutation

fog-3 mutation

glp-1 mutation

mes-1 mutation

pgl-1 mutation

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