186 | Figure 5: Hac1-independent resistance to tunicamycin in afg3∆ and rpl20bΔ cells | ✘ | — | afg3;hac1 | — | — | 30.0 | — | 30.7 | 32.0 | 50.0 | 40 |
209 | Figure 4 | Calorie restriction extends lifespan by regulating vacuolar acidity. | ✔ | S288c | WT | — | — | — | — | 31.0 | 31.5 | 50.0 | 32 |
164 | Supplemental Figure 3: Growth curves and lifespan curves of respiratory dead or deficient strains | ✘ | — | idh2 | — | — | 30.0 | — | 30.7 | 31.0 | 60.0 | 595 |
175 | Supplemental Figure 4: Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves | ✘ | — | afg3 | — | — | 30.0 | — | 30.7 | 31.0 | 43.0 | — |
136 | Figure 6: Deletion of AFG3 reduces cytoplasmic translation and extends life span by a Sir2-independent, Gcn4-dependent mechanism | ✘ | — | sir2;fob1;afg3 | — | — | 30.0 | — | 29.1 | 30.0 | 45.0 | 40 |
156 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✘ | — | msn2;msn4 | — | — | 30.0 | — | 29.3 | 30.0 | 57.0 | 623 |
193 | Figure 3 | Reduced vacuolar acidity causes mitochondrial dysfunction by disrupting amino acid homeostasis. | ✔ | S288c | WT | — | — | — | — | 28.95 | 29.0 | 51.0 | 32 |
213 | Figure 4 | Calorie restriction extends lifespan by regulating vacuolar acidity. | ✔ | S288c | WT | — | — | — | — | 29.0 | 29.0 | 50.0 | 38 |
153 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✔ | — | wild-type | — | — | 30.0 | — | 28.3 | 29.0 | 46.0 | 55 |
158 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✘ | — | hac1 | — | — | 30.0 | — | 29.1 | 29.0 | 57.0 | 543 |
196 | Figure 2 | Vacuolar acidity is reduced in ageing cells and regulates mitochondrial function and lifespan. | ✔ | S288c | WT | — | — | — | — | 28.0 | 28.0 | 50.0 | 50 |
221 | Figure 3. Increased life span of cardiotrophin 1 (CT-1)–null mice. | ✔ | C57BL6 | WT | — | — | — | — | — | 28.0 | — | 18 |
170 | Supplemental Figure 4: Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves | ✘ | — | mrpl23 | — | — | 30.0 | — | 28.2 | 28.0 | 51.0 | — |
184 | Figure 5: Hac1-independent resistance to tunicamycin in afg3∆ and rpl20bΔ cells | ✘ | — | afg3 | — | — | 30.0 | — | 28.4 | 28.0 | 56.0 | 160 |
154 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✘ | — | cta1 | — | — | 30.0 | — | 29.0 | 27.0 | 54.0 | 45 |
166 | Supplemental Figure 3: Growth curves and lifespan curves of respiratory dead or deficient strains | ✘ | — | atp5 | — | — | 30.0 | — | 27.3 | 27.0 | 53.0 | 55 |
524 | Fig. 3. Animal survival and growth | ✘ | Wistar | — | Mutation | — | — | — | 41.0 | 26.0 | 58.0 | 6 |
157 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✔ | — | wild-type | — | — | 30.0 | — | 26.5 | 26.0 | 56.0 | 545 |
155 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✔ | — | wild-type | — | — | 30.0 | — | 26.2 | 26.0 | 42.0 | 600 |
185 | Figure 5: Hac1-independent resistance to tunicamycin in afg3∆ and rpl20bΔ cells | ✘ | — | hac1 | — | — | 30.0 | — | 25.6 | 26.0 | 40.0 | 20 |
161 | Supplemental Figure 3: Growth curves and lifespan curves of respiratory dead or deficient strains | ✔ | — | wild-type | — | — | 30.0 | — | 26.3 | 26.0 | 59.0 | 425 |
174 | Supplemental Figure 4: Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves | ✘ | — | rho0 | — | — | 30.0 | — | 26.1 | 26.0 | 50.0 | — |
217 | Supplementary Figure 3. Phenotypes of VPH2 overexpression mimic those observed with VMA1 overexpression. | ✔ | S288c | WT | — | — | — | — | 26.0 | 26.0 | 50.0 | 53 |
173 | Supplemental Figure 4: Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves | ✔ | — | wild-type | — | — | 30.0 | — | 26.7 | 26.0 | 57.0 | — |
163 | Supplemental Figure 3: Growth curves and lifespan curves of respiratory dead or deficient strains | ✔ | — | wild-type | — | — | 30.0 | — | 26.6 | 26.0 | 52.0 | 764 |