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Denigma
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Lifespan
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Interventions
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Mouse Lifespan Experiments
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Interventions
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Species:
+
-
Norway rat «
Manipulation:
+
-
Mutation «
Loss‑of‑Function «
Anti‑Sense Transgene (2)
name
effect
species
mean
median
maximum
Heterozygous Gh1 anti-sense transgene
Animals carrying a single copy of an anti-sense Gh1 transgene (tg/-) live on average 7-10% longer. tg/- animals are dwarfs and exhibit reduced levels of serum IGF1 [
12057928
].
Rat
+7 to +10
—
—
Homozygous Gh1 anti-sense transgene
Animals carrying two copies of a Gh1 anti-sense transgene (tg/tg) have a slighlty shorter lifespan (by 5-10%) compared to -/- animals. tg/tg animals are dwarfs and exhibit reduced levels of serum IGF1 [
12057928
].
Rat
-5 to -10
—
—
2 interventions
Interventions are an extension of
GenAge
and
GenDR
.