| spg-7 RNAi | Kockdown of spg-7 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. RNA interference of spg-7 in adulthood results in a 23% increase in mean lifespan [17411345]. | Worm | 0 to +23 | — | — |
| arf-3 RNA | RNA interference of arf-3 does not affect lifespan of wild-type but suppresses lifespan extension by isp-1 mutation [22829775]. | Worm | 0 | — | — |
| alg-1 RNAi | Adult-specific knockdown of the C. elegans argonaute-like gene 1 *alg-1* results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. | Worm | -9.6 to -16.1 | — | -13.7 |
| CG5389 RNAi | RNAi of complex V subunit CG5389 results in increased mean longevity under standard laboratory food conditions (3% yeast) in males. RNAi started from the development results in a mild lifespan increase in both sexes (3-11% in females and 3-8% in males). Post-developmental RNAi and silencing limited to neurons has variable effects with reduction in lifespan of up to 9% [19747824]. Under rich media conditions CG5389 knockdown throughout development and adulthood increases mean lifespan by 26% and abolished the lifespan extension by DR (started in the adulthood) in males. Suppression of CG5389 only during the adulthood either via RNAi by tub-GS or via oligomycin (a specific inhibitor of complex V) feeding prevents an increase in longevity under DR (started in the adulthood) in males [19968629]. | Fly | -9 to +26 | — | — |
| wnk-1 RNAi | RNA interference of wnk-1 decreases lifespan by 9% and suppresses lifespan extension by eat-2 mutation [22829775]. | Worm | -9 | — | — |
| gsa-1 RNAi | RNAi against gsa-1 decreases mean and maximum lifespan by 83-85% and 48%, respectively [18059442]. | Worm | -83-85 | — | -48 |
| mpk-1 RNAi | RNAi against F43C1.2B (encoding mpk-1) decreases mean and maximum lifespan by 8-14% and 14%, respectively [18059442]. | Worm | -8-14 | — | -8 |
| pas-3 RNAi | RNA interference of pas-3 shortens mean lifespan by 7% and suppresses lifespan extension by isp-1 mutation [22829775]. | Worm | -7 | — | — |
| gdi-1 RNAi | RNAi against gdi-1 started after the animal reaches the late L4 stage decreases mean lifespan by 6-7% [22103665]. gdi-1 RNAi decrease median lifespan by 34% in daf-2 mutants [18006689]. | Worm | -6 to -7 | — | — |
| C15H9.9 RNAi | RNAi against C15H9.9 started after the animal reaches the late L4 stage decreases mean lifespan by 6-7% [22103665]. | Worm | -6 to -7 | — | — |
| cpf-2 RNAi | RNA interference of cpf-2 decreases mean lifespan by 6% and suppresses lifespan extension by eat-2 mutation [22829775]. | Worm | -6 | — | — |
| snap-29 RNAi | RNAi against snap-29 starting in the adulthood decreases mean and maximum lifespan by 49 and 72%, respectively [23144747]. | Worm | -48.6 | — | -72.0 |
| his-46 RNAi | Knockdown of his-46 via RNAi started after the animal reached the late L4 stage decreases mean lifespan by 4% [22103665]. | Worm | -4 | — | — |
| snap-1 RNAi | snap-1 RNAi in the adulthood reduces mean and maximum lifespan by 40 and 50%, respectively [23144747]. | Worm | -39.9 | — | -50.0 |
| rab-5 RNAi | rab-5 RNAi in the adulthood reduces the lifespan by 38.0% [New longevity regulators]. | Worm | -38.0 | — | — |
| car mutation | Loss-of-function mutation in car results in reduction of mean lifespan by 34 - 63% and maximum lifespan by 28 - 29% [17435236]. | Fly | -34 to -63 | — | -28 to -29 |
| ccr-4 RNAi | RNA interference of ccr-4 decreases median lifespan by 33% in wild type animals, 37% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. | Worm | -33 | — | — |
| nhr-49 RNAi | RNA interference of nhr-49 shortens lifespan by 30-40% and alters fatty acid composition [15719061]. | Worm | -30 to -40 | — | — |
| rpt-5 RNAi | RNAi against rpt-5 started after the animal reached the late L4 stage decreases mean lifespan by 30-33% [22103665]. | Worm | -30 to -33 | — | — |
| dcp-66 RNAi | dcp-66 RNAi shortens the mean lifespan by 29% and suppresses lifespan extension by isp-1 mutation, but does not significantly affect lifespan extension neither by eat-2 nor daf-2 mutation [22829775]. | Worm | -29 | — | — |
| phi-50 RNAi | RNA interference of phi-50 decreases mean lifespan by 29% and suppresses lifespan extension by isp-1 and eat-2 mutation but does not significantly affect lifespan extension by daf-2 [22829775]. | Worm | -29 | — | — |
| rpt-1 RNAi | rpt-1 RNAi in the adulthood decreases the mean and maximum lifespan by 28 and 50%, respectively [23144747]. | Worm | -28.4 | — | -50.0 |
| pat-3 RNAi | pat-3 RNAi in the adulthood decreases mean and maximum lifespan by 28% and 50%, respectively [23144747]. | Worm | -28.1 | — | -50.0 |
| Aut1 RNAi | Aut1 depletion by RNAi form the first day of imaginal stage shortens lifespan by 28% on average in Drosophila and causes morphological behavioural features of premature aging [18219227]. | Fly | -28 | — | — |
| gei-4 RNAi | gei-4 RNAi in the adulthood reduces mean and maximum lifespan by 27 and 38% [23144747]. | Worm | -27.0 | — | -38.0 |
GenAge
GenDR
