| rps-20 RNAi | Knockdown of rps-20 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 10-24% with no affect on maximum lifespan [22103665]. | Worm | +10 to +24 | — | 0 |
| asb-1 RNAi | asb-1 RNAi in the adulthood extends the mean lifespan by 7% without changing the maximum lifespan [23144747]. | Worm | +6.4 | — | 0 |
| rpb-8 RNAi | rpb-8 RNAi in the adulthood extends the mean lifespan by 6% without any apparent effect on maximum lifespan [23144747]. | Worm | +6.4 | — | 0 |
| gpd-3 RNAi | gpd-3 RNAi in the adulthood extends the mean lifespan by 5% without a change in maximum lifespan [23144747]. | Worm | +5.3 | — | 0 |
| rsr-1 RNAi | rsr-1 RNAi in the adulthood extends the mean lifespan by 6% without an effect on maximum lifespan [23144747]. | Worm | +6.1 | — | 0 |
| aps-1 RNAi | aps-1 RNAi in the adulthood extends mean lifespan by 8% without any apparent effect on maximum lifespan [23144747]. | Worm | +7.9 | — | 0 |
| hmg-4 RNAi | hmg-4 RNAi in the adulthood extends mean lifespan by 7%, without an effect on maximum lifespan [23144747]. | Worm | +6.5 | — | 0 |
| daf-3 mutation | daf-3(mgDf90) mutation decreases mean lifespan by 0-16% and maximum lifespan by up to 9-21%. daf-3(mgDf90) decreases mean lifespan even by 19% [17900898]. Mutation of daf-3 results in a wild-type lifespan, but greatly extends the lifespan of the long-lived daf-9 mutant [11782415]. daf-3 mutations are dauer defective. | Worm | 0 to -19 | — | -9 to -21 |
| rps-0 RNAi | Knockdown of rps-0 via RNAi started after the animal reached the late L4 stage extends mean lifespan by 15-21%, but decreases maximum lifespan by 8% [22103665]. | Worm | +15 to +21 | — | -8 |
| mpk-1 RNAi | RNAi against F43C1.2B (encoding mpk-1) decreases mean and maximum lifespan by 8-14% and 14%, respectively [18059442]. | Worm | -8-14 | — | -8 |
| snap-29 RNAi | RNAi against snap-29 starting in the adulthood decreases mean and maximum lifespan by 49 and 72%, respectively [23144747]. | Worm | -48.6 | — | -72.0 |
| pash-1 mutation | pash-1 mutants have a decreased lifespan and display phenotypic and molecular signs of advantaged age earlier.
pash-1(mj100) temperature sensitive loss-of-function mutation decreases (at the permissive temperature) mean and maximum lifespan by 31 and 71%, respectively. At the restrictive temperature pash-1 mutants are slightly short-lived with a mean and maximum lifespan reduction by 13 and 54%. Lifespan of pash-1 mutants is reduced by a 24h upshift to 25 degree Celsius at the young adult stage with (36 and 78% reduction mean and maximum lifespan, respectively) [23097426].
The rescue of pash-1 expression all tissues restored almost normal lifespan. Rescue specifically in hypodermis, pharynx muscle, gut had no effect on lifespan. Rescue in body wall muscle marginal extended the lifespan, while rescue specifically in the neurons significantly restored mean but not maximum lifespan. Lifespan was also restored by combined rescue in hypodermis and muscle [23097426]. | Worm | -31 | — | -71 |
| ncbp-2 RNAi | RNAi against ncbp-2 decreases mean and maximum lifespan by 23-25% and 7%, respectively [18059442]. | Worm | -23 to -25 | — | -7 |
| daf-16 RNAi | Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016].
RNAi against daf-16 decreases lifespan of wild-type, daf-2 or glp-1 mutants [22509016; 16530050]. daf-16 RNAi completely blocks lifespan extension by daf-2 mutation, but only partially by bDR. daf-16 RNAi attenuates protection against oxidative stress by bDR. Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016]. daf-16 RNAi decreases mean lifespan by 27% [18828672].
| Worm | -27 to 50 | — | -54 |
| snap-1 RNAi | snap-1 RNAi in the adulthood reduces mean and maximum lifespan by 40 and 50%, respectively [23144747]. | Worm | -39.9 | — | -50.0 |
| pat-3 RNAi | pat-3 RNAi in the adulthood decreases mean and maximum lifespan by 28% and 50%, respectively [23144747]. | Worm | -28.1 | — | -50.0 |
| rpt-1 RNAi | rpt-1 RNAi in the adulthood decreases the mean and maximum lifespan by 28 and 50%, respectively [23144747]. | Worm | -28.4 | — | -50.0 |
| bec-1 RNAi | bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [12958363]. | Worm | -14 | — | -5 |
| gsa-1 RNAi | RNAi against gsa-1 decreases mean and maximum lifespan by 83-85% and 48%, respectively [18059442]. | Worm | -83-85 | — | -48 |
| gei-4 RNAi | gei-4 RNAi in the adulthood reduces mean and maximum lifespan by 27 and 38% [23144747]. | Worm | -27.0 | — | -38.0 |
| unc-10 mutation | Mutation in unc-10 reduces maximum lifespan 35% [17592521]. | Worm | — | — | -35 |
| hsf-1 RNAi | hsf-1 RNAi abrogates lifespan extension by daf-2(e1370) mutation, but not eat-2(ad1116) or isp-1(qm150). HSF-1, like DAF-16, is required for daf-2 mutations to extend lifespan [12750521]. RNA interference of hsf-1 suppresses normal dauer formation and life-extension due to insulin-like signaling [14668486]. hsf-1 RNAi also prevents lifespan extension by bDR. bDR significantly reduces paralysis of Q35YFP or ABeta42 transgenic animals and hsf-1 RNAi totally cancels this effect. hsf-1 RNAi attenuates lifespan extension by bDR, but only partially that of daf-2 mutation. hsf-1 RNAi attenuates protection against oxidative stress by bDR. hsf-1 expression is induced by bDR [19924292]. RNAi of hsf-1 shortens median and maximum lifespan by approximately 35%. hsf-1 RNAi animals exhibit phenotypes associated with accelerated aging (as assyed by Nomarsky microscopy) [12136014]. | Worm | — | -35 | -35 |
| Y47D3A.29 RNAi | RNAi against Y47D3A.29 decreases mean and maximum lifespan by 19-26% and 34% [18059442]. | Worm | -19-26 | — | -34 |
| pnc-1 RNAi | pnc-1 knockdown by RNAi decreases maximum lifespan by 30% [17335870]. | Worm | — | — | -30 |
| daf-16 mutation | daf-16(m26) mutation slightly, insignificantly decreases lifespan, but completely suppresses lifespan extension of daf-2(e1370) adults [8247153]. daf-16 is required for lifespan extension by mutation of daf-2 or age-1 [8247153]. Mutations in daf-16 suppressed life-extension caused by mutations in daf-2 [8247153]. Loss of function alleles of daf-16 shorten lifespan, but some alleles have lifespan equal to wild-type [8247153]. daf-16 mutation significantly reduces lifespan under AL (-20%), but does not prevent lifespan extension by sDR. In another experiment daf-16 mutation totally suppresses lifespan extension by sDR [16720740]. sDR does not stimulate DAF-16 translocation to the nucleus, but daf-16 mutation cancelled out the ability of sDR to extend lifespan and to delay the decline in locomotor activity [17900900]. DR by bacterial dilution extends lifespan of daf-16 mutants [17538612]. daf-16 mutation decreases lifespan under AL, but fails to prevent bDR to further extend lifespan [18331616]. IF-induced lifespan-extension by either 24h/48h/72h per 4 days is significantly diminished in null mutants of daf-16. All these regimens extend lifespan of daf-16 to a lesser extent than wild-type. daf-16 partially mediates IF-induced longevity [19079239]. Glucose or glycerol does not shorten lifespan of daf-16 mutants [19883616]. daf-16 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of daf-16 mutants, but to a lesser extent than that of wild-type. eat-2 mutation extends the lifespan of daf-16 mutants to the same extent than that of wild-type. Resveratrol extends lifespan of daf-16 mutants [19239417]. daf-16 RNAi completely blocks lifespan extension by daf-2 mutation, but only partially by bDR. daf-16 RNAi attenuates protection against oxidative stress by bDR. daf-16 expression is induced by bDR [19924292]. Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016]. DAF-16 reduces expression of rsks-1 and daf-15 [15253933; 22560223]. daf-16(mu86) mutation decreases mean (44%) and maximum (18%) lifespan [15905404]. daf-16(mgDf47) decreases mean (18-37%) and maximum (29%) lifespan [18828672]. daf-16 mutants are dauer defective [7219552] and completely suppress all the phenotypes of daf-2 and age-1 mutations, including lifespan extension, dauer arrest, reduced fertility, and viability defects [8247153; 7789761; 9504918; 7789761]. Mutations in daf-16 also suppress lifespan extension of animals that have a germ line ablation [10360574]. Sex-specific lifespan potential requires daf-16 [10747056].
daf-16 mutation suppresses enhanced UV resistance as well as increase longevity of daf-2, daf-23, spe-26, and clk-1 mutants. Mutation in daf-16 does not alter the reduced fertility in spe-26. daf-16 mutants are more fertile than wild-type [8807294]. | Worm | -18 to -37 | — | -29 |
GenAge
GenDR
