| NMD4 deletion | Deletion of NMD4 increases replicative lifespan [16293764]. NMD4 deletion results in replicative lifespan increase by 25% in the alpha strain and decrease by 20% in a strain [19030232]. | Yeast | -20 to +25 | — | — |
| NDI1 deletion | Deletion of NDI1 results in chronological lifespan extension [16436509]. | Yeast | — | — | — |
| MXR2 deletion | Deletion of MXR2 (alias MsrB) has no effect on replicative lifespan under normal growth conditions, but simulatonous deletion of MXR2 together with MXR1 dramatically reduces replicative lifespan by 63% [15141092]. | Yeast | — | — | — |
| MXR1 deletion | Deletion of MXR1 (alias MsrA) decreases (by 25%) the replicative lifespan [15141092]. Deletion of MXR1 decreases replicative lifespan [19049972]. MXR1 deletion decreases replicative lifespan on either glucose or lactate as carbon source [20799725]. Although deletion or overexpression of MXR2 (alias MsrB) has no effect under normal growth conditions, the simultaneous deletion of MXR1 and MXR2 reduces the lifespan by 63% [15141092]. | Yeast | -25 | — | — |
| MRL4 deletion | MRS4 deletion decreases mean replicative lifespan by 30% in the alpha strain and 40% in a strain [18340043; 19030232]. | Yeast | -30 to -40 | — | — |
| MEP3 deletion | Deletion of MEP3 extends chronological lifespan [16418483]. | Yeast | — | — | — |
| MEP2 deletion | Deletion of MEP2 extends chronological lifespan [16418483]. | Yeast | — | — | — |
| MEC1 deletion | MEC1 mutants have a 3-fold reduced mean and maximum chronological lifespan under conditions of medium depletion [17710147]. | Yeast | — | — | — |
| LIN1 deletion | Deletion of LIN1 increases replicative lifespan [16293764]. LIN1 deletion increases replicative lifespan by 40% in the alpha strain [19030232]. | Yeast | +40 | — | — |
| KSS1 deletion | Deletion of KSS1 results in increased sensitivity to heat shock and oxidative stress and a 25% reduction in median chronological lifespan [17662940]. | Yeast | — | -25 | — |
| TEC1 deletion | Absence of TEC1 causes a significant shortened chronological lifespan, but does not block chronological lifespan extension by rapamycin [21840851]. | Yeast | — | — | — |
| SIT4 deletion | SIT4 deletion slightly increases chronological lifespan and totally abolishes the lifespan shortening due to ISC1 deletion [21707788]. | Yeast | — | — | — |
| ISC1 deletion | ISC1 deletion decreases chronological lifespan [21707788; 21707788]. CTA1
overexpression partially suppresses the shortened lifespan by ISC1. Deletion of SIT4 totally rescues the short lifespan of ISC1 mutants [21707788]. HOG1 deletion partially suppresses the premature aging phenotype and short lifespan of ISC1 deletion [22445853]. | Yeast | — | — | — |
| IPT1 deletion | IPT1 deletion decreases mean replicative lifespan by 30% in the alpha strain [19030232]. | Yeast | -30 | — | — |
| INP54 deletion | INP54 deletion increases replicative lifespan by 30% in the alpha strain [19030232]. Deletion of INP54 results in an increase in replicative lifespan by 15% in the alpha strain and a decrease by 15% in the a strain [18340043]. | Yeast | -15 to +30 | — | — |
| INP51 deletion | Deletion of INP51 increases replicative lifespan by 10% in the alpha strain and in a strain [18340043; 19030232]. | Yeast | +10 | — | — |
| INM1 deletion | Deletion of INM1 increases replicative lifespan [16293764]. INM1 deletion results in a replicative lifespan increase by 50% in the alpha strain and a decrease by 10% in a strain [19030232]. | Yeast | -10 to +50 | — | — |
| IDP3 deletion | Deletion of IDP3 results in a replicative lifespan increase by 15% in the alpha strain and decrease by 20% in the a strain [18340043; 19030232]. | Yeast | -20 to +15 | — | — |
| HAT2 deletion | HAT2 deletion mutants have an by 30% extended mean replicative lifespan. A hat2 mutant or a hat1hat2 double mutant, but not a hat1 mutant, have an extended lifespan [16023114]. | Yeast | +30 | — | — |
| GLN3 deletion | Deletion of GLN3 extends chronological lifespan [16418483]. GLN3 deletion decreases replicative lifespan by 20% in the alpha strain [19030232]. GLN3 deletion in the vineyard strain dramatically shortens chronological lifespan, while extends that of the laboratory strain [21901113]. | Yeast | -20 | — | — |
| GIN4 deletion | Deletion of GIN4 decreases replicative lifespan by 35% in the alpha strain [18340043; 19030232]. | Yeast | -35 | — | — |
| GCN5 deletion | Deletion of GCN5 decreases replicative lifespan of extension of rho+ and rho0 cells as well as suppresses lifespan extension by the retrograde response [15547318]. Deletion of GCN5 strongly reduces chronological lifespan [19801973]. | Yeast | — | — | — |
| GCN2 deletion | Deletion of GCN2 decreases replicative lifespan by 10% in a strain [18340043]. GCN2 deletion decreases replicative lifespan by 10-20% in both alpha and a strains [19030232]. | Yeast | -10 to-20 | — | — |
| FBP1 deletion | Deletion of FBP1 increases survival during the first 15 days during chronologocal aging, but does not increase chronological lifespan. FBP1 deletion reduces production of reactive oxygen species [16199065]. | Yeast | — | — | — |
| CYT2 mutation | Mutation of CYT2 decreases replicative lifespan by 25% in the alpha strain [18340043; 19030232]. | Yeast | -25 | — | — |
GenAge
GenDR
