wis1 | — | Constitutive active mutation of wis1 extends chronological lifespan and there is no further beneficial effect of DR [20075862]. | Fission yeast |
sty1 | — | Deleting sty1 cancels out chronological lifespan extension and enhanced heat stress resistance by DR. Sty1 (phosphorylated) and Sty1-dependent gene transcription (atf1, gpx1, cta1, fbp1) is activated during DR in the stationary phase, but are barely activated in glucose rich medium [20075862]. | Fission yeast |
sck2 | serine/threonine protein kinase Sck2 | Deletion of sck3 increases maximum chronological lifespan by 200%. Deletion mutant accumulated less reactive oxygen species and had delayed initiation of apoptosis. Additional deletion of pka1 further extend the lifespan of sck3 mutants [16822282]. | Fission yeast |
pka1 | cAMP-dependent protein kinase 1 | pka1 knockouts exhibits a three-fold increase in chronological lifespan with up to 187% longer maximum lifespan [16822282]. Deleting ser/thr cAMP-activated protein kinase pka1 extends chronological lifespan under normal condition, but there is no additive effect with DR [20075862]. | Fission yeast |
gpa2 | Guanine nucleotide-binding protein alpha-2 subunit | gpa2 (alias git8) encodes the alpha subunit of a heterotrimeric G protein, which acts downstream of Git3. Git8 activity accelerates aging and inhibits the lifespan-extending effect of DR. Constitutive active mutation of gpa2 decreases chronological lifespan under AL (2% glucose) and almost completely cancels out the lifespan extending effect of DR (0.2% glucose) [19266076]. | Fission yeast |
git3 | — | git3 encodes a G protein-coupled receptor for glucose. git3 deletion increases chronological lifespan in conditions where glucose consumption is not affected. Constitutive activation of the G-alpha subunit acting downstream of Git3 accelerates aging and inhibits the effect of DR. The anti-aging effect of DR and git3 deletion mutation is accompanied by increased respiration and lower ROS production [19266076]. | Fission yeast |
atf1 | activating transcription factor 1 | Activation of transcription factor Atf1 by Sty1 is required for chronological lifespan extension and enhanced heat stress resistance by DR. Deleting atf1 cancels out DR-mediated chronological lifespan extension and enhanced heat stress resistance. Overexpressing atf1 is not sufficient to promote chronological lifespan extension in cells lacking sty1 [20075862]. | Fission yeast |