| sir-2.4 | yeast SIR related 2.4 | RNA interference against sir-2.4 or overexpression of SIR-2.4 do not change the mean or maximum lifespan. Neither sir-2.4 RNAi nor SIR-2.4 overexpression affects the increased lifespan of daf-2(e1370) mutants [Tishkoff et al. 2012]. | Nematode |
| asp-3 | ASpartyl Protease 3 | RNA interference against asp-3 significantly reduces lifespan of eat-2(ad1116) mutants, without any significant affect on the lifespan of wild-type. Mean and 75%ile lifespan of eat-2 mutants is reduced by 13-14% and 5-9% by asp-3 RNAi. ASP-3 is upregulated in eat-2 mutants [22810224]. | Nematode |
| acdh-12 | Acyl CoA DeHydrogenase 12 | RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. | Nematode |
| pod-2 | Polarity and Osmotic sensitivity Defect 2 | RNA interference of pod-2 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type. POD-2 is downregulated in eat-2 [22810224]. | Nematode |
| acdh-1 | Acyl CoA DeHydrogenase 1 | RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. ACDH-1 significantly upregulated in eat-2. Increased content of ACDH-1 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| pyc-1 | PYruvate Carboxylase 1 | RNA interference of pyc-1 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type. PYC-1 is downregulated in eat-2 mutants [22810224]. | Nematode |
| vit-1 | Vitellogenin-1 | vit-1 RNAi animals have a mean lifespan that 103.3% of controls, but not significant different. vit-1 is differentially expressed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| unc-80 | UNCoordinated | The unc-80(e1069) allele has no significant effect on lifespan [9789046].
unc-80 mutant displays irregular movement [4366476] | Nematode |
| unc-79 | UNCoordinated | The unc-79(e1068) allele has no significant effect on lifespan [9789046].
unc-78 mutants display irregular movement [4366476]. | Nematode |
| unc-78 | UNCoordinated 78 | Mutation in unc-78 has no effect on lifespan [9789046].
unc-78 mutants move slowly [7190524]. | Nematode |
| unc-7 | UNCoordinated | Mutation of unc-7 has no effect on lifespan [9789046].
unc-67 mutants are uncoordinated [4366476]. | Nematode |
| unc-6 | UNCoordinated 6 | Mutation in unc-6 has no effect on lifespan [9789046].
unc-6 mutants are uncoordinated [4366476]. | Nematode |
| unc-54 | UNCoordinated 54 | Mutation in unc-54 has no effect on lifespan [9789046].
unc-54 mutants are paralyzed [4366476]. | Nematode |
| unc-49 | UNCoordinated 49 | The unc-49(e382) allele has no significant effect on lifespan [9789046].
unc-49 mutants are uncoordinated [4366476]. | Nematode |
| unc-47 | UNCoordinated 47 | The unc-47(e367) allele has no significant effect on lifespan [9789046].
unc-47 mutants are uncoordinated [4366476]. | Nematode |
| unc-46 | UNCoordinated 46 | unc-46(e177) allele has no significant effect on lifespan [9789046].
unc-46 mutants are uncoordinated [4366476]. | Nematode |
| unc-30 | UNCoordinated 30 | Mutations in unc-30 have no significant effect on lifespan [9789046].
unc-30 mutants are uncoordinated [4366476]. | Nematode |
| unc-29 | UNCoordinated | Mutation in unc-29 has no effect on lifespan [9789046] and fails to extend male lifespan [10747056].
unc-29 mutants are uncoordinated [4366476]. | Nematode |
| unc-25 | UNCoordinated 25 | Mutations in unc-25 have no effect on lifespan [9789046].
unc-25 mutants are defective for foraging, locomotion, and defecation [8332190] as well as uncoordinated [4366476]. | Nematode |
| unc-24 | UNCordinated 24 | Mutations in unc-24 have no significant effect on lifespan [9789046] and unc-24(e138) fails to extend male lifespan [10747056].
unc-24 mutant is uncoordinated and displays irregular movement [4366476; 8667025]. | Nematode |
| unc-2 | UNCoordinated 2 | Loss of function in unc-2 has no effect on lifespan [9789046].
unc-2 mutant is uncoordinated [4366476] and its rate of pharyngeal pumping is reduced [8325482]. | Nematode |
| unc-15 | UNCoordinated 15 | Mutation of unc-15 has no effect on lifespan [9789046]. Some alleles of un-15 display severe paralysis [4366476; 2051482]. | Nematode |
| unc-1 | UNCoordinated 1 | Mutation in unc-1 has no effect on lifespan [9789046]. | Nematode |
| tax-2 | abnormal CHEmotaxis | Loss of function mutation in tax-2 has no effect on lifespan [10617200].
tax-2 mutants are defective in chemotaxis, thermotaxis, odorant defect and have some dye-filling defects [8893026] as well as are exhibit some defects in dauer formation [10064800]. | Nematode |
| sip-1 | Stress Induced Protein 1 | RNAi of sip-1 has no effect on wild-type adult lifespan, but slightly shortens the long lifespan of age-1(hx546) mutant animals [14668486]. | Nematode |
