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Symbol: prdx-2 Name: PeRoxireDoXin Entrez gene ID: 266858 Ensembl gene ID: F09E5.15 Species: Worm (Taxid: 6239) Functional description: Protein PRDX-2; PeRoxireDoXin family member (prdx-2) [Source:RefSeq peptide;Acc:NP_001122604] [Ensembl]; prdx-2 encodes one of two C. elegans typical 2-Cys peroxiredoxins, peroxidase enzymes that reduce hydrogen peroxide and contribute to the oxidative-stress response of multicellular organisms; loss of prdx-2 activity results in increased sensitivity to sublethal doses of hydrogen peroxide and increased resistance to heavy metals, likely via increased expression of Phase II detoxification enzymes such as GCS-1 in a SKN-1-independent manner; in addition, loss of prdx-2 results in decreased longevity and conditions that elevate levels of hyperoxidized PRDX-2 result in increased thermotolerance; PRDX-2 is expressed from early embryogenesis through postembryonic development, where it is detected in the intestine, gonad, and neurons; PRDX-2 appears to be a cytoplasmic protein, excluded from the nucleus; intestinal expression of PRDX-2 is necessary and sufficient for survival in the presence of hydrogen peroxide, but cannot rescue the heavy-metal resistance and longevity phenotypes of prdx-2 mutants. [WormBase] Observation: RNA interference resulted in decreased lifespan and earlier accumulation of lipofuscin. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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