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Symbol: atg-7 Name: AuTophaGy (yeast Atg homolog) 7 Alias: atgr-7 Entrez gene ID: 178005 Ensembl gene ID: M7.5 Species: Worm (Taxid: 6239) Functional description: Protein ATG-7; AuTophaGy (yeast Atg homolog) family member (atg-7) [Source:RefSeq peptide;Acc:NP_502064] [Ensembl]; atg-7 encodes an E1 ubiquitin-activating-like enzyme orthologous to the autophagic budding yeast protein Apg7p; ATG-7 is required for normal dauer morphogenesis and autophagy in daf-2 mutant animals; ATG-7, along with other autophagic proteins such as BEC-1 and ATG-18, protects cells from polyglutamine aggregates like those found in Huntington's disease and other neurodegenerative disorders. [WormBase] Observation: RNA interference against atg-7 shortens mean lifespan by 23% and maximum lifespan by 30% in a eat-2 mutant background but not in wild-type animals. Thus, atg7 RNAi does not affect lifespan of wild-type, but totally cancels out the lifespan extension effect of eat-2 mutation [17912023]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Note: DR-Essential Gene Edit \ Update (Admin) | Delete |
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