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Symbol: tax-2 Name: abnormal CHEmotaxis Entrez gene ID: 172723 Ensembl gene ID: F36F2.5 Species: Worm (Taxid: 6239) Functional description: Protein TAX-2; abnormal CHEmotaxis family member (tax-2) [Source:RefSeq peptide;Acc:NP_492427] [Ensembl]; tax-2 encodes a cyclic nucleotide-gated channel beta subunit orthologous to the human gene ROD PHOTORECEPTOR CNG-CHANNEL BETA SUBUNIT (CNGB1; OMIM:600724), which when mutated leads to disease; TAX-2 activity is required for chemosensation, thermosensation, regulation of dauer larval development, normal axon guidance for some sensory neurons, and regulation of axonal outgrowth and morphology in late larval stages; a tax-2::GFP promoter fusion is expressed in nine pairs of amphid sensory neurons and a TAX-2::GFP fusion protein localizes to developing axons and sensory cilia. [WormBase] Observation: Loss of function mutation in tax-2 has no effect on lifespan [10617200]. tax-2 mutants are defective in chemotaxis, thermotaxis, odorant defect and have some dye-filling defects [8893026] as well as are exhibit some defects in dauer formation [10064800]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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