Authors: Kim DJ; Yi SM; Lee SY; Kang HS; Choi YH; Song YW; Park SC
Abstract: Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity.
Keywords: Adaptor Proteins, Signal Transducing; Aged; Aged, 80 and over; Carrier Proteins/*genetics; Female; Gene Frequency; Genetic Testing/methods; Haplotypes; Humans; Longevity/*genetics; Male; Middle Aged; Nuclear Proteins/*genetics; Polymorphism, Single Nucleotide
Journal: Human genetics Volume: 119 Issue: 3 Pages: 353-4 Date: Feb. 14, 2006 PMID: 16474933 |
Kim DJ, Yi SM, Lee SY, Kang HS, Choi YH, Song YW, Park SC (2006) Association between the MLH1 gene and longevity. Human genetics 119: 353-4.
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