Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
89 Chromosomal anomalies 969 — — — age — — — Chromosomal anomalies (rearrangements and aneuploidies) during cell division increases with age in cultured lymphocytes and fibroblasts [30,31 in Lauri et al. 2012].
90 Accumulation of DNA damage 10090 — — — age — — — DNA damage accumulates with age in mouse hematopoietic stem cells [32 in Lauri et al. 2012].
91 LysoPC(18:4) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of LysoPC(18:4) decrease from 3 to 22 months [22661299].
92 SM(d18:1/12:0) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of SM(d18:1/12:0) decreasefrom 3 to 22 months [22661299].
93 Tetracosahexaenoic acid decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of Tetracosahexaenoic acid decrease from 3 to 22 months [22661299].
94 7alpha-dihydroxy-4-cholesten-4-one decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of 7alpha-dihydroxy-4-cholesten-4-one decreases from 3 to 33 months [22661299].
95 Ceramides increase — — — — age — — — Sphingosine-linked fatty acids like ceramides serve as "damage-associated molecular patterns" (DAMPs) are increased in aged tissue and cause inflammatory damage via activation of Nlrp3 inflammasome [Vandanmagsar et al. 2011; Youm et al. 2012].
96 Loss of histone proteins from the genome 4932 — 20832724 — age — — — Normal aging is accompanied by a profound loss of histone proteins from the genome [20832724].
97 Diminished cognitive skills 9606 — — — age — — — Cognitive skill such as learning and memory diminish with age [http://www.sciencedaily.com/releases/2012/06/120629211902.htm].
99 Decreased body fat 10090 — — — Diet DR AL — Body fat decreases upon DR [6608731].
102 Increased fat synthesis and oxidation 10090 — — — diet DR AL — During DR there is an increased fat synthesis and oxidation [19887594].
103 Decreased stem cell activity — — 20504968 — age — — — Advanced age is associated with decreased stem cell activity [20504968].
121 Smaller body size 6239 — 22810224 — mutation eat-2 wild-type — eat-2 mutants are noticeable smaller than wild-type [22810224].
124 Reduced expression of autophagy genes 7227 — 18059160 neural age old young — The expression of several autophagy genes is reduced in neural tissues as a normal part of aging [18059160].
125 Insoluble ubiquitinated proteins accumulate 7227 — 18059160 neuronal age old young — Insoluble ubiquitinated proteins, markers of neuronal aging and degeneration, accumulate with aging in concomitantly with the age-dependent suppression of autopagy [18059160].
126 Elevated long-chain lactosylceramides 9606 — 21687659 fibroblasts age old young — Long-chain lactosylceramides (LacCers) are significantly elevated in human fibroblasts isolated from elderly individuals [21687659].
127 Accumulation of long-chain glycosphingolipids 10090 — 21687659 kidney age 17 month 3 month — Measurement of sphingolipid profiles in young (3 months), middle aged (9 moths) and old (17 months) C57BL/6 mice in kidney reveals a dramatic elevations in long-chain hexosylceramides (HexCer) and lactosylceramides, with C14- and C16-lactosylcermaides (LacCers) elevated as much as 8 and 12-fold, respectively. Similar changes occur in liver and brain. DR prevents the decline in kidney function, inhibits the accumulation of long-chain HexCer/LacCers and and also prevents the age-associated elevation of enzymes involved in their synthesis [21687659].
128 Accumulation of long-chain glycosphingolipids 10090 — 21687659 liver age 17 months 3 months — Measurement of sphingolipid profiles in young (3 months), middle aged (9 moths) and old (17 months) C57BL/6 mice in liver reveals a dramatic elevations in long-chain hexosylceramides (HexCer) and lactosylceramides, with C14- and C16-lactosylcermaides (LacCers) elevated as much as 8 and 12-fold, respectively. Similar changes occur in kidney and brain [21687659].
129 Accumulation of long-chain glycosphingolipids 10090 — 21687659 brain age 17 months 3 months — Measurement of sphingolipid profiles in young (3 months), middle aged (9 moths) and old (17 months) C57BL/6 mice in brain reveals a dramatic elevations in long-chain hexosylceramides (HexCer) and lactosylceramides, with C14- and C16-lactosylcermaides (LacCers) elevated as much as 8 and 12-fold, respectively. Similar changes occur in kidney and liver [21687659].
130 Melatonin decreases — — 18212404 — age old young — Melatonin level decrease with age [reviewed in 18212404].
84 Cell proliferation increases 1016 11744049 — — Diet — — — 24 month DR in rats enhances cell proliferation in duodenum and forestomach mucosal tissue [11744049].
81 elt-5 expression increases 6239 17608836 17608836 — age — — — Expression of elt-5 increases with during devleopment and aging [17608836].
63 Fertility declines 9606 20041217 — whole body age — — females Female fertility declines in the mid-adulthood and reproduction ceases, followed by a long post-reproductive period [Refs in 20041217].
39 AMP/ATP increases 6239 Apfeld et al., 2004 15574588 whole body Age 4 day 18 day Hemaphrodite AMP/ATP ratio in living animals increases from <0.1 at day 4 of adulthood to 0.8 at day 18 (an age near the maximum lifespan of the population). Linear regression indicates a strong correlation between AMP/ATP ratio and life expectancy.
40 Accumulation of lipofuscin-like fluorescent pigment 6239 Apfeld et al., 2004 15574588 intestine Age 1 day 7 day Hemaphrodite A lipofuscin-like fluorescent pigment accumulates in an age-dependent manner in the intestine (Garigan et al., 2002; Herndon et al., 2002). It accumulates at a faster rate in aak-2 mutant, which have a shortened lifespan [15574588].

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