Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:
| ID | name | taxid | reference | pmid | tissue | comparision | start | stop | gender | description |
|---|---|---|---|---|---|---|---|---|---|---|
| 25 | Citrate increases | 10099 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
| 27 | Trimethylamine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
| 31 | Glycerophosphocholine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
| 34 | Scyllo-inositol increases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
| 121 | Smaller body size | 6239 | — | 22810224 | — | mutation | eat-2 | wild-type | — | eat-2 mutants are noticeable smaller than wild-type [22810224]. |
| 98 | Shift in metabolism towards increasing fatty acid syntheses and breakdown | 7227 | Katewa et al. 2012 | — | muscle | diet | DR (0.5% yeast extract) | AL (5% yeast extract) | female/male | Flies on DR shift their metabolism toward increasing fatty acid synthesis and breakdown, specifically in muscle tissues, which is required for varoius responses to DR [22768842]. |
| 100 | Increase in steady-state triglyceride content | 7227 | Katewa et al. 2012 | — | — | diet | DR (0.5% yeast extract) | AL (5% yeast extract) | female/male | Flies on DR exhibit an increase in steady-state levels of triglyceride content [22768842]. |
| 104 | Hsp12 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Hsp12 levels [Herbert et al. in press]. |
| 105 | Eno1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Eno1 levels [Herbert et al. in press]. |
| 106 | Hxk1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Hxk1 levels [Herbert et al. in press]. |
| 107 | Rtc3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Rtc3 levels [Herbert et al. in press]. |
| 108 | Rgil induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Eno1 levels [Herbert et al. in press]. |
| 109 | Sbp1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Sbp1 levels [Herbert et al. in press]. |
| 110 | Yef3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Yef3 levels [Herbert et al. in press]. |
| 111 | Ctt1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Ctt1 levels [Herbert et al. in press]. |
| 112 | Eno1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Eno1 levels [Herbert et al. in press]. |
| 113 | Fba1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Fba1 levels [Herbert et al. in press]. |
| 114 | Fba1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Fba1 levels [Herbert et al. in press]. |
| 115 | Hsp26 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Hsp26 levels [Herbert et al. in press]. |
| 116 | Hsp31 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Hsp31 levels [Herbert et al. in press]. |
| 117 | Lys9 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Lys9 levels [Herbert et al. in press]. |
| 118 | Rtc3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Rtc3 levels [Herbert et al. in press]. |
| 119 | Rgi1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Rgi1 levels [Herbert et al. in press]. |
| 120 | Oye2 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Oye2 levels [Herbert et al. in press]. |
| 55 | DHEA deline slows | 9544 | Lane et al., 199 | 9215277 | serum | diet | DR | — | males/females | DR slows postmaturational decline in serum DHEAS levels form the age of 6.5 to 9.5 [9215277]. |
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